Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis
Author: Lena Ohannesian,Anthony Streeter
Publsiher: CRC Press
Total Pages: 608
Release: 2001-11-09
ISBN: 0824741943
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Pharmaceutical Analysis Book Excerpt:

Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.

HPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists
Author: Yuri V. Kazakevich,Rosario LoBrutto
Publsiher: John Wiley & Sons
Total Pages: 1080
Release: 2007-02-16
ISBN: 0470087943
Category: Science
Language: EN, FR, DE, ES & NL

HPLC for Pharmaceutical Scientists Book Excerpt:

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Promising Drug Molecules of Natural Origin

Promising Drug Molecules of Natural Origin
Author: Rohit Dutt,Anil K. Sharma,Raj K. Keservani,Vandana Garg
Publsiher: CRC Press
Total Pages: 458
Release: 2020-11-04
ISBN: 1000765156
Category: Science
Language: EN, FR, DE, ES & NL

Promising Drug Molecules of Natural Origin Book Excerpt:

This new volume, Promising Drug Molecules of Natural Origin, explores potential beneficial drug substances derived from nature. It presents the general principles, characteristics, evaluation techniques, and applications involved in drug molecules from natural sources, such as plants and marine life. With chapters from renowned experts from around the world, the chapters in this volume address the challenges of standardization of herbal medicines, methods of characterization of natural medicines and phyto-constituents, and quality control methods for herbal medicines. Several chapters in the book focus on the evolution of phyto-constituents in cancer therapeutics, while others deal with applications for other diseases, such as diabetes and neuroinflammatory disorders. The volume also specifically reviews heterocyclic drugs from plants. This volume will be a valuable resource for faculty and advanced students in pharmaceutics as well as researchers, scientists, and industry professionals in medicine and drug development.

Encyclopedia of Chromatography Print

Encyclopedia of Chromatography  Print
Author: Jack Cazes
Publsiher: CRC Press
Total Pages: 927
Release: 2001-06-29
ISBN: 9780824705114
Category: Science
Language: EN, FR, DE, ES & NL

Encyclopedia of Chromatography Print Book Excerpt:

This practical, single-volume source collects up-to-date information on chromatographic techniques and methodologies for the solution of analytical and preparative problems applicable across a broad spectrum of disciplines including biotechnology, pharmaceuticals, environmental sciences, polymers, food additives and nutrients, pathology, toxicology, fossil fuels, and nuclear chemistry. It highlights real-world applications, easy-to-read fundamentals of problem solving and material identification methods, and detailed references. Written by over 180 esteemed international authorities and containing over 300 chapters, 2600 works cited, and 1000 drawings, equations, tables, and photographs, the Encyclopedia of Chromatography covers high-performance liquid, thin-layer, gas, affinity, countercurrent, supercritical fluid, gel permeation, and size exclusion chromatographies as well as capillary electrophoresis, field-flow fractionation, hyphenated techniques, and more. PRINT/ONLINE PRICING OPTIONS AVAILABLE UPON REQUEST AT [email protected]

HPLC Method Development for Pharmaceuticals

HPLC Method Development for Pharmaceuticals
Author: Satinder Ahuja,Henrik Rasmussen
Publsiher: Elsevier
Total Pages: 532
Release: 2011-09-21
ISBN: 0080554199
Category: Medical
Language: EN, FR, DE, ES & NL

HPLC Method Development for Pharmaceuticals Book Excerpt:

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

Liquid Chromatography

Liquid Chromatography
Author: G. Baird
Publsiher: Elsevier Inc. Chapters
Total Pages: 688
Release: 2013-01-08
ISBN: 0128071265
Category: Science
Language: EN, FR, DE, ES & NL

Liquid Chromatography Book Excerpt:

Clinical chemistry is the discipline within laboratory medicine concerned with measuring the concentrations of analytes in blood, body fluids, and tissues. Liquid chromatography is already commonly used in the clinical chemistry laboratory for measuring the concentrations of small molecules, such as drugs and hormones, using a variety of solid phases for separation and numerous detection modalities, most important mass spectrometry. Additional liquid chromatographic methods are now being developed for measuring the concentrations of proteins in blood and tissues, taking advantage of the rapid development of novel mass-spectrometry instruments and methodologies.

Selectivity and Detectability Optimizations in HPLC

Selectivity and Detectability Optimizations in HPLC
Author: Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 624
Release: 1989-06-06
ISBN: 9780471626459
Category: Science
Language: EN, FR, DE, ES & NL

Selectivity and Detectability Optimizations in HPLC Book Excerpt:

High Performance Liquid Chromatography Edited by Phyllis Brown and Richard Hartwick This contributed volume is designed to consolidate the basic theories of chromatography along with the more exciting developments in the field. This monograph addresses some questions that concern researchers in separation science, including: what is the current state of the art in liquid chromatography; has the development of liquid chromatography plateaued; if so, what new methods will take its place or complement it; and if not, where will the new frontiers be and what direction will liquid chromatography take? 1989 (0 471-84506-X) 688 pp. Quantitative Structure-Chromatographic Retention Relationships R. Kaliszan Written by a pioneer in the field, this book extends and updates research on quantitative structure retention relationships by consolidating and critically reviewing the extensive literature on the subject, while also providing the basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Among the topics covered are the nature of chromatographic interactions, molecular interpretation of distribution processes in chromatography, topological indices as retention descriptors, and multiparameter structure-chromatographic retention relationships. 1987 (0 471-85983-4) 303 pp. Detectors for Liquid Chromatography Edited by Edward S. Yeung With its singular coverage of this fast-growing field, Detectors for Liquid Chromatography presents the state of the art in this subject area. It offers a comprehensive examination of the basic principles behind the detector response, instrumentation, and selected applications for comparison and evaluation of potential. Specifically, topics given in-depth coverage include polarimetric, indirect absorbance, refractive index detectors, absorption detectors for HPLC, FTIR and fluorometric detection, detection based on electrical and electromechanical measurements, and mass spectroscopy as an on-line detector for HPLC. 1986 (0 471-82169-1) 366 pp.

Thin Layer Chromatography in Drug Analysis

Thin Layer Chromatography in Drug Analysis
Author: Lukasz Komsta,Monika Waksmundzka-Hajnos,Joseph Sherma
Publsiher: CRC Press
Total Pages: 1067
Release: 2013-12-20
ISBN: 1466507160
Category: Medical
Language: EN, FR, DE, ES & NL

Thin Layer Chromatography in Drug Analysis Book Excerpt:

Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date

Introduction to Pharmaceutical Chemical Analysis

Introduction to Pharmaceutical Chemical Analysis
Author: Steen Honoré Hansen,Stig Pedersen-Bjergaard,Knut Rasmussen
Publsiher: John Wiley & Sons
Total Pages: 624
Release: 2011-10-18
ISBN: 1119954339
Category: Science
Language: EN, FR, DE, ES & NL

Introduction to Pharmaceutical Chemical Analysis Book Excerpt:

This textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide. In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the pharmacy student, to teach the requirements in “analytical chemistry” for the 5 years pharmacy curriculum, but the textbook is also intended for analytical chemists moving into the field of pharmaceutical analysis. Addresses the basic concepts, then establishes the foundations for the common analytical methods that are currently used in the quantitative and qualitative chemical analysis of pharmaceutical drugs Provides an understanding of common analytical techniques used in all areas of pharmaceutical development Suitable for a foundation course in chemical and pharmaceutical sciences Aimed at undergraduate students of degrees in Pharmaceutical Science/Chemistry Analytical Science/Chemistry, Forensic analysis Includes many illustrative examples

Mass Spectrometry in Drug Discovery

Mass Spectrometry in Drug Discovery
Author: David T. Rossi,Michael Sinz
Publsiher: CRC Press
Total Pages: 436
Release: 2001-11-07
ISBN: 9781420002478
Category: Medical
Language: EN, FR, DE, ES & NL

Mass Spectrometry in Drug Discovery Book Excerpt:

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 788
Release: 2020-06-19
ISBN: 0444640711
Category: Science
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Excerpt:

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS

Identification and Quantification of Drugs  Metabolites and Metabolizing Enzymes by LC MS
Author: Swapan Chowdhury
Publsiher: Elsevier
Total Pages: 354
Release: 2005-11-04
ISBN: 9780080456065
Category: Science
Language: EN, FR, DE, ES & NL

Identification and Quantification of Drugs Metabolites and Metabolizing Enzymes by LC MS Book Excerpt:

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography
Author: Steven H.Y. Wong
Publsiher: Routledge
Total Pages: 512
Release: 2017-09-19
ISBN: 1351408461
Category: Medical
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography Book Excerpt:

First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.

Chromatographic Separations Based on Molecular Recognition

Chromatographic Separations Based on Molecular Recognition
Author: Kiyokatsu Jinno
Publsiher: Wiley-VCH
Total Pages: 426
Release: 1997-03-21
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Chromatographic Separations Based on Molecular Recognition Book Excerpt:

This book provides an in-depth understanding of molecular recognition mechanisms in designing chromatographical processes for separations. The title explains the importance of chemistry in chromatography and molecule-molecule interaction mechanisms and extends the concepts of separation to isomers and chiral isomers. "Chromatographic Separations Based on Molecular Recognition" discusses the theoretical interpretations of chromatographic retention processes, explains the molecular recognition concept for the separation of various isomers, and provides a foundation in separation science which will lead to a better grasp of other chemical fields and simplify the design and synthesis of novel stationary phases.

Chirality in Drug Research

Chirality in Drug Research
Author: Eric Francotte,Wolfgang Lindner
Publsiher: John Wiley & Sons
Total Pages: 370
Release: 2007-09-24
ISBN: 3527608710
Category: Science
Language: EN, FR, DE, ES & NL

Chirality in Drug Research Book Excerpt:

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Advances in Chromatography

Advances in Chromatography
Author: Eli Grushka,Nelu Grinberg
Publsiher: CRC Press
Total Pages: 328
Release: 2016-04-19
ISBN: 1466569662
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Chromatography Book Excerpt:

For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 51, the series editors have invited established, well-known chemists from across the globe to offer cutting-edge reviews on their areas of expertise—from theoretical aspects to novel and established applications of chromatographic techniques. Featured topics include Nonequilibrium Thermodynamics in Nonlinear Chromatography and Electrophoresis: Theory and Applications Biomimetic Chromatography: A Useful Tool in the Drug Discovery Process Solid-Phase Microextraction for In Vivo Pharmacokinetics and Other Stages of Drug Development Identification and Detection of Antibiotic Drugs and Their Degradation Products in Aquatic Samples Sample Preparation for Chromatographic Analysis Development of HPLC Retention Index QSAR Models for Nontargeted Metabolomics Thin Layer Chromatography with a Controlled Gas Phase Influencing on the Separation The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

An Introduction to HPLC for Pharmaceutical Analysis

An Introduction to HPLC for Pharmaceutical Analysis
Author: Oona McPolin
Publsiher: Lulu.com
Total Pages: 139
Release: 2009-03-01
ISBN: 0956152805
Category: Medical
Language: EN, FR, DE, ES & NL

An Introduction to HPLC for Pharmaceutical Analysis Book Excerpt:

If you are new to HPLC, this book provides an invaluable guide to how HPLC is actually used when analysing pharmaceuticals. It is full of practical advice on the operation of HPLC systems combined with the necessary theoretical knowledge to ensure understanding of the technique. Key features include: A thorough discussion of the stationary phase enabling the reader to make sense of the many parameters used to describe a HPLC column; Practical advice and helpful hints for the preparation and use of mobile phase; A complete overview of each of the different components which together make up a HPLC system; A description of the contents of a typical HPLC analytical method and how to interpret these; A step-by-step guide on how to follow a method and set up a HPLC analysis; A discussion of system suitability criteria and how to interpret the values obtained during an analysis; Explanation of the common methods of calibration and quantification used for pharmaceutical analysis.

Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis
Author: Lena A. Ohannesian,Anthony J. Streeter
Publsiher: CRC Press
Total Pages: 608
Release: 2001-11-09
ISBN: 9781135568078
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Pharmaceutical Analysis Book Excerpt:

Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.

Preparative Chromatography for Separation of Proteins

Preparative Chromatography for Separation of Proteins
Author: Arne Staby,Anurag S. Rathore,Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 608
Release: 2017-03-06
ISBN: 1119031109
Category: Science
Language: EN, FR, DE, ES & NL

Preparative Chromatography for Separation of Proteins Book Excerpt:

"Preparative Chromatography for Separation of Proteins addresses a wide range of the most current modeling techniques, strategies, and case studies of industrial separation of proteins and peptides to aid in the efficiency and efficacy of this broadly-used technique in the purification of biopharmaceuticals"--

Chromatography

Chromatography
Author: Leonardo Calderon
Publsiher: BoD – Books on Demand
Total Pages: 440
Release: 2012-10-24
ISBN: 9535108131
Category: Science
Language: EN, FR, DE, ES & NL

Chromatography Book Excerpt:

Nowadays, Chromatography is the most versatile and widespread technique employed in modern chemical analysis and plays a vital role in the advancement of chemistry, biology, medicine and related fields of research. Because of the inherent simplicity and ease of operation, it can be used together with a wide range of detection systems, including electrochemical, photometric and mass spectrometry, being an invaluable laboratory tool for the separation and identification of compounds. The purpose of this book is not only to present the latest state and development tendencies of chromatography, but to bring the reader useful information on separation sciences to enable him to use chromatography on his research field. Taking into account the large amount of knowledge about chromatography theory and practice presented in the book, it has three major parts: applications, theory and sample preparation. The book is also intended for both graduate and postgraduate students in fields such as chemistry, biology, biotechnology, forensic, medicine, pharmacology and engineering, and as a reference for professionals and practitioners.