Cancer Genome and Tumor Microenvironment

Cancer Genome and Tumor Microenvironment
Author: Andrei Thomas-Tikhonenko
Publsiher: Springer Science & Business Media
Total Pages: 480
Release: 2010-01-23
ISBN: 9781441907110
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Genome and Tumor Microenvironment Book Excerpt:

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

Cancer Genome and Tumor Microenvironment

Cancer Genome and Tumor Microenvironment
Author: Andrei Thomas-Tikhonenko
Publsiher: Unknown
Total Pages: 512
Release: 2010-09-13
ISBN: 9781441907127
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Cancer Genome and Tumor Microenvironment Book Excerpt:

Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment

Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment
Author: Zhenyu Jia,Kexin Xu,Farah Rahmatpanah
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-19
ISBN: 2889740986
Category: Medical
Language: EN, FR, DE, ES & NL

Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment Book Excerpt:

Cancer Genomics

Cancer Genomics
Author: Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow
Publsiher: Elsevier Inc. Chapters
Total Pages: 510
Release: 2013-11-21
ISBN: 0128061111
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Genomics Book Excerpt:

Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors explain only a proportion of the observed variation in clinical outcome from patient to patient. Furthermore, over-treatment of indolent and low-risk cancers leads to inappropriate morbidity following radiotherapy or surgery. As such, better predictors of individualized prognosis and treatment response are urgently needed to triage patients to customized and intensified CaP treatment. Recent developments in next-generation sequencing have made it possible to identify prognostic and predictive signatures based on genomic profiles. Herein, we review the recent genetic data pertaining to prostate cancer carcinogenesis, progression, castrate-resistance and metastases. We discuss the genetic basis of CaP progression from localized to systemic disease (e.g. point mutations, copy number alterations and structural variants) and important considerations for CaP biology including intra- and inter-prostatic heterogeneity, multifocality and multiclonality, TMPRSS2–ERG and other ETS-family gene fusions and the role of the tumor microenvironment (e.g. hypoxia and the contribution of caner-associated stroma). Finally, we focus on the use of genomic markers as prognostic factors for local failure and for systemic disease, as novel risk stratification tools, in triaging patients to existing treatment options and, ultimately, the potential of genomics for the identification of molecular targets for CaP therapy. We conclude by summarizing selected outstanding questions in CaP biology that can be addressed effectively through international cooperation between genome sequencing projects such as The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC).

The Role of Tumor Microenvironment in Primary Liver Cancer Therapeutic Resistance

The Role of Tumor Microenvironment in Primary Liver Cancer Therapeutic Resistance
Author: Jiang Chen,Jian Chen,Zhigang Ren,Xiaochen Wang,Qiuran Xu
Publsiher: Frontiers Media SA
Total Pages: 133
Release: 2022-09-01
ISBN: 2889768821
Category: Science
Language: EN, FR, DE, ES & NL

The Role of Tumor Microenvironment in Primary Liver Cancer Therapeutic Resistance Book Excerpt:

Tumor penetrating Delivery of Small Interfering RNA Therapeutics

Tumor penetrating Delivery of Small Interfering RNA Therapeutics
Author: Yin Ren (Ph. D.),Harvard--MIT Program in Health Sciences and Technology
Publsiher: Unknown
Total Pages: 254
Release: 2012
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Tumor penetrating Delivery of Small Interfering RNA Therapeutics Book Excerpt:

Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of cancer difficult, as many genes are not amenable to manipulation by small molecules or antibodies. RNA interference (RNAi) provides a direct way to assess and act on putative cancer targets. However, the translation of RNAi into the clinic has been thwarted by the "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells. This thesis sought to develop nanotechnology-based platforms to rapidly discover and validate cancer targets in vivo. First, we developed versatile surface chemistries for nanoparticle tumor targeting. Leveraging new discoveries in amplified transvascular transport, we designed a siRNA delivery system that integrates the tumor specificity and tissue-penetrating ability of tumor-penetrating peptides with membrane penetration properties of protein transduction domains to direct siRNA to tumors in vivo. Second, we utilized this delivery system to bridge the gap between cancer genomic discovery and in vivo target validation. Comprehensive analysis of ovarian cancer genomes identified candidate targets that are undruggable by traditional approaches. Tumor-penetrating delivery of siRNA against these genes potently impeded the growth of ovarian tumors in mice and improved survival, thereby credentialing their roles in tumor initiation and maintenance. Lastly, we described efforts extending this platform for clinical translation. Mechanistic studies identified functional properties that favored receptor-specific siRNA delivery. We also explored a strategy to improve the microdistribution of successively dosed siRNA therapeutics through modulating the tumor microenvironment. Finally, we investigated the utility of the system in primary human tumors derived from patients with ovarian cancer. Together, these findings illustrate that the combination of cancer genomics with the engineering of siRNA delivery nanomaterials establishes a platform for discovering genes amenable to RNAi therapies. As efforts in genome sequencing accelerate, this platform illustrates a path to clinical translation in humans.

The Tumor Microenvironment Recent Advances and Novel Therapeutic Approaches

The Tumor Microenvironment  Recent Advances and Novel Therapeutic Approaches
Author: Sandra Orsulic,Hasan Korkaya
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-12-03
ISBN: 288971781X
Category: Science
Language: EN, FR, DE, ES & NL

The Tumor Microenvironment Recent Advances and Novel Therapeutic Approaches Book Excerpt:

Distinct Cellular Functional Profiles in Pan cancer Expression Analysis of Cancers with Alterations in Oncogenes C MYC and N MYC

Distinct Cellular Functional Profiles in Pan cancer Expression Analysis of Cancers with Alterations in Oncogenes C MYC and N MYC
Author: Anne B. Richardson
Publsiher: Unknown
Total Pages: 98
Release: 2018
ISBN: 1928374650XXX
Category: Cancer cells
Language: EN, FR, DE, ES & NL

Distinct Cellular Functional Profiles in Pan cancer Expression Analysis of Cancers with Alterations in Oncogenes C MYC and N MYC Book Excerpt:

Cancerous cells may contain a vast array of dysregulated or altered genes that contribute to tumorigenesis, but there are often a few prominent oncogenic drivers that are very commonly found in a variety of cancers. The MYC gene family, composed of c-MYC, n-MYC, and l-MYC, is a group of basic helix-loop-helix leucine-zipper (bHLHZ) transcription factors that regulate expression of 15% of the human genome. MYC oncogenes drive the transcription of a variety of genes involved in the cell cycle, apoptosis, and cell growth. When constitutively expressed, they have been implicated in the genesis and progression of a variety of cancer types by contributing to unchecked cell proliferation. However, little research has been done on systemic, pan-cancer patterns and effects that MYC oncogenes may have on tumorigenesis. Using data from the Cancer Genome Atlas, I analyzed upregulated gene sets across 33 different tumor types associated with increased activity of c-MYC or its paralog n-MYC, in order to find pan-cancer patterns of gene expression and better understand the mechanisms of MYC-driven cancer. I confirmed the presence of a "canonical" functional profile previously documented in the literature, consisting of upregulated biological processes such as DNA replication and repair, RNA transcription, RNA processing, chromatin regulation, and protein translation. However, I also found a novel "non-canonical" functional profile correlated with a diverse set of cell signaling pathways, immune system function, and the extracellular matrix, which may be involved in the maintenance of a tumor microenvironment. These findings may be important for identifying potential therapeutic drug targets, as well as further elucidating the causes and mechanisms of MYC-driven cancer.

Inflammatory Tumor Immune Microenvironment Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis

Inflammatory Tumor Immune Microenvironment  Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis
Author: Xu Wang,Tengchuan Jin,Christopher James Pirozzi,Xueli Zhang,Shu-Heng Jiang
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-03-25
ISBN: 2889747549
Category: Medical
Language: EN, FR, DE, ES & NL

Inflammatory Tumor Immune Microenvironment Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis Book Excerpt:

Systems Biology of Tumor Physiology

Systems Biology of Tumor Physiology
Author: David H. Nguyen
Publsiher: Springer
Total Pages: 56
Release: 2015-12-11
ISBN: 3319256017
Category: Medical
Language: EN, FR, DE, ES & NL

Systems Biology of Tumor Physiology Book Excerpt:

This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.​

Gene Therapy of Cancer

Gene Therapy of Cancer
Author: Edmund C. Lattime,Stanton L. Gerson
Publsiher: Academic Press
Total Pages: 554
Release: 2013-08-28
ISBN: 0123946328
Category: Science
Language: EN, FR, DE, ES & NL

Gene Therapy of Cancer Book Excerpt:

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Cancer Biology How Science Works

Cancer Biology  How Science Works
Author: Carsten Carlberg,Eunike Velleuer
Publsiher: Springer Nature
Total Pages: 167
Release: 2021-07-05
ISBN: 3030756998
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Biology How Science Works Book Excerpt:

Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.

Molecular Immune Signatures of T cell Infiltration in Cancer

Molecular Immune Signatures of T cell Infiltration in Cancer
Author: Eric Daniel Levy
Publsiher: Unknown
Total Pages: 92
Release: 2016
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Molecular Immune Signatures of T cell Infiltration in Cancer Book Excerpt:

There is currently a strong interest in cancer research to profile the tumor-immune microenvironment to understand the complicated interplay of immune targeting and escape. With the recent developments of immune checkpoint inhibitors, which overcome the defenses cancer cells develop to prevent the immune system from targeting them, there has been an increasing importance in furthering our understanding of patients' immune systems and the infiltration into tumors to lead to further breakthroughs in therapy. Here, we develop and apply an analysis framework designed to characterize the tumor immune microenvironment through the identification of markers of T-cell infiltration in tumor tissue. This allows us to re-analyze a large public dataset of tumor sequencing data, The Cancer Genome Atlas, in order to evaluate and characterize markers of infiltrating T-cells across multiple cancer types. First, we use a targeted deep sequencing approach as a validation to prove the accuracy of extracting T-cell markers from genome-wide tumor data. Then, we use our approach to identify and analyze T-cell infiltration across breast cancer samples, and evaluate their correspondence with other makers of immune infiltration and prognostic value. Finally, we extend our analysis methodology to 10,084 tumors from 28 cancer types, in order to evaluate differences in molecular markers of immune infiltration between these cancer types. This work adds to the set of methodologies that can be used to profile immune infiltration in tumor samples, and highlights a new molecular marker for T-cell infiltration. This framework can be used in future studies that use deeper sequencing and experimental designs that generate the data to evaluate more thoroughly questions of immune infiltration compared to cancer progression and treatment. Using the methods developed here, the profiling of molecular markers of T-cell infiltration will further our understanding of the interaction between the immune system and tumors.

Molecular Oncology Underlying Mechanisms and Translational Advancements

Molecular Oncology  Underlying Mechanisms and Translational Advancements
Author: Ammad Ahmad Farooqi,Muhammad Ismail
Publsiher: Springer
Total Pages: 302
Release: 2017-03-29
ISBN: 3319530828
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular Oncology Underlying Mechanisms and Translational Advancements Book Excerpt:

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Manipulating the Immunological Tumor Microenvironment

Manipulating the Immunological Tumor Microenvironment
Author: Peng Qu,Huanfa Yi,Keqiang Chen
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-03-31
ISBN: 2889748405
Category: Medical
Language: EN, FR, DE, ES & NL

Manipulating the Immunological Tumor Microenvironment Book Excerpt:

Microfluidic Tools to Recapitulate the Tumor Microenvironment

Microfluidic Tools to Recapitulate the Tumor Microenvironment
Author: Luis Fernando Alonzo
Publsiher: Unknown
Total Pages: 76
Release: 2014
ISBN: 9781321448184
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Microfluidic Tools to Recapitulate the Tumor Microenvironment Book Excerpt:

Treatments for cancer remain elusive due, in large part, to the dynamic and unstable genome of most cancer cells. More recently it has become evident that tumor growth and progression to metastasis depends on the ability to recruit normal cells, such as endothelial cells, fibroblasts, as key accomplices. These observations suggest that selective targeting of normal cells, which have a stable genome, could be an effective alternative or complimentary approach in the overall management of the disease. Understanding of such relationship is key for the design of anti-metastatic therapeutics. However, much of the data reported in this field has been performed in xenograft models and/or 2D cultures; which are limited by the number of controllable variables, extrapolation to human tumor physiology, and not amenable for a high-throughput design. This work aims to address the role of the tumor microenvironment using a novel in vitro platform that combines microfluidic and tissue engineering technology to create a 3D tumor microarray in which the tumors receive their nutrients through perfused human microcirculation. This model is capable of replicating the physiology of the in vivo tumor microenvironment; thus providing relevant physiological results. Most importantly, the impact of creating an in vitro 3D metastasis model with perfused human capillary bed could significantly enhance high-throughput anti-metastatic drug screening.

Biomedical Translational Research

Biomedical Translational Research
Author: R.C. Sobti,Awtar Krishan Ganju
Publsiher: Springer Nature
Total Pages: 491
Release: 2022-07-16
ISBN: 9811688451
Category: Medical
Language: EN, FR, DE, ES & NL

Biomedical Translational Research Book Excerpt:

The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.

Single cell Molecular Characterization for Improving Cancer Immunotherapy

Single cell Molecular Characterization for Improving Cancer Immunotherapy
Author: Qihui Shi,Wei Wei,Ziming Li
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-22
ISBN: 2889744795
Category: Medical
Language: EN, FR, DE, ES & NL

Single cell Molecular Characterization for Improving Cancer Immunotherapy Book Excerpt:

Topic Editor Qihui Shi is the scientific co-founder of JunHealth, a company aiming to developing single-cell sequencing technologies for clinical applications, and received research funding from BeiGene.

Bayesian Statistical Inference for Tumor Microenvironment Compositions

Bayesian Statistical Inference for Tumor Microenvironment Compositions
Author: Tinyi Chu
Publsiher: Unknown
Total Pages: 181
Release: 2019
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Bayesian Statistical Inference for Tumor Microenvironment Compositions Book Excerpt:

The complex interaction between tumor and its microenvironment is essential for oncogenesis, survival and growth of tumor. These interactions allow tumor to uptake nutrient from environment and evade from immune surveillances. Understanding these interactions is fundamental to the design of immunotherapies and other targeted therapies. Advances in sequencing technologies have enabled measurement of gene transcription and regulation across large cohorts of cancer patients and also down to the single cell resolution. In this work, using glioblastoma (GBM) as a model system, I present the bioinformatic characterization of tumors and their microenvironment, and the statistical models towards an unsupervised and automated way of understanding the compositions. The first part describes the new sequencing method, Chromatin Run-on Sequencing (ChRO-seq), and its use in characterizing the transcription regulatory landscape in primary glioblastoma. Taking advantage of the ability for ChRO-seq to quantify nascent RNAs directly from solid tissues, I developed bioinformatic tools called dREG-HD to map the genome-wide positions of transcription regulatory elements (TREs) based on their nascent RNA patterns, which formed the basis for quantifying the enhancer activity. As ChRO-seq also enables simultaneous quantification of transcription activity of genes, I developed the tool tfTarget to map the network formed between transcription factor, TREs and target genes. Using tfTarget I identified tumor-associated transcription modules and regulatory networks associated with known GBM subtypes. More importantly, I identified three transcription factors from the immune module that negatively correlated with patient survival. This work showed that ChRO-seq is a powerful tool for understanding transcription regulation in complex diseases, highlighting the clinical importance of tumor microenvironment in GBM. The second part develops a Bayesian statistical model for understanding the tumor compositions using bulk sample RNA-seq and/or ChRO-seq collected from large patient cohorts in conjunction with prior knowledge learned from the single cell RNA-seq and/or ATAC-seq data collected from normal and tumor tissues. This model is expected to address the following questions of central importance in cancer biology. First, what transcription pathways are ectopically regulated in tumor patients, and to what extent in each patient? Secondly, what are the cell type compositions in the tumor microenvironment of each patient? Lastly, do any of pathways or the cells present in the microenvironment interact among each other? Answers to these questions shall provide insights into new druggable targets through modulating tumor microenvironment.

Bioinformatics Approaches to Understanding the Breast Cancer Microenvironment

Bioinformatics Approaches to Understanding the Breast Cancer Microenvironment
Author: François Pepin
Publsiher: Unknown
Total Pages: 135
Release: 2010
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Bioinformatics Approaches to Understanding the Breast Cancer Microenvironment Book Excerpt: