Cytoskeletal Mechanics

Author by : Mohammad R. K. Mofrad
Languange : en
Publisher by : Cambridge University Press
Format Available : PDF, ePub, Mobi
Total Read : 48
Total Download : 734
File Size : 44,9 Mb
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Description : This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.


Cytoskeletal Mechanics

Author by : Mohammad R. K. Mofrad
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 72
Total Download : 187
File Size : 45,8 Mb
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Description :


Cytoskeletal Mechanics

Author by : Mohammad R. K. Mofrad
Languange : en
Publisher by : Cambridge University Press
Format Available : PDF, ePub, Mobi
Total Read : 89
Total Download : 516
File Size : 47,6 Mb
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Description : This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors of this book come from the biophysics, bioengineering, and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is our hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.


Cytoskeletal Mechanics

Author by : Mohammad R. K. Mofrad
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 20
Total Download : 256
File Size : 47,7 Mb
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Description : This book presents views on approaches to modeling cell mechanics. The diversity of opinions stems from the different backgrounds of those who have contributed to the field. The authors come from the biophysics, bioengineering, and physical chemistry communities, and each joins the discussion with their unique perspective on biological systems.


The Effects Of Membrane And Cytoskeletal Mechanics On Cell Adhesiveness

Author by : David Shearer
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 14
Total Download : 207
File Size : 48,5 Mb
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Description : The cytoskeleton, the internal network of filaments that regulates cell shape and structure, has been implicated in several critical aspects of cell adhesion. Its role, however, has primarily been demonstrated as a component of the numerous intracellular signaling events that regulate cell surface receptors. In this study we sought to gain insight into how the mechanical properties of the cytoskeleton could affect adhesion. Specifically, we addressed how membrane deformability, which we demonstrate is critically dependent upon tethering to the cytoskeleton, could impact a whole cell adhesion assay. To modify membrane deformability, we treated cells with the pharmacological agents phalloidin, Latrinculin B, Cytochalasin D, colchicine, and Paclitaxel, which have varying effects on microfilaments and microtubules, two of the main constituents of the cytoskeleton. We found that dissolution of the actin cytoskeleton could reduce the number of adherent cells to a callogen-coated substrate by over 85%. We theorize that this is due largely to the inhibition of signaling events associated with the cytoskeleton, but it may also be affected by changes in shape and deformability. To truly understand the implications of this experiment, we believe further study using high-resolution force technology such as atomic force microscopy or magnetic bead microrheometry is necessary.


Cytoskeletal Mechanics In Endothelial Cells

Author by : Robert John Russsell
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 71
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File Size : 48,8 Mb
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Description : ABSTRACT: An important function of normal endothelial cells is the ability to sense and transduce applied mechanical forces due to blood flow through the vasculature. Defects in endothelial mechano-sensing result in numerous pathologies including atherosclerosis. The actomyosin and microtubule cytoskeleton gives endothelial cells structural support and the ability to both sense and respond to external forces. This dissertation focuses on how the actomyosin and microtubule cytoskeleton generate and respond to forces in endothelial cells. Tensile force within endothelial cells is generated in actomyosin stress fibers, which are composed of contractile units called sarcomeres. Using femtosecond laser ablation, we severed living stress fibers and measured sarcomere contraction under zero tension. The time dependent trajectories of contracting sarcomeres suggested three distinct phases: an instantaneous initial response, a sustained change in length at constant velocity and finally a steady state.


Mechanics Of Motor Proteins And The Cytoskeleton

Author by : Jonathon Howard
Languange : en
Publisher by : Sinauer Associates Incorporated
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 573
File Size : 51,8 Mb
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Description : This work is aimed at biology, biochemistry and chemistry students who want to learn about the principles of protein mechanics and how this topic applies to the morphology and motility of cells.


Mechanical Engineering Of The Cytoskeleton In Developmental Biology

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 99
Total Download : 973
File Size : 54,9 Mb
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Description : Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.


Advances In Cytoskeleton Research And Application 2012 Edition

Author by : Anonim
Languange : en
Publisher by : ScholarlyEditions
Format Available : PDF, ePub, Mobi
Total Read : 26
Total Download : 428
File Size : 45,9 Mb
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Description : Advances in Cytoskeleton Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cytoskeleton. The editors have built Advances in Cytoskeleton Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cytoskeleton in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Cytoskeleton Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.


Cell Mechanics

Author by : Yu-Li Wang
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 29
Total Download : 570
File Size : 40,7 Mb
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Description : Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells


Advances In Cell Mechanics

Author by : Shaofan Li
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 50
Total Download : 906
File Size : 40,5 Mb
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Description : "Advances in Cell Mechanics" presents the latest developments in cell mechanics and biophysics, mainly focusing on interdisciplinary research in cell biology and the biophysics of cells. Moreover, a unique feature of the book is its emphasis on the molecular and complex continuum modeling and simulations of the cells. It may be the first work that brings rigorous and quantitative scientific analysis and state-of-the-art simulation technology into cell biology research. The book is intended for researchers and graduate students working in the fields of molecular cell biology, bio-engineering and bio-mechanics, soft matter physics, computational mechanics, bio-chemistry and bio-medicine. All contributors are leading scholars in their respective fields. Dr. Shaofan Li is a professor and an expert for computational mechanics at the University of California-Berkeley, USA; Dr. Bohua Sun is a professor at Cape Peninsula University of Technology, South Africa.


Actin Cytoskeleton In Cancer Progression And Metastasis Part B

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 21
Total Download : 544
File Size : 48,9 Mb
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Description : Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications


Advances In Soft Matter Mechanics

Author by : Shaofan Li
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 21
Total Download : 112
File Size : 53,6 Mb
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Description : This book covers developments in soft matter mechanics and physics from the perspective of applied and computational mechanics. It Includes a selection of recent works on the subject and details the application of soft matter mechanics on engineering problems.


Actin Cytoskeleton In Cancer Progression And Metastasis Part C

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 84
Total Download : 313
File Size : 45,5 Mb
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Description : Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications


Nuclear Mechanics And Genome Regulation

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 72
Total Download : 328
File Size : 53,5 Mb
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Description : In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields


Endothelial Cytoskeleton

Author by : Juan A. Rosado
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 27
Total Download : 930
File Size : 45,8 Mb
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Description : This book presents a concise synthesis of the current knowledge and recent advances in the structure, organization and functional role of the cytoskeleton in endothelial cells. Particular attention has been given to the different features of the regulation of vascular function mediated by the endothelium. Since cytoskeleton is a scaffolding element that regulates the architecture of the cell and additionally controls several fundamental aspects of intracellular signaling, this book will serve as a comprehensive resource for those interested in these fascinating biological processes associated with vascular biology. The book has been divided into two major sections: general aspects of the endothelial cytoskeleton and the role of the role of the endothelial cytoskeleton in different functions of the vascular wall.


Actin Cytoskeleton In Cancer Progression And Metastasis Part C

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 72
Total Download : 903
File Size : 43,9 Mb
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Description : Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications


The Computational Mechanics Of Bone Tissue

Author by : Jorge Belinha
Languange : en
Publisher by : Springer Nature
Format Available : PDF, ePub, Mobi
Total Read : 21
Total Download : 132
File Size : 47,5 Mb
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Description : This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.


Cell And Matrix Mechanics

Author by : Roland Kaunas
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 412
File Size : 45,5 Mb
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Description : Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.


Microcirculation In Cancer Metastasis

Author by : F. William Orr
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 74
Total Download : 163
File Size : 45,6 Mb
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Description : Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.


Actin Cytoskeleton In Cancer Progression And Metastasis Part A

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 35
Total Download : 361
File Size : 40,7 Mb
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Description : Actin Cytoskeleton in Cancer Progression and Metastasis - Part A, Volume 355 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications


Nuclear Organization In Development And Disease

Author by : Derek J. Chadwick
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 58
Total Download : 181
File Size : 40,8 Mb
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Description : This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: How nuclear structure and location within a nucleus affect gene expression Chromatin organization and cell differentiation The nature of the interactions between the nuclear envelope and the cytoskeleton The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.


Biology And Mechanics Of Blood Flows

Author by : Marc Thiriet
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 62
Total Download : 934
File Size : 41,7 Mb
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Description : This authoritative work presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. The book provides a survey of relevant cell components and processes, with detailed coverage of the electrical and mechanical behaviors of vascular cells, tissues, and organs. Biological and mechanical glossaries are provided.


Complex Fluids In Biological Systems

Author by : Saverio E. Spagnolie
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 83
Total Download : 308
File Size : 49,9 Mb
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Description : This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solutions in the numerical simulation of biologically relevant complex fluid flows This volume will be accessible to advanced undergraduate and beginning graduate students in engineering, mathematics, biology, and the physical sciences, but will appeal to anyone interested in the intricate and beautiful nature of complex fluids in the context of living systems.