Description : This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.
Description : With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.
Description : What you don't know might be killing you ... Read on only if you are serious about your health and well-being. You know the pain and cramping after eating. The bloating. The discomfort. The allergies flaring up... In his book Robert M. Fleischer offers you a proven step-by-step approach to safely eliminate the main culprit causing food related inflammation and allergies. In this book you'll: Find out how allergies and inflammation can weaken the immune system, leaving you wide open to attack. Uncover the secrets of gluten and food allergies (you absolutely have to read this chapter) Discover obvious and not so obvious symptoms. Discover how gluten can keep you awake at night. This is your opportunity to gain the knowledge that could make a big difference in your life. You'll learn: How gluten sensitivity can lead to the three big killers, and the steps you can take to prevent this Serious and debilitating complications you should know about How using conventional treatments for allergies and inflammation could be putting you at risk for more threatening health conditions You probably already know that conventional treatment only serves to mask the symptoms; and in this book you'll discover how you have more control over your well-being than just taking a pill. The further on you read, you'll begin to understand how essential it is to be armed with this knowledge. You will be armed with: Food lists that can change your life Menu plans Quick and easy recipes and much more ... Everything is outlined for you, step by step. All you have to do is read this book and apply your knowledge. In the end it could save your life. Drift back in time to when eating was pure pleasure, with no pain or fear to go with that. Imagine what it would be like if you could eat a meal without having any discomfort. What will this mean for you? Now including SPECIAL BONUS eBOOK! : Your Guide To Healthy Eating This is the ebook that will allow you to stop the yo-yo diet nightmare once and for all and turn your weight loss and fitness dreams into reality! You'll learn how to: Lose weight Improve your health Send your energy skyrocketing Stop your junk food cravings Think more clearly Sleep better Be far more productive in life!
Description : The Inflammation Spectrum, Dr Will Cole's follow up to Ketotarian, teaches us how inflammation is often the catalyst for most common health woes. Arriving at a time where issues of inflammation and gut health are becoming increasingly prominent within mainstream discourses, Dr Will Cole offers us a solution to this growing issue. The Inflammation Spectrum teaches us that ultimately how we feel is symbiotically linked to what we consume; indeed, food, in Cole's words, 'constantly and dynamically influences' our health. Subsequently he teaches readers how to do nutrition the right way, providing us with a personal guide which seeks to aid readers to find out which foods their bodies love, hate and need to feel great! Cole's book informs us to think twice before consuming pharmaceutical drugs to "fix" issues of inflammation and instead proposes that readers reassess their eating habits, using 'food as thy medicine'. This book, Dr Mark Hyman suggests, is for 'anyone who is fed up with fad diets' as Cole uses his years of experience in functional-medicine to teach us how to love our bodies enough to nourish it with delicious, healing foods. From personal quizzes to scientific breakdowns The Inflammation Spectrum offers empowering advice and puts readers on the path to achieving food freedom and optimal health.
Description : Since its first publication in 1936, Sabiston Textbook of Surgery has been regarded as the preeminent source for definitive guidance in all areas of general surgery. The 20th edition continues the rich tradition of quality that has made this classic text synonymous with the specialty and a part of generations of surgery residents and practitioners. Meticulously updated throughout, this classic text concisely covers the breadth of material needed for certification and practice of general surgery. Detailed, full-color intraoperative illustrations capture key teaching moments, allowing you to better understand the basic science of surgery, make the most informed decisions and achieve optimal outcomes for every patient. Understand the underlying science and its clinical application to make informed surgical decisions and achieve optimal outcomes. Overcome tough challenges, manage unusual situations, and avoid complications with the most trusted advice in your field. Get the depth of coverage you need in an easily accessible, single volume organized by organ and along traditional lines beginning with principles common to surgical specialties including fluid and electrolyte management, metabolic support, and wound healing. Subsequent sections review the management of injury, transplantation, oncology, breast, endocrine, and abdominal procedures. Explore topics encountered by general surgery residents in training as well as in-depth coverage of subspecialty areas including head and neck, thoracic, vascular, urology, neurosurgery, pediatrics, and gynecology. Visually grasp and retain difficult concepts thanks to a full-color design featuring an abundance of illustrations, intraoperative photographs, and tables as well as more schematic diagrams that facilitate the comprehension of surgical techniques and procedures. Glean all essential, up-to-date, need-to-know information about the latest surgical perspectives and approaches to treatment including innovations in minimally invasive surgery and percutaneous devices. Streamline clinical decision making with an increased number of schematic diagrams and key data on surgical outcomes.
Description : Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk was selected for The First Clinical Research Bookshelf - Essential reading for clinical research professionals by the Journal of Clinical Research Best Practices. Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk provides drug safety/pharmacovogilance professionals, pharmaceutical and clinical research scientists, statisticians, programmers, medical writers, and technicians with an accessible, practical framework for the analysis, summary and interpretation of drug safety data. The only guide of its kind, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is an invaluable reference for pre- and post-marketing risk assessment. With decades of pharmaceutical research and drug safety expertise, authors Dr. Klepper and Dr. Cobert discuss how quality planning, safety training, and data standardization result in significant cost, time, and resource savings. Through illustrative, step-by-step instruction, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is the definitive guide to drug safety data analysis and reporting. Key features include: * Step-by-step instruction on how to analyze, summarize and interpret safety data for mandatory governmental safety reports * Pragmatic tips...and mistakes to avoid * Simple explanations of what safety data are collected, and what the data mean * Practical approaches to determining a drug effect and understanding its clinical significance * Guidance for determining risk throughout the lifecycle of a drug, biologic or nutraceutical * Examples of user-friendly data displays that enhance safety signal identification * Ways to improve data quality and reduce the time, resources and costs involved in mandatory safety reporting * Relevant material for the required training of drug safety/pharmacovigilance professionals * SPECIAL FEATURE: Actual examples of an Integrated Analysis of Safety (IAS) -used in the preparation of the Integrated Summary of Safety (ISS) and the Summary of Clinical Safety (SCS) reports -, and the Periodic Safety Update Report (PSUR)
Description : This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.