An Evidence Based Approach To The Management Of Nasopharyngeal Cancer

An Evidence-Based Approach to the Management of Nasopharyngeal Cancer: From Basic Science to Clinical Presentation and Treatment provides a comprehensive overview with updated management procedures for nasopharyngeal carcinoma. Written by experts on the subject, it is organized in a simple yet comprehensive manner to aid in the understanding of this complex condition. The book discusses several topics related to NPC, including epidemiology, pathophysiology, risk factors and treatment (surgical and non-surgical). Additionally, it discusses key features of clinical presentation of NPC, recent advances and promising new therapies. This will be a valuable source for clinicians, graduate students, oncologists and several members of the biomedical field who are interested in understanding nasopharyngeal cancer in a practical and applicable way. Discusses current trends in surgery, including the use of endoscopy and robotic and navigation technology in the management of NPC Presents a summary with diagrams and workflows at the end of every chapter as a quick reference guide Encompasses colorful figures of pathology, clinical cases, endoscopic findings, surgical approaches, resection of tumors, brachytherapy and robotic and navigation technology so readers fully comprehend content

Radiation Oncology: An Evidence-Based Approach (ROEBA) is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions on the basis of the best available scientific evidence. Ease of use is ensured by a structured, reader-friendly format that offers rapid access to evidence-based recommendations. ROEBA’s orientation is entirely practical, in that the focus is solely on diagnostic/staging and treatment issues. Detailed diagnostic and therapeutic guidelines are provided for multidisciplinary cancer management as well as radiation therapy techniques. The evidence underlying each recommendation is clearly and concisely explained, and the strength of the recommendations and evidence is systemically graded. Furthermore, diagnostic and treatment algorithms are provided for the commonly diagnosed cancers. This ground-breaking text on radiation oncology is an essential tool for physicians in their daily clinical practice.

Designed to synthesize the collective wisdom of a tumor board, the book presents a multidisciplinary, evidence-based approach to the contemporary management of head and neck cancer. Expert authors and contributors provide a balanced literature review that provides the reader with a solid understanding of the fundamental concepts of the disease entity, descriptions of anatomy, physiology, and clinical presentation, discussion of diagnostic workup and the various management techniques.Highlights: Each chapter features the clinical insights of a surgeon, a medical oncologist, and a radiation oncologist Comprehensive coverage of the most important disease sites, including the oral cavity, oropharynx, hypopharynx, larynx, thyroid gland, salivary glands, nasal cavity and paranasal sinus, nasopharynx, and skin Numerous case examples at the end of each chapter aid comprehension of each major malignancy and enable readers to match real life cases to the clinical situations described in the text Practical discussion of managing carcinoma of unknown primary site More than 140 illustrations demonstrate key concepts and surgical techniques The book is invaluable for practitioners, residents, and students in otolaryngology-head and neck surgery, radiation oncology, and medical oncology, as well as for fellows in head and neck surgical oncology and major reconstructive surgery.

Nasopharyngeal Carcinoma: From Etiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong Kong. It encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of scientist-clinician collaboration, focusing on bench-to-bedside approach. Basic science is covered, discussing genetics and genomics in NPC and its epidemiology and the role of Epstein-Barr Virus (EBV). Translational research is also covered, presenting topics such as animal models, plasma EBV DNA, molecular imaging and immunotherapy, amongst other topics. This book is a valuable source for cancer researchers, oncologists, medical oncologists and several members of the biomedical field who are interested in learning more about NPC management from both clinical and research perspectives. Written by members of the Centre for Nasopharyngeal Carcinoma Research Extensively covers various aspects of NPC, including basic science and the clinical advances of both scientists and clinicians Discusses the molecular information gained through laboratory studies to stimulate research on new treatment strategies

This reference comprehensively covers the clinical aspects of head and neck neoplasms while also highlighting the relationship that exists between inflammation and these cancers. This relationship is critical as it dictates the risks, assessment, treatment, and prognosis of head and neck cancer patients. The book starts with an introduction to the inflammation ecosystem in head and neck malignancy, followed by detailed discussions on the types of head and neck malignancy and their histological classification. The book then provides information about specialized topics relevant to the specialty of head and neck oncology. Key Features: - Comprehensive coverage of head and neck cancers with topic-based chapters - Introductory text explaining the basics of inflammation - Detailed information on the relationship between inflammation and head and neck neoplasms - Information about the classification of head and neck cancers - Methods for diagnosis and treatment - Special topics such as complications caused by HPV infections, chemoradiation, immune-targeted therapy, and inflammatory biomarkers - References for further reading The combination of basic and advanced topics makes this book an informative reference for medical students and professionals at all levels. Residents specializing in otolaryngology, oncology, and surgery as well as researchers studying inflammation will also gain an understanding of the subject in relation to oncogenesis.

“Overall, this is an excellent book on an important topic in cancer that medical oncologists, pharmacologists, and nurses, as well as related healthcare professionals, may find very helpful.” Score: 100, 5 Stars, Doody’s Medical Reviews Head and Neck Cancers: Evidence-Based Treatment presents a practical, state-of-the-art resource for any clinical oncologist treating or managing patients with head and neck cancers, including oropharyngeal cancer, cancer of the oral cavity, laryngeal cancer, nasopharyngeal cancer, hypopharyngeal cancer, cancer of the sinuses and the skull base, salivary gland cancer, and neck lymphadenopathy. Section 1 of the book covers the most pertinent details on the epidemiology, biology, diagnosis and staging of the disease including topics such as the genomic landscape of squamous cell carcinoma of the head and neck and novel imaging modalities. Section 2 discusses the evidence-based treatment modalities for conventional and novel chemotherapy regimens, the evidence behind emerging radiation therapy techniques and the minimally invasive surgical advances changing the landscape of care. The chapters in Section 3 are dedicated to site-specific management, including management guidelines, tables with FDA-approved therapies and relevant ongoing clinical trials as well as instructive clinical cases with important discussion on outcomes and follow up care. Finally, Section 4 focuses on recurrent and metastatic disease and Section 5 provides the essentials on supportive care, including managing the elderly, managing patients suffering from dysphagia and oral complications, and must-know details of quality of life assessment and patient-reported outcomes. Emphasizing the practice-changing techniques and the latest evidence-based treatment advances including targeted therapies, immunotherapy, transoral robotic surgery, and radiation therapy precision, this comprehensive yet accessible textbook is indispensable for any clinical oncologist of each discipline wanting a balanced and evidence-based reference on managing patients with head and neck malignancies. Key Features: Includes didactic clinical cases for each type of head and neck cancer Numerous tables highlight FDA approved therapies and ongoing clinical trials Provides evidence-based recommendations for treating head and neck cancers at each stage of the disease with conventional and novel treatment strategies Covers strategies for managing acute and late complications to treatment

Nasopharyngeal Cancer - Multidisciplinary Management provides a comprehensive account of the current state of knowledge on nasopharyngeal cancer and its multidisciplinary management. The first ten chapters document contain essential background information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequently, the various treatment options and combinations in a range of settings are examined in depth. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical treatment, follow-up, treatment of metastatic disease, treatment-related complications, and nasopharyngeal cancer in children. This is an important book that will prove essential reading for the radiation oncology community worldwide and meet the need for substantial improvements in knowledge of modern techniques.

Get a quick, expert overview of the many key facets of today’s otolaryngology practice with this concise, practical resource. Dr. Luke Rudmik and a leading team of experts in the field address high-interest clinical topics in this fast-changing field. Presents an evidence-based, clinical approach to leading topics in otolaryngology. Covers key topics such as management of vertigo; management of adult sensorineural hearing loss; reflux in sinusitis; balloon catheter dilation in rhinology; epistaxis; functional rhinoplasty; sublingual immunotherapy for allergic rhinitis; pediatric obstructive sleep apnea; pediatric tonsillectomy; evaluation and management of unilateral vocal fold paralysis; management of hoarseness; endoscopic skull base resection for malignancy; management of glottic cancer; management of well-differentiated thyroid cancer; and management of the clinical node-negative neck in early stage oral cavity squamous cell carcinoma. Consolidates today’s available information and experience in this challenging area into one convenient resource.

The concept of Evidence Based Medicine (EBM) has flourished in recent years and it seems that clinicians, more than ever, crave evidence from the medical literature to inform their clinical care decision making. While it is heartening that great volumes of evidence may exist, it is a daunting task to assimilate, critically review, prioritize, grade, and operationalize this crucial information. This volume of Otolaryngologic Clinics attempts to do just that. This book examines Evidence Based Practices on topics of critical importance to otolaryngologists-head and neck surgeons. The evidence has been gathered and is presented by leaders in their respective fields. Topics cover evidence-based practice of: Management of Vertigo, Management of Adult Sensory Neural Hearing Loss, Cochlear Implantation, Reflux in Sinusitus, Balloon Dilation in Otolaryngology, Postoperative Care in Endoscopic Sinus Surgery, Functional Rhinoplasty, Sublingual Immunotherapy for Allergic Rhinitis, Adult Obstructive Sleep Apnea, Pediatric Obstructive Sleep Apnea, Pediatric Tonsillectomy, Management of Vocal Cord Paralysis, Management of Hoarseness, Endoscopic Skull Base Resection for Malignancy, Management of Glottic Cancer, Management of Thyroid Cancer, and Management of N0 Neck.

This book provides up-to-date guidance that will assist radiation oncologists during the day-to-day management of nasopharyngeal cancer. After discussion of diagnosis and staging, target delineation techniques and treatment planning are described for both intensity-modulated and particle radiation therapy. Detailed information is then presented on the application of radiation therapy in different disease settings, from early stage disease to metastatic disease. Due attention is paid to the role of multimodality treatment and new and advanced technologies in particular circumstances, such as local recurrence. In addition, follow-up and the management of late toxicities are explained and management strategies are documented for special situations and groups, including pediatric patients. The book is published within the Springer series Practical Guides in Radiation Oncology. Like other volumes in the series, it is designed for hands-on use by both radiation oncology residents and practicing radiation oncologists. It will also be of value for head and neck physicians.

This evidence-based guide to the current management of cancer cases at all head and neck sites will assist in the appropriate selection and delineation of tumor volumes/fields for intensity-modulated radiation therapy (IMRT), including volumetric modulated arc therapy (VMAT). Each tumor site-related chapter presents, from the perspective of an academic expert, several actual cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, treatment delivery, and follow-up. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The book will be of value for residents, fellows, practicing radiation oncologists, and medical physicists interested in clinical radiation oncology

This quick and user-friendly guide is your ready reference for information on palliative care.

Evidence-Based Practice of Palliative Medicine is the only book that uses a practical, question-and-answer approach to address evidence-based decision making in palliative medicine. Dr. Nathan E. Goldstein and Dr. R. Sean Morrison equip you to evaluate the available evidence alongside of current practice guidelines, so you can provide optimal care for patients and families who are dealing with serious illness. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Confidently navigate clinical challenges with chapters that explore interventions, assessment techniques, treatment modalities, recommendations / guidelines, and available resources - all with a focus on patient and family-centered care. Build a context for best practices from high-quality evidence gathered by multiple leading authorities. Make informed decisions efficiently with treatment algorithms included throughout the book.

Required reading for professionals needing a contemporary overview of the wealth of research on acupuncture and moxibustion in cancer care, this survey includes opinions from key experts and is the first to examine in depth the latest scientific evidence.

The most comprehensive guide ever created for head, face, and neck (HFN) pain, this multi-author book offers the very latest research and therapeutic information on this important and hugely interdisciplinary topic. A unique professional reference, it is also easy to use as a textbook within diverse educational institutions and programs. Content adheres strictly to the latest established guidelines for pain management in the medical and dental professions.

The use of evidence-based guidelines and algorithms is widely encouraged in modern psychiatric settings, yet many practitioners find it challenging to apply and incorporate the latest evidence-based psychosocial and biological interventions. Now, practitioners have an outstanding new resource at their fingertips. How to Practice Evidence-Based Psychiatry: Basic Principles and Case Studies accomplishes two goals: it explains the methods and philosophy of evidence-based psychiatry, and it describes ways in which psychiatrists and other mental health specialists can incorporate evidence-based psychiatry into their clinical practices. Uniquely relevant to psychiatric clinicians, this is the only book on evidence-based medicine specific to the field of psychiatry that addresses integrated psychopharmacology and psychotherapies. This new book first provides an expansion on the popular text the Concise Guide to Evidence-Based Psychiatry, updating the sections on clinical trials, the teaching of evidence-based medicine, and the effective treatment of patients with complex comorbid conditions. It then allows experts from a variety of specialty areas and practice settings to describe how they incorporate the latest evidence and outcome studies into interesting and inspiring cases of their own. The book starts with the assumption that clinicians must adapt guidelines, algorithms, other sources of evidence, and the interpretation of this evidence to each individual patient. It describes basic statistical concepts in an easily understood format and offers separate chapters devoted to systematic reviews and meta-analyses, clinical practice guidelines, diagnostic tests, surveys of disease frequency, and prognosis and psychometric measurement. It also presents an easily relatable discussion of many of the major issues of evidence-based psychiatry, such as use of the "Five-Step" evidence-based medicine model. The first section can be used both as an introduction to the topic and a ready reference for researching the literature and appraising evidence. The second section includes relevant case examples of major psychiatric disorders, and the third presents case examples from diverse treatment settings. In these sections, 24 contributing clinicians from a variety of practice settings discuss situations in which they followed aspects of evidence-based care. The text includes tables and charts throughout the text, including algorithms, guidelines, and examples of simple, therapist-devised measures of progress, further enhance learning, retention, and clinical practice. How to Practice Evidence-Based Psychiatry: Basic Principles and Case Studies is a valuable new tool that will help residents, practicing psychiatrists, and other mental health workers find the most useful and relevant information to inform and improve their everyday practices.

Emergent operative technologies and surgical approaches have transformed today’s otolaryngology-head and neck surgery, and the 3rd Edition of Operative Otolaryngology brings you up to date with all that’s new in the field. You’ll find detailed, superbly illustrated guidance on all of the endoscopic, microscopic, laser, surgically-implantable, radio-surgical, neurophysiological monitoring, and MR- and CT-imaging technological advances that now define contemporary operative OHNS – all in one comprehensive, two-volume reference. Covers everything from why a procedure should be performed to the latest surgical techniques to post-operative management and outcomes – from experts in otolaryngology, plastic surgery, oral and maxillofacial surgery, neurological surgery, and ophthalmology. Features a newly streamlined, templated chapter format that makes information easier to access quickly. Combines all pediatric procedures into one comprehensive section for quick reference. Offers expanded coverage of endoscopic techniques for cranial base surgery, plus information on the latest endoscopic cancer techniques including robotic surgery, minimally invasive thyroid surgery, and new techniques for the treatment of obstructive sleep apnea including implantable nerve stimulators. Contains state-of-the-art guidance on the ear/temporal bone/skull base, including fully- and semi-implantable auditory implants, vestibular implants, imaging advances, radiosurgical treatment of posterior fossa and skull base neoplasms, intraoperative monitoring of cranial nerve and CNS function, minimally-invasive surgical approaches to the entire skull base, vertigo and postural disequilibrium, and much more.

The emphasis on cancer management in the past was based primarily on control rates from multidisciplinary input in management. There has always been a recognition that one would like to achieve the best result with the least complication, but never has there been any major emphasis on evidence-based outcome studies, nor on functional preservation and quality of life. The authors of this book have dealt very effectively with the various tumor types in head and neck cancer with the experts in the ? eld of management. The contents range from epidemiology and treatment outcome, treatment techniques with the potential impact on the quality of life such as dysphagia, to the various options relative to high technology radiation therapy programs for mana- ment. The potential for improving form and function through surgical care as an integrated part of the program is dealt with very effectively as well as the potentials for chemotherapy and the use of targeted agents have on quality of life issues. The volume also addresses toxicity, quality of life, and techniques for prevention of adverse effects, as well as the potentials for rehabilitation and supportive care. The authors have clearly done an extraordinarily good job in addressing the mul- plicity of problems that impact upon the functional preservation and quality of life in head and neck radiation therapy. Philadelphia Luther W.

​Written for residents and practitioners of otolaryngology, medical oncology, radiation oncology, and maxiollofacial surgery, this book provides the reader with a comprehensive, concise discussion of the best evidence available on which to base clinical decisions needed when managing patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. Because of its accessible and practical format, this book is considerably different than other related titles on the market. Formatted with questions at the beginning of each chapter that are then answered with evidence and best practices available for each case, each chapter addresses situations the clinician is likely to face in the diagnostic evaluation and treatment of a patient with cancer of the head and neck.​ Most clinical decisions in the management of cancers of the head and neck region are based on the results of a few controlled, randomized clinical trial trials (Evidence Level I). However, most decision-making is based on the results of case-control studies (Evidence Level II), descriptive studies, reports of expert committees, or opinions of respected authorities (Evidence Level III). This information is scattered throughout the literature and often comingled with information about other topics. Therefore, there is a need for a publication in which the evidence pertinent to making decisions regarding a particular clinical problem is distilled from the literature and presented in a single concise, clinical, situation-driven source. Cancer of the Oral Cavity, Pharynx and Larynx: Evidence-Based Decision Making is just such a resource.