Biomarkers in Bipolar Disorders

Biomarkers in Bipolar Disorders
Author: Rodrigo Machado-Vieira,Jair Soares
Publsiher: Academic Press
Total Pages: 528
Release: 2022-01-16
ISBN: 012821399X
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Bipolar Disorders Book Excerpt:

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder. Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder Presents techniques and main findings in transcriptome research related to CNS synaptic function Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder Discusses current genetic findings, integrating tests for treatments leading to personalized treatments

Genetic Mechanisms of Biomarkers in Schizophrenia Bipolar Disorder and Depression

Genetic Mechanisms of Biomarkers in Schizophrenia  Bipolar Disorder and Depression
Author: Hongsheng Gui,Shaohua Hu,Qiang Wang,Xiancang Ma,Sarah Tarbox-Berry
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-01
ISBN: 2889714381
Category: Medical
Language: EN, FR, DE, ES & NL

Genetic Mechanisms of Biomarkers in Schizophrenia Bipolar Disorder and Depression Book Excerpt:

Advances in Treatment of Bipolar Disorders

Advances in Treatment of Bipolar Disorders
Author: Edited by Terence A. Ketter M.D.
Publsiher: American Psychiatric Pub
Total Pages: 338
Release: 2015-04-09
ISBN: 1585624179
Category: Medical
Language: EN, FR, DE, ES & NL

Advances in Treatment of Bipolar Disorders Book Excerpt:

Advances in Treatment of Bipolar Disorders provides clinicians with a well-written and timely guide to the most recent advances in the treatment of patients with this complex disorder. Staying abreast of new research developments and treatment options presents a daunting challenge, but the editor and coauthors have compiled the most important evidence-based findings from controlled studies and U.S. Food and Drug Administration approved indications, facilitating integration of these findings into clinical practice. This volume strives to provide clinicians with the necessary information to enable them to balance the likelihood of benefit (using “number needed to treat” analyses) versus harm (using “number needed to harm” analyses) in order to provide individualized, state-of-the-art, evidence-based care. The most current research findings are complemented by the authors’ extensive personal clinical experiences, resulting in a volume that reflects the most up-to-date thinking about the diagnosis and management of bipolar disorder. Advances in Treatment of Bipolar Disorders belongs in every mental health clinician’s library.

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder
Author: Joao Luciano de Quevedo,Andre Ferrer Carvalho,Eduard Vieta
Publsiher: Academic Press
Total Pages: 470
Release: 2020-11-25
ISBN: 012819183X
Category: Medical
Language: EN, FR, DE, ES & NL

Neurobiology of Bipolar Disorder Book Excerpt:

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders
Author: Paul C. Guest
Publsiher: Springer
Total Pages: 328
Release: 2019-02-12
ISBN: 3030055426
Category: Science
Language: EN, FR, DE, ES & NL

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders Book Excerpt:

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Biomarkers in Psychiatry

Biomarkers in Psychiatry
Author: Judith Pratt,Jeremy Hall
Publsiher: Springer
Total Pages: 437
Release: 2019-01-05
ISBN: 3319996428
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Psychiatry Book Excerpt:

This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

The Handbook of Neuropsychiatric Biomarkers  Endophenotypes and Genes
Author: Michael S. Ritsner
Publsiher: Springer Science & Business Media
Total Pages: 243
Release: 2009-04-21
ISBN: 1402098316
Category: Medical
Language: EN, FR, DE, ES & NL

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes Book Excerpt:

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

The Handbook of Neuropsychiatric Biomarkers  Endophenotypes and Genes
Author: Michael Ritsner
Publsiher: Springer Science & Business Media
Total Pages: 273
Release: 2009-04-21
ISBN: 1402094647
Category: Medical
Language: EN, FR, DE, ES & NL

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes Book Excerpt:

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Bipolar Disorders New Insights for the Healthcare Professional 2012 Edition

Bipolar Disorders  New Insights for the Healthcare Professional  2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 182
Release: 2012-12-10
ISBN: 146497103X
Category: Psychology
Language: EN, FR, DE, ES & NL

Bipolar Disorders New Insights for the Healthcare Professional 2012 Edition Book Excerpt:

Bipolar Disorders: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bipolar Disorders. The editors have built Bipolar Disorders: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bipolar Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bipolar Disorders: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Schizophrenia Bulletin

Schizophrenia Bulletin
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2007
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Schizophrenia Bulletin Book Excerpt:

The Handbook of Biomarkers

The Handbook of Biomarkers
Author: Kewal K. Jain
Publsiher: Humana Press
Total Pages: 760
Release: 2017-09-16
ISBN: 1493974319
Category: Science
Language: EN, FR, DE, ES & NL

The Handbook of Biomarkers Book Excerpt:

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

Bipolar Disorders

Bipolar Disorders
Author: Jair C. Soares,Allan H. Young
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2016-05-25
ISBN: 1316565165
Category: Medical
Language: EN, FR, DE, ES & NL

Bipolar Disorders Book Excerpt:

Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally.

Neuroprogression and Staging in Bipolar Disorder

Neuroprogression and Staging in Bipolar Disorder
Author: Flávio Kapczinski,Eduard Vieta,Pedro V. S. Magalhães,Michael Berk
Publsiher: OUP Oxford
Total Pages: 368
Release: 2015-06-11
ISBN: 0191019968
Category: Medical
Language: EN, FR, DE, ES & NL

Neuroprogression and Staging in Bipolar Disorder Book Excerpt:

After the original proposals of staging for psychotic disorders developed by McGorry and colleagues, a few systems have been put forward specifically for people with bipolar disorder. There is now consistent evidence that, at least for a significant portion of people with this disease, clinical course and outcome are not as benign as initially described. The evidence thus far points to relevant differences between early and late stages of bipolar disorders in the clinical course of illness, neurobiology and systemic pathology. These differences all suggest that staging is a viable addition to clinical care in bipolar disorder. Neuroprogression and Staging in Bipolar Disorder provides a comprehensive summary of the current state of the evidence regarding the use of staging systems in bipolar disorder. Edited by the leading researchers in the field, the book systematically covers the theoretical basis for staging, comparisons between different proposals, neurobiological underpinnings, the current evidence-base, limitations and future directions, and clinical implications and recommendations for practice. The book provides a solid and in-depth outline and thus to influence research and practice in the field of bipolar disorder.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author: Claudio Carini,Mark Fidock,Alain van Gool
Publsiher: CRC Press
Total Pages: 631
Release: 2019-04-16
ISBN: 0429576730
Category: Mathematics
Language: EN, FR, DE, ES & NL

Handbook of Biomarkers and Precision Medicine Book Excerpt:

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Deconstructing Psychosis

Deconstructing Psychosis
Author: Carol A. Tamminga,Paul J. Sirovatka,Darrel A. Regier,Jim van Os
Publsiher: American Psychiatric Pub
Total Pages: 202
Release: 2009-08-11
ISBN: 0890426570
Category: Medical
Language: EN, FR, DE, ES & NL

Deconstructing Psychosis Book Excerpt:

Deconstructing Psychosis: Refining the Research Agenda for DSM-V provides an all-important summary of the latest research about the diagnosis and pathophysiology of psychosis. This volume gives the reader an inside look at how psychotic phenomena are represented in the current diagnostic system and how DSM-V might better address the needs of patients with such disorders. The book presents a selection of papers reporting the proceedings of a conference titled "Deconstructing Psychosis" convened by the American Psychiatric Association (APA) in collaboration with the World Health Organization (WHO) and the U.S. National Institutes of Health (NIH). The conference was designed to be a key element in the multiphase research review process for the fifth revision of DSM. This book is one in a series of ten that reflects some of the most current and critical examinations of psychiatric disorders and psychotic syndromes. APA published the fourth edition of DSM in 1994 and a text revision in 2000. DSM-V is scheduled for publication in 2013. Deconstructing Psychosis: Refining the Research Agenda for DSM-V examines the current evidence regarding the diagnosis and pathophysiology of common psychotic syndromes including: Schizophrenia Bipolar disorder Major depressive psychosis Substance-induced psychosis It also addresses broad issues relating to diagnosis such as the ways in which psychosis cuts across multiple diagnostic categories. Beyond merely summarizing the current state of the science, the authors of these papers critique the current research and clinical evidence, and raise questions about gaps in our knowledge. The book provides recommendations for the most promising areas of research in psychosis, which may lead to more refined treatments based on a better understanding of what biological and environmental factors contribute to its development and symptoms. In the learned editors' selection of papers for inclusion in this volume, they have exhibited their conviction that DSM-V is a "living document" that will reflect the pace of progress in multiple areas, ranging from molecular genetics and brain imaging to social, behavioral, and anthropological science. As a book on the narrowly defined topic of linking the classification of psychotic syndromes with their underlying pathophysiology and potential etiology, there is no other writing of comparable content available today.

Biomarkers for Psychiatric Disorders

Biomarkers for Psychiatric Disorders
Author: Chris Turck
Publsiher: Springer Science & Business Media
Total Pages: 538
Release: 2009-04-29
ISBN: 9780387792514
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers for Psychiatric Disorders Book Excerpt:

Biomarkers hold immense promise for the early detection of disease. Unlike other disorders like diabetes and heart disease where a limited number of biological markers are at hand that allow the physician to come up with a reliable diagnosis, there are currently no such markers available for affective disorders. As in any other disease area a major goal is therefore the identification of early markers that can categorize subsets of subjects in a consistent manner. This will allow a more precise definition and categorization of affective disorders and in turn facilitate investigations of the pathogenesis of the diseases and enhance our ability for treatment. This edited volume will not only address the area of affective disorders but also other brain disorders that are neurological in nature, including Multiple Sclerosis and Alzheimer Disease.

The Search for Biomarkers in Psychiatry

The Search for Biomarkers in Psychiatry
Author: Jorge Manzanares,Maria S. Garcia-Gutierrez,Francisco Navarrete Rueda,Piotr Gałecki
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-09-14
ISBN: 2889713016
Category: Medical
Language: EN, FR, DE, ES & NL

The Search for Biomarkers in Psychiatry Book Excerpt:

Child and Adolescent Psychiatry

Child and Adolescent Psychiatry
Author: Savita Malhotra,Paramala Santosh
Publsiher: Springer
Total Pages: 488
Release: 2016-11-25
ISBN: 813223619X
Category: Psychology
Language: EN, FR, DE, ES & NL

Child and Adolescent Psychiatry Book Excerpt:

This is a comprehensive volume on issues and concerns relating to child and adolescent mental health in Asia, which includes contributions from experts in child psychiatry from Asia and other parts of the world. The chapters provide accurate and detailed accounts of the current state of knowledge integrating research approaches and findings from clinical studies. Each chapter discusses existing information, emphasizes areas of growth and provides fresh insights on a particular topic especially as these might relate to Asian populations. The book integrates various clinical and scientific perspectives on psychiatric disorders in children and adolescents with a focus on Asia. The various sections deal with important topics in child and adolescent psychiatry: the current understanding of mental disorders and the ways in which possible influences might work in the development of psychopathology; substance use disorders, their neurobiological correlates and implications for the developing brain; early environmental influences in the psychopathology of psychiatric disorders in children; issues of parenting, child rearing and cultural practices in Asia, which influence personality development and adaptation; life-long impact of early parental loss; early diagnosis and intervention in recognizing and treating psychopathology; psychopharmacology of neurodevelopmental disorders in children; non-pharmacological treatments for children; mental health gap, and telepsychiatry as an innovative model to provide services for children; and a pressing need for a comprehensive child mental health policy across nations.

Seminars in Old Age Psychiatry

Seminars in Old Age Psychiatry
Author: Rob Butler,Cornelius Katona
Publsiher: Cambridge University Press
Total Pages: 304
Release: 2019-06-30
ISBN: 1108723985
Category: Medical
Language: EN, FR, DE, ES & NL

Seminars in Old Age Psychiatry Book Excerpt:

A concise and updated guide to the mental health of older people that includes sections on training, guidelines and treatments.

The Science and Practice of Lithium Therapy

The Science and Practice of Lithium Therapy
Author: Gin S. Malhi,Marc Masson,Frank Bellivier
Publsiher: Springer
Total Pages: 342
Release: 2016-11-24
ISBN: 3319459236
Category: Medical
Language: EN, FR, DE, ES & NL

The Science and Practice of Lithium Therapy Book Excerpt:

This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide, and those that are recipients of lithium therapy.