Systemic Drug Delivery Strategies

Systemic Drug Delivery Strategies
Author: Mansoor M. Amiji,Lara Scheherazade Milane
Publsiher: Academic Press
Total Pages: 588
Release: 2021-08-21
ISBN: 0323909256
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Systemic Drug Delivery Strategies Book Excerpt:

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Cancer Immunology and Immunotherapy

Cancer Immunology and Immunotherapy
Author: Mansoor M. Amiji,Lara Scheherazade Milane
Publsiher: Academic Press
Total Pages: 548
Release: 2021-08-18
ISBN: 012823637X
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Cancer Immunology and Immunotherapy Book Excerpt:

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Engineering Technologies and Clinical Translation

Engineering Technologies and Clinical Translation
Author: Mansoor M. Amiji,Lara Scheherazade Milane
Publsiher: Academic Press
Total Pages: 524
Release: 2021-08-25
ISBN: 0323909507
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Engineering Technologies and Clinical Translation Book Excerpt:

Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Explores engineering technologies and their clinical translation in a comprehensive way Presents forecasting on the future of nanotechnology and drug delivery for IO Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side

Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer
Author: Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publsiher: Elsevier
Total Pages: 572
Release: 2021-06-24
ISBN: 0323900798
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Advanced Drug Delivery Systems in the Management of Cancer Book Excerpt:

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Drug Delivery Technology Development in Canada

Drug Delivery Technology Development in Canada
Author: Kishor M.Wasan,Ildiko Badea
Publsiher: MDPI
Total Pages: 352
Release: 2019-12-19
ISBN: 303928004X
Category: Science
Language: EN, FR, DE, ES & NL

Drug Delivery Technology Development in Canada Book Excerpt:

Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed from the inventions conceived and developed within academic institutions that have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases. This Special Issue serves to highlight and capture the contemporary progress of drug delivery within the prevailing Canadian context. We invite articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

Nano Oncologicals

Nano Oncologicals
Author: Maria José Alonso,Marcos Garcia-Fuentes
Publsiher: Springer
Total Pages: 473
Release: 2014-10-15
ISBN: 3319080849
Category: Medical
Language: EN, FR, DE, ES & NL

Nano Oncologicals Book Excerpt:

This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines). Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Immunotherapy A Novel Facet of Modern Therapeutics

Immunotherapy     A Novel Facet of Modern Therapeutics
Author: Sujata P. Sawarkar,Vandana S. Nikam,Shariq Syed
Publsiher: Springer Nature
Total Pages: 262
Release: 2020-12-16
ISBN: 9811590389
Category: Medical
Language: EN, FR, DE, ES & NL

Immunotherapy A Novel Facet of Modern Therapeutics Book Excerpt:

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Drug Delivery Systems

Drug Delivery Systems
Author: Kewal K. Jain
Publsiher: Springer Science & Business Media
Total Pages: 251
Release: 2008-03-07
ISBN: 1588298914
Category: Science
Language: EN, FR, DE, ES & NL

Drug Delivery Systems Book Excerpt:

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Human Immune System

Human Immune System
Author: Shyamasree Ghosh
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 151
Release: 2022-02-21
ISBN: 3110655853
Category: Science
Language: EN, FR, DE, ES & NL

Human Immune System Book Excerpt:

The fast development in the field of nanotechnology has led to a high variety of nanoparticles. Nanoparticles find importance in every sphere of human lives and more so in the recent years have tremendous applications in the sector of biomedical clinical medicine as diagnostic, prognostic and imaging tools. Their risk to human and animal life as well as to the environment is still unclear. Therefore, the study of the impact of nanoparticles on human and animal life is important. Volume I highlights the impact of nanoparticles on the human immune system. While discussing the basic biology of the immune system, this book highlights the downstream effect of nanoparticles on the human immune system. Research studies on the development of better and more effective nanoparticles with more precise and accurate effects and with toxic minimal side effects are discussed in the book. Both volumes are also included in a set ISBN 978-3-11-065666-4.

Textbook of Personalized Medicine

Textbook of Personalized Medicine
Author: Kewal K. Jain
Publsiher: Springer Nature
Total Pages: 744
Release: 2020-12-05
ISBN: 3030620808
Category: Medical
Language: EN, FR, DE, ES & NL

Textbook of Personalized Medicine Book Excerpt:

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Multifunctional Nanoparticles for Drug Delivery Applications

Multifunctional Nanoparticles for Drug Delivery Applications
Author: Sonke Svenson,Robert K. Prud'homme
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2012-02-22
ISBN: 146142304X
Category: Medical
Language: EN, FR, DE, ES & NL

Multifunctional Nanoparticles for Drug Delivery Applications Book Excerpt:

This book presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles.

Virus Based Nanoparticles Cancer Drug Delivery

Virus Based Nanoparticles Cancer Drug Delivery
Author: Anna Czapar
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN: 1928374650XXX
Category: Cancer
Language: EN, FR, DE, ES & NL

Virus Based Nanoparticles Cancer Drug Delivery Book Excerpt:

Cancer is one of the leading causes of death in the world. Nanotechnology has emerged as one way to improve cancer patient survival; nanoparticles can carry large payloads of chemotherapeutics and can be engineered to accumulate preferentially in target solid tumors, limiting off-target adverse effects while overcoming development of drug resistance. Another avenue is the use of nanoparticles for immunotherapy – rather then delivering toxic payloads, immune-stimulatory agents are deployed to activate the body’s immune system against cancer. A wide range of nanoparticles, including synthetic and naturally occurring, have been investigated both for drug delivery and cancer immunotherapy in pre-clinical and clinical trials. My thesis focused on the development of plant viruses for drug delivery and immunotherapy, specifically I worked with the tobacco mosaic virus (TMV) and cowpea mosaic virus (CPMV). Compared to their synthetic counterparts as well as mammalian viral vectors, plant viruses have the advantage of having a high degree of quality control (genetically encoded materials are highly monodisperse) and of being non-infectious to mammals. The different size and shape of TMV and CPMV allows them to be utilized for different applications: I focused my efforts with TMV on drug delivery studies and developed CPMV as an immunotherapy approach. TMV is a rigid, rod-shaped virus (300 nm x 18nm); the high aspect ratio allows for enhanced tumor penetration and reduced immune cell uptake. My studies with TMV focused on developing this platform as a carrier for platinum chemotherapeutics for treatment of breast and ovarian cancer. To further improve the TMV-based drug delivery system, I investigated polymer coatings to avoid premature immune clearance. Next, I turned toward the icosahedral CPMV particles for cancer immunotherapy application making use of its natural immune stimulation. It has previously been shown that CPMV is a potent in situ vaccine, when administered intratumorally, CPMV primes an anti-tumor response. In this work, I developed a slow release formulation of the CPMV in situ vaccine to alleviate the need for repeat administration. Overall my work has expanded the understanding of plant viruses for cancer therapy in two areas: drug delivery and immunotherapy and provides a stepping-stone toward translation.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
Author: Loutfy H. Madkour
Publsiher: Academic Press
Total Pages: 650
Release: 2019-08-27
ISBN: 0128197781
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book Excerpt:

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Advances and Challenges in Nanomedicine

Advances and Challenges in Nanomedicine
Author: Susan Hua,Sherry Y. Wu
Publsiher: Frontiers Media SA
Total Pages: 155
Release: 2019-02-28
ISBN: 2889457451
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Advances and Challenges in Nanomedicine Book Excerpt:

Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. Nanomedicines have demonstrated significant therapeutic advantages for a multitude of biomedical applications, however the clinical translation of these nanotechnology platforms has not progressed as quickly as the plethora of positive results would have suggested. Understanding the advances in nanomedicine to date and the challenges that still need to be overcome, will allow future research to improve on existing platforms and to address the current translational and regulatory limitations. This eBook “Advances and Challenges in Nanomedicine” has brought together experts in the fields of nanomedicine, nanotechnology, nanotoxicology, pharmaceutics, manufacturing, and translation to discuss the application of nanotechnology to drug delivery. This information is presented as original research, opinion, perspective, and review articles. The goal of this eBook is to generate collaborative discussion on the current status, general trends, challenges, strategies, and future direction of pharmaceutical nanotechnology, as well as highlight current and emerging nanoparticulate platforms with potential medical applications.

Protein Instability at Interfaces During Drug Product Development

Protein Instability at Interfaces During Drug Product Development
Author: Jinjiang Li,Mary E. Krause,Raymond Tu
Publsiher: Springer Nature
Total Pages: 338
Release: 2021-02-12
ISBN: 3030571777
Category: Medical
Language: EN, FR, DE, ES & NL

Protein Instability at Interfaces During Drug Product Development Book Excerpt:

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Chemistry Entrepreneurship

Chemistry Entrepreneurship
Author: Javier García-Martínez,Kunhao Li
Publsiher: John Wiley & Sons
Total Pages: 325
Release: 2021-12-06
ISBN: 3527345442
Category: Science
Language: EN, FR, DE, ES & NL

Chemistry Entrepreneurship Book Excerpt:

A groundbreaking guide to the commercialization of scientific breakthroughs in chemistry, from successful entrepreneurs Chemistry Entrepreneurship is a step-by-step guide that is specifically devoted to understanding what it takes to start and grow a new company in the chemistry sector. Comprehensive in scope, the book covers the various aspects of the creation of a new chemical enterprise including: the protection of the invention, the business plan, the transfer from the research center or university, the financing, the legal setup, the launching of the company and its growth and exit strategies. This hands-on book contains the information needed to help to determine if you have what it takes to be a chemistry entrepreneur, explains how to take an ideas out of the lab and into the real world, reveals how to develop your burgeoning business, and shows how to sustain and grow your business. This much-needed resource also includes interviews with founding scientists who created their own successful chemical companies. This important book: Provides the practical information on how to start a company based on a scientific breakthrough Offers information on the mindset it takes to become, and remain, successful in the marketplace Presents case studies from world-renowned and highly experienced professionals who have successfully started a company Written for chemists in industry, chemists, materials scientists, chemical engineers, Chemistry Entrepreneurship is a guide for becoming a founder of a successful chemical company.

Cancer Vaccines

Cancer Vaccines
Author: Adrian Bot,Mihail Obrocea,Francesco M. Marincola
Publsiher: CRC Press
Total Pages: 280
Release: 2011-08-23
ISBN: 9781841848297
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Vaccines Book Excerpt:

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Development of Biopharmaceutical Drug Device Products

Development of Biopharmaceutical Drug Device Products
Author: Feroz Jameel,John W. Skoug,Robert R. Nesbitt
Publsiher: Springer Nature
Total Pages: 893
Release: 2020-03-13
ISBN: 3030314154
Category: Medical
Language: EN, FR, DE, ES & NL

Development of Biopharmaceutical Drug Device Products Book Excerpt:

The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies have raised the bar for the development and manufacture of antibody-based products, expecting to see the use of Quality by Design (QbD) elements demonstrating an in-depth understanding of product and process based on sound science. Drug delivery systems have become an increasingly important part of the therapy and most biopharmaceuticals for self-administration are being marketed as combination products. A survey of the market indicates that there is a strong need for a new book that will provide “one stop shopping” for the latest information and knowledge of the scientific and engineering advances made over the last few years in the area of biopharmaceutical product development. The new book entitled Development of Biopharmaceutical Drug Device Products is a reference text for scientists and engineers in the biopharmaceutical industry, academia or regulatory agencies. With insightful chapters from experts in the field, this new book reviews first principles, covers recent technological advancements and provides case studies and regulatory strategies relating to the development and manufacture of antibody-based products. It covers topics such as the importance of early preformulation studies during drug discovery to influence molecular selection for development, formulation strategies for new modalities, and the analytical techniques used to characterize them. It also addresses important considerations for later stage development such as the development of robust formulations and processes, including process engineering and modeling of manufacturing unit operations, the design of analytical comparability studies, and characterization of primary containers (pre-filled syringes and vials).Finally, the latter half of the book reviews key considerations to ensure the development and approval of a patient-centered delivery system design. This involves the evolving regulatory framework with perspectives from both the US and EU industry experts, the role of international standards, design control/risk management, human factors and its importance in the product development and regulatory approval process, as well as review of the risk-based approach to bridging between devices used in clinical trials and the to-be-marketed device. Finally, case studies are provided throughout.The typical readership would have biology and/or engineering degrees and would include researchers, scientific leaders, industry specialists and technology developers working in the biopharmaceutical field.

The Biotech Investor s Bible

The Biotech Investor s Bible
Author: George Wolff
Publsiher: John Wiley & Sons
Total Pages: 336
Release: 2001-06-13
ISBN: 9780471412793
Category: Business & Economics
Language: EN, FR, DE, ES & NL

The Biotech Investor s Bible Book Excerpt:

A one-stop source for investing in biotech-with detailed coverage of the science, the business, the players, and the strategies for one of today's most promising (and volatile) industries To invest in biotech is to invest in the future, and as such, investors need to learn the nuances of the science they're putting their money on. The core asset of biotech companies is knowledge, and sound investment decisions are impossible without an understanding of this complex science. That's where The Biotech Investor's Bible fits in. This much-needed, one-of-a-kind resource simplifies the complex science surrounding the business of biotech and clarifies subtle distinctions within the context of their financial repercussions. The book explains the basics of genetics, patents, and therapies; and teaches investors how to value biotech companies and their state-of-the art products and technology. The Biotech Investor's Bible offers an informative summary of the relatively short history of the industry and provides a comprehensive review of various industry sectors.

Withrow and MacEwen s Small Animal Clinical Oncology E Book

Withrow and MacEwen s Small Animal Clinical Oncology   E Book
Author: David M. Vail,Douglas Thamm,Julias Liptak
Publsiher: Elsevier Health Sciences
Total Pages: 864
Release: 2019-07-23
ISBN: 0323594972
Category: Medical
Language: EN, FR, DE, ES & NL

Withrow and MacEwen s Small Animal Clinical Oncology E Book Book Excerpt:

Considered the definitive reference on canine and feline oncology, Withrow & MacEwen's Small Animal Clinical Oncology, 6th Edition focuses on the most effective, cutting-edge techniques. This comprehensive textbook gives you a complete understanding of cancer in dogs and cats — what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice today. The thoroughly updated sixth edition includes information on the complications of cancer, pain management, and the latest treatment modalities — preparing general practitioners to diagnose and treat pets rather than referring them to a specialist. With important updates on recently approved and in-development drugs, and new co-authors adding their own unique perspectives, this user-friendly text is a must-have resource for current, evidence-based therapeutic strategies on canine and feline oncology. Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. Each contributor is a recognized expert in his or her specialty, reflecting the most current information by highly respected experts in the field of veterinary oncology. Full-color format provides you with accurate visual depictions of specific diseases and procedures, enhances visual appeal, and is used functionally in tables and boxes to highlight key information. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet’s pain and nutritional complications as well as the pet owner’s grief when treatment is not successful. Comprehensive references at the end of each chapter and topic ensures you can be confident the information provided is accurate and up to date. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Chemotherapy protocols are included when case studies prove clinical efficacy. Information on the best interventional techniques is quickly accessible all in one chapter. Nearly 400 color images provide accurate depictions of specific diseases and procedures. Focus on the most effective treatment options saves time by emphasizing proven treatment options that have been vetted by experts in the field. NEW! Expert co-authors and contributors bring a valuable perspective with research experience. NEW! Thoroughly UPDATED content includes important updates on recently approved and in-development veterinary cancer drugs, and critical advances in radiation delivery.