100 Years of Human Chorionic Gonadotropin

100 Years of Human Chorionic Gonadotropin
Author: Laurence A. Cole,Stephen A. Butler
Publsiher: Unknown
Total Pages: 358
Release: 2020-02-17
ISBN: 0128200502
Category: Medical
Language: EN, FR, DE, ES & NL

100 Years of Human Chorionic Gonadotropin Book Excerpt:

100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer

Human Gonadotropins

Human Gonadotropins
Author: Laurence A. Cole,Stephen A. Butler
Publsiher: Elsevier
Total Pages: 268
Release: 2022-07-15
ISBN: 0128226323
Category: Medical
Language: EN, FR, DE, ES & NL

Human Gonadotropins Book Excerpt:

Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice. Covers the evolution, structure, synthesis, and functions of gonadotropins in meticulous detail Includes sections on Degradation, Antibodies and Immunoassays, Commercial Products and Standards, and Receptors and Intermediaries Details a section on Reproduction and Cancer, covering gestational trophoblastic diseases, ovarian cystic disorders, and hCG and cancer

Human Chorionic Gonadotropin hCG

Human Chorionic Gonadotropin  hCG
Author: Laurence A. Cole
Publsiher: Elsevier
Total Pages: 446
Release: 2014-12-11
ISBN: 0128008210
Category: Medical
Language: EN, FR, DE, ES & NL

Human Chorionic Gonadotropin hCG Book Excerpt:

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus. It provides comprehensive information on hCG from basic science to clinical medicine The second edition will include coverage of the many new discoveries that have been made in the last five years Updated material with new findings in the field

Chorionic Gonadotropin

Chorionic Gonadotropin
Author: Sheldon J. Segal
Publsiher: Springer Science & Business Media
Total Pages: 508
Release: 2012-12-06
ISBN: 1468410628
Category: Medical
Language: EN, FR, DE, ES & NL

Chorionic Gonadotropin Book Excerpt:

This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.

Human Chorionic Gonadotropin and Gonadotropin releasing Hormone Influence Pregnancy Survival and Resynchronized Ovulation Before Timed Artificial Insemination in Holstein Cattle

Human Chorionic Gonadotropin and Gonadotropin releasing Hormone Influence Pregnancy Survival and Resynchronized Ovulation Before Timed Artificial Insemination in Holstein Cattle
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Human Chorionic Gonadotropin and Gonadotropin releasing Hormone Influence Pregnancy Survival and Resynchronized Ovulation Before Timed Artificial Insemination in Holstein Cattle Book Excerpt:

A study was performed to determine the minimum effective dose of human chorionic gonadotropin (hCG) needed to induce ovulation of follicles in cattle (Exp. 1). Another study determined the effects of replacing the first injection of GnRH (d -7) with hCG or saline in a Resynch-Ovsynch protocol [injection of GnRH 7 d before and 48 h after PGF[subscript2alpha] before a resynchronized fixed-timed AI (TAI)] on pregnancy rates in cows diagnosed not pregnant and pregnancy survival in cows diagnosed pregnant (d 0; Exp. 2). A final study determined the ovulation potential of hCG compared with GnRH and saline (Exp. 3). In Exp. 1, ovaries of Holstein cows were mapped by using transrectal ultrasonography 7 d before pregnancy diagnosis. Cows were assigned to treatments of saline, 100 [Mu]g of GnRH, or 500, 1,000, 2,000, or 3,000 IU of hCG. Ovarian structures were monitored 7 d later and proportion of cows and follicles that ovulated were recorded. In Exp. 2, cows in 4 herds were assigned to treatments of 1,000 IU of hCG, 100 [Mu]g of GnRH, or left as untreated controls 7 d before pregnancy diagnosis. Nonpregnant cows were given PGF[subscript2alpha] (d 0), then inseminated 72 h later, concurrent with a GnRH injection. Pregnancy rates tended (P = 0.08) to be increased by GnRH (17.9%; n = 703) compared with control (12.9%; n = 505), but not hCG (16.5%; n = 541). Incidences of ovulation in nonpregnant cows (Exp. 3) were: hCG (51.6%; n = 126), GnRH (46.1%; n = 102), and control (28.1%; n = 96), whereas those in pregnant cows were: hCG (59.3%; n = 59), GnRH (24.5%; n = 49), and control (6.9%; n = 58). We concluded that: 1) a minimum dose of 1,000 IU of hCG resulted in a greater ovulatory response than saline, GnRH, or 500 IU of hCG (Exp. 1); 2) initiating a Resynch-Ovsynch protocol 7 d before pregnancy diagnosis with saline reduced timed AI pregnancy rates (Exp. 2); and 3) incidence of new CL was greater after hCG than GnRH in pregnant cows, but not in nonpregnant cows (Exp. 3).

100 Years of Research

100 Years of Research
Author: Anonim
Publsiher: Unknown
Total Pages: 182
Release: 1983
ISBN: 1928374650XXX
Category: Agricultural research
Language: EN, FR, DE, ES & NL

100 Years of Research Book Excerpt:

Effect of Human Chorionic Gonadotropin hcg Post ovulation on Time to Conceptus Attachment in Lactating Dairy Cows

Effect of Human Chorionic Gonadotropin  hcg  Post ovulation on Time to Conceptus Attachment in Lactating Dairy Cows
Author: Alisson Da Mota Santos
Publsiher: Unknown
Total Pages: 118
Release: 2022
ISBN: 1928374650XXX
Category: Electronic dissertations
Language: EN, FR, DE, ES & NL

Effect of Human Chorionic Gonadotropin hcg Post ovulation on Time to Conceptus Attachment in Lactating Dairy Cows Book Excerpt:

Increasing progesterone (P4) during conceptus development is crucial for establishment of pregnancy in dairy cattle. We developed a robust technique to estimate d of conceptus attachment (CA) based on daily within-cow changes in concentrations of pregnancy-specific protein B (PSPB; BioPRYN). Highest sensitivity and specificity were obtained with a 12.5% increase in addition to 2 consecutive d of continuous increases when predicting CA. We hypothesized that increasing serum P4 post-ovulation would favor embryonic development and reduce time to CA in lactating dairy cows. The first objective was to determine the effects of treatment with hCG on d2, d5, and d2 and 5 post-ovulation on luteal function and serum P4. Treatment with hCG on d 2 & 5 or on d 5 increased P4 by inducing accessory CL (aCL) and increasing the volume of existing CL. On d 2, hCG increased P4 on d 5 post-ovulation. The second objective was to investigate the effects of treatment with hCG on time to CA. Treatment on d 5 reduced the percentage of cows with CA and increased time to CA. Primiparous cows benefited from ipsilateral aCL against pregnancy loss before d 100 post-AI/ovulation. Delayed time to CA was associated with pregnancy losses before d 35. The highest quartile of P4 on d 5, but not on d 19 & 20, was associated with reduced time to CA. Our hypothesis was not confirmed. Yet, early serum P4, but not late, was associated with time to conceptus attachment in multiparous dairy cows. Our findings indicated that treatment with hCG post-ovulation was not financially advantageous as treatment on d 5 or aCL induced by treatment reduced annual herd profits compared to standard reproductive programs such as Double-Ovsynch and Ovsynch.

The Scandinavian Journal of Clinical Laboratory Investigation

The Scandinavian Journal of Clinical   Laboratory Investigation
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1977
ISBN: 1928374650XXX
Category: Clinical medicine
Language: EN, FR, DE, ES & NL

The Scandinavian Journal of Clinical Laboratory Investigation Book Excerpt:

The Year Book of Endocrinology

The Year Book of Endocrinology
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN: 1928374650XXX
Category: Endocrinology
Language: EN, FR, DE, ES & NL

The Year Book of Endocrinology Book Excerpt:

100 Years of Science and Technology in Texas

100 Years of Science and Technology in Texas
Author: Leo J. Klosterman,Loyd S. Swenson,Sylvia Rose
Publsiher: Unknown
Total Pages: 391
Release: 1986
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

100 Years of Science and Technology in Texas Book Excerpt:

Science and technology have played an important role in shaping twentieth century Texas. During the one hundred years between 1886 and 1986 there occurred growth and change of revolutionary magnitude.

Contemporary Ob gyn

Contemporary Ob gyn
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1990
ISBN: 1928374650XXX
Category: Gynecology
Language: EN, FR, DE, ES & NL

Contemporary Ob gyn Book Excerpt:

Teratology

Teratology
Author: Anonim
Publsiher: Unknown
Total Pages: 844
Release: 1991
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Teratology Book Excerpt:

The Journal of Urology

The Journal of Urology
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1990-04
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Journal of Urology Book Excerpt:

Veterinary Forum

Veterinary Forum
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1996
ISBN: 1928374650XXX
Category: Veterinary medicine
Language: EN, FR, DE, ES & NL

Veterinary Forum Book Excerpt:

Vademecum International

Vademecum International
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1969
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Vademecum International Book Excerpt:

Excerpta Medica

Excerpta Medica
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN: 1928374650XXX
Category: Endocrine glands
Language: EN, FR, DE, ES & NL

Excerpta Medica Book Excerpt:

Laboratory Animal Science

Laboratory Animal Science
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1978
ISBN: 1928374650XXX
Category: Laboratory animals
Language: EN, FR, DE, ES & NL

Laboratory Animal Science Book Excerpt:

Year Book of Obstetrics and Gynecology 1992

Year Book of Obstetrics and Gynecology  1992
Author: Daniel R. Mishell
Publsiher: Mosby Incorporated
Total Pages: 525
Release: 1992-05
ISBN: 9780815160144
Category: Medical
Language: EN, FR, DE, ES & NL

Year Book of Obstetrics and Gynecology 1992 Book Excerpt:

Year Book of Obstetrics and Gynecology 1982

Year Book of Obstetrics and Gynecology  1982
Author: Roy M. Pitkin,Frank J. Zlatnik
Publsiher: Unknown
Total Pages: 487
Release: 1982-04
ISBN: 9780815166917
Category: Gnecology
Language: EN, FR, DE, ES & NL

Year Book of Obstetrics and Gynecology 1982 Book Excerpt:

Chronobiologia

Chronobiologia
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN: 1928374650XXX
Category: Biological rhythms
Language: EN, FR, DE, ES & NL

Chronobiologia Book Excerpt: