Drug Delivery and Targeting

Drug Delivery and Targeting
Author: Anya M. Hillery,Andrew W. Lloyd,James Swarbrick
Publsiher: CRC Press
Total Pages: 512
Release: 2002-01-24
ISBN: 9780415271974
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery and Targeting Book Excerpt:

The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including: *Methods to optimize therapeutic efficacy, and the related commercial implications *Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination *Attempts to minimize toxicity or alter immunogenicity *Methods to achieve rate-controlled drug release and effective drug targeting *Novel and established routes of delivery *Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy This volume is indispensable for pharmaceutical students, scientists and researchers.

Targeting of Drugs and Delivery Systems

Targeting of Drugs and Delivery Systems
Author: Anonim
Publsiher: Unknown
Total Pages: 148
Release: 1995
ISBN: 1928374650XXX
Category: Drug targeting
Language: EN, FR, DE, ES & NL

Targeting of Drugs and Delivery Systems Book Excerpt:

Optimization of Aerosol Drug Delivery

Optimization of Aerosol Drug Delivery
Author: Leon Gradon,J.C. Marijnissen
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2003-11-30
ISBN: 9781402016516
Category: Medical
Language: EN, FR, DE, ES & NL

Optimization of Aerosol Drug Delivery Book Excerpt:

Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

Targeted Drug Delivery

Targeted Drug Delivery
Author: Y. BACHHAV
Publsiher: VCH
Total Pages: 448
Release: 2022-10-19
ISBN: 9783527347810
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Targeted Drug Delivery Book Excerpt:

Drug Delivery Systems

Drug Delivery Systems
Author: Peter Johnson,John Gareth Lloyd-Jones
Publsiher: Vch Pub
Total Pages: 292
Release: 1987
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Systems Book Excerpt:

Drug Delivery Approaches

Drug Delivery Approaches
Author: Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Publsiher: John Wiley & Sons
Total Pages: 528
Release: 2021-07-27
ISBN: 1119772737
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Approaches Book Excerpt:

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Current Technologies To Increase The Transdermal Delivery Of Drugs

Current Technologies To Increase The Transdermal Delivery Of Drugs
Author: José Juan Escobar-Chávez
Publsiher: Bentham Science Publishers
Total Pages: 146
Release: 2010
ISBN: 1608051919
Category: Medical
Language: EN, FR, DE, ES & NL

Current Technologies To Increase The Transdermal Delivery Of Drugs Book Excerpt:

This e-book provides an overview of current technologies used to increase the topical/transdermal delivery of drugs, its protocols, advantages and limitations. It includes exclusive chapters on chemical enhancers, Iontophoresis, Sonophoresis, Electroporation, Microneedles and the more recent use of micro/nanoparticles to deliver drugs throughout the skin. The e-book's generalized approach on the topic is aimed to be helpful in drug discovery, drug delivery and toxicological research and to provide a broader perspective on the topic to readers with respect to current literature available on the.

Delivery of Drugs

Delivery of Drugs
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 242
Release: 2020-02-01
ISBN: 0128177772
Category: Medical
Language: EN, FR, DE, ES & NL

Delivery of Drugs Book Excerpt:

Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes
Author: Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
Publsiher: Academic Press
Total Pages: 552
Release: 2017-05-23
ISBN: 0128097183
Category: Medical
Language: EN, FR, DE, ES & NL

Nanotechnology Based Approaches for Targeting and Delivery of Drugs and Genes Book Excerpt:

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Polymeric Drugs and Drug Delivery Systems

Polymeric Drugs and Drug Delivery Systems
Author: Raphael M. Ottenbrite,Sung Wan Kim
Publsiher: CRC Press
Total Pages: 332
Release: 2019-04-30
ISBN: 9781420010251
Category: Science
Language: EN, FR, DE, ES & NL

Polymeric Drugs and Drug Delivery Systems Book Excerpt:

Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w

Transdermal Drug Delivery

Transdermal Drug Delivery
Author: Jonathan Hadgraft,Richard H. Guy
Publsiher: Marcel Dekker Incorporated
Total Pages: 324
Release: 1989
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Transdermal Drug Delivery Book Excerpt:

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
Author: Pavan Muttil,Nitesh K. Kunda
Publsiher: Springer Nature
Total Pages: 277
Release: 2020-03-18
ISBN: 3030359107
Category: Medical
Language: EN, FR, DE, ES & NL

Mucosal Delivery of Drugs and Biologics in Nanoparticles Book Excerpt:

Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Drug Delivery

Drug Delivery
Author: Eric P. Holowka,Sujata K. Bhatia
Publsiher: Springer
Total Pages: 355
Release: 2014-11-22
ISBN: 1493919989
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Drug Delivery Book Excerpt:

Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Nanomaterials Evolution and Advancement towards Therapeutic Drug Delivery Part II

Nanomaterials  Evolution and Advancement towards Therapeutic Drug Delivery  Part II
Author: Surendra Nimesh,Nidhi Gupta,Ramesh Chandra
Publsiher: Bentham Science Publishers
Total Pages: 315
Release: 2021-06-02
ISBN: 168108824X
Category: Science
Language: EN, FR, DE, ES & NL

Nanomaterials Evolution and Advancement towards Therapeutic Drug Delivery Part II Book Excerpt:

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part II covers the following topics: · Solid lipid nanoparticles and nanostructured lipid carriers · Silica based nanomaterials · Hydrogels · Metallic nanoparticles · Computational and experimental binding interactions of drug and β-cyclodextrin · Clinical milestones in nanotherapeutics · Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Pharmaceutical Applications of Polymers for Drug Delivery

Pharmaceutical Applications of Polymers for Drug Delivery
Author: David Jones
Publsiher: iSmithers Rapra Publishing
Total Pages: 124
Release: 2004
ISBN: 9781859574799
Category: Science
Language: EN, FR, DE, ES & NL

Pharmaceutical Applications of Polymers for Drug Delivery Book Excerpt:

Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.

Oral Drug Delivery

Oral Drug Delivery
Author: Josias H. Hamman
Publsiher: Unknown
Total Pages: 260
Release: 2007
ISBN: 9780620401227
Category: Oral medication
Language: EN, FR, DE, ES & NL

Oral Drug Delivery Book Excerpt:

Modified Release Drug Delivery Technology

Modified Release Drug Delivery Technology
Author: Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts
Publsiher: CRC Press
Total Pages: 1066
Release: 2002-11-07
ISBN: 9780824708696
Category: Medical
Language: EN, FR, DE, ES & NL

Modified Release Drug Delivery Technology Book Excerpt:

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

Application of Ionic Liquids in Drug Delivery

Application of Ionic Liquids in Drug Delivery
Author: Masahiro Goto,Muhammad Moniruzzaman
Publsiher: Springer Nature
Total Pages: 242
Release: 2021-08-27
ISBN: 9811643652
Category: Science
Language: EN, FR, DE, ES & NL

Application of Ionic Liquids in Drug Delivery Book Excerpt:

This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights into the development of the biologically functionalized ionic liquids suitable for medical and pharmaceutical applications. Ionic liquids have been used as potential solvents or materials in the fields of pharmaceutical drug delivery and formulations because of their unique and tunable physicochemical and biological properties. Readers find explanations of the diverse approaches to the application of ionic liquids in drug solubility, active pharmaceutical ingredient (API) formulation, and drug delivery systems, such as topical, transdermal, and oral delivery, with particular emphasis on recent developments. Particular attention is given to the development of ionic liquid-assisted effective drug delivery techniques for sparingly soluble or insoluble drug molecules. This book also discusses the biological activities of ionic liquids for possible applications in drug formulation and drug delivery systems. Scientists in disciplines such as chemistry, biology, and pharmaceutics find this book instructive and informative for developing ionic liquid-based drug formulations or drug delivery systems.

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems
Author: Jonathan Hadgraft
Publsiher: CRC Press
Total Pages: 328
Release: 2002-10-29
ISBN: 0203909682
Category: Medical
Language: EN, FR, DE, ES & NL

Transdermal Drug Delivery Systems Book Excerpt:

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Advanced Drug Delivery

Advanced Drug Delivery
Author: Ashim Mitra,Chi H. Lee,Kun Cheng
Publsiher: Wiley
Total Pages: 550
Release: 2013-11-04
ISBN: 9781118022665
Category: Medical
Language: EN, FR, DE, ES & NL

Advanced Drug Delivery Book Excerpt:

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.