Disease Pathways

Disease Pathways
Author: Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publsiher: Elsevier
Total Pages: 732
Release: 2019-10-18
ISBN: 0128170875
Category: Science
Language: EN, FR, DE, ES & NL

Disease Pathways Book Excerpt:

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Advancing Genomics for Rare Disease Diagnosis and Therapy Development

Advancing Genomics for Rare Disease Diagnosis and Therapy Development
Author: Zhichao Liu,Weida Tong,Tieliu Shi,Mike Mikailov,Ruth Roberts
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-08
ISBN: 2889661628
Category: Science
Language: EN, FR, DE, ES & NL

Advancing Genomics for Rare Disease Diagnosis and Therapy Development Book Excerpt:

The Person with Alzheimer s Disease

The Person with Alzheimer s Disease
Author: Phyllis Braudy Harris
Publsiher: JHU Press
Total Pages: 336
Release: 2002-06-06
ISBN: 9780801868771
Category: Family & Relationships
Language: EN, FR, DE, ES & NL

The Person with Alzheimer s Disease Book Excerpt:

The first book to provide a comprehensive look at what it's like to have dementia and the subjective experience of living with progressive memory loss. Few families are untouched by Alzheimer's disease or a related dementia. Moving accounts of what it is like to care for someone with this disease have already been published, as well as how-to books that offer caregivers advice and information on coping. But this book is the first to provide a comprehensive report of what it is like to have dementia oneself—the subjective experience of living with progressive memory loss. Each chapter discusses a different aspect of having dementia, from the initial assessment and diagnosis through placement in a nursing home. The discussions are grounded in qualitative research and case studies, which convey the variable and personal nature of the experience. They seek to help clinicians, researchers, students, and caregivers (both professionals and family members) understand the experience of dementia, and thereby to promote better caregiving through a person-centered approach. Contributors: Kathleen Kahn-Denis, Judson Retirement Community; Casey Durkin, a psychotherapist in Cleveland, Ohio; Jane Gilliard, Dementia Voice, UK; Phyllis Braudy Harris, John Carroll University; John Keady, University of Wales, UK; John Killick, University of Stirling, UK; Rebecca G. Logsdon, University of Washington; Charlie Murphy, University of Stirling, UK; Alison Phinney, University of British Columbia, Canada; Steven R. Sabat, Georgetown University; Dorothy Seman, Alzheimer's Family Care Center, Chicago; Lisa Snyder, University of California, San Diego; Jane Stansell, Alzheimer's Family Care Center, Chicago; Gloria Sterin, Shaker Heights, Ohio; Jon C. Stuckey, Messiah College; Robyn Yale, Consultant to the Alzheimer's Association, San Francisco; Rosalie Young, Wayne State University School of Medicine.

Polypharmacology

Polypharmacology
Author: Zhiguo Wang,Baofeng Yang
Publsiher: Springer Nature
Total Pages: 870
Release: 2022-08-01
ISBN: 3031049985
Category: Medical
Language: EN, FR, DE, ES & NL

Polypharmacology Book Excerpt:

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
Author: Jules J. Berman
Publsiher: Academic Press
Total Pages: 398
Release: 2018-01-26
ISBN: 0128143940
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Precision Medicine and the Reinvention of Human Disease Book Excerpt:

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Role of Inflammation in Neurodegenerative Diseases

Role of Inflammation in Neurodegenerative Diseases
Author: Maya Koronyo-Hamaoui,Sally Ann Frautschy,Jorge Ivan Alvarez
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-07-13
ISBN: 2889765628
Category: Medical
Language: EN, FR, DE, ES & NL

Role of Inflammation in Neurodegenerative Diseases Book Excerpt:

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation Development Disease and Repair After Injury

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation  Development  Disease and Repair After Injury
Author: Zhouguang Wang,Xiaokun Li,Li Lin,Saverio Bellusci,Jin-San Zhang
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-11-19
ISBN: 2889661288
Category: Science
Language: EN, FR, DE, ES & NL

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation Development Disease and Repair After Injury Book Excerpt:

The Identification and Characterization of the Hydrolethalus Syndrome Gene HYLS1 on 11q24

The Identification and Characterization of the Hydrolethalus Syndrome Gene  HYLS1  on 11q24
Author: Lisa Marja-Lanyi Mee
Publsiher: Unknown
Total Pages: 236
Release: 2005
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Identification and Characterization of the Hydrolethalus Syndrome Gene HYLS1 on 11q24 Book Excerpt:

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 574
Release: 2020-04-02
ISBN: 0444642617
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson s Disease Book Excerpt:

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

OECD Reviews of Public Health Latvia A Healthier Tomorrow

OECD Reviews of Public Health  Latvia A Healthier Tomorrow
Author: OECD
Publsiher: OECD Publishing
Total Pages: 168
Release: 2020-12-22
ISBN: 926461964X
Category: Electronic Book
Language: EN, FR, DE, ES & NL

OECD Reviews of Public Health Latvia A Healthier Tomorrow Book Excerpt:

Latvia sees high rates of obesity, smoking and alcohol consumption. In turn, this results in a high incidence of preventable diseases, such as heart disease, diabetes and many cancers. This puts a burden on a health system which is already operating on a very tight budget as compared to other OECD countries.

Medinfo 2007

Medinfo 2007
Author: Klaus A. Kuhn,James R. Warren,Tze-Yun Leong
Publsiher: IOS Press
Total Pages: 1499
Release: 2007
ISBN: 1586037749
Category: Medical informatics
Language: EN, FR, DE, ES & NL

Medinfo 2007 Book Excerpt:

Contains papers which reflect the breadth and depth of the field of biomedical and health informatics, covering topics such as; health information systems, education, standards, consumer health and human factors, emerging technologies, sustainability, organizational and economic issues, genomics, and image and signal processing.

Biotechnology Annual Review

Biotechnology Annual Review
Author: M. Raafat El-Gewely
Publsiher: Elsevier
Total Pages: 450
Release: 2005-08-29
ISBN: 9780444519528
Category: Reference
Language: EN, FR, DE, ES & NL

Biotechnology Annual Review Book Excerpt:

Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists' knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, vehicles for the production of biotechnology products and methods for their detection, separation and analysis - to topics that are focused on the role of biotechnology in the health sciences. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training.

Drugs

Drugs
Author: Rick Ng
Publsiher: John Wiley & Sons
Total Pages: 560
Release: 2015-04-13
ISBN: 1118907221
Category: Science
Language: EN, FR, DE, ES & NL

Drugs Book Excerpt:

The third edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, Drugs: From Discovery to Approval, Third Edition quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. The third edition incorporates the latest developments and updates in the pharmaceutical community, provides more comprehensive coverage of topics, and includes more materials and case studies suited to college and university use. Biotechnology is a dynamic field with changes across R&D, clinical trials, manufacturing and regulatory processes, and the third edition of the text provides timely updates for those in this rapidly growing field.

Fetal Maternal Immune Interactions in Pregnancy

Fetal Maternal Immune Interactions in Pregnancy
Author: Nandor Gabor Than,Sinuhe Hahn,Simona W. Rossi,Julia Szekeres-Bartho
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-01-24
ISBN: 2889632423
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Fetal Maternal Immune Interactions in Pregnancy Book Excerpt:

Integrating Clinical and Translational Research Networks Building Team Medicine

Integrating Clinical and Translational Research Networks   Building Team Medicine
Author: Ravi Salgia,Prakash Kulkarni
Publsiher: MDPI
Total Pages: 250
Release: 2021-01-29
ISBN: 303650396X
Category: Medical
Language: EN, FR, DE, ES & NL

Integrating Clinical and Translational Research Networks Building Team Medicine Book Excerpt:

Medical centers are widely recognized as vital components of the healthcare system. However, academic medical centers are differentiated from their community counterparts by their mission, which typically focuses on clinical care, education, and research. Nonetheless, community clinics/hospitals fill a critical need and play a complementary role serving as the primary sites for health care in most communities. Furthermore, it is now increasingly recognized that in addition to physicians, physician-scientists, and other healthcare-related professionals, basic research scientists also contribute significantly to the emerging inter- and cross-disciplinary, team-oriented culture of translational science. Therefore, approaches that combine the knowledge, skills, experience, expertise, and visions of clinicians in academic medical centers and their affiliated community centers and hospitals, together with basic research scientists, are critical in shaping the emerging culture of translational research so that patients from the urban as well as suburban settings can avail the benefits of the latest developments in science and medicine. ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’ is an embodiment of this ethos at the City of Hope National Medical Center in Duarte, California. It includes a series of papers authored by teams of leading clinicians, basic research scientists, and translational researchers. The authors discuss how engaging and collaborating with community-based practices, where the majority of older patients with cancer receive their care, can ensure that these patients receive the highest-quality, evidence-based care. Based on our collective experience at City of Hope, we would like to stress that the success of academic-community collaborative programs not only depends on the goodwill and vision of the participants but also on the medical administration, academic leadership, and policymakers who define the principles and rules by which cooperation within the health care industry occurs. We trust that our experience embodied in this singular compendium will serve as a ‘Rosetta Stone’ for other institutions and practitioners.

Biocomputing 2017

Biocomputing 2017
Author: Russ B Altman,A Keith Dunker,Lawrence Hunter,Marylyn D Ritchie,Tiffany A Murray,Teri E Klein
Publsiher: World Scientific Publishing Company
Total Pages: 668
Release: 2016-11-23
ISBN: 9813207809
Category: Science
Language: EN, FR, DE, ES & NL

Biocomputing 2017 Book Excerpt:

The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 – 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Pan genomics Applications Challenges and Future Prospects

Pan genomics  Applications  Challenges  and Future Prospects
Author: Debmalya Barh,Siomar C. Soares,Sandeep Tiwari,Vasco Azevedo
Publsiher: Academic Press
Total Pages: 474
Release: 2020-03-06
ISBN: 0128170778
Category: Medical
Language: EN, FR, DE, ES & NL

Pan genomics Applications Challenges and Future Prospects Book Excerpt:

Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives Discusses current bioinformatics tools and strategies for exploiting pangenomics data Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability

Introduction to Biological Networks

Introduction to Biological Networks
Author: Alpan Raval,Animesh Ray
Publsiher: CRC Press
Total Pages: 335
Release: 2013-04-24
ISBN: 1584884630
Category: Mathematics
Language: EN, FR, DE, ES & NL

Introduction to Biological Networks Book Excerpt:

The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network biology for physical scientists and biologists involved in interdisciplinary research. The book focuses on the concept of molecular and genetic interaction networks as a paradigm for interpreting the complexity of molecular biology at a genomic scale. The authors describe the experimental methods used to discover and test networks of interaction among biological molecules. They also present computational methods for predicting the interaction networks, discuss general mechanisms of network formation and evolution, and explore the application of network approaches to important problems in biology and medicine. With many examples throughout and clear explanations of key concepts, this book is the first to offer a broad treatment of genomics-inspired network biology with sufficient mathematical and biological rigor. It gives readers a conceptual understanding of this burgeoning scientific field.

Genetics and Genomics in Medicine

Genetics and Genomics in Medicine
Author: Tom Strachan,Judith Goodship,Patrick Chinnery
Publsiher: Taylor & Francis
Total Pages: 544
Release: 2014-06-02
ISBN: 1317594304
Category: Medical
Language: EN, FR, DE, ES & NL

Genetics and Genomics in Medicine Book Excerpt:

Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti

WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT TM HEART DISEASE

WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT  TM   HEART DISEASE
Author: Mark Houston
Publsiher: Hachette UK
Total Pages: 320
Release: 2012-02-06
ISBN: 1455506532
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT TM HEART DISEASE Book Excerpt:

A groundbreaking program that reveals what really causes heart disease-- and what can be done to prevent and treat its devastating effects on long-term health. Coronary heart disease has long been the number one killer in this country, and for decades, we have been told about five basic risk factors: elevated cholesterol, high blood pressure, diabetes, obesity, and smoking. But the truth is that heart disease is much more complex-- with close to 400 risk factors! In this innovative guide, Dr. Mark Houston helps readers discover the causes of heart disease, how to prevent and treat its debilitating effects via nutrition, nutritional supplements, exercise, weight management, and lays to rest to various myths (cholesterol is not the primary cause) based on scientific studies and medical publications. Readers will also learn how to identify the risk factors most likely to endanger them and construct an arsenal of non-pharmacological preventative strategies that can counteract this most deadly disease.