Developmental and Fetal Origins of Differences in Monozygotic Twins

Developmental and Fetal Origins of Differences in Monozygotic Twins
Author: Alexandra Matias,Isaac Blickstein
Publsiher: Academic Press
Total Pages: 386
Release: 2020-05-15
ISBN: 0128203072
Category: Medical
Language: EN, FR, DE, ES & NL

Developmental and Fetal Origins of Differences in Monozygotic Twins Book Excerpt:

Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout. Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis Features contributions from international experts in twin genetics and developmental biology

Perinatology

Perinatology
Author: Renato Augusto Moreira de Sá
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN: 3030834344
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Perinatology Book Excerpt:

Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia

Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia
Author: Henry Houlden,Alan Edward Renton,Francesca Luisa Conforti
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-06-28
ISBN: 2889669041
Category: Science
Language: EN, FR, DE, ES & NL

Multifaceted Genes in Amyotrophic Lateral Sclerosis Frontotemporal Dementia Book Excerpt:

Gamete and Embryo fetal Origins of Adult Diseases

Gamete and Embryo fetal Origins of Adult Diseases
Author: He-Feng Huang,Jian-Zhong Sheng
Publsiher: Springer Science & Business Media
Total Pages: 222
Release: 2013-11-19
ISBN: 9400777728
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Gamete and Embryo fetal Origins of Adult Diseases Book Excerpt:

The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians. Editor He-Feng Huang, M.D., is Professor and President of Women’s Hospital, School of Medicine, Zhejiang University, China. Editor Jian-Zhong Sheng, Ph.D., is Professor at the Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, China.

RUNX Proteins in Development and Cancer

RUNX Proteins in Development and Cancer
Author: Yoram Groner,Yoshiaki Ito,Paul Liu,James C. Neil,Nancy A. Speck,Andre van Wijnen
Publsiher: Springer
Total Pages: 515
Release: 2017-03-15
ISBN: 9811032335
Category: Medical
Language: EN, FR, DE, ES & NL

RUNX Proteins in Development and Cancer Book Excerpt:

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Family matters

Family matters
Author: Deborah A. Lawlor,Gita D. Mishra
Publsiher: OUP Oxford
Total Pages: 352
Release: 2009-04-02
ISBN: 0191575224
Category: Medical
Language: EN, FR, DE, ES & NL

Family matters Book Excerpt:

Family-based studies, including intergenerational, sibling, and twin studies, are increasingly being used to explore life course epidemiology. However, there are issues relating to study design and the statistical analysis of family-based studies that are still not well understood, and comprehending the underlying assumptions of these studies and drawing the inferences from them can be complex. This book provides the knowledge and skills required to design, analyse, and correctly interpret family-based studies. It explains what these studies can tell us about life course epidemiology; provides practical guidance on how to set-up and maintain birth cohorts for completing family-based studies in life course epidemiology; describes how to undertake appropriate statistical analyses of family-based studies and correctly interpret results from these analyses; and provides examples that illustrate the ways in which family-based studies can enhance our understanding of life course epidemiology. In addition, there is discussion of difficulties specific to setting up such studies in low- and middle-income countries, and issues relating to proxy informants, where parents provide information on children and vice versa, or siblings provide information about each other. Examples of how family-based studies have been used in understanding the life course epidemiology of cardiovascular disease, mental health, and reproductive health illustrate the applicability of the research to these areas, but also more generally to the wider field of life course epidemiology.

Fanaroff and Martin s Neonatal Perinatal Medicine

Fanaroff and Martin s Neonatal Perinatal Medicine
Author: Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publsiher: Elsevier Health Sciences
Total Pages: 1850
Release: 2019-04-11
ISBN: 0323567096
Category: Medical
Language: EN, FR, DE, ES & NL

Fanaroff and Martin s Neonatal Perinatal Medicine Book Excerpt:

Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.

Handbook of Behavior Genetics

Handbook of Behavior Genetics
Author: Yong-Kyu Kim
Publsiher: Springer Science & Business Media
Total Pages: 564
Release: 2009-03-25
ISBN: 0387767274
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Behavior Genetics Book Excerpt:

This handbook provides research guidelines to study roles of the genes and other factors involved in a variety of complex behaviors. Utilizing methodologies and theories commonly used in behavior genetics, each chapter features an overview of the selected topic, current issues, as well as current and future research.

Fanaroff and Martin s Neonatal Perinatal Medicine E Book

Fanaroff and Martin s Neonatal Perinatal Medicine E Book
Author: Richard J. Martin,Avroy A. Fanaroff,Michele C. Walsh
Publsiher: Elsevier Health Sciences
Total Pages: 1936
Release: 2014-08-20
ISBN: 0323295371
Category: Medical
Language: EN, FR, DE, ES & NL

Fanaroff and Martin s Neonatal Perinatal Medicine E Book Book Excerpt:

Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.

Principles of Sex based Differences in Physiology

Principles of Sex based Differences in Physiology
Author: Virginia M. Miller,Virginia L. Miller,Meredith Hay
Publsiher: Gulf Professional Publishing
Total Pages: 356
Release: 2004
ISBN: 9780444514974
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Sex based Differences in Physiology Book Excerpt:

Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers. This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.

Genetics and Genomics in Medicine

Genetics and Genomics in Medicine
Author: Tom Strachan,Judith Goodship,Patrick Chinnery
Publsiher: Taylor & Francis
Total Pages: 544
Release: 2014-06-02
ISBN: 1317594304
Category: Medical
Language: EN, FR, DE, ES & NL

Genetics and Genomics in Medicine Book Excerpt:

Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 1500
Release: 1994
ISBN: 1928374650XXX
Category: Medicine
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Excerpt:

BMJ

BMJ
Author: Anonim
Publsiher: Unknown
Total Pages: 630
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

BMJ Book Excerpt:

The Encyclopedia of Schizophrenia and Other Psychotic Disorders

The Encyclopedia of Schizophrenia and Other Psychotic Disorders
Author: Richard Noll
Publsiher: Infobase Publishing
Total Pages: 409
Release: 2009-01-01
ISBN: 0816075085
Category: Psychology
Language: EN, FR, DE, ES & NL

The Encyclopedia of Schizophrenia and Other Psychotic Disorders Book Excerpt:

Deals with the subject of Schizophrenia and Other Psychotic Disorders. With more than 600 entries, this work features a foreword and an introduction, and references and appendixes. Its coverage includes the history, treatment, diagnosis, and medical research and theories regarding this class of mental illness.

Environmental Epigenetics

Environmental Epigenetics
Author: L. Joseph Su,Tung-chin Chiang
Publsiher: Springer
Total Pages: 321
Release: 2015-05-18
ISBN: 1447166787
Category: Medical
Language: EN, FR, DE, ES & NL

Environmental Epigenetics Book Excerpt:

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Early Life Origins of Health and Disease

Early Life Origins of Health and Disease
Author: E. Marelyn Wintour-Coghlan,Julie Owens
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2007-02-26
ISBN: 0387326324
Category: Medical
Language: EN, FR, DE, ES & NL

Early Life Origins of Health and Disease Book Excerpt:

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.

Twin Mythconceptions

Twin Mythconceptions
Author: Nancy L. Segal
Publsiher: Academic Press
Total Pages: 334
Release: 2017-02-08
ISBN: 0128039957
Category: Psychology
Language: EN, FR, DE, ES & NL

Twin Mythconceptions Book Excerpt:

Twin Mythconceptions: False Beliefs, Fables, and Facts about Twins sheds new light on over 70 commonly held ideas and beliefs about the origins and development of identical and fraternal twins. Using the latest scientific findings from psychology, psychiatry, biology, and education, the book separates fact from fiction. Each idea about twins is described, followed by both a short answer about the truth, and then a longer, more detailed explanation. Coverage includes embryology of twins, twin types, intellectual growth, personality traits, sexual orientation of twins, marital relationships, epigenetic analyses, and more. Five appendices cover selected topics in greater depth, such as the frequency of different twin types and the varieties of polar body twin pairs. This book will inform and entertain behavioral and life science researchers, health professionals, twins, parents of twins, and anyone interested in the fascinating topic of twins. Identifies common misunderstandings about twins Provides scientific answers to questions about twins Encompasses the biology, psychology, genetics, and personality of twins Includes discussion of identical, fraternal same-sex, and fraternal opposite-sex twins Allows for quick answers to common questions and more detailed explanations

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
Author: Shuai Li,John Hopper
Publsiher: Academic Press
Total Pages: 374
Release: 2021-08-31
ISBN: 0128209526
Category: Medical
Language: EN, FR, DE, ES & NL

Twin and Family Studies of Epigenetics Book Excerpt:

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Epigenetics in Human Disease

Epigenetics in Human Disease
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 592
Release: 2012-07-26
ISBN: 0123884160
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics in Human Disease Book Excerpt:

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Pathology of Multiple Pregnancy

Pathology of Multiple Pregnancy
Author: Virginia J. Baldwin
Publsiher: Springer Science & Business Media
Total Pages: 434
Release: 1994
ISBN: 9780387940113
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Pathology of Multiple Pregnancy Book Excerpt:

Pathology of Multiple Pregnancy collates case material from over 500 autopsies (including embryos) and 1200 placentas from twins, triplets, and higher multiples with selected literature on human multiple reproduction. It emphasizes important new concepts of pathophysiology and interpretation of less than ideal outcomes of multiple conception based on over 30 years experience in the field. Aspects of perinatal pathology unique to twins and higher multiples are emphasized, with practical suggestions for the service pathologist, including items of potential medico-legal significance. Controversial topics, such as the value of studies of concordance for diseases or malformations, and the significance of inter-twin anastomoses, are addressed and suggestions made for further investigation. A close working relationship between pathologists and clinical colleagues is encouraged by discussion of clinico-pathological correlations. And, the most recent discussions on mechanisms of twinning and genetic versus environmental influences on the development of twins are presented.