Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set

Burger s Medicinal Chemistry  Drug Discovery and Development  8 Volume Set
Author: Anonim
Publsiher: John Wiley & Sons
Total Pages: 6032
Release: 2021-04-20
ISBN: 111953030X
Category: Science
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set Book Excerpt:

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Burgers Medicinal Chemistry and Drug Discovery

Burgers Medicinal Chemistry and Drug Discovery
Author: Manfred E. Wolff
Publsiher: Unknown
Total Pages: 1064
Release: 1995
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Burgers Medicinal Chemistry and Drug Discovery Book Excerpt:

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery and Drug Development

Burger s Medicinal Chemistry and Drug Discovery  Drug Discovery and Drug Development
Author: Donald J. Abraham
Publsiher: Wiley-Interscience
Total Pages: 840
Release: 2003-01-23
ISBN: 9780471370284
Category: Science
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery and Drug Development Book Excerpt:

This is Volume 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley.com/bmcdd

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery

Burger s Medicinal Chemistry and Drug Discovery  Drug Discovery
Author: Donald J. Abraham
Publsiher: Wiley-Interscience
Total Pages: 968
Release: 2003
ISBN: 9780471270904
Category: Science
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry and Drug Discovery Drug Discovery Book Excerpt:

This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley.com/bmcdd

Ethnomedicine and Drug Discovery

Ethnomedicine and Drug Discovery
Author: M.M. Iwu,J. Wootton
Publsiher: Elsevier
Total Pages: 344
Release: 2002-03-01
ISBN: 9780080531250
Category: Medical
Language: EN, FR, DE, ES & NL

Ethnomedicine and Drug Discovery Book Excerpt:

The emergence of new infectious, chronic and drug resistant diseases have prompted scientists to look towards medicinal plants as agents for treatment and prevention. This book provides an interphase between ethnomedical and ethnobotanical approaches to new drug discovery and advances in biotechnology and molecular science that has made it increasingly feasible to transform traditional medicines into modern drugs. These novel approaches also raise new issues and the volume explores economic, ethical and policy considerations of drug development based on indigenous knowledge or traditional medicine. This work also features standardization and development of phytomedicines for major therapeutic indications, including emerging infectious diseases affecting developing and developed countries. The publication provides state-of-the-art information on the most innovative science, the research, the industry, the market, and the future of ethnomedicine and drug discovery.

Burger s Medicinal Chemistry and Drug Discovery Therapeutic Agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic Agents
Author: Manfred E. Wolff
Publsiher: Wiley-Interscience
Total Pages: 879
Release: 1997-04-24
ISBN: 9780471575603
Category: Science
Language: EN, FR, DE, ES & NL

Burger s Medicinal Chemistry and Drug Discovery Therapeutic Agents Book Excerpt:

The final volume in the standard-setting reference on therapeutic designed drugs . . . BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 5: Therapeutic Agents This volume on Therapeutic Agents completes Burger's incisive, systematic examination of the fascinating new world of custom-designed therapeutic agents. Volume 5 highlights the link between chemical structure and biological activity, and explores chemotherapeutic agents, CNS and endocrine drugs, and radiological agents. It continues the authoritative coverage begun in earlier volumes and contains a comprehensive index for the entire edition. * Antimalarial agents * Agents affecting the action of * Cognition enhancers, agents, and prostaglandins pharmacodynamic models for * Agents affecting the action of Alzheimer's disease leukotrienes and thromboxanes * Antidepressant agent * Histamine H1 receptor antagonists * Antianxiety agents * Antiviral agents, RNA viruses * Antipsychotic agents other than HIV * Antihistamines, topical ocular * Radiopaques * Antiinflammatory steroids Essential to research in drug discovery and design, Volume 5 of Burger's Medicinal Chemistry and Drug Discovery is a cornerstone reference for professionals in the biopharmaceutical industry and academic research. Burger's Medicinal Chemistry, Fifth Edition consists of five volumes: * Volume 1: Principles and Practice (0-471-57556-9) 1994 * ". . . an essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."--Journal of Medicinal Chemistry * Volume 2: Therapeutic Agents (0-471-57557-7) 1996 * Volume 3: Therapeutic Agents (0-471-57558-5) 1996 * Volume 4: Therapeutic Agents (0-471-57559-3) 1997 * Volume 5: Therapeutic Agents (0-471-57560-7) 1997

Pharmacophore Perception Development and Use in Drug Design

Pharmacophore Perception  Development  and Use in Drug Design
Author: Osman F. Güner
Publsiher: Internat'l University Line
Total Pages: 537
Release: 2000
ISBN: 9780963681768
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacophore Perception Development and Use in Drug Design Book Excerpt:

In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMFA; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores. Annotation copyrighted by Book News, Inc., Portland, OR

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 422
Release: 2012-12-02
ISBN: 0080571239
Category: Science
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Drug Design and Drug Action Book Excerpt:

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Drug Discovery and Development E Book

Drug Discovery and Development   E Book
Author: Raymond G Hill
Publsiher: Elsevier Health Sciences
Total Pages: 368
Release: 2012-07-20
ISBN: 0702053163
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Discovery and Development E Book Book Excerpt:

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment

Quantitative Structure Activity Relationships in Drug Design  Predictive Toxicology  and Risk Assessment
Author: Roy, Kunal
Publsiher: IGI Global
Total Pages: 727
Release: 2015-02-28
ISBN: 1466681373
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment Book Excerpt:

Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
Author: Simon Ward
Publsiher: Academic Press
Total Pages: 7200
Release: 2017-07-01
ISBN: 9780128032008
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Comprehensive Medicinal Chemistry III Book Excerpt:

Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Medicinal Chemistry

Medicinal Chemistry
Author: Ashutosh Kar
Publsiher: New Age International
Total Pages: 933
Release: 2007-01-01
ISBN: 8122419704
Category: Drugs
Language: EN, FR, DE, ES & NL

Medicinal Chemistry Book Excerpt:

The Qualified Success And General Appeal Of Medicinal Chemistry Is Not Only Confined To The Indian Subcontinent, But It Has Also Won An Overwhelming Popularity In Other Parts Of The World. Specific Care Has Been Taken To Maintain And Sustain The Fundamental Philosophy Of The Textbook Embracing Rigidly The Original Pattern And Style Of Presentation With A Particular Expatiated Treatment Of Synthesis Of Potential Medicinal Compounds For The Ultimate Benefits Of The Teachers And The Taught Alike.The Present Thoroughly Revised And Skilfully Expanded Fourth Edition Essentially Contains Three New And Important Chapters, Namely : Molecular Modeling And Drug Design (Chapter 3), Adrenocortical Steroids (Chapter 24), And Antimycobacterial Agents (Chapter 26) So As To Make The Textbook More Useful To Its Readers.With The Advent Of Thirty Chapters The Present Updated Form Of Medicinal Chemistry Will Prove To Be An Asset For M. Pharm./B. Pharm. Degree Students, M. Sc. Pharmaceutical Chemistry, M.Sc. Applied Chemistry And M. Sc. Industrial Chemistry Throughout The Indian Universities.Medicinal Chemistry Appears As A Newly Designed And Artistically Presented In A Two-Colour Scheme So As To Facilitate A Distinctly More Effective Use Of The Book.This Highly Readable, Lucid, Handy, And Exceptionally Knowledgeable Textbook Will Definitely Win A Better, Bigger, And Confident Place For Itself Amongst Its Valued Readers.

Drug Discovery and Development Volume 1

Drug Discovery and Development  Volume 1
Author: Mukund S. Chorghade
Publsiher: John Wiley & Sons
Total Pages: 476
Release: 2006-07-18
ISBN: 047178009X
Category: Science
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Volume 1 Book Excerpt:

This two volume set provides a comprehensive account of the entiresequence of operations involved in discovering a drug through theactual delivery of the drug to clinicians and medicalpractitioners. Includes case studies of the discovery of erythromycin analogs(antibiotics), Tagamet, and Ultiva (remifentanil) Discusses the discovery of agents for the treatment andmanagement of bacterial infections, Parkinson's disease, psoriasis,ulcers and stomach pain, atopic dermatitis, asthma, and cancer Contains chapters on combinatorial chemistry, molecularbiology-based drug discovery, genomics, and chemogenomics The first volume of this set thoroughly describesconceptualizing a drug, creating a library of candidates fortesting, screening those candidates for in vitro and in vivoactivity, conducting and analyzing the results of clinical trials,and revising the drug as necessary.

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery  Chemotherapeutic agents
Author: Alfred Burger
Publsiher: Unknown
Total Pages: 135
Release: 2003
ISBN: 1928374650XXX
Category: Drug development
Language: EN, FR, DE, ES & NL

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents Book Excerpt:

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author: Jie Jack Li
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2013-04-26
ISBN: 1118354435
Category: Science
Language: EN, FR, DE, ES & NL

Heterocyclic Chemistry in Drug Discovery Book Excerpt:

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Oral Formulation Roadmap from Early Drug Discovery to Development

Oral Formulation Roadmap from Early Drug Discovery to Development
Author: Elizabeth Kwong
Publsiher: John Wiley & Sons
Total Pages: 272
Release: 2017-01-03
ISBN: 1118907906
Category: Medical
Language: EN, FR, DE, ES & NL

Oral Formulation Roadmap from Early Drug Discovery to Development Book Excerpt:

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection • Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology
Author: Daan J. A. Crommelin,Robert D. Sindelar,Bernd Meibohm
Publsiher: Springer Science & Business Media
Total Pages: 544
Release: 2013-10-22
ISBN: 1461464862
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmaceutical Biotechnology Book Excerpt:

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery
Author: Dastmalchi, Siavoush
Publsiher: IGI Global
Total Pages: 456
Release: 2016-05-03
ISBN: 1522501169
Category: Medical
Language: EN, FR, DE, ES & NL

Methods and Algorithms for Molecular Docking Based Drug Design and Discovery Book Excerpt:

The role of technology in the medical field has resulted in significant developments within the pharmaceutical industry. Computational approaches have emerged as a crucial method in further advancing drug design and development. Methods and Algorithms for Molecular Docking-Based Drug Design and Discovery presents emerging research on the application of computer-assisted design methods for drugs, emphasizing the benefits and improvements that molecular docking has caused within the pharmaceutical industry. Focusing on validation methods, search algorithms, and scoring functions, this book is a pivotal resource for professionals, researchers, students, and practitioners in the field of theoretical and computational chemistry.

Interdisciplinary Research and Applications in Bioinformatics Computational Biology and Environmental Sciences

Interdisciplinary Research and Applications in Bioinformatics  Computational Biology  and Environmental Sciences
Author: Liu, Limin Angela,Wei, Dongqing,Li, Yixue
Publsiher: IGI Global
Total Pages: 396
Release: 2010-10-31
ISBN: 1609600665
Category: Computers
Language: EN, FR, DE, ES & NL

Interdisciplinary Research and Applications in Bioinformatics Computational Biology and Environmental Sciences Book Excerpt:

"This book presents cutting-edge research in the field of computational and systems biology, presenting studies ranging from the atomic/molecular level to the genomic level and covering a wide spectrum of important biological problems and applications"--Provided by publisher.

Chirality in Drug Research

Chirality in Drug Research
Author: Eric Francotte,Wolfgang Lindner
Publsiher: John Wiley & Sons
Total Pages: 370
Release: 2007-09-24
ISBN: 3527608710
Category: Science
Language: EN, FR, DE, ES & NL

Chirality in Drug Research Book Excerpt:

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.