Bone Repair Biomaterials

Bone Repair Biomaterials
Author: J A Planell,S M Best,D Lacroix,A Merolli
Publsiher: Elsevier
Total Pages: 496
Release: 2009-08-26
ISBN: 1845696611
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Bone Repair Biomaterials Book Excerpt:

Bone repair is a fundamental part of the rapidly expanding medical care sector and has benefited from many recent technological developments. With an increasing number of technologies available, it is vital that the correct technique is selected for specific clinical procedures. This unique book will provide a comprehensive review of the materials science, engineering principles and recent advances in this important area. The first part of the book reviews the fundamentals of bone repair and regeneration. Chapters in the second part discuss the science and properties of biomaterials used for bone repair such as metals, ceramics, polymers and composites. The final section of the book discusses clinical applications and considerations with chapters on such topics as orthopaedic surgery, tissue engineering, implant retrieval and ethics of bone repair biomaterials. With its distinguished editors and team of international contributors, Bone repair biomaterials is an invaluable reference for researchers and clinicians within the biomedical industry and academia. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Reviews the fundamentals of bone repair and regeneration addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair with specific chapters assessing metals, ceramics, polymers and composites

Bone Repair Biomaterials

Bone Repair Biomaterials
Author: Kendell Pawelec,J. A. Planell
Publsiher: Woodhead Publishing
Total Pages: 440
Release: 2018-11-29
ISBN: 0081024525
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Bone Repair Biomaterials Book Excerpt:

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Translating Biomaterials for Bone Graft

Translating Biomaterials for Bone Graft
Author: Joo L. Ong,Teja Guda
Publsiher: CRC Press
Total Pages: 263
Release: 2017-01-06
ISBN: 1315363518
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Translating Biomaterials for Bone Graft Book Excerpt:

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Biomimetic biomaterials

Biomimetic biomaterials
Author: K.A. Hing
Publsiher: Elsevier Inc. Chapters
Total Pages: 344
Release: 2013-09-30
ISBN: 012808815X
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Biomimetic biomaterials Book Excerpt:

This chapter reviews basic bone biology and bone graft technology to give an insight into the increasingly biomimetic approach being pursued in this field. Many current synthetic bone graft substitute materials have calcium phosphate chemistries reflecting the composition of bone mineral, and hierarchical pore structures similar to cancellous bone. Significant research effort has been devoted to understanding how slight variations in chemistry and pore structure impact a graft material’s ability to support or stimulate bone healing. It appears that the best results are obtained when a graft chemistry or structure is designed to mimic the natural tissue.

Biomaterials for Bone Regeneration

Biomaterials for Bone Regeneration
Author: P. Dubruel,S. Van Vlierberghe
Publsiher: Elsevier
Total Pages: 502
Release: 2014-06-09
ISBN: 0857098101
Category: Medical
Language: EN, FR, DE, ES & NL

Biomaterials for Bone Regeneration Book Excerpt:

Novel Biomaterials for Bone Regeneration provides a comprehensive review of currently available biomaterials and how they can be applied in bone regeneration. In recent decades, there has been a shift from the idea of using biomaterials as passive substitutes for damaged bones towards the concept of biomaterials as aids for the regeneration of a host's own bone tissue. This has generated an important field of research and a range of technological developments. Part one of this book discusses a wide range of materials, including calcium phosphate cements, hydrogels, biopolymers, synthetic polymers, and shape memory polymers. Part two then turns to the processing and surface modification of biomaterials, as well as how biomaterials can be evaluated both for their mechanical properties and for immunocompatibility with the host. Finally, part three covers a variety of cellular approaches, and production and delivery of biomaterials for bone regeneration. Chapters also consider the potential of electromagnetic and ultrasonic stimulation of biomaterials to aid in the regenerative process. Novel Biomaterials for Bone Regeneration represents an important resource for academics, clinicians, and industry professionals working in the area of biomedical materials, providing them with both an overview of the current state-of-the-art, and an indication of potential future developments. Provides comprehensive coverage of novel materials, techniques, and applications of biomaterials for bone regeneration Provides vital information on the various types of materials used in bone regeneration Discusses processing, modification, and evaluation techniques of biomaterials, and looks at cellular approaches and stimulation of biomaterials for bone regeneration

Bone Substitute Biomaterials

Bone Substitute Biomaterials
Author: K. Mallick
Publsiher: Elsevier
Total Pages: 352
Release: 2014-08-05
ISBN: 0857099035
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Bone Substitute Biomaterials Book Excerpt:

Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms. Provides a detailed and accurate overview of the bone substitute biomaterials, a fundamental part of the biomaterials and biomedical sector Provides readers with the principles of bone substitute biomaterials Reviews biomaterials for bone regeneration

Biomaterials in Orthopedics

Biomaterials in Orthopedics
Author: Michael J. Yaszemski
Publsiher: CRC Press
Total Pages: 458
Release: 2003-10-17
ISBN: 082475686X
Category: Medical
Language: EN, FR, DE, ES & NL

Biomaterials in Orthopedics Book Excerpt:

Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,

A Tissue Regeneration Approach to Bone and Cartilage Repair

A Tissue Regeneration Approach to Bone and Cartilage Repair
Author: Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publsiher: Springer
Total Pages: 254
Release: 2014-12-05
ISBN: 3319132660
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

A Tissue Regeneration Approach to Bone and Cartilage Repair Book Excerpt:

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Wound Healing Biomaterials Volume 2

Wound Healing Biomaterials   Volume 2
Author: Magnus Ågren
Publsiher: Woodhead Publishing
Total Pages: 542
Release: 2016-05-30
ISBN: 0081006063
Category: Medical
Language: EN, FR, DE, ES & NL

Wound Healing Biomaterials Volume 2 Book Excerpt:

Wound Healing Biomaterials: Volume Two, Functional Biomaterials discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal wounds opening up a new area of research in biomaterials and the ways they can be applied to the challenges associated with wound care. Much research is now concerned with new therapies, regeneration methods, and the use of biomaterials that can assist in wound healing and alter healing responses. This book provides readers with a thorough review of the functional biomaterials used for wound healing, with chapters discussing the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and functional dressings for wound care. Includes more systematic and comprehensive coverage on the topic of wound care Provides thorough coverage of all specific therapies and biomaterials for wound healing Contains clear layout and organization that is carefully arranged with clear titles and comprehensive section headings Details specific sections on the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and more

Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization

Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization
Author: Sebastian Wilfried Schotten
Publsiher: Unknown
Total Pages: 222
Release: 2011
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization Book Excerpt:

Octacalcium Phosphate Biomaterials

Octacalcium Phosphate Biomaterials
Author: Gerard Insley,Osamu Suzuki
Publsiher: Woodhead Publishing
Total Pages: 374
Release: 2019-11-20
ISBN: 0081025122
Category: Medical
Language: EN, FR, DE, ES & NL

Octacalcium Phosphate Biomaterials Book Excerpt:

Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration

Engineered Bone

Engineered Bone
Author: Herve Petite
Publsiher: CRC Press
Total Pages: 225
Release: 2005-08-15
ISBN: 149871353X
Category: Science
Language: EN, FR, DE, ES & NL

Engineered Bone Book Excerpt:

This book addresses relevant issues that tissue-engineering researchers must consider when planning new strategies, especially in the bone and cartilage field. It describes transcription factors that are essential in bone development, and deals with bone healing.

Encyclopedic Handbook of Biomaterials and Bioengineering v 1 2 Materials

Encyclopedic Handbook of Biomaterials and Bioengineering  v  1 2  Materials
Author: Donald Lee Wise
Publsiher: CRC Press
Total Pages: 851
Release: 1995
ISBN: 9780824795955
Category: Biomedical engineering
Language: EN, FR, DE, ES & NL

Encyclopedic Handbook of Biomaterials and Bioengineering v 1 2 Materials Book Excerpt:

Principles of Bone Regeneration

Principles of Bone Regeneration
Author: Jona J. Sela,Itai A. Bab
Publsiher: Springer Science & Business Media
Total Pages: 156
Release: 2012-03-10
ISBN: 1461420598
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Principles of Bone Regeneration Book Excerpt:

Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.

The Nanoscience and Technology of Renewable Biomaterials

The Nanoscience and Technology of Renewable Biomaterials
Author: Lucian A. Lucia,Orlando Rojas
Publsiher: John Wiley & Sons
Total Pages: 366
Release: 2009-07-23
ISBN: 9781444307481
Category: Science
Language: EN, FR, DE, ES & NL

The Nanoscience and Technology of Renewable Biomaterials Book Excerpt:

The unique nanoscale properties of renewable biomaterials presentvaluable opportunities in the field of nanoscience and technology.Lignocellulosic biomass is an important industrial resource whichcan be used for the production of highly efficient andenvironmentally sustainable nanomaterials. The Nanoscience and Technology of Renewable Biomaterialspresents the latest advances in biomass nanotechnology, includingleading research from academia and industry, as well as a futurevision for the nanotechnology of forest products. Topics covered include: A fundamental review of the relationship betweennanotechnology and lignocellulosic biomass Characterization methods for biomass on the nanometerscale Cellulose, hemicelluloses and lignin as nanoscopicbiomaterials-physical features, chemical properties and potentialnanoproducts Nanoscale surface engineering Renewable materials as scaffolds for tissue engineering Nanoscopically-controlled drug delivery This book will be a valuable resource for chemists, chemicalengineers, bioscience researchers and materials scientists who areinterested in harnessing the nanotechnological features ofrenewable biomaterials.

Orthopedic Biomaterials

Orthopedic Biomaterials
Author: Bingyun Li,Thomas Webster
Publsiher: Springer
Total Pages: 496
Release: 2018-08-17
ISBN: 3319895427
Category: Medical
Language: EN, FR, DE, ES & NL

Orthopedic Biomaterials Book Excerpt:

This book covers the latest progress in the biology and manufacturing of orthopedic biomaterials, as well as key industry perspectives. Topics covered include the development of biomaterial-based medical products for orthopedic applications, anti-infection technologies for orthopedic implants, additive manufacturing of orthopedic implants, and more. This is an ideal book for graduate students, researchers and professionals working with orthopedic biomaterials and tissue engineering. This book also: Provides an industry perspective on technologies to prevent orthopedic implant related infection Thoroughly covers how to modulate innate inflammatory reactions in the application of orthopedic biomaterials Details the state-of-the-art research on 3D printed porous bone constructs

Materials for Biomedical Engineering Absorbable Polymers

Materials for Biomedical Engineering  Absorbable Polymers
Author: Alexandru Grumezescu,Valentina Grumezescu
Publsiher: Elsevier
Total Pages: 462
Release: 2019-06-28
ISBN: 0128184167
Category: Medical
Language: EN, FR, DE, ES & NL

Materials for Biomedical Engineering Absorbable Polymers Book Excerpt:

Materials for Biomedical Engineering: Absorbable Polymers provides a detailed and comprehensive review of recent progress in absorbable biopolymers and their impact on biomedical engineering. The book's main focus lies in their classification, processing, properties and performance, biocompatibility, and their applications in tissue engineering, drug delivery, bone repair and regenerative medicine. The most up-to-date methods used to obtain such polymers and how to improve their properties is discussed in detail. This book provides readers with a comprehensive and updated review of the latest research in the field of absorbable polymers for biomedical applications. Provides knowledge of the range of absorbable polymers currently available, enabling the reader to make optimal materials selection decisions Presents detailed information on current and proposed applications of the latest developments Includes a strong emphasis on chemistry and physico-chemical characterization of these materials and their application in biomedical engineering

Encyclopedic Handbook of Biomaterials and Bioengineering v 1 2 Applications

Encyclopedic Handbook of Biomaterials and Bioengineering  v  1 2  Applications
Author: Donald Lee Wise
Publsiher: CRC Press
Total Pages: 939
Release: 1995
ISBN: 9780824795962
Category: Biomedical engineering
Language: EN, FR, DE, ES & NL

Encyclopedic Handbook of Biomaterials and Bioengineering v 1 2 Applications Book Excerpt:

This book provides exhaustive treatment of materials used in or on the human body - ranging from biopolymers for controlled release drug delivery systems to metal plates used in bone repair and absorbable devices such as sutures.

Nanoscale Engineering of Biomaterials Properties and Applications

Nanoscale Engineering of Biomaterials  Properties and Applications
Author: Lalit M. Pandey,Abshar Hasan
Publsiher: Springer Nature
Total Pages: 696
Release: 2022
ISBN: 9811636672
Category: Biology
Language: EN, FR, DE, ES & NL

Nanoscale Engineering of Biomaterials Properties and Applications Book Excerpt:

This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.

Natural and Cell derived Matrices as Biomaterials in Bone Regeneration

Natural  and Cell derived Matrices as Biomaterials in Bone Regeneration
Author: Jenna N. Harvestine
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN: 9780438930759
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Natural and Cell derived Matrices as Biomaterials in Bone Regeneration Book Excerpt:

With over 2 million bone graft procedures ever year, bone is the second most transplanted material behind blood. However, limited tissue supply and post-operative concerns for donor site pain and morbidity motivate alternative strategies to drive bone regeneration. Mesenchymal stem cells (MSCs) are found within multiple tissue compartments in the postnatal organism, making them widely accessible for autologous cell therapy and a promising alternative to bone grafts. However, loss of osteogenic phenotype, poor cell viability, and insufficient vasculature infiltration after implantation challenge clinical application of tissue engineered constructs. Cell-derived extracellular matrix (ECM), is a biomimetic platform that provides a natural niche to promote trophic factor secretion, cell adhesion, survival, and osteogenic differentiation. We hypothesized a cell-secreted ECM would select endothelial and stem/progenitor cell populations from tissue aspirates to enhance cell survival and instruct cell function, resulting in improved osteogenic potential. First, we hypothesized MSC-derived ECM-coated scaffolds would enhance osteogenic differentiation and bone formation by culture expanded bone marrow-derived MSCs. Human MSCs cultured on ECM-coated scaffolds exhibited increased metabolic activity and decreased apoptosis compared to uncoated scaffolds. In short-term culture, MSCs on ECM-coated substrates secreted more proangiogenic factors while maintaining markers of osteogenic differentiation. Upon implantation, we detected improved survival of MSCs on ECM-coated scaffolds over 3 weeks. Histological evaluation revealed enhanced cellularization and osteogenic differentiation in ECM-coated scaffolds compared to controls. To determine whether the bioactivity of cell-secreted ECM was dependent on cell source, we assessed the osteogenic response of human stromal vascular fraction (SVF) on ECMs secreted by bone marrow-derived mesenchymal stem cells (MSCs) as well as adipose stem/stromal cells (ASCs) and human dermal fibroblasts (HDFs). Mass spectrometry analysis identified 278, 225, and 150 distinct proteins within MSC-, ASC-, and HDF-derived ECMs, respectively, suggesting that stromal cell-derived ECMs are more complex than HDF-derived ECMs which contained nearly 50% fewer distinct proteins. Regardless of ECM source, SVF deposited over 8- and 1.3-fold more calcium compared to tissue culture plastic (TCP) and collagen-coated controls, respectively. Flow cytometry confirmed that SVF cultured on ECM retained CD31 and CD34 positive cell populations better than TCP confirming a role for accessory cells in osteogenic differentiation by tissue aspirates. In addition to lipoaspirates, bone marrow aspirates (BMA) contain a rich source of cells for use in several clinical indications including bone repair. However, progenitor cells such as MSCs account for a small fraction of nucleated cells in BMA, requiring extensive in vitro culture for expansion. We hypothesized that cell-secreted ECM could be used to sequester MSCs and accessory cells from BMA for bone regeneration. To generate 3D implantable constructs, BMA was resuspended in media with or without type I collagen or ECM and injected into a perfusion bioreactor system. Compared to uncoated scaffolds, we observed a 30- and 143- fold increase in MSCs when fresh BMA was cultured on collagen- or ECM-coated scaffolds, respectively. Upon subcutaneous implantation, ECM-coated scaffolds promoted cell survival and early vascularization, yet bone formation was comparable across all implant groups, suggesting additional osteogenic cues are necessary. To determine if osteogenic pre-conditioning would improve the bone forming potential of BMA, cells were perfused on ECM-coated scaffold for either 20 hours or 14 days to generate naïve and pre-conditioned constructs, respectively. Naïve constructs secreted high levels of pro-angiogenic growth factors, while pre-conditioned cells exhibited an osteogenic phenotype and scaffolds contained more MSCs and endothelial cells. Constructs were implanted into 3.5 mm defects made in the calvariae of nude rats then monitored for vascular invasion and bone formation over 10 weeks. Vascular infiltration into pre-conditioned implants occurred rapidly over the first 14 days, resulting in greater vessel density compared to naïve implants which peaked at 28 days. Early advantages in vessel formation correlated to increased bone volume and tissue mineral density in pre-conditioned implants at 10 weeks confirming the synergy between angiogenesis and bone formation. Collectively, this dissertation describes the capacity of cell-secreted ECM to sequester, maintain, and direct osteogenic differentiation by two clinically investigated tissue aspirates for bone tissue engineering. Novel strategies that augment bone repair using autologous tissues address a critically unmet need and have direct implications to improve current standards of care at the forefront of orthopaedic regenerative medicine.