Description : If you have ever wondered what it would be like to travel the road that a drug addict has chosen, sit back and read about the road into living hell—and back. Marty Gruber abused drugs for 45 years, and he attempted suicide immediately before he found the door of escape from drug abuse, and the key to a meaningful life. With the aid of Providence Marty found long term meaning, and in the process he has been given the privilege of warning teens about the trap of drug abuse. Research performed in 2010 shows that 48.2 percent of America’s high school seniors have tried illicit drugs. In 2011 the National Institute on Drug Abuse (NIDA) reported that drug abuse cost the United States six hundred and nine billion dollars ($609,000,000,000 is not a typo). Most drug addicts die from their addiction because becoming drug free requires help, and many never find that help. Research shows that for each dollar invested in drug abuse prevention, a savings of up to ten dollars in rehabilitation treatment can be achieved. A teenager can’t see as far down the road as a seventy-five-year-old man who has already been down that road to just short of its logical end—death. In Marty’s case, this was attempted suicide. Marty has returned to warn others not to take the road leading to drug abuse.
Description : Alphabetically arranged entries focus on issues relating to substance abuse, including date rape, fetal alcohol syndrome, and HIV/AIDS.
Description : Demonstrates that important new drugs are the results of innovative work done at taxpayer-funded universities and at the National Institutes of Health, rather than by pharmaceutical firms who reap the profit and drive up the cost of prescription drugs.
Description : Searching for Magic Bullets reveals the quest of consumers, health professionals, and drug developers to find safer and faster methods of bringing new medications to the marketplace. Authors Basara and Montagne explore the current drug development and approval processes, their strengths and weaknesses, and the mechanisms by which patients and organizations evade these processes. Readers learn about the fundamentals of traditional and nontraditional drug discovery and development as they occur in the U.S., as well as the views of consumers, patients, and health professionals. Specific case studies of non-traditional drug development and acquisition strategies are highlighted, including AIDS medications, orphan drugs, and patient importation of medications. Basara and Montagne establish the differences in both knowledge and opinions of health consumers and health professionals regarding drug development, as well as how these differences often lead to frustration, dissatisfaction, and misappropriation of resources. The authors pinpoint the need for consumers and patients to know much more about the discovery and development of medicines, and for health professionals and students to understand patients’concerns, needs and beliefs, including their reasons for considering alternative methods of drug development and acquisition. Searching for Magic Bullets is a springboard from which consumers, health professionals, and students can discuss, debate, and resolve these issues and begin to develop more capable drug development and approval systems. This groundbreaking new book enlightens health professionals about patients’views regarding medication discovery and development and informs consumers and patients about the sometimes conflicting views of health professionals. It is divided into three sections: drug development and approval in the U.S., a case study of orphan drugs, and risky and sometimes illegal ways in which consumers evade the traditional drug development and approval systems. An Overview of the Chapters: A Review of the Drug Development Process of the Pharmaceutical Industry: Presents the steps that must be taken when researching and developing a new medication. The Food and Drug Administration and the Drug Approval Process: Describes the history and scope of the FDA, the steps involved in acquiring drug approval, and the various stages of clinical testing. Orphan Drug Legislation: A review of the Orphan Drug Act of 1983 and the changes that have recently been proposed by Congress. The impact of the Act is highlighted through a description of products that have been made available since the legislation was enacted. Issues of controversy are also highlighted. Non-traditional Methods of Drug Development: The role of patients and consumers in drug development and evaluation is discussed, with an emphasis on the perceived shortcomings of the formal system. Patient Influence on Drug Development and Regulation: The influence of patient advocacy groups and consumers is discussed in relation to the development and approval of orphan drugs, the fast-tracking of specific medications, and the use of unapproved and alternative therapies. Prescription Drug Importation: Clarifies the current drug importation regulations, as well as provides specific directions for patients wishing to receive such products or learn more about FDA importation laws. The final chapter summarizes safe and rational techniques that empower consumers in their search for beneficial drug therapies. Resources and strategies for obtaining and using information are provided as a reference for readers. A glossary of terms, acronyms, and a directory of supplemental information sources strengthens the reader's understanding of the information presented. Who Benefits From This Book? Consumers and patients can use Searching for Magic Bullets as an accurate source of information about significant but often confusing medical issues. The FDA and the way medications are developed are easily misunderstood, while alternative therapies and medication sources are often believed to be the only options. Patients will learn the viewpoints of the pharmaceutical industry, the government, and their health care professionals; the rationale for various steps in the drug development process; the risks and benefits of participation in clinical trials; how to obtain the highest quality care, make informed health decisions, and reduce health care costs; and finally, how to cope with a rare disease and/or limited access to approved medications. The result is an informed, influential, and active patient. For health professionals, this book reviews the steps of drug development and approval and provides explanations for drug development decisions; drug approval time lag; and patient frustrations, misinterpretations, and expectations. It is critical for health professionals to understand the needs of patients and to determine how they can work with patients to find acceptable solutions. The literature references and medical information sources are invaluable in this regard. Pharmaceutical industry executives, product managers, clinical researchers, and sales representatives will find a concise and timely examination of the ways in which medications are discovered, developed, marketed, and used by patients. Discussions of orphan drug development, biotechnology products, and patient issues may also provide new insights into these often misunderstood areas. Pharmacy, medical, nursing, and other students will find this book a consolidated reference source and guidebook for information about the primary issues surrounding drug development and the FDA approval process. Patients’knowledge of alternative medical therapies will only increase and health care curricula must include material that helps students understand patients’perceptions of the medication development and approval systems, as well as the importance of patients in health care decisionmaking. The disadvantages of current drug development and approval systems are described with the hope that future health professionals can amend these processes and ultimately enhance patient care.
Description : The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
Description : Reports on Federal evaluations of innovative programs, such as community policing, to reduce crime and drug abuse. Provides information on approaches that are promising and worthy of wider adoption and on issues that require clarification and redirection. 11 photos.
Description : Investigator-initiated clinical research into the mechanisms underlying health and disease states, with a focus on energy requirements, body composition and obesity. A spectrum of metabolism ranging from prolonged starvation to catastrophic diabetic ketoacidosis is presented. Research was conducted at the General Clinical Research Center in Temple University Hospital. The data were collected from volunteers and analyzed between 1965-2004.
Description : This volume of the ASA Special Series contains the written version of the presentations given at the ASA 2009 Annual Conference on "The Search for "Truth" in Arbitration: Is finding the Truth what Dispute Resolution is about?" This volume explores the role and the relevance of "truth" in dispute resolution and specifically in commercial arbitration; the different notions of truth in different legal cultures; the users' view in that respect; and the consequences of these different perspectives and approaches for the practice of international arbitration. Part one provides the "philosophical" background to the subsequent discussions of some practical issues from the perspective of the users of arbitration services as well as of the providers of these services, arbitrators and counsel. Next, two practical issues that have for a long time been a hot topic in commercial arbitration practice, cross-examination and document production, are expolored from different perspectives. Finally formalism in arbitral proceedings is discussed – is formalism good or evil? It has been concluded that formal requirements should never be handled in a way that would hinder a tribunal or a court from accomplishing the main task with which it was entrusted either by the parties or by the State: applying the substantive law to the issues before them and finding a just and fair solution to the parties' dispute. The presentations published in this volume of the ASA Special Series will contribute to the discussion of the ever intriguing question "Is Finding the "Truth" what Dispute Resolution is about?"
Description : When Wade Franklin returns to his hometown of Taylor’s Crossing, Georgia, his future hangs in the balance. He is in love with his lifelong friend and college sweetheart, Pamela Palmer, but will she take him back after a two-year absence? He left without saying goodbye or giving any explanation, and now it is time to reveal his reasons for doing so. Pam is finally making a life of her own as editor of the local newspaper, the Taylor Times, and her world is shaken when Wade returns to town. An incidental meeting provides the opportunity to renew their friendship, and both are keenly aware that the bond between them is still very strong. As their relationship deepens, Wade is completely honest with Pam, and his story launches them on a path that literally changes their lives. His truthfulness about his father’s undercover assignment and unsolved murder sets the stage for a web of intrigue that reaches from Atlanta, Georgia, to New York City. Searching is a poignant story of love, faith, and the certainty of God’s provision in times of need. It presents an intricately woven tapestry of characters who struggle with the flaws of humanity—broken hearts, shattered dreams, and painful memories. From beginning to end, their lives are under the watchful eye and the guiding hand of the Lord, as he awakens their hearts to an awareness of who he is and offers love, forgiveness, and salvation to those who seek him in faith.
Description : A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspectsof molecular discovery, as well as the thought processes behind experimental approaches. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.