A Pharmacology Primer

A Pharmacology Primer
Author: Terry Kenakin
Publsiher: Academic Press
Total Pages: 488
Release: 2018-10-26
ISBN: 0128139587
Category: Medical
Language: EN, FR, DE, ES & NL

A Pharmacology Primer Book Excerpt:

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

A Pharmacology Primer

A Pharmacology Primer
Author: Terry Kenakin
Publsiher: Elsevier
Total Pages: 318
Release: 2010-07-26
ISBN: 9780080465302
Category: Medical
Language: EN, FR, DE, ES & NL

A Pharmacology Primer Book Excerpt:

The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. Over 30 new figures and tables More human interest information to provide readers with historical facts on pharmacology research New section on therapeutics to help identify diseaes and drug treatments New section on new biological concepts relevant to pharmacological research (i.e., systems biology) New study sections organized with ASPET and other international pharmacology organizations New coverage of pharmacokinetics and drug disposition

A Pharmacology Primer

A Pharmacology Primer
Author: Terry Kenakin
Publsiher: Academic Press
Total Pages: 416
Release: 2009-02-07
ISBN: 9780080923338
Category: Medical
Language: EN, FR, DE, ES & NL

A Pharmacology Primer Book Excerpt:

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer. *New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. *Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. *Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles. *Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.

The Pharmacology Primer

The Pharmacology Primer
Author: Deluca
Publsiher: Unknown
Total Pages: 135
Release: 2012-11-01
ISBN: 9780763758202
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Pharmacology Primer Book Excerpt:

Memorizing Pharmacology A Relaxed Approach

Memorizing Pharmacology  A Relaxed Approach
Author: Tony Guerra
Publsiher: Lulu.com
Total Pages: 240
Release: 2016-02-28
ISBN: 1329898443
Category: Science
Language: EN, FR, DE, ES & NL

Memorizing Pharmacology A Relaxed Approach Book Excerpt:

"As a working parent of 4yearold triplet daughters, I understand time management presents one of the greatest barriers to my pharmacology students' success. Many students feel that cold sense of overwhelm and information overload. This easytoread guide organizes pharmacology into manageable, logical steps you can fit in short pockets of time. The proven system helps you memorize medications quickly and form immediate connections. With mnemonics from students and instructors, you'll see how both sides approach learning. After you've finished the 200 Top Drugs in this book, reading pharmacology exam questions will seem like reading plain English. You'll have a new understanding of pharmacology to do better in class, clinical and your board exam. You'll feel the confidence you'd hoped for as a future health professional. For patients and caregivers, this book provides a means to memorize medications to quickly and articulately communicate with your health providers." --from the back cover.

Memorizing Pharmacology A Relaxed Approach Audiobook Script

Memorizing Pharmacology  A Relaxed Approach Audiobook Script
Author: Anthony Guerra
Publsiher: Lulu.com
Total Pages: 258
Release: 2017-07-02
ISBN: 1387051741
Category: Science
Language: EN, FR, DE, ES & NL

Memorizing Pharmacology A Relaxed Approach Audiobook Script Book Excerpt:

As a working parent of five-year-old triplet daughters, I understand time management presents one of the greatest barriers to my pharmacology students' success. Many students feel that cold sense of overwhelm and information overload. This guide organizes pharmacology into manageable, logical steps you can fit in short pockets of time. The proven system helps you memorize medications quickly and form immediate connections. With mnemonics from students and instructors, you'll see how both sides approach learning. After you've finished the 200 Top Drugs in this book, reading pharmacology exam questions will seem like reading plain English. You'll have a new understanding of pharmacology to do better in class, clinical and your board exam. You'll feel the confidence you'd hoped for as a future health professional. For patients and caregivers, this book provides a means to memorize your own medications to better communicate with your health providers.

Pharmacology

Pharmacology
Author: Miles Hacker,William S. Messer,Kenneth A. Bachmann
Publsiher: Academic Press
Total Pages: 608
Release: 2009-06-19
ISBN: 9780080919225
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacology Book Excerpt:

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Pharmacology and Treatment of Substance Abuse

Pharmacology and Treatment of Substance Abuse
Author: Lee M. Cohen,Frank L. Collins, Jr.,Alice Young,Dennis E. McChargue,Thad R. Leffingwell,Katrina L. Cook
Publsiher: Routledge
Total Pages: 704
Release: 2013-03-01
ISBN: 1135704007
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacology and Treatment of Substance Abuse Book Excerpt:

Given the prevalence of substance abuse in general clinical populations, it is important for healthcare providers to have knowledge and skill in the treatment of these problems. Evidence-Based Practice (EBP) involves the integration of the best evidence with clinical expertise and patient values. This text is designed as a bridge for practitioners that will provide up-to-date evidence reviews as well as information on how to best keep up with emerging trends in the field. The editors have gathered expert authors to provide a much needed summary of the current status of the evidence based practice for both the assessment and treatment of specific substance use disorders.

Clinical Pharmacology During Pregnancy

Clinical Pharmacology During Pregnancy
Author: Donald Mattison,Lee-Ann Halbert
Publsiher: Academic Press
Total Pages: 506
Release: 2021-09-24
ISBN: 0128189037
Category: Medical
Language: EN, FR, DE, ES & NL

Clinical Pharmacology During Pregnancy Book Excerpt:

Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations. Uses an evidence-based approach for therapeutics during pregnancy Presents a summary of specific medications by indication, including up-to-date information on dosing and efficacy in pregnancy for the given indication Includes significant new sections on physiologic changes and the ethics of pharmacological research in pregnancy

GPCR Molecular Pharmacology and Drug Targeting

GPCR Molecular Pharmacology and Drug Targeting
Author: Annette Gilchrist
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2010-12-10
ISBN: 9781118035177
Category: Medical
Language: EN, FR, DE, ES & NL

GPCR Molecular Pharmacology and Drug Targeting Book Excerpt:

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.

Practical Pharmacology for the Pharmaceutical Sciences

Practical Pharmacology for the Pharmaceutical Sciences
Author: D. Michael Salmon
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2013-12-19
ISBN: 1118696565
Category: Medical
Language: EN, FR, DE, ES & NL

Practical Pharmacology for the Pharmaceutical Sciences Book Excerpt:

Practical Pharmacology for the Pharmaceutical Sciences is a lab survival guide for those studying Pharmacology, providing hands-on advice on developing pharmacology laboratory and data handling skills. Suitable for both undergraduates and postgraduates, it focuses on laboratory techniques rather than computer-simulated data. It also guides the reader through the process of communicating experimental results in a variety of formats, including posters, oral presentations and project reports. Split into three main areas, the following topics are covered in detail: Preparation for Experimental Pharmacology Legal aspects Fundamentals of Pharmacology Definitions, calculations and statistics Experiments in Pharmacology Microtitre-based techniques using isolated cells In vitro techniques using isolated tissues and organs Biochemical techniques using cell-free systems Communicating experimental results Data presentation How to write scientific reports Pharmacological literature Supported with numerous questions throughout the text, as well as step by step instructions for practical experiments, this book presents an approach to learning pharmacology through an appreciation of authentic experimental data.

Chemokines

Chemokines
Author: Anonim
Publsiher: Academic Press
Total Pages: 654
Release: 2016-02-24
ISBN: 0128021950
Category: Medical
Language: EN, FR, DE, ES & NL

Chemokines Book Excerpt:

Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in chemokines Contains sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokine, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies

The Physiology and Pharmacology of Leucine rich Repeat GPCRs

The Physiology and Pharmacology of Leucine rich Repeat GPCRs
Author: Brian J. Arey,James A. Dias
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-08-05
ISBN: 2889199584
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Physiology and Pharmacology of Leucine rich Repeat GPCRs Book Excerpt:

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within the transmembrane domains as well as extracellular and intracellular domains. One such family of Class A receptors is characterized by multiple leucine- rich repeats within their amino- terminal domains (the Leucine-rich Repeat family (LRR)). This family of GPCRs are best represented by the glycoprotein hormone receptors (LHR, FSHR and TSHR) which have been studied extensively but also includes receptors for the peptide hormone relaxin (RXFP1 and RXFP2 (RXFP2 also binds insulin-like peptide 3)) and three other receptors (LGR4, LGR5 and LGR6). LGR4-6 were, until recently, considered orphan receptors. However, emerging data have revealed that these proteins are the receptors for a family of growth factors called R-spondins. Over the last 20 years much has been learned about LRR receptors, including the development of synthetic agonists and antagonists, new insights into signaling (including signaling bias) and the physiological role these receptors play in regulating the function of many tissues. This topic will focus on what is known concerning the regulation of these receptors, their signaling pathways, functional consequences of activation and pharmacology.

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman,Mark W. Holladay
Publsiher: Academic Press
Total Pages: 536
Release: 2014-03-29
ISBN: 0123820316
Category: Medical
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Excerpt:

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Nociceptin Orphanin FQ Peptide Receptor

The Nociceptin Orphanin FQ Peptide Receptor
Author: Mei-Chuan Ko,Girolamo Caló
Publsiher: Springer
Total Pages: 417
Release: 2019-07-13
ISBN: 3030201864
Category: Medical
Language: EN, FR, DE, ES & NL

The Nociceptin Orphanin FQ Peptide Receptor Book Excerpt:

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

Pharmacology Primer for Medications in Nuclear Medicine and Medical Imaging

Pharmacology Primer for Medications in Nuclear Medicine and Medical Imaging
Author: Geoffrey Currie
Publsiher: Unknown
Total Pages: 135
Release: 2020-11
ISBN: 9780932004970
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Pharmacology Primer for Medications in Nuclear Medicine and Medical Imaging Book Excerpt:

Pharmacology in Rehabilitation Update

Pharmacology in Rehabilitation Update
Author: Charles D. Ciccone, PT, PhD
Publsiher: F.A. Davis
Total Pages: 720
Release: 2022-01-17
ISBN: 1719645353
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacology in Rehabilitation Update Book Excerpt:

Up-to-date, must-know coverage: Bring your understanding of the rapidly evolving world of pharmacological agents and their impact on rehabilitation up to date with the Updated 5th Edition of the field’s signature reference. An easy-to-understand writing style and easy-to-follow design help you to understand the what, why, and how of this complex subject to ensure the most effective plans of care for your patients.

Using the Pharmaceutical Literature

Using the Pharmaceutical Literature
Author: Sharon Srodin
Publsiher: CRC Press
Total Pages: 344
Release: 2006-02-16
ISBN: 0849374529
Category: Medical
Language: EN, FR, DE, ES & NL

Using the Pharmaceutical Literature Book Excerpt:

Gathering information of critical importance for professionals in the pharmaceutical and medical device industries, this guide provides a comprehensive overview of key resources, such as databases, on-line directories, reports, and periodicals-providing at-a-glance guidance and collection development tools for information professionals in this field. Each chapter corresponds to a key stage or component of the drug development processin a typical pharmaceutical company and covers the types of information typically required at that particular phase.

The Handbook of Medicinal Chemistry

The Handbook of Medicinal Chemistry
Author: Andrew Davis,Simon. E. Ward
Publsiher: Royal Society of Chemistry
Total Pages: 753
Release: 2014-12-09
ISBN: 1849736251
Category: Science
Language: EN, FR, DE, ES & NL

The Handbook of Medicinal Chemistry Book Excerpt:

Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

Medication Workbook for Pharmacy Technicians A Pharmacology Primer

Medication Workbook for Pharmacy Technicians  A Pharmacology Primer
Author: David R. Bright,Mary F. Powers
Publsiher: Morton Publishing Company
Total Pages: 360
Release: 2012-01-01
ISBN: 1617310905
Category: Medical
Language: EN, FR, DE, ES & NL

Medication Workbook for Pharmacy Technicians A Pharmacology Primer Book Excerpt:

Officially endorsed by the American Pharmacists Association (APhA), this practical workbook provides a basic introduction to pharmacology and reinforces the use of medications for prospective technicians to work in a pharmacy and to help prepare them for the pharmacy technician national certification exams.