Computer Simulation And Data Analysis In Molecular Biology And Biophysics

Author by : Victor Bloomfield
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 48
Total Download : 382
File Size : 47,7 Mb
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Description : This book provides an introduction to two important aspects of modern bioch- istry, molecular biology, and biophysics: computer simulation and data analysis. My aim is to introduce the tools that will enable students to learn and use some f- damental methods to construct quantitative models of biological mechanisms, both deterministicandwithsomeelementsofrandomness;tolearnhowconceptsofpr- ability can help to understand important features of DNA sequences; and to apply a useful set of statistical methods to analysis of experimental data. The availability of very capable but inexpensive personal computers and software makes it possible to do such work at a much higher level, but in a much easier way, than ever before. TheExecutiveSummaryofthein?uential2003reportfromtheNationalAcademy of Sciences, “BIO 2010: Transforming Undergraduate Education for Future - search Biologists” [12], begins The interplay of the recombinant DNA, instrumentation, and digital revolutions has p- foundly transformed biological research. The con?uence of these three innovations has led to important discoveries, such as the mapping of the human genome. How biologists design, perform, and analyze experiments is changing swiftly. Biological concepts and models are becoming more quantitative, and biological research has become critically dependent on concepts and methods drawn from other scienti?c disciplines. The connections between the biological sciences and the physical sciences, mathematics, and computer science are rapidly becoming deeper and more extensive.


Computer Simulation And Data Analysis In Molecular Biology And Biophysics

Author by : Victor Bloomfield
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 170
File Size : 45,6 Mb
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Description : This book provides an introduction to two important aspects of modern bioch- istry, molecular biology, and biophysics: computer simulation and data analysis. My aim is to introduce the tools that will enable students to learn and use some f- damental methods to construct quantitative models of biological mechanisms, both deterministicandwithsomeelementsofrandomness;tolearnhowconceptsofpr- ability can help to understand important features of DNA sequences; and to apply a useful set of statistical methods to analysis of experimental data. The availability of very capable but inexpensive personal computers and software makes it possible to do such work at a much higher level, but in a much easier way, than ever before. TheExecutiveSummaryofthein?uential2003reportfromtheNationalAcademy of Sciences, “BIO 2010: Transforming Undergraduate Education for Future - search Biologists” [12], begins The interplay of the recombinant DNA, instrumentation, and digital revolutions has p- foundly transformed biological research. The con?uence of these three innovations has led to important discoveries, such as the mapping of the human genome. How biologists design, perform, and analyze experiments is changing swiftly. Biological concepts and models are becoming more quantitative, and biological research has become critically dependent on concepts and methods drawn from other scienti?c disciplines. The connections between the biological sciences and the physical sciences, mathematics, and computer science are rapidly becoming deeper and more extensive.


Using R For Numerical Analysis In Science And Engineering

Author by : Victor A. Bloomfield
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 29
Total Download : 812
File Size : 47,7 Mb
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Description : Instead of presenting the standard theoretical treatments that underlie the various numerical methods used by scientists and engineers, Using R for Numerical Analysis in Science and Engineering shows how to use R and its add-on packages to obtain numerical solutions to the complex mathematical problems commonly faced by scientists and engineers. This practical guide to the capabilities of R demonstrates Monte Carlo, stochastic, deterministic, and other numerical methods through an abundance of worked examples and code, covering the solution of systems of linear algebraic equations and nonlinear equations as well as ordinary differential equations and partial differential equations. It not only shows how to use R’s powerful graphic tools to construct the types of plots most useful in scientific and engineering work, but also: Explains how to statistically analyze and fit data to linear and nonlinear models Explores numerical differentiation, integration, and optimization Describes how to find eigenvalues and eigenfunctions Discusses interpolation and curve fitting Considers the analysis of time series Using R for Numerical Analysis in Science and Engineering provides a solid introduction to the most useful numerical methods for scientific and engineering data analysis using R.


Computational Science Iccs 2009

Author by : Gabrielle Allen
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 78
Total Download : 845
File Size : 51,5 Mb
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Description : The two-volume set LNCS 5544-5545 constitutes the refereed proceedings of the 9th International Conference on Computational Science, ICCS 2009, held in Baton Rouge, LA, USA in May 2008. The 60 revised papers of the main conference track presented together with the abstracts of 5 keynote talks and the 138 revised papers from 13 workshops were carefully reviewed and selected for inclusion in the three volumes. The general main track of ICSS 2009 was organized in about 20 parallel sessions addressing the following topics: e-Science Applications and Systems, Scheduling, Software Services and Tools, New Hardware and Its Applications, Computer Networks, Simulation of Complex Systems, Image Processing, Optimization Techniques, and Numerical Methods.


Using R For Numerical Analysis In Science And Engineering

Author by : Victor A. Bloomfield
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 56
Total Download : 246
File Size : 44,9 Mb
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Description : Instead of presenting the standard theoretical treatments that underlie the various numerical methods used by scientists and engineers, Using R for Numerical Analysis in Science and Engineering shows how to use R and its add-on packages to obtain numerical solutions to the complex mathematical problems commonly faced by scientists and engineers. This practical guide to the capabilities of R demonstrates Monte Carlo, stochastic, deterministic, and other numerical methods through an abundance of worked examples and code, covering the solution of systems of linear algebraic equations and nonlinear equations as well as ordinary differential equations and partial differential equations. It not only shows how to use R’s powerful graphic tools to construct the types of plots most useful in scientific and engineering work, but also: Explains how to statistically analyze and fit data to linear and nonlinear models Explores numerical differentiation, integration, and optimization Describes how to find eigenvalues and eigenfunctions Discusses interpolation and curve fitting Considers the analysis of time series Using R for Numerical Analysis in Science and Engineering provides a solid introduction to the most useful numerical methods for scientific and engineering data analysis using R.


Multivariate Methods Of Representing Relations In R For Prioritization Purposes

Author by : Wayne L. Myers
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 31
Total Download : 423
File Size : 47,9 Mb
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Description : This monograph is multivariate, multi-perspective and multipurpose. We intend to be innovatively integrative through statistical synthesis. Innovation requires capacity to operate in ways that are not ordinary, which means that conventional computations and generic graphics will not meet the needs of an adaptive approach. Flexible formulation and special schematics are essential elements that must be manageable and economical.


Pharmaceutical Biotechnology

Author by : Adalberto Pessoa
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 16
Total Download : 325
File Size : 55,6 Mb
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Description : Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals. Features: Discusses specific points of great current relevance in relation to new processes as well as traditional processes Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream Includes chapters that allow a broad evaluation of the production process Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries. Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.


Biophysical Techniques

Author by : Iain Campbell
Languange : en
Publisher by : Oxford University Press
Format Available : PDF, ePub, Mobi
Total Read : 51
Total Download : 525
File Size : 42,8 Mb
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Description : Biophysical Techniques explains in a readily-accessible way the basics of the various biophysical methods available so students can understand the principles behind the different methods used, and begin to appreciate which tools can be used to probe different biological questions, and the pros and cons of each.


Research Grants Index

Author by : National Institutes of Health (U.S.). Division of Research Grants
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 398
File Size : 43,8 Mb
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Description :


Biophysics

Author by : Mark C. Leake
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 32
Total Download : 297
File Size : 52,6 Mb
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Description : An Up-to-Date Toolbox for Probing Biology Biophysics: Tools and Techniques covers the experimental and theoretical tools and techniques of biophysics. It addresses the purpose, science, and application of all physical science instrumentation and analysis methods used in current research labs. The book first presents the historical background, concepts, and motivation for using a physical science toolbox to understand biology. It then familiarizes students from the physical sciences with essential biological knowledge. The text subsequently focuses on experimental biophysical techniques that primarily detect biological components or measure/control biological forces. The author describes the science and application of key tools used in imaging, detection, general quantitation, and biomolecular interaction studies, which span multiple length and time scales of biological processes both in the test tube and in the living organism. Moving on to theoretical biophysics tools, the book presents computational and analytical mathematical methods for tackling challenging biological questions. It concludes with a discussion of the future of this exciting field. Future innovators will need to be trained in multidisciplinary science to be successful in industry, academia, and government support agencies. Addressing this challenge, this textbook educates future leaders on the development and application of novel physical science approaches to solve complex problems linked to biological questions.


Computer Analysis Of Genetic Macromolecules

Author by : N. A. Kolchanov
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 67
Total Download : 266
File Size : 50,5 Mb
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Description : Molecular biology and genetics are fast-growing fields with significant results and findings being reported virtually every day. Raw data from the wet lab accumulate at an astonishing rate, making it necessary to analyze the biological data with the use of computers. This book reveals how the current challenges of molecular biology and genetics are met with computer and mathematical treatments. A combined effort of the Computational Genetics and Biophysics Group (Supercomputer Computations Research Institute, USA), the Theoretical Molecular Genetics (Russian Academy of Sciences, Russia) and the Bioinformatics Group (Consiglio Nazionale delle Ricerche, Italy), many of these findings are firsthand discoveries made by these groups. The book emphasizes the fundamental principles of the structural-functional organization of the 3 major classes of genetic macromolecules: DNA, RNA and proteins. It also introduces universally applicable theoretical principles into the enormous realm of raw data and develops an integrative, theoretical computer approach to the analysis of these macromolecules to gain insights into the complexities of their function and evolution.


Cutting Edge Techniques In Biophysics Biochemistry And Cell Biology From Principle To Applications

Author by : Neetu Mishra
Languange : en
Publisher by : Bentham Science Publishers
Format Available : PDF, ePub, Mobi
Total Read : 74
Total Download : 950
File Size : 41,7 Mb
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Description : Advances in biomedical research have had a profound effect on human health outcomes over the last century. Biophysical, biochemical and cellular techniques are now the backbone of modern biomedical research. Understanding these laboratory techniques is a prerequisite for investigating the processes responsible for human diseases and discovering new treatment methods. Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications Provides information about basic and advanced analytical techniques applied in specific areas of life science and biomedical Key Features: - Book chapters present a broad overview of sophisticated analytical techniques used in biophysics, biochemistry and cell biology. - Techniques covered include in vitro cell culture techniques, flow cytometry, real time PCR, X-ray crystallography, RNA sequencing - Information about industrial and biomedical applications of techniques, (drug screening, disease models, functional assays, disease diagnosis, gene expression analysis and protein structure determination) is included. The book is an excellent introduction for students (as a textbook) and researchers (as a reference work). The information it presents will prepare readers to understand and develop research methods in life science laboratories for different projects and activities.


Research Awards Index

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 17
Total Download : 668
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The Digital Patient

Author by : C. D. Combs
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 73
Total Download : 667
File Size : 49,7 Mb
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Description : A modern guide to computational models and constructive simulation for personalized patient care using the Digital Patient The healthcare industry’s emphasis is shifting from merely reacting to disease to preventing disease and promoting wellness. Addressing one of the more hopeful Big Data undertakings, The Digital Patient: Advancing Healthcare, Research, and Education presents a timely resource on the construction and deployment of the Digital Patient and its effects on healthcare, research, and education. The Digital Patient will not be constructed based solely on new information from all the “omics” fields; it also includes systems analysis, Big Data, and the various efforts to model the human physiome and represent it virtually. The Digital Patient will be realized through the purposeful collaboration of patients as well as scientific, clinical, and policy researchers. The Digital Patient: Advancing Healthcare, Research, and Education addresses the international research efforts that are leading to the development of the Digital Patient, the wealth of ongoing research in systems biology and multiscale simulation, and the imminent applications within the domain of personalized healthcare. Chapter coverage includes: The visible human The physiological human The virtual human Research in systems biology Multi-scale modeling Personalized medicine Self-quantification Visualization Computational modeling Interdisciplinary collaboration The Digital Patient: Advancing Healthcare, Research, and Education is a useful reference for simulation professionals such as clinicians, medical directors, managers, simulation technologists, faculty members, and educators involved in research and development in the life sciences, physical sciences, and engineering. The book is also an ideal supplement for graduate-level courses related to human modeling, simulation, and visualization.


The British National Bibliography

Author by : Arthur James Wells
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 94
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Mathematical Modeling Of Biological Systems Volume I

Author by : Andreas Deutsch
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 50
Total Download : 125
File Size : 49,5 Mb
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Description : Volume I of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. The chapters are thematically organized into the following main areas: cellular biophysics, regulatory networks, developmental biology, biomedical applications, data analysis and model validation. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.


Computational Biochemistry And Biophysics

Author by : Oren M. Becker
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 233
File Size : 48,8 Mb
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Description : Covering theoretical methods and computational techniques in biomolecular research, this book focuses on approaches for the treatment of macromolecules, including proteins, nucleic acids, and bilayer membranes. It uses concepts in free energy calculations, conformational analysis, reaction rates, and transition pathways to calculate and interpret b


Bioinformatics

Author by : Prakash S. Lohar
Languange : en
Publisher by : MJP Publisher
Format Available : PDF, ePub, Mobi
Total Read : 19
Total Download : 776
File Size : 52,8 Mb
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Description : Introduction Evolution of Computers Biological Macromolecules Basic Techniques in Bioinformatics Biological Databases Sequence Alignment Multiple Sequence Alignments Computational Gene Prediction Proteomics Genomics Latest Information Covers Basics of Computers Includes Programming Languages Emphasis on Techniques Elaborative Style Many Web Resources and URLs Review Questions Glossary References Index.


Peterson S Graduate Programs In The Biological Sciences 2012

Author by : Peterson's
Languange : en
Publisher by : Peterson's
Format Available : PDF, ePub, Mobi
Total Read : 21
Total Download : 488
File Size : 42,5 Mb
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Description : Peterson's Graduate Programs in the Biological Sciences 2012 contains a wealth of information on accredited institutions offering graduate degree programs in these fields. Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, postbaccalaureate distance degrees, faculty, students, requirements, expenses, financial support, faculty research, and unit head and application contact information. There are helpful links to in-depth descriptions about a specific graduate program or department, faculty members and their research, and more. There are also valuable articles on financial assistance, the graduate admissions process, advice for international and minority students, and facts about accreditation, with a current list of accrediting agencies.


Elements Of Biotechnology

Author by : P. K. Gupta
Languange : en
Publisher by : Rastogi Publications
Format Available : PDF, ePub, Mobi
Total Read : 11
Total Download : 157
File Size : 51,8 Mb
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Description :


Computational Biology And Chemistry

Author by : Payam Behzadi
Languange : en
Publisher by : BoD – Books on Demand
Format Available : PDF, ePub, Mobi
Total Read : 42
Total Download : 204
File Size : 54,8 Mb
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Description :


Molecular Kinetics In Condensed Phases

Author by : Ron Elber
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 69
Total Download : 619
File Size : 41,6 Mb
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Description : A guide to the theoretical and computational toolkits for the modern study of molecular kinetics in condensed phases Molecular Kinetics in Condensed Phases: Theory, Simulation and Analysis puts the focus on the theory, algorithms, simulations methods and analysis of molecular kinetics in condensed phases. The authors – noted experts on the topic – offer a detailed and thorough description of modern theories and simulation methods to model molecular events. They highlight the rigorous stochastic modelling of molecular processes and the use of mathematical models to reproduce experimental observations, such as rate coefficients, mean first passage times and transition path times. The book’s exploration of simulations examines atomically detailed modelling of molecules in action and the connections of these simulations to theory and experiment. The authors also explore the applications that range from simple intuitive examples of one- and two-dimensional systems to complex solvated macromolecules. This important book: Offers an introduction to the topic that combines theory, simulation and analysis Presents a guide written by authors that are well-known and highly regarded leaders in their fields Contains detailed examples and explanation of how to conduct computer simulations of kinetics. A detailed study of a two-dimensional system and of a solvated peptide are discussed. Discusses modern developments in the field and explains their connection to the more traditional concepts in chemical dynamics Written for students and academic researchers in the fields of chemical kinetics, chemistry, computational statistical mechanics, biophysics and computational biology, Molecular Kinetics in Condensed Phases is the authoritative guide to the theoretical and computational toolkits for the study of molecular kinetics in condensed phases.


Biotechnology Concepts Methodologies Tools And Applications

Author by : Management Association, Information Resources
Languange : en
Publisher by : IGI Global
Format Available : PDF, ePub, Mobi
Total Read : 99
Total Download : 710
File Size : 49,9 Mb
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Description : Biotechnology can be defined as the manipulation of biological process, systems, and organisms in the production of various products. With applications in a number of fields such as biomedical, chemical, mechanical, and civil engineering, research on the development of biologically inspired materials is essential to further advancement. Biotechnology: Concepts, Methodologies, Tools, and Applications is a vital reference source for the latest research findings on the application of biotechnology in medicine, engineering, agriculture, food production, and other areas. It also examines the economic impacts of biotechnology use. Highlighting a range of topics such as pharmacogenomics, biomedical engineering, and bioinformatics, this multi-volume book is ideally designed for engineers, pharmacists, medical professionals, practitioners, academicians, and researchers interested in the applications of biotechnology.


Molecular Description Of Biological Membrane Components By Computer Aided Conformational Analysis

Author by : Robert Brasseur
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 23
Total Download : 734
File Size : 52,9 Mb
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Description : The goal of these two volumes is to help fill the gap between theory and experiment in membrane science. This is the only work available today which covers the domain of computer-aided conformational analyses of membranes. Written in a detailed, yet comprehensive manner, this book uses the semi-empirical approach as a way to give a molecular description of the membrane structure in organized systems. This interesting work establishes the validity and quality of the prediction by making a permanent comparison with the experimental data. This reference aims to use this comparison to open a new avenue in the molecular description of the biological membrane. Those involved with biochemistry, biophysics, pharmacology, and biology will find these volumes interesting and informative.


Artificial Intelligence For Computational Modeling Of The Heart

Author by : Tommaso Mansi
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 83
Total Download : 491
File Size : 54,6 Mb
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Description : Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient’s heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation


An Introduction To Chemoinformatics

Author by : Andrew R. Leach
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 21
Total Download : 543
File Size : 48,7 Mb
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Description : This book aims to provide an introduction to the major techniques of chemoinformatics. It is the first text written specifically for this field. The first part of the book deals with the representation of 2D and 3D molecular structures, the calculation of molecular descriptors and the construction of mathematical models. The second part describes other important topics including molecular similarity and diversity, the analysis of large data sets, virtual screening, and library design. Simple illustrative examples are used throughout to illustrate key concepts, supplemented with case studies from the literature.