Drug Delivery Aspects

Drug Delivery Aspects
Author: Ranjita Shegokar
Publsiher: Academic Press
Total Pages: 278
Release: 2020-04-10
ISBN: 0128212225
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Drug Delivery Aspects Book Excerpt:

Drug Delivery Aspects: Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, and scale-up of nano and micro carriers. Various aspects like conversion of micro-nano particles into solid dosage form, large scale industry manufacturing challenges of nanocarriers, regulatory considerations on drug device combinations are featured in this volume. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. The Multifunctional Drug Delivery Systems books provide a platform to discuss opportunities and challenges in development of micro-nanomedicine and other drug delivery systems, review industrial manufacturing challenges, discuss current and future market trends, facilitate the insight sharing within various expertise area, and establish collaborations between academic scientists, industrial and clinical researchers. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems.

Delivery of Drugs

Delivery of Drugs
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 242
Release: 2020-02-01
ISBN: 0128177772
Category: Medical
Language: EN, FR, DE, ES & NL

Delivery of Drugs Book Excerpt:

Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Chemical Aspects of Drug Delivery Systems

Chemical Aspects of Drug Delivery Systems
Author: D R Karsa,R A Stephenson
Publsiher: Royal Society of Chemistry
Total Pages: 170
Release: 2007-10-31
ISBN: 1847550371
Category: Medical
Language: EN, FR, DE, ES & NL

Chemical Aspects of Drug Delivery Systems Book Excerpt:

Despite advances in the development of new drugs, a drug may never reach the target organ, or it may be difficult to achieve the necessary level of drug in the body. Large doses can result in serious side effects and can harm normal, as well as diseased, cells and organs, and for this reason it is vital that controlled release and the targeting of delivery systems must evolve in parallel to drug research. Chemical Aspects of Drug Delivery Systems reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field. Delivery systems described include carbohydrate derivatives, novel nonionic surfactant vesicles and various polymers, including polyacrylates and aqueous shellac solutions, as well as hydrogels. In addition, many of the key issues, such as the understanding of biosystems and targets and the development of materials to provide the deserved carrier and excipient properties for controlled, targeted drug delivery, are considered in depth. This book will be of equal interest to undergraduate, graduate, researcher and those in the pharmaceutical industries, and it complements two previous RSC Special Publications, Encapsulation and Controlled Release and Excipients and Delivery Systems for Pharmaceutical Formulations.

Drug Delivery Aspects

Drug Delivery Aspects
Author: Ranjita Shegokar
Publsiher: Academic Press
Total Pages: 266
Release: 2020-03-27
ISBN: 0128218509
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Drug Delivery Aspects Book Excerpt:

Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses engineering and large-scale manufacturing of nanocarriers Considers preclinical, regulatory and ethical guidelines on nanoparticles Contains in-depth discussions on delivery of biologics, vaccines and sterilisation Industrial view on solid dispersions, milling techniques

Drug Delivery Trends

Drug Delivery Trends
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 246
Release: 2020-03-01
ISBN: 012817871X
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Trends Book Excerpt:

Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses trends in drug delivery systems and selected dosage forms Illustrates regulatory, preclinical and quality principles Contains in-depth investigation of upcoming types of drug delivery systems

Nanopharmaceuticals

Nanopharmaceuticals
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 244
Release: 2020-01-10
ISBN: 0128177799
Category: Medical
Language: EN, FR, DE, ES & NL

Nanopharmaceuticals Book Excerpt:

Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 Encompasses functional aspects of nanocarriers Discusses Intellectual Property landscapes of micro-nano drug carriers Contains in-depth investigation of specific aspects of drug delivery systems

Chemical Aspects of Drug Delivery Systems

Chemical Aspects of Drug Delivery Systems
Author: D. R. Karsa,R. A. Stephenson,British Association for Chemical Specialties. Waterborne Polymers Group
Publsiher: Royal Society of Chemistry
Total Pages: 234
Release: 1996
ISBN: 9780854047062
Category: Medical
Language: EN, FR, DE, ES & NL

Chemical Aspects of Drug Delivery Systems Book Excerpt:

This book reflects the modern challenge to devise effective drug delivery and targeting systems, giving particular emphasis to recent innovations in the field.

Current Aspects of Nasal Drug Delivery

Current Aspects of Nasal Drug Delivery
Author: Paul Merkus
Publsiher: Unknown
Total Pages: 199
Release: 2006
ISBN: 9789090202785
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Current Aspects of Nasal Drug Delivery Book Excerpt:

Pharmaceutical Dosage Forms and Drug Delivery Second Edition

Pharmaceutical Dosage Forms and Drug Delivery  Second Edition
Author: Ram I. Mahato,Ajit S. Narang
Publsiher: CRC Press
Total Pages: 512
Release: 2011-10-25
ISBN: 1439849188
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmaceutical Dosage Forms and Drug Delivery Second Edition Book Excerpt:

In the second edition of Pharmaceutical Dosage Forms and Drug Delivery the authors integrate aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, emphasizing the increased attention that the recent spectacular advances in dosage form design and drug delivery, gene therapy, and nanotechnology have brought to the field. Highlights of the Second Edition: Additional author Ajit S. Narang brings an industrial practitioner perspective with increased focus on pharmacy math and statistics, and powders and granules Reorganized into three parts: Introduction, Physicochemical Principles, and Dosage Forms Chapters on pharmaceutical calculations, compounding principles, and powders and granules provide a complete spectrum of application of pharmaceutical principles Expansion of review questions and answers clarifies concepts for students and adds to their grasp of key concepts covered in the chapter Coverage of complexation and protein binding aspects of physical pharmacy includes the basic concepts as well as recent progress in the field Although there are numerous books on the science of pharmaceutics and dosage form design, most cover different areas of the discipline and do not provide an integrated approach to the topics. This book not only provides a singular perspective of the overall field, but it supplies a unified source of information for students, instructors, and professionals.

Liposomes in Relation to Peptide Interactions and Potential Drug Delivery Aspects

Liposomes in Relation to Peptide Interactions and Potential Drug Delivery Aspects
Author: Tina Bjeldskov Pedersen
Publsiher: Unknown
Total Pages: 108
Release: 2001
ISBN: 9788778344991
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Liposomes in Relation to Peptide Interactions and Potential Drug Delivery Aspects Book Excerpt:

Bioadhesives in Drug Delivery

Bioadhesives in Drug Delivery
Author: K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2020-05-26
ISBN: 1119640261
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Bioadhesives in Drug Delivery Book Excerpt:

This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Drug Delivery Approaches and Nanosystems Volume 2

Drug Delivery Approaches and Nanosystems  Volume 2
Author: Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publsiher: CRC Press
Total Pages: 374
Release: 2017-11-15
ISBN: 1351846663
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Approaches and Nanosystems Volume 2 Book Excerpt:

This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.

Nanodispersions for Drug Delivery

Nanodispersions for Drug Delivery
Author: Raj K. Keservani,Anil K. Sharma
Publsiher: CRC Press
Total Pages: 400
Release: 2018-09-24
ISBN: 135104754X
Category: Medical
Language: EN, FR, DE, ES & NL

Nanodispersions for Drug Delivery Book Excerpt:

This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems. The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves. Key features: • Provides an overview of nanoemulsions for drug delivery • Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems • Presents information relevant to specific routes of applications of nanoemulsions • Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration • Explores nanomicellar approaches for drug delivery • Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery

Oral Drug Delivery for Modified Release Formulations

Oral Drug Delivery for Modified Release Formulations
Author: Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts
Publsiher: John Wiley & Sons
Total Pages: 496
Release: 2022-04-26
ISBN: 1119772699
Category: Medical
Language: EN, FR, DE, ES & NL

Oral Drug Delivery for Modified Release Formulations Book Excerpt:

ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Multiparticulate Oral Drug Delivery

Multiparticulate Oral Drug Delivery
Author: Isaac Ghebre-Selassie
Publsiher: CRC Press
Total Pages: 496
Release: 2019-08-30
ISBN: 9780367402044
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Multiparticulate Oral Drug Delivery Book Excerpt:

This definitive reference explores the various aspects of multiparticulate dosage form development-assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms. Discussing-for the first time in a comprehensive manner-alternative pelletization techniques such as balling (spherical agglomeration), spray congealing, and cryopelletization, Multiparticulate Oral Drug Delivery describes formulation and processing variables that affect the formation, integrity, and performance of coatings derived from molten materials and polymeric solutions and dispersions analyzes the biopharmaceutical aspects and in vivo performance of multiparticulate drug delivery systems details the idiosyncrasies of the manufacturing process of hard-shell gelatin capsules explains the different kinds of packaging materials and machinery and the importance of packaging during the development phase and beyond previews the marketing considerations of multiparticulate systems in the years to come presents practical solutions to problems encountered in the area of film-coating processes and more!

Site specific Drug Delivery

Site specific Drug Delivery
Author: Eric Tomlinson,Stanley S. Davis
Publsiher: John Wiley & Sons
Total Pages: 164
Release: 1986
ISBN: 1928374650XXX
Category: Chemotherapy
Language: EN, FR, DE, ES & NL

Site specific Drug Delivery Book Excerpt:

Recent advances in cell and molecular biology are providing exciting opportunities for the rational design of novel highly specific and effective therapeutic agents. These opportunities will often only be turned into clinical success through strategies which ensure the delivery of such agents to the desired site of action. This is achieved via processes which prevent loss of drug activity, avoid toxicity and provide cost- effective and convenient therapy. This book addresses some of the biological opportunities and scientific challenges for the site-specific delivery of drugs, and indicates the formidable obstacles which face the pharmaceutical industry and academia alike.

Pharmaceutical Dosage Forms and Drug Delivery

Pharmaceutical Dosage Forms and Drug Delivery
Author: Ram I. Mahato,Ajit S. Narang
Publsiher: CRC Press
Total Pages: 336
Release: 2007-06-07
ISBN: 1420009206
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmaceutical Dosage Forms and Drug Delivery Book Excerpt:

Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery elucidates basic physicochemical principles and their application in the design of dosage forms. The author addresses the relevance of these principles to the biopharmaceutical aspects of drugs. He explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms. The book covers physicochemical principles of dosage design, biopharmaceutical and physiological considerations, types of commonly used pharmaceutical dosage forms, introduction to polymeric biomaterials, protein and nucleic acid-based dosage forms, and novel and targeted drug delivery systems. It highlights the physicochemical parameters used for the design, development, and evaluation of biotechnological dosage forms and describes the biological barriers to drug absorption. Containing the right blend of mathematics, equations, diagrams, pictorials, and other pertinent information, this book provides a unified perspective that creates a greater overall understanding of basic science and cutting-edge technology.

Ophthalmic Drug Delivery

Ophthalmic Drug Delivery
Author: M.F. Saettone,M. Bucci,P. Speiser
Publsiher: Springer Science & Business Media
Total Pages: 197
Release: 2013-11-11
ISBN: 1475741758
Category: Medical
Language: EN, FR, DE, ES & NL

Ophthalmic Drug Delivery Book Excerpt:

This book contains the proceedings of the International Symposium on Ophthalmie Drug Delivery, which was held in Pisa in October 1986. Topical ophthalmic therapy is a matter of interest to specialists from different fields (medical, pharmaceutical, chemical, technological, etc.), who, unfortunately, have a tendency to meet separately, thus limiting a diffusion of knowledge, ideas and experience that would greatly favour the overall pro gress in this area of research. The Symposium, for the first time in Europe, provided the opportunity for specialists from different disciplines and from different countfies to meet, to discuss and to share their experience. This multidisciplinary approach is reflected in the wide variety of topics that appear in the book. The papers are aimed at reviewing many of the complex, interrelated, medical pharmaceutical and technological facets of topical ophthalmic therapy. lt is our hope that they may stimulate further thought in this fascinating field, and may provide possible guidelines for future research. The editors wish to express their appreciation to the sponsors of the Symposium: Fidia Research Laboratories, whose generosity permitted the meeting tobe held, and the ltalian National Research Council (CNR, Progetto Finalizzato Chimica Fine e Secondaria) who gave its scientific tutorship. Thanks are also due to the other Symposium contributors, ACRAF SpA, Rome, and Allergan Italia SpA, Rome. The assistance, support and coopera tion given before, during and after the Symposium by Dr. Patrizia Chetoni, Dr. Maria Tilde Torracca and Dr. Elena Parolini arealso gratefully acknowledged.

Innovative Dosage Forms

Innovative Dosage Forms
Author: Yogeshwar Bachhav
Publsiher: John Wiley & Sons
Total Pages: 352
Release: 2019-08-09
ISBN: 3527812202
Category: Science
Language: EN, FR, DE, ES & NL

Innovative Dosage Forms Book Excerpt:

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Biopharmaceutical Aspects of Oral Drug Delivery

Biopharmaceutical Aspects of Oral Drug Delivery
Author: Werenfriedus Adrianus Faassen
Publsiher: Unknown
Total Pages: 157
Release: 2005
ISBN: 9789039337561
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Biopharmaceutical Aspects of Oral Drug Delivery Book Excerpt: