Structure Function Relationships Of Proteolytic Enzymes

Author by : P. Desnuelle
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 81
Total Download : 302
File Size : 42,5 Mb
GET BOOK

Description : Structure–Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.


The Journal Of Biological Chemistry

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 84
Total Download : 656
File Size : 41,7 Mb
GET BOOK

Description : Vols. 3-140 include the society's Proceedings, 1907-41


Chemical Reagents For Protein Modification Fourth Edition

Author by : Roger L. Lundblad
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 19
Total Download : 157
File Size : 48,5 Mb
GET BOOK

Description : The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics. Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters: Alkylating Agents Acylating Agents Nitration and Nitrosylation Oxidation Modification of Proteins with Reducing Agents There is greatly increased coverage of the chemical modification of cysteine, which is critical for bioconjugate synthesis. The chapter on reduction also provides information necessary for bioconjugate synthesis as well as for the processing of inclusion bodies. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. This new version has increased significance to biopharmaceuticals. Much of the information is in tabular form, which enables the rapid location of cited material.


Handbook Of Proteolytic Enzymes

Author by : Alan J. Barrett
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 49
Total Download : 632
File Size : 43,7 Mb
GET BOOK

Description : The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field


Handbook Of Proteolytic Enzymes Volume 1

Author by : Alan J. Barrett
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 44
Total Download : 924
File Size : 41,5 Mb
GET BOOK

Description : Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.


Cumulated Index Medicus

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 24
Total Download : 887
File Size : 52,7 Mb
GET BOOK

Description :


Amino Acids Peptides And Proteins

Author by : G T Young
Languange : en
Publisher by : Royal Society of Chemistry
Format Available : PDF, ePub, Mobi
Total Read : 62
Total Download : 336
File Size : 41,9 Mb
GET BOOK

Description : Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.


Amino Acids Peptides And Proteins

Author by : G. T. Young
Languange : en
Publisher by : Royal Society of Chemistry
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 677
File Size : 55,8 Mb
GET BOOK

Description : Indispensable reference source for researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia.


The Enzymes

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 70
Total Download : 529
File Size : 52,8 Mb
GET BOOK

Description : The Enzymes


Biochemistry Abstracts

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 67
Total Download : 649
File Size : 50,8 Mb
GET BOOK

Description :


Hydrolytic Enzymes

Author by : K. Brocklehurst
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 56
Total Download : 611
File Size : 40,7 Mb
GET BOOK

Description : This newest volume in the impressive New Comprehensive Biochemistry series presents up-to-date discussions of six types of hydrolytic enzyme that are well characterized structurally: aspartic-, cysteins-, and serine-proteinases, carboxypeptidase A, pancreatic ribonuclease A, and the phosphomonoesterases. The emphasis is on molecular mechanisms deduced by crystallographic, kinetic, spectroscopic and molecular genetic studies. The chapters on the various types of proteinases are complemented by others on proteinase inhibitors and intracellular proteolysis. This book will prove valuable to researchers in general biochemistry, particularly those with interest in enzyme mechanism and protein chemistry, and to Honours and Postgraduate students.


Nutritional Improvement Of Food And Feed Proteins

Author by : Mendel Friedman
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 89
Total Download : 910
File Size : 50,9 Mb
GET BOOK

Description : The nutritional quality of a protein depends on the proportion of its amino acids-especially the essential amino acids-their physio logical availability, and the specific requirements of the consumer. Availability varies and depends on protein source, interaction with other dietary components, and the consumer's age and physiological state. In many foods, especially those from plants, low levels of various essential amino acids limits their nutritive value. This is particularly important for cereals (which may be inadequate in the essential amino acids isoleucine, lysine, threonine, and tryto phan) and legumes (which are often poor sources of methionine). Moreover, these commodities are principle sources of protein for much of the earth's rapidly growing population. At the current annual growth rate of about 2 percent, the world population of about 4 billion will increase to 6.5 billion by the year 2000 and to 17 billion by the year 2050. Five hundred milliQn people are presently estimated to suffer protein malnutrition, with about fifteen thousand daily deaths. The ratio of malnourished to adequately nourished will almost surely increase. For these reasons, and especially in view of the limited availability of high quality (largely animal) protein to feed present and future populations, improvement of food and feed quality is especially important.


Cytolytic Lymphocytes And Complement Effectors Of The Immune System

Author by : Eckhard R. Podack
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 755
File Size : 54,6 Mb
GET BOOK

Description : These volumes, Cytolytic Lymphocytes and Complement: Effectors of the Immune System, originate from the realization that pathways of recognition and killings of foreign targets follow similar routes in the humoral and cellular part of the immune system. In particular, the homology of immunoglobins with the T-cell-MHC-antigen receptor at the beginning of the recognition sequence and the homology of complement component C9 with lymphocyte perforin 1 (P1) as pore formers at the end of the effector sequence are striking examples.


The Enzymes

Author by : Paul D. Boyer
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 67
Total Download : 567
File Size : 46,5 Mb
GET BOOK

Description :


Tietz Fundamentals Of Clinical Chemistry And Molecular Diagnostics 8 E South Asia Edition E Book

Author by : Nader Rifai
Languange : en
Publisher by : Elsevier India
Format Available : PDF, ePub, Mobi
Total Read : 71
Total Download : 553
File Size : 44,9 Mb
GET BOOK

Description : Get the foundational knowledge you need to successfully work in a real-world, clinical lab with Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 8th Edition. From highly respected clinical chemistry expert Nader Rifai, this condensed, easier-to-understand version of the acclaimed Tietz Textbook of Clinical Chemistry and Molecular Diagnostics uses a laboratory perspective to guide you through selecting and performing diagnostic lab tests and accurately evaluating the results. Coverage includes laboratory principles, analytical techniques, instrumentation, analytes, pathophysiology, and more. This eighth edition features new clinical cases from The Coakley Collection, new questions from The Deacon's Challenge of Biochemical Calculations Collection, plus new content throughout the text to ensure you stay ahead of all the latest techniques, instrumentation, and technologies. Condensed version of the clinical chemistry bible offers the same authoritative and well-presented content in a much more focused and streamlined manner. Coverage of analytical techniques and instrumentation includes optical techniques, electrochemistry, electrophoresis, chromatography, mass spectrometry, enzymology, immunochemical techniques, microchips, automation, and point of care testing. Updated chapters on molecular diagnostics cover the principles of molecular biology, nucleic acid techniques and applications, and genomes and nucleic acid alterations, reflecting the changes in this rapidly evolving field. Learning objectives, key words, and review questions are included in each chapter to support learning. More than 500 illustrations plus easy-to-read tables help readers better understand and remember key concepts


Chemistry Of Protein Conjugation And Cross Linking

Author by : Shan S. Wong
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 66
Total Download : 662
File Size : 45,7 Mb
GET BOOK

Description : Chemical cross-linking reagents have attained great practical use in industry as well as in basic research, and an understanding of their fundamental principles of reaction is paramount to their applications. With broad coverage of the development and application of these reagents, Chemistry of Protein Conjugation and Cross-Linking discusses the mechanism of reaction and allows you to put the theory into practice. The book offers an explanation of the underlying mechanism of chemical modification, surveys all the bifunctional reagents used in bioconjugation and cross-linking, and provides a review of practical applications of these reagents in various areas of biochemistry, molecular biology, biotechnology, nucleic acid chemistry, immunochemistry, and diagnostic and biomedical disciplines. It contains numerous examples and illustrations, plus step-by-step explanations to reaction procedures. It is an excellent introduction and a comprehensive reference about chemical modification.


Handbook Of Biochemistry And Molecular Biology Fourth Edition

Author by : Roger L. Lundblad
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 20
Total Download : 445
File Size : 44,7 Mb
GET BOOK

Description : Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fourth edition of the Handbook of Biochemistry and Molecular Biology represents a dramatic revision — the first in two decades — of one of biochemistry's most referenced works. This edition gathers a wealth of information not easily obtained, including information not found on the web. Offering a molecular perspective not available 20 years ago, it provides physical and chemical data on proteins, nucleic acids, lipids, and carbohydrates. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. Just a small sampling of the wealth of information found inside the handbook: Buffers and buffer solutions Heat capacities and combustion levels Reagents for the chemical modification of proteins Comprehensive classification system for lipids Biological characteristics of vitamins A huge variety of UV data Recommendations for nomenclature and tables in biochemical thermodynamics Guidelines for NMR measurements for determination of high and low pKa values Viscosity and density tables Chemical and physical properties of various commercial plastics Generic source-based nomenclature for polymers Therapeutic enzymes About the Editors: Roger L. Lundblad, Ph.D. Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD degree in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at the Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently Dr. Lundblad is an independent consultant and writer in biotechnology in Chapel Hill, North Carolina. He is an adjunct Professor of Pathology at the University of North Carolina at Chapel Hill and Editor-in-Chief of the Internet Journal of Genomics and Proteomics. Fiona M. Macdonald, Ph.D., F.R.S.C. Fiona M. Macdonald received her BSc in chemistry from Durham University, UK. She obtained her PhD in inorganic biochemistry at Birkbeck College, University of London, studying under Peter Sadler. Having spent most of her career in scientific publishing, she is now at Taylor and Francis and is involved in developing chemical information products.


Hemostasis And Thrombosis

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 254
File Size : 52,5 Mb
GET BOOK

Description : Monthly, with annual cumulation. Recurring bibliography from MEDLARS data base. Index medicus format. Entries arranged under subject, review, and author sections. Subject, author indexes.


Interactions Between Proteolytic Enzymes And Their Protein Substrates And Inhibitors

Author by : Yuan Lin
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 94
Total Download : 575
File Size : 50,6 Mb
GET BOOK

Description : The last thing Jake Bryan knew was the roar of the World Trade Center collapsing on top of him and his fellow firefighters. The man in the hospital bed remembers nothing. Not rusing with his teammates up the stairway of the south tower to help trapped victims. Not being blasted from the building. and not the woman sitting by his bedside who says she is his wife. Jamie Bryan will do anything to help her beloved husband regain his memory, and with it their storybook family life with their small daughter, Sierra. But that means helping Jake redisover the one thing Jamie has never shared with him: his deep faith in God.


Introduction To Enzyme And Coenzyme Chemistry

Author by : T. D. H. Bugg
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 91
Total Download : 142
File Size : 44,5 Mb
GET BOOK

Description : Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.


Tetrahedron Reports On Organic Chemistry

Author by : Derek Barton
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 83
Total Download : 419
File Size : 45,5 Mb
GET BOOK

Description : Tetrahedron Reports on Organic Chemistry