Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Svetlana Dambinova,Ronald L Hayes,Kevin K.W. Wang
Publsiher: Royal Society of Chemistry
Total Pages: 246
Release: 2012-05-24
ISBN: 1849734747
Category: Science
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Excerpt:

Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students.

On Biomarkers in Traumatic Brain Injury

On Biomarkers in Traumatic Brain Injury
Author: Anonim
Publsiher: Unknown
Total Pages: 96
Release: 2015
ISBN: 9789175498645
Category: Electronic Book
Language: EN, FR, DE, ES & NL

On Biomarkers in Traumatic Brain Injury Book Excerpt:

Biomarkers of Traumatic Brain Injury with a Focus on Blast Injury

Biomarkers of Traumatic Brain Injury with a Focus on Blast Injury
Author: Stuart Edward Harrisson,University of Newcastle upon Tyne. Institute of Cellular Medicine
Publsiher: Unknown
Total Pages: 195
Release: 2014
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Biomarkers of Traumatic Brain Injury with a Focus on Blast Injury Book Excerpt:

Blood Biomarkers for Traumatic Brain Injury

Blood Biomarkers for Traumatic Brain Injury
Author: Anonim
Publsiher: Unknown
Total Pages: 70
Release: 2015
ISBN: 9789162896706
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Blood Biomarkers for Traumatic Brain Injury Book Excerpt:

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders
Author: Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 650
Release: 2014-10-28
ISBN: 1482239825
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers of Brain Injury and Neurological Disorders Book Excerpt:

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Biomarkers of Brain Damage A Complex Challenge with Great Potential

Biomarkers of Brain Damage     A Complex Challenge with Great Potential
Author: Olli Tenovuo,Jean-charles Sanchez,Damir Janigro,Johan Undén
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-05-10
ISBN: 2889667545
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers of Brain Damage A Complex Challenge with Great Potential Book Excerpt:

Olli Tenovuo is consultant and member of SAB for NeuroTrauma Sciences LLC (Georgia, USA) and ABCDx SA (Geneva, Switzerland). Jean-Charles Sanchez has a research grant to disclose from ABCDx SA, (Geneva, Switzerland). Damir Janigro is the CEO of FloTBI Inc. (Cleveland, USA), a company interested in biomarkers of neurological diseases.

Biomarkers of Brain Injury in Children Potential Uses and Limitations

Biomarkers of Brain Injury in Children Potential Uses and Limitations
Author: Jirí Zurek
Publsiher: LAP Lambert Academic Publishing
Total Pages: 120
Release: 2011-02
ISBN: 9783844311808
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Biomarkers of Brain Injury in Children Potential Uses and Limitations Book Excerpt:

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Clinical examination has limited ability to assess injury severity or predict outcome. The identification of pathology- specific biomarkers can assist in the diagnosis and estimation of prognosis, and can serve as surrogate markers for monitoring the effectiveness of a treatment. Most of these biomarkers are mediators of responses to injury and subsequent cell damage or cell death. For patients with severe TBI, a biomarker may be helpful to predict which patients are likely to experience secondary insults and help prognosticate. The aims of this study were the correlations amongs biomarkers of brain injury in children with severity of brain injury, mortality and prediction of the final outcome.

Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Alan H.B. Wu,W. Frank Peacock
Publsiher: Academic Press
Total Pages: 486
Release: 2020-07-10
ISBN: 0128167300
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Excerpt:

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities. Offers strategies for the selection and implementation of traumatic brain injury biomarkers Discusses the importance of autoantibodies and post translational modifications for TBI Covers the analytical tools needed to implement TBI biomarkers, including the specifications for testing instruments and interpretative software

Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers

Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers
Author: Firas Kobeissy
Publsiher: LAP Lambert Academic Publishing
Total Pages: 152
Release: 2014-09-30
ISBN: 9783659614941
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Neuroproteomics of Drug Abuse and Traumatic Brain Injury Biomarkers Book Excerpt:

Brain injury can exist in different forms; such conditions occur after mechanical trauma, such as traumatic brain injury (TBI) or after exposure to a number of recreational drugs such as MDMA, methamphetamine, or cocaine. Recent findings have provided some preliminary data showing that brain injury and drug abuse insults may share common pathway(s)leading to neuronal cell injury. Such pathways may be mediated by the activation of the protease families: the pronecrotic calpain and the proapoptotic caspase systems. These proteases can act on a number of substrates including the cytoskeletal proteins resulting in the breakdown products of such proteins can be used as biomarkers for brain injury insult (mechanical and chemical). The field of proteomics has been introduced as a new discipline for biomarker identification that allows for deciphering protein expression at very low concentrations. Having this in mind, neuroproteomics approach has been applied to identify the differential alterations of protein markers involved in two models of experimental traumatic brain injury as well as in drug abuse which showed high similarity in the underlying mechanisms leading to neuronal injury.

Clinical Features Biomechanics and Advanced Biomarkers Across the Spectrum of Traumatic Brain Injury

Clinical Features  Biomechanics and Advanced Biomarkers Across the Spectrum of Traumatic Brain Injury
Author: Karl Augustinus Zimmerman
Publsiher: Unknown
Total Pages: 135
Release: 2021
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Clinical Features Biomechanics and Advanced Biomarkers Across the Spectrum of Traumatic Brain Injury Book Excerpt:

Imaging Biomarkers in the Hyper acute Phase Following Traumatic Brain Injury

Imaging Biomarkers in the Hyper acute Phase Following Traumatic Brain Injury
Author: Tim Lawrence
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Imaging Biomarkers in the Hyper acute Phase Following Traumatic Brain Injury Book Excerpt:

Neurotrauma

Neurotrauma
Author: Kevin Wang
Publsiher: Oxford University Press, USA
Total Pages: 528
Release: 2018-12-05
ISBN: 0190279435
Category: Medical
Language: EN, FR, DE, ES & NL

Neurotrauma Book Excerpt:

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Towards translating research to clinical practice Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury

Towards translating research to clinical practice  Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury
Author: Stefania Mondello, Ronald L Hayes,András Büki, Frank C Tortella, Kevin K W Wang
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2015-02-25
ISBN: 2889193918
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Towards translating research to clinical practice Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury Book Excerpt:

Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines.

MRI Data Harmonization for Multi center Comparison of Quantitative Biomarkers in Traumatic Brain Injury

MRI Data Harmonization for Multi center Comparison of Quantitative Biomarkers in Traumatic Brain Injury
Author: Charlotte Timmermans
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

MRI Data Harmonization for Multi center Comparison of Quantitative Biomarkers in Traumatic Brain Injury Book Excerpt:

Neurotrauma

Neurotrauma
Author: Kevin Wang
Publsiher: Oxford University Press
Total Pages: 624
Release: 2018-11-07
ISBN: 0190279443
Category: Medical
Language: EN, FR, DE, ES & NL

Neurotrauma Book Excerpt:

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Traumatic Brain Injury

Traumatic Brain Injury
Author: Anada Raj Poovindran
Publsiher: Unknown
Total Pages: 364
Release: 2015
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Excerpt:

Biomarkers in Trauma Injury and Critical Care

Biomarkers in Trauma  Injury and Critical Care
Author: Rajkumar Rajendram,Victor R. Preedy,Vinood B. Patel
Publsiher: Springer
Total Pages: 135
Release: 2024-11-10
ISBN: 9783031073946
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Trauma Injury and Critical Care Book Excerpt:

This handbook systematically presents biomarkers of traumatic injuries To name a few, traumatic brain injury, liver injury, burn severity, muscle heart damage and acute inflammation in polytrauma and their biomarker detection are discussed. Biomarkers and the method used in Critical Care and Critically III Patients are depicted and so are Biomarkers in Trauma and in special conditions. Special biomarker components are elucidated and models for modelling Trauma in research are shown. This systematic handbook provides an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and medical doctors that wish to gain a thorough overview on diverse injuries, trauma and their methods of detection.

Development of a Traumatic Brain Injury Assessment Score Using Novel Biomarkers Discovered Through Autoimmune Profiling

Development of a Traumatic Brain Injury Assessment Score Using Novel Biomarkers Discovered Through Autoimmune Profiling
Author: John E. Buonora
Publsiher: Unknown
Total Pages: 130
Release: 2013
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Development of a Traumatic Brain Injury Assessment Score Using Novel Biomarkers Discovered Through Autoimmune Profiling Book Excerpt:

Utility of Serum Biomarkers in the Diagnosis and Stratification of Mild Traumatic Brain Injury

Utility of Serum Biomarkers in the Diagnosis and Stratification of Mild Traumatic Brain Injury
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Utility of Serum Biomarkers in the Diagnosis and Stratification of Mild Traumatic Brain Injury Book Excerpt:

Traumatic Brain Injury

Traumatic Brain Injury
Author: Yongxia Zhou
Publsiher: BoD – Books on Demand
Total Pages: 166
Release: 2019-09-11
ISBN: 1789842956
Category: Medical
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Excerpt:

Traumatic brain injury (TBI) is a significant public health problem. There are several advanced techniques available for the investigation of disease neurobiology, diagnosis, and treatment. This book covers many topics in the active TBI research field such as cumulative mild head injury review, brain changes, and risk factors, as well as post-concussion syndrome (PCS) definition, classification, and association with brain dysfunction. Brain changes, including blood flow, intracranial pressure, and neuroinflammation, the neurobiological basis of neuroprotective activation, as well as correlation with PCS, including sleep, are illustrated further. Furthermore, multiple biomarkers, including S-100?, UCH-L1, and GFAP for blood-brain barrier breakdown and neuronal injury, are reviewed thoroughly. Lastly, well-evaluated neuroprotective agents, hypothermia as a neuroprotective effect in TBI, and effects investigation, as well as sedation in TBI as a neurocritical and therapeutic strategy with different assessments, are reported. This book introduces readers to a number of perspectives, including TBI disease pathophysiology and post-concussion syndrome classification, associated brain changes, imaging diagnosis, and several useful biomarkers with high sensitivities, as well as multiple therapeutic strategies. Various advanced technical developments, upfront neuroimaging, and clinical data are presented together with comprehensive, up-to-date, and interesting examples. Detailed reviews and accurate illustrations together with objective and informative discussions of several challenging problems such as PCS and neuroprotective treatments are the advantages of this book. Finally, this book will hopefully convey the clinical aspects of TBI and help guide diagnosis and therapeutic research in this field.