Progress in Biological Chirality

Progress in Biological Chirality
Author: Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publsiher: Elsevier
Total Pages: 444
Release: 2004-12-13
ISBN: 9780080474038
Category: Science
Language: EN, FR, DE, ES & NL

Progress in Biological Chirality Book Excerpt:

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 268
Release: 2019-11-06
ISBN: 0128123389
Category: Science
Language: EN, FR, DE, ES & NL

Biological Chirality Book Excerpt:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 212
Release: 2011-07-27
ISBN: 1439840024
Category: Medical
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Excerpt:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 216
Release: 1995-09-11
ISBN: 9780849391408
Category: Medical
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Excerpt:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Advances in BioChirality

Advances in BioChirality
Author: C. Zucchi,L. Caglioti,Gyula Palyi
Publsiher: Elsevier
Total Pages: 407
Release: 1999-09-08
ISBN: 9780080526621
Category: Science
Language: EN, FR, DE, ES & NL

Advances in BioChirality Book Excerpt:

Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Organometallic Chirality

Organometallic Chirality
Author: Gyula Pályi,Luciano Caglioti
Publsiher: Mucchi Editore
Total Pages: 284
Release: 2008
ISBN: 8870004910
Category: Science
Language: EN, FR, DE, ES & NL

Organometallic Chirality Book Excerpt:

Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 350
Release: 2019-09-15
ISBN: 9780128122129
Category: Science
Language: EN, FR, DE, ES & NL

Biological Chirality Book Excerpt:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

On Chirality and the Universal Asymmetry

On Chirality and the Universal Asymmetry
Author: Georges H. Wagnière
Publsiher: John Wiley & Sons
Total Pages: 256
Release: 2008-09-26
ISBN: 3906390608
Category: Science
Language: EN, FR, DE, ES & NL

On Chirality and the Universal Asymmetry Book Excerpt:

Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.

Encyclopedia of Biocolloid and Biointerface Science 2 Volume Set

Encyclopedia of Biocolloid and Biointerface Science  2 Volume Set
Author: Hiroyuki Ohshima
Publsiher: John Wiley & Sons
Total Pages: 1188
Release: 2016-09-26
ISBN: 1118542762
Category: Science
Language: EN, FR, DE, ES & NL

Encyclopedia of Biocolloid and Biointerface Science 2 Volume Set Book Excerpt:

This encyclopedia uniquely concentrates on biocolloids and biointerfaces rather than the broader field of colloid and interface science. Biocolloids and biointerfaces are the youngest but increasingly prominent studied area of colloid and interface science, and this encyclopedia uses "soft particles" and "soft interface" as surface models in observing phenomena in biological systems. Provides a detailed description of the fundamental theories, dealing with the physicochemical and theoretical aspects of biocolloid and biointerface science Offers a detailed description of soft interfaces or surfaces Includes detailed description of applications of fundamental biocolloid and biointerface theories to nano-, bio, and environmental sciences A useful and timely resource for researchers and graduates in the field of biocolloid and biointerface science, as well as engineers in the field of nanotechnology, bioscience, and environmental science.

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN: 9781118075630
Category: Science
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Excerpt:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Chiral Nanoprobes for Biological Applications

Chiral Nanoprobes for Biological Applications
Author: Chuanlai Xu
Publsiher: John Wiley & Sons
Total Pages: 308
Release: 2022-05-16
ISBN: 3527349421
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Chiral Nanoprobes for Biological Applications Book Excerpt:

A comprehensive overview exploring the biological applications of chiral nanomaterials Chirality has been the centerpiece of many multidisciplinary fields within the broader umbrella of the sciences. Recent advancements in nanoscience have spurred a growing interest in the dynamic field of chiral nanomaterials. In particular, the recent breakthroughs in chiral nanocrystals have presented an intriguing avenue whose potential application may address some key issues at the heart of nanosciences. While little attention has been focused on the biological implications of such advances, this arena is attracting theoretical and applicative interests. Seeking to provide a thorough introduction to the field as well as fill this gap in scholarship, Chiral Nanoprobes for Biological Applications first provides a comprehensive review of the state-of-the-art development of strong chiroptical nanomaterials, describing how a synthesis and self-assembly approach can enable one to design and create a number of functional chiral nanomaterials. From there, the authors discuss the biological applications of chiral nanomaterials, such as extracellular bioanalysis, intracellular bioanalysis, and chiral recognition, as well as photothermal and photodynamics therapy. In doing so, the book seeks emphasize the potential in multidisciplinary approaches to this up-and-coming field. Chiral Nanoprobes for Biological Applications readers will also find: A particular emphasis on milestones achieved for key chiral nanoprobes research from the last five years A discussion of future research directions A helpful guide for new researchers and established professionals alike Chiral Nanoprobes for Biological Applications is a useful reference for materials scientists, biochemists, protein chemists, stereo chemists, polymer chemists, and physical chemists. It is also a useful tool for libraries.

Chirality and Biological Activity

Chirality and Biological Activity
Author: Hartmut Frank,Bo Holmstedt,Bernard Testa
Publsiher: Wiley-Liss
Total Pages: 312
Release: 1990
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity Book Excerpt:

Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Amplification of Chirality

Amplification of Chirality
Author: Kenso Soai
Publsiher: Springer Science & Business Media
Total Pages: 205
Release: 2009-11-04
ISBN: 3540778691
Category: Science
Language: EN, FR, DE, ES & NL

Amplification of Chirality Book Excerpt:

Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.

Asymmetry in Biological Homochirality

Asymmetry in Biological Homochirality
Author: David Hochberg
Publsiher: MDPI
Total Pages: 102
Release: 2021-06-04
ISBN: 3036504427
Category: Science
Language: EN, FR, DE, ES & NL

Asymmetry in Biological Homochirality Book Excerpt:

Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

Biochirality

Biochirality
Author: Pedro Cintas
Publsiher: Springer
Total Pages: 316
Release: 2014-07-08
ISBN: 3642376266
Category: Science
Language: EN, FR, DE, ES & NL

Biochirality Book Excerpt:

Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

Current Topics in Chirality

Current Topics in Chirality
Author: Takashiro Akitsu
Publsiher: BoD – Books on Demand
Total Pages: 198
Release: 2021-09-01
ISBN: 1839689536
Category: Science
Language: EN, FR, DE, ES & NL

Current Topics in Chirality Book Excerpt:

Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Chiral Nanoprobes for Biological Applications

Chiral Nanoprobes for Biological Applications
Author: Chuanlai Xu
Publsiher: John Wiley & Sons
Total Pages: 304
Release: 2022-05-04
ISBN: 3527833595
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Chiral Nanoprobes for Biological Applications Book Excerpt:

A comprehensive overview exploring the biological applications of chiral nanomaterials Chirality has been the centerpiece of many multidisciplinary fields within the broader umbrella of the sciences. Recent advancements in nanoscience have spurred a growing interest in the dynamic field of chiral nanomaterials. In particular, the recent breakthroughs in chiral nanocrystals have presented an intriguing avenue whose potential application may address some key issues at the heart of nanosciences. While little attention has been focused on the biological implications of such advances, this arena is attracting theoretical and applicative interests. Seeking to provide a thorough introduction to the field as well as fill this gap in scholarship, Chiral Nanoprobes for Biological Applications first provides a comprehensive review of the state-of-the-art development of strong chiroptical nanomaterials, describing how a synthesis and self-assembly approach can enable one to design and create a number of functional chiral nanomaterials. From there, the authors discuss the biological applications of chiral nanomaterials, such as extracellular bioanalysis, intracellular bioanalysis, and chiral recognition, as well as photothermal and photodynamics therapy. In doing so, the book seeks emphasize the potential in multidisciplinary approaches to this up-and-coming field. Chiral Nanoprobes for Biological Applications readers will also find: A particular emphasis on milestones achieved for key chiral nanoprobes research from the last five years A discussion of future research directions A helpful guide for new researchers and established professionals alike Chiral Nanoprobes for Biological Applications is a useful reference for materials scientists, biochemists, protein chemists, stereo chemists, polymer chemists, and physical chemists. It is also a useful tool for libraries.

Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures

Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures
Author: Ron Naaman,David N Beratan,David Waldeck
Publsiher: Springer
Total Pages: 312
Release: 2011-02-15
ISBN: 364218104X
Category: Science
Language: EN, FR, DE, ES & NL

Electronic and Magnetic Properties of Chiral Molecules and Supramolecular Architectures Book Excerpt:

Time-dependent density functional response theory for electronic chiroptical properties of chiral molecules; by Jochen Autschbach, Lucia Nitsch–Velasquez, and Mark Rudolph * Chiroptical Properties of Charge-Transfer Compounds; by Yoshihisa Inoue, Tadashi Mori * G-C content independent long-range charge transfer through DNA; by Tetsuro Majima * Induced chirality in porphiryn aggregates: the role of weak and strong interactions; by Roberto Purrello * Vibrational circular dichroism spectroscopy of chiral molecules in solution; by Yunjie Xu * Magneto-electric properties of self-assembled monolayers of chiral molecules; by Zeev Vager and Ron Naaman * Theory of adsorption induced chirality and electron transfer through chiral systems; by Spiros Skourtis and David Beratan * Chiral-selective surface chemistry induced by spin-polarized secondary electrons; by Richard Rosenberg

What you need to know about Chiral Drugs Nomenclature Pharmacology Mechanisms Metabolism Toxicology etc An Overview

   What you need to know about Chiral Drugs  Nomenclature  Pharmacology  Mechanisms  Metabolism  Toxicology etc  An Overview
Author: DR. HAKIM SABOOWALA
Publsiher: Dr.Hakim Saboowala
Total Pages: 73
Release: 2019-08-14
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

What you need to know about Chiral Drugs Nomenclature Pharmacology Mechanisms Metabolism Toxicology etc An Overview Book Excerpt:

Approximately more than half of the drugs recently/currently in use are chiral compounds and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. Although they have the same chemical structure, most isomers of chiral drugs exhibit marked differences in biological activities such as: · Pharmacology, · Toxicology, · Pharmacokinetics, · Metabolism etc. Therefore, it is important to promote the chiral separation and analysis of racemic drugs in pharmaceutical industry as well as in clinic in order to eliminate the unwanted isomer from the preparation and to find an optimal treatment and a right therapeutic control for the patient. An attempt has been made to review the nomenclature, pharmacology, toxicology, pharmacokinetics, metabolism etc. of some usual chiral drugs as well as their mechanisms of these properties. Additionally, different techniques used for the chiral separation in pharmaceutical industry as well as in clinical analyses have also been considered. …….Dr.H.K.Saboowala.M.B.(Bom) M.R.S.H.(London)

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems

Studies of Chirality  Supramolecular Structure  Order and Reactivity in and from Biological Systems
Author: Jie Song
Publsiher: Unknown
Total Pages: 332
Release: 1999
ISBN: 1928374650XXX
Category: Electronic dissertations
Language: EN, FR, DE, ES & NL

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems Book Excerpt: