Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery
Author: Shanta Bhar
Publsiher: Elsevier
Total Pages: 315
Release: 2020-10
ISBN: 9780128193747
Category: Science
Language: EN, FR, DE, ES & NL

Domino Reactions in Drug Discovery Book Excerpt:

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Domino Reactions

Domino Reactions
Author: Lutz F. Tietze
Publsiher: John Wiley & Sons
Total Pages: 648
Release: 2013-12-23
ISBN: 3527671323
Category: Science
Language: EN, FR, DE, ES & NL

Domino Reactions Book Excerpt:

The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an internationally renowned expert, and the book is edited by L. F. Tietze, who established the concept of domino reactions. The one-stop source for all synthetic chemists to improve the synthetic efficiency and allow an ecologically and economically beneficial preparation of every chemical compound.

Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions

Synthesis of Aromatic Heterocycles by Palladium 0  catalyzed Domino Reactions and Cyclization of Hydrazone Dianions
Author: Thang Ngoc Ngo
Publsiher: Unknown
Total Pages: 135
Release: 2016
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions Book Excerpt:

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
Author: Lutz F. Tietze,Gordon Brasche,Kersten Gericke
Publsiher: John Wiley & Sons
Total Pages: 631
Release: 2006-12-13
ISBN: 3527608680
Category: Science
Language: EN, FR, DE, ES & NL

Domino Reactions in Organic Synthesis Book Excerpt:

Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Diversity Oriented Synthesis

Diversity Oriented Synthesis
Author: Andrea Trabocchi
Publsiher: John Wiley & Sons
Total Pages: 664
Release: 2013-06-17
ISBN: 1118618149
Category: Science
Language: EN, FR, DE, ES & NL

Diversity Oriented Synthesis Book Excerpt:

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology. Diversity-Oriented Synthesis begins with an introductorychapter that explores the basics, including a discussion of therelationship between diversity-oriented synthesis and classiccombinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of smallmolecules using diversity-oriented principles, includingpeptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis bydescribing chemical libraries Provides modern approaches to screening diversity-orientedsynthetic libraries, including high-throughput and high-contentscreening, small molecule microarrays, and smart screeningassays Presents the applications of diversity-oriented syntheticlibraries and small molecules in drug discovery and chemicalbiology, reporting the results of key studies and forecasting therole of diversity-oriented synthesis in future biomedicalresearch This book has been written and edited by leading internationalexperts in organic synthesis and its applications. Theircontributions are based on a thorough review of the currentliterature as well as their own firsthand experience developingsynthetic methods and applications. Clearly written and extensively referenced,Diversity-Oriented Synthesis introduces novices to thishighly promising field of research and serves as a springboard forexperts to advance their own research studies and develop newapplications.

Asymmetric Domino Reactions

Asymmetric Domino Reactions
Author: Helene Pellissier
Publsiher: Royal Society of Chemistry
Total Pages: 500
Release: 2013-03-13
ISBN: 184973710X
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Asymmetric Domino Reactions Book Excerpt:

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
Author: Larry Yet
Publsiher: John Wiley & Sons
Total Pages: 560
Release: 2018-03-07
ISBN: 1118686357
Category: Medical
Language: EN, FR, DE, ES & NL

Privileged Structures in Drug Discovery Book Excerpt:

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
Author: Zbigniew J. Witczak,Roman Bielski
Publsiher: John Wiley & Sons
Total Pages: 368
Release: 2016-01-14
ISBN: 1119044391
Category: Science
Language: EN, FR, DE, ES & NL

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience Book Excerpt:

The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (cascade, tandem)reactions are always intramolecular. They are usually very fast,clean and offer highly complex structures in a one pot process.Intramolecular rearrangements offer very similar advantages andoften lead to highly complex products as well. Although manyrecently isolated carbohydrates fulfill various sophisticatedfunctions, their structures are often very complex. The editorscover the broadest scope of novel methodologies possible. All thesynthetic and application aspects of domino/cascade reactions areexplored in this book. A second theme that will be covered isintramolecular rearrangement, which is also fast, stereoselective,and often constitutes one or more steps of domino /cascade process.Selected examples of intramolecular rearrangements are presented.Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules,which are normally difficult to synthesize via alternative routes.It appears that domino and intramolecular rearrangements areideally suited to synthesize certain specific modifiedmonosaccharides. What is particularly important is that bothprocesses are intermolecular and almost always yield products withvery well-defined stereochemistry. This high definition isabsolutely crucial when synthesizing advanced, modified mono andoligosaccharides. The choice of contributors reflects anemphasis on both therapeutic and pharmacological aspects of carbohydratechemistry.

Small Molecule Drug Discovery

Small Molecule Drug Discovery
Author: Andrea Trabocchi,Elena Lenci
Publsiher: Elsevier
Total Pages: 356
Release: 2019-11-23
ISBN: 0128183500
Category: Science
Language: EN, FR, DE, ES & NL

Small Molecule Drug Discovery Book Excerpt:

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Aromatic Polycyclic Hydrocarbons Advances in Research and Application 2013 Edition

Aromatic Polycyclic Hydrocarbons   Advances in Research and Application  2013 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 527
Release: 2013-06-21
ISBN: 1481685260
Category: Science
Language: EN, FR, DE, ES & NL

Aromatic Polycyclic Hydrocarbons Advances in Research and Application 2013 Edition Book Excerpt:

Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Naphthalenes. The editors have built Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Naphthalenes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Aromatic Polycyclic Hydrocarbons—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Flow Chemistry in Drug Discovery

Flow Chemistry in Drug Discovery
Author: Jesus Alcazar
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN: 3030855929
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Flow Chemistry in Drug Discovery Book Excerpt:

Drug Discovery and Development

Drug Discovery and Development
Author: Ramarao Poduri
Publsiher: Springer Nature
Total Pages: 522
Release: 2021-02-15
ISBN: 9811555346
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Excerpt:

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Imidazole Based Drug Discovery

Imidazole Based Drug Discovery
Author: Shikha Agarwal
Publsiher: Elsevier
Total Pages: 372
Release: 2021-12-10
ISBN: 0323903630
Category: Science
Language: EN, FR, DE, ES & NL

Imidazole Based Drug Discovery Book Excerpt:

Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications of imidazole derivatives that are useful to researchers working on designing more promising clinical lead compounds with this scaffold. It also includes information on past decades of research on the synthesis and biological applications of imidazole derivatives. This is an ideal resource for researchers in organic chemistry both in academic and industrial settings, as well as postgraduates in chemistry and medicinal chemistry. Reviews the most current developments and future perspectives of imidazole on different disease therapies to achieve the ultimate goal of disease eradication Discusses the role of imidazole in contemporary science, technological innovation, drug development, critical challenges and future research directions Covers emerging trends on different eco-benign pathways to synthesize imidazole derivatives for the development of simpler synthetic protocols

Innovations in Green Chemistry and Green Engineering

Innovations in Green Chemistry and Green Engineering
Author: Paul T. Anastas,Julie B. Zimmerman
Publsiher: Springer Science & Business Media
Total Pages: 334
Release: 2012-12-13
ISBN: 146145817X
Category: Science
Language: EN, FR, DE, ES & NL

Innovations in Green Chemistry and Green Engineering Book Excerpt:

Processes that meet the objectives of green chemistry and chemical engineering minimize waste and energy use, and eliminate toxic by-products. Given the ubiquitous nature of products from chemical processes in our lives, green chemistry and chemical engineering are vital components of any sustainable future. Gathering together ten peer-reviewed articles from the Encyclopedia of Sustainability Science and Technology, Innovations in Green Chemistry and Green Engineering provides a comprehensive introduction to the state-of-the-art in this key area of sustainability research. Worldwide experts present the latest developments on topics ranging from organic batteries and green catalytic transformations to green nanoscience and nanotoxicology. An essential, one-stop reference for professionals in research and industry, this book also fills the need for an authoritative course text in environmental and green chemistry and chemical engineering at the upper-division undergraduate and graduate levels.

Multicomponent Reactions

Multicomponent Reactions
Author: Jieping Zhu,Hugues Bienaymé
Publsiher: John Wiley & Sons
Total Pages: 484
Release: 2006-03-06
ISBN: 3527604243
Category: Science
Language: EN, FR, DE, ES & NL

Multicomponent Reactions Book Excerpt:

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions
Author: Helene Pellissier
Publsiher: John Wiley & Sons
Total Pages: 1000
Release: 2019-08-02
ISBN: 3527822518
Category: Science
Language: EN, FR, DE, ES & NL

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book Excerpt:

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.

Solid supported Combinatorial and Parallel Synthesis of Small molecular weight Compound Libraries

Solid supported Combinatorial and Parallel Synthesis of Small molecular weight Compound Libraries
Author: D. Obrecht,J.M. Villalgordo
Publsiher: Elsevier
Total Pages: 339
Release: 1998-10-16
ISBN: 9780080432571
Category: Medical
Language: EN, FR, DE, ES & NL

Solid supported Combinatorial and Parallel Synthesis of Small molecular weight Compound Libraries Book Excerpt:

This book gives an overview of the current state of the art of combinatorial organic synthesis. While the main focus is on multicomponent and multigeneration strategies using polymeric supports, there is also a Chapter on solution strategies using polymer-grafted reagents which allow minimisation of work-up procedures. Some of the most important strategies and tools are presented and summarised, with an explanation of the pivotal role of organic synthesis in the creation of diversity.

Rhodium Catalysis

Rhodium Catalysis
Author: Carmen Claver
Publsiher: Springer
Total Pages: 288
Release: 2017-12-15
ISBN: 3319666657
Category: Science
Language: EN, FR, DE, ES & NL

Rhodium Catalysis Book Excerpt:

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.

Multicomponent Reactions

Multicomponent Reactions
Author: Raquel P. Herrera,Eugenia Marqués-López
Publsiher: John Wiley & Sons
Total Pages: 528
Release: 2015-03-30
ISBN: 111886400X
Category: Science
Language: EN, FR, DE, ES & NL

Multicomponent Reactions Book Excerpt:

Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II
Author: Romano V. A. Orru,Eelco Ruijter
Publsiher: Springer
Total Pages: 292
Release: 2010-07-26
ISBN: 3642154557
Category: Science
Language: EN, FR, DE, ES & NL

Synthesis of Heterocycles via Multicomponent Reactions II Book Excerpt:

Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery