Author by : Pranab Kumar Das
Languange : un
Publisher by : Frontiers Media SA
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 935
File Size : 42,9 Mb
Description : Leprosy is one of the oldest recorded debilitating diseases affecting mankind, the immunopathology of which is characterized by fluctuating granulomatous inflammation that targets mainly skin and peripheral nerve. The disease is caused by infection with Mycobacterium leprae, a slow growing obligatory intracellular and non-cultivatable organism. The disease is manifested with diverse pathology due to varied immune (both innate and adaptive) responses of the hosts as a result of cognate interaction with the organism. Of note, leprosy can be regarded as a unique model to elucidate the complexity of host immunity at both skin and systemic levels.