Bone Cancer

Bone Cancer
Author: Dominique Heymann
Publsiher: Academic Press
Total Pages: 504
Release: 2009-08-20
ISBN: 9780080953885
Category: Medical
Language: EN, FR, DE, ES & NL

Bone Cancer Book Excerpt:

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Clinical Atlas of 3D Printing Bone Reconstruction

Clinical Atlas of 3D Printing Bone Reconstruction
Author: Hyun-Guy Kang
Publsiher: Springer Nature
Total Pages: 442
Release: 2021-06-12
ISBN: 9811620431
Category: Medical
Language: EN, FR, DE, ES & NL

Clinical Atlas of 3D Printing Bone Reconstruction Book Excerpt:

This book provides practitioners with comprehensive guidance on the application of 3D printing technology in the bone reconstruction. The 3D printed implants need to be able to maximize function and minimize complications by reinforcing strength and changing shape beyond anatomically identical design. Many of the clinical cases in this book, including pre-operative images, surgical planning, design and fabrication, 3D printing implants and guides, surgery and postoperative images, will suffice to capture the sensation of the 3D printing bone reconstruction. This book is composed of photos with minimum descriptions so that the readers can develop their imaginative view.

Symposium on Bone Tumors

Symposium on Bone Tumors
Author: Anonim
Publsiher: Unknown
Total Pages: 29
Release: 1970
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Symposium on Bone Tumors Book Excerpt:

The Accuracy of 3D Planned Bone Tumor Resections Using Patient specific Instruments

The Accuracy of 3D Planned Bone Tumor Resections Using Patient specific Instruments
Author: Yannik Stutz
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Accuracy of 3D Planned Bone Tumor Resections Using Patient specific Instruments Book Excerpt:

Bone Tumor Pathology An Issue of Surgical Pathology Clinics

Bone Tumor Pathology  An Issue of Surgical Pathology Clinics
Author: Judith V.M.G. Bovée
Publsiher: Elsevier Health Sciences
Total Pages: 135
Release: 2017-08-19
ISBN: 0323545750
Category: Medical
Language: EN, FR, DE, ES & NL

Bone Tumor Pathology An Issue of Surgical Pathology Clinics Book Excerpt:

This issue of Surgical Pathology Clinics, edited by Dr. Judith V.M.G. Bovée, will discuss the latest updates in Bone Tumor Pathology. Topics covered in this issue include, but are not limited to Molecular pathology of bone tumors; Ewing sarcoma; Ewing-like tumors; Vascular tumors of bone; Giant cell containing tumours of bone; Cartilaginous tumours; bone forming tumours; jaw tumours, among others.

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
Author: Subhas C. Kundu,Rui L Reis
Publsiher: Elsevier
Total Pages: 772
Release: 2020-08-22
ISBN: 012818129X
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Biomaterials for 3D Tumor Modeling Book Excerpt:

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Oxford Handbook of Paediatrics 3e

Oxford Handbook of Paediatrics 3e
Author: Robert C. Tasker,Carlo L. Acerini,Edward Holloway,Asma Shah,Pete Lilitos
Publsiher: Oxford University Press
Total Pages: 1104
Release: 2021-01-04
ISBN: 0192507184
Category: Medical
Language: EN, FR, DE, ES & NL

Oxford Handbook of Paediatrics 3e Book Excerpt:

Now fully revised and updated with the latest guidelines, this new edition of the Oxford Handbook of Paediatrics is an easy-to-use and compact guide to all aspects of acute and chronic paediatrics. The team of specialist contributors and editors have successfully condensed many years of clinical experience into a pocket-sized compendium of clinical problems and treatment options. Taking a child-centred approach to the subject, the book provides comprehensive coverage of areas such as neonatology, surgery, genetics and congenital malformations, and child protection in a user-friendly and succinct style. Sections are also devoted to covering the treatment of children in the community, and the psychological effects of illness on both the child and their family. All chapters have been updated for this new edition, and the practical advice and experience contained within this handbook will be invaluable to all those involved in the care of the younger patient.

Development of a 3D Microenvironment for Human Bone Metastasis

Development of a 3D Microenvironment for Human Bone Metastasis
Author: Antone Nour
Publsiher: Unknown
Total Pages: 135
Release: 2021
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Development of a 3D Microenvironment for Human Bone Metastasis Book Excerpt:

"Bone is a dynamic tissue maintained through remodeling whereby it is constantly broken down and repaired through an equilibrium of osteoclast and osteoblast activity. However, when various cancers invade the bone, they disrupt this balance, leading to harmful bone structure and function changes. Radiotherapy, chemotherapy, and surgical resection are the main clinical approaches to bone metastases. Studying cancer cells in vitro relies on 2D monolayer cultures, which in no way represents the physiological tissue microenvironment in vivo. Therefore, preclinical and translational cancer research trends move toward organoid studies and 3D biomimetic models to provide more clinical relevance. Here, we set out to generate a bioink consisting of alginate, gelatin, and nanocrystal hydroxyapatite loaded with primary human osteoblasts and MSCs to produce a robust 3D bone-like microenvironment to study human bone metastasis. A hydrogel (3% alginate; 7% gelatin) model for cancer cell migration was modified to incorporate nanocrystal hydroxyapatite, primary human osteoblasts, and primary human bone marrow-derived stromal cells. Primary osteoblasts were isolated from vertebral bodies of organ donors, and bone marrow MSCs were purchased from Rooster Bio. The constructs were cultured over 28 days in a control medium (DMEM) or osteogenic medium (OM) with and without 0.5 mg/mL nano-hydroxyapatite (HA). Live/Dead® assays were performed to quantify viability, fixed frozen sections were stained with Alizarin Red for calcified matrix deposition, and Mayer's Hematoxylin and Eosin (H&E) staining to observe cells nuclei. High osteoblast viability in all conditions was observed after 28 days of culture: 92.5 ± 2.5 % for DMEM/HA-, 85.9 ± 6.2 % for OM/HA-, 91.3 ± 3.18 % for DMEM/HA+ and 88.6 ± 0.38 % for OM/HA+ respectively. MSCs were cultured for 21 days and showed 71.93 ± 4.59 % for DMEM/HA-, 68.56 ± 5.84 % for OM/HA-, 63.46 ± 4.78 % for DMEM/HA+ and 63.40 ± 1.16 % for OM/HA+. Moreover, cells grown in DMEM without HA had the least amount of mineralized bone matrix. Cells grown in OM/HA+ were found to have the most bone mineralized matrix. Our data indicate that the combination of 0.5 mg/mL nano-hydroxyapatite with OM produces a favorable bone-like microenvironment for primary human osteoblasts and MSCs. Our preliminary work with low-cost bioprinting indicates that this bioink is extrudable and will be ideal for screening therapeutics against patient-derived tumor cells. This work will allow a better understanding of interactions between normal osteoblasts, stromal cells, osteocytes, and patient-derived bone metastatic cells while also placing higher clinical relevance on therapeutics screening"--

Bone Marrow Adipose Tissue Formation Function and Impact on Health and Disease

Bone Marrow Adipose Tissue  Formation  Function  and Impact on Health and Disease
Author: William P. Cawthorn,Erica L. Scheller
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-08-15
ISBN: 288945245X
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Bone Marrow Adipose Tissue Formation Function and Impact on Health and Disease Book Excerpt:

Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells
Author: Saba Choudhary
Publsiher: Unknown
Total Pages: 88
Release: 2018
ISBN: 9780438241718
Category: Bones
Language: EN, FR, DE, ES & NL

Human Ex Vivo 3d Bone Metastasis Model Recapitulates Osteocyte Response to Prostate Cancer Cells Book Excerpt:

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors Current Opportunities and Future Challenges

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors  Current Opportunities and Future Challenges
Author: Thomas G. P. Grünewald,Simone Fulda
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-04-05
ISBN: 2889198197
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors Current Opportunities and Future Challenges Book Excerpt:

Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and be relevant for a broad readership. This Frontiers Research Topic intended to provide a platform for active and interdisciplinary discussion, to summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and to offer new perspectives on how to further promote and accelerate the translational process. It comprises high-quality original articles and timely reviews.

Lancaster City and County Politics

Lancaster City and County Politics
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1922
ISBN: 1928374650XXX
Category: Agriculture
Language: EN, FR, DE, ES & NL

Lancaster City and County Politics Book Excerpt:

Lancaster City and County Politics gives an unusual perspective of the area's politics. Newspaper articles representing both the Republican Party and Democratic Party develop the unique look. It also contains information about women's involvement in politics. Local, state and federal government branches are all discussed in the book. There are also articles about the major political issues in 1922, such as prohibition, daylight savings time, and education funding. Individuals mentioned in the scrapbooks include John A. McSparran, William Johnson, Scott W. Baker, Gifford Pinchot, W. W. Greist, W. D. Marburger, Samuel E. Shull, Frank Musser, and Milton T. Garvin.

Harrison s Hematology and Oncology 3E

Harrison s Hematology and Oncology  3E
Author: Dan L. Longo
Publsiher: McGraw Hill Professional
Total Pages: 135
Release: 2016-09-22
ISBN: 1259835820
Category: Medical
Language: EN, FR, DE, ES & NL

Harrison s Hematology and Oncology 3E Book Excerpt:

Hematology and Oncology – backed by the unmatched authority of Harrison’s A Doody's Core Title for 2019! Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: • Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities • Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas • Integration of pathophysiology with clinical management • High-yield board review questions make this text ideal for keeping current or preparing for the boards • Valuable appendix of laboratory values of clinical importance

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading
Author: Paolo E. Palacio,City University of New York. City College
Publsiher: Unknown
Total Pages: 110
Release: 2011
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non invasive Mechanical Loading Book Excerpt:

This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to grow cancer cells, induce tumors in a rat model, measure tumor development, inject a radioactive tracer, apply mechanical loading non-invasively, and image and quantify drug uptake distribution in bone tumors. Assessment of 99mTc-labeled pamidronate uptake was completed in vivo using planar microSPECT (2D gamma camera scans) employing a rat model of bone metastases. The pilot study using this methodology demonstrated that non-invasive mechanical loading enhanced drug delivery to cancerous tibial tumors by 34% when compared to contralateral non-loaded, non-tumor bearing tibiae. Several improvements to this approach have been developed including 1) improved cancer cell viability after injection, 2) enhancement of cancer cell inoculation by arthrotomy surgery instead of direct tibial injection, 3) shifting from gamma camera to 3D microPET imaging, 4) use of tumor-bearing tibiae as controls, 5) use of the clinically relevant Herceptin as the injected drug, and 6) implementation of high-resolution microCT and histology to assess bone destruction from tumor growth. If additional studies in the rat model using these improved techniques demonstrate load-induced enhancement of drug delivery, the approach will be attempted in the clinic. Clinical studies will implement exercise and/or non-invasive mechanical activity to enhance drug delivery. If successful, this approach would result in an improvement in the quality of life of patients suffering from bone cancer.

Novel cancer related biomarkers

Novel cancer related biomarkers
Author: Viktor Magdolen
Publsiher: Walter de Gruyter
Total Pages: 241
Release: 2013-01-01
ISBN: 3110303663
Category: Science
Language: EN, FR, DE, ES & NL

Novel cancer related biomarkers Book Excerpt:

This volume on kallikrein-related peptidases (KLKs) reviews the role of these proteases as biomarkers in a wide range of malignancies including cancers of the lung, prostate, breast, ovary, kidney, stomach, and colon. It provides clinicians, physician scientists, and cancer researchers with in-depth overviews on the emerging clinical relevance of KLK protein or gene expression in these malignancies.

Craniofacial Reconstruction After Oral Cancer Using 3D Modeled and Additively Manufactured Chemotherapy Releasing Bone Implants

Craniofacial Reconstruction After Oral Cancer Using 3D Modeled and Additively Manufactured Chemotherapy Releasing Bone Implants
Author: Anonim
Publsiher: Unknown
Total Pages: 96
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Craniofacial Reconstruction After Oral Cancer Using 3D Modeled and Additively Manufactured Chemotherapy Releasing Bone Implants Book Excerpt:

Routledge Library Editions Energy Resources

Routledge Library Editions  Energy Resources
Author: Various
Publsiher: Routledge
Total Pages: 2942
Release: 2021-06-23
ISBN: 1000398080
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Routledge Library Editions Energy Resources Book Excerpt:

Reissuing works originally published between 1961 and 1990, this set of 12 books offers a selection of scholarship on the history of natural resources. Many of the titles discuss the nuclear power debate from various angles while others look at coal, or resources and energy in the third world.

100 Questions Answers About Esophageal Cancer

100 Questions   Answers About Esophageal Cancer
Author: Pamela K. Ginex,Maureen Jingeleski,Bart L. Frazzitta,Manjit S. Bains
Publsiher: Jones & Bartlett Learning
Total Pages: 185
Release: 2009-03-06
ISBN: 1449630979
Category: Medical
Language: EN, FR, DE, ES & NL

100 Questions Answers About Esophageal Cancer Book Excerpt:

EMPOWER YOURSELF! Whether you’re a newly diagnosed esophageal cancer patient, a survivor, or a friend or relative of either, this book offers help. The only text to provide the doctor’s and patient’s views, 100 Questions & Answers About Esophageal Cancer, Second Edition gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by two oncology nurses and a gastric surgeon, with extensive commentary from an esophageal cancer survivor, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

100 Questions and Answers about Vulvar Cancer and Other Diseases of the Vulva and the Vagina

100 Questions and Answers about Vulvar Cancer and Other Diseases of the Vulva and the Vagina
Author: Lara Burrows,Debra S. Heller,Lara J Burrows, MD, MSC
Publsiher: Jones & Bartlett Publishers
Total Pages: 131
Release: 2009-10-07
ISBN: 0763789313
Category: Medical
Language: EN, FR, DE, ES & NL

100 Questions and Answers about Vulvar Cancer and Other Diseases of the Vulva and the Vagina Book Excerpt:

EMPOWER YOURSELF! Whether you're a newly diagnosed patient or are a friend or loved one of someone suffering from a vulva/vaginal disease, this book offers help. The only text available to provide both the doctor's and patient's views, 100 Questions & Answers About Vulvar Cancer and Other Diseases of the Vulva and Vagina provides practical, authoritative answers to 100 of the most common questions asked by women diagnosed with cancer of the vulva/vagina and related gynecologic diseases. Written by an expert medical pathologist, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

100 Questions Answers About Uterine Cancer

100 Questions   Answers About Uterine Cancer
Author: Don S. Dizon,Linda R. Duska
Publsiher: Jones & Bartlett Learning
Total Pages: 134
Release: 2010-10-22
ISBN: 1449631290
Category: Medical
Language: EN, FR, DE, ES & NL

100 Questions Answers About Uterine Cancer Book Excerpt:

Whether you are a newly diagnosed uterine cancer patient, a survivor, or a friend or relative of either, this book offers help. 100 Questions and Answers About Uterine Cancer addresses the issues that are specific to the woman with uterine cancer. Written by two renowned gynecologic oncologists and including “insider” advice from an actual patient, this book gives you authoritative, practical answers to your questions about uterine cancer. It explains important facts about symptoms and the diagnosis process, treatment options, post-treatment quality of life, coping strategies, and sources of patient and family support. This book is an invaluable resource for anyone dealing with the physical and emotional turmoil of this frightening disease.