Dynamics Structure And Function Of Biological Macromolecules

Author by : North Atlantic Treaty Organization. Scientific Affairs Division
Languange : en
Publisher by : IOS Press
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Description : A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.


Macromolecular Crystallography

Author by : Maria Armenia Carrondo
Languange : en
Publisher by : Springer Science & Business Media
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Description : This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.


Methods In Molecular Biophysics

Author by : Igor N. Serdyuk
Languange : en
Publisher by : Cambridge University Press
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Description : A comprehensive graduate textbook explaining key physical methods in biology, reflecting the very latest research in this fast-moving field.


Dynamics And The Problem Of Recognition In Biological Macromolecules

Author by : Oleg Jardetzky
Languange : en
Publisher by : Springer Science & Business Media
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Total Read : 35
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Description : From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.


Dynamics Of Proteins And Nucleic Acids

Author by : J. Andrew McCammon
Languange : en
Publisher by : Cambridge University Press
Format Available : PDF, ePub, Mobi
Total Read : 47
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Description : This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.


Protein And Rna Structure And Function By Nmr Spectroscopy

Author by : Eric M. Danhart
Languange : en
Publisher by : Unknown
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Total Read : 59
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Description : The central dogma of molecular biology, which describes the flow of information from genes to proteins, requires the function of a multitude of proteins and RNA molecules. Nuclear magnetic resonance (NMR) spectroscopy, a powerful method for characterizing structures and dynamics of biological macromolecules, allows us to gain significant insights into how these molecules function, enabling scientific advances that can lead to disease prevention or therapeutic development. The studies presented here describe the application of NMR spectroscopy to the characterization of two different macromolecules directly involved in regulating processes of the central dogma and another that hijacks these processes for its function.


Protein Conformational Dynamics

Author by : Ke-li Han
Languange : en
Publisher by : Springer Science & Business Media
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Total Read : 11
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Description : This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.


Molecular Biophysics For The Life Sciences

Author by : Norma Allewell
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 70
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Description : This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions.


Modeling The Structure Dynamics And Interactions Of Biological Molecules

Author by : Zhen Xia
Languange : en
Publisher by : Unknown
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Total Read : 91
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Description : Biological molecules are essential parts of organisms and participate in a variety of biological processes within cells. Understanding the relationship between sequence, structure, and function of biological molecules are of fundamental importance in life science and the health care industry. In this dissertation, a multi-scale approach was utilized to develop coarse-grained molecular models for protein and RNA simulations. By simplifying the atomistic representation of a biomolecular system, the coarse-grained approach enables the molecular dynamics simulations to reveal the biological processes, which occur on the time and length scales that are inaccessible to the all-atom models. For RNA, an "intermediate" coarse-grained model was proposed to provide both accuracy and efficiency for RNA 3D structure modeling and prediction. The overall potential parameters were derived based on structural statistics sampled from experimental structures. For protein, a general, transferable coarse-grain framework based on the Gay-Berne potential and electrostatic point multipole expansion was developed for polypeptide simulations. Next, an advanced atomistic model was developed to model electrostatic interaction with high resolution and incorporates electronic polarization effect that is ignored in conventional atomistic models. The last part of my thesis work involves applying all-atom molecular simulations to address important questions and problems in biophysics and structural biology. For example, the interaction between protein and miRNA, the recognition mechanism of antigen and antibody, and the structure dynamics of protein in mixed denaturants.


Protein Dynamics Function And Design

Author by : Oleg Jardetzky
Languange : en
Publisher by : Plenum Publishing Corporation
Format Available : PDF, ePub, Mobi
Total Read : 78
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Description : This text offers a survey of the state of research worldwide on the interactions and dynamics of large biological molecules such as DNA and proteins and on the effects of dynamics upon structure determination. Authors from renowned laboratories and institutions discuss new findings and new directions for the greater understanding of the interactions of molecules to create life-processes. Although the topics covered in the book require a relatively advanced understanding of biomedical/biochemical and biophysical science, the overall range of expertise and focus provides a broad survey of experimental techniques and approaches to the problem of understanding molecular recognition and interaction and the potential for drug design and development.


Structure And Dynamics Of Membranes

Author by : R. Lipowsky
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 44
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Description : The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateral phase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes with polymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process of contact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned about the interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.


Dynamic Aspects Of Conformation Changes In Biological Macromolecules

Author by : C. Sadron
Languange : en
Publisher by : Springer Science & Business Media
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Total Read : 72
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Description : On the day after the 1959 Cambridge Congress, during which the International Union of Pure and Applied Biophysics was founded, a biophysics section was formed within the Society of Physical Chemistry (Societe de Chimie Physique). Since then, three of the Society's annual meetings (the 11th, 17th, and 23rd) were devoted exclusively to the physico-chemical study of biological systems. The first of these was held in June 1961 at a hotel in Col de Voza, at the foot of an alpine glacier above Chamonix. The second, in May 1967, took place in the more learned setting of the venerable rooms of the National Museum of Natural History in Paris. The third - the one dealt with in the present volume - was recently held at Orleans-La Source in the newly built lecture theatres of the young University, which is near the great Institutes of the National Centre for Scientific Research (CNRS), on the Sologne plateau. These three stages are milestones of an evolution which characterises (at least schematically) the explosive evolution of biological physico-chemistry. The first colloquium, with the title 'Deoxyribonucleic Acid: Structure, Synthesis and Functions', actually marks the first contact of the physical chemist with one of the then most prestigious biological macromolecules, the structure of which had just been discovered, and in this way celebrated one of the first and most striking successes of molecular biology.


Guide To Programs

Author by : National Science Foundation (U.S.)
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 60
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Nuclear Magnetic Resonance Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 89
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Description : The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Nuclear Magnetic Resonance of Biological Macromolecules, Part C is written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules. * One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences


Water And Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Macmillan International Higher Education
Format Available : PDF, ePub, Mobi
Total Read : 18
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Protein Nmr Spectroscopy

Author by : Lu-Yun Lian
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 69
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Description : Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.


Nuclear Magnetic Resonance Probes Of Molecular Dynamics

Author by : R. Tycko
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
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Description : Nuclear Magnetic Resonance Probes of Molecular Dynamics describes the theoretical basis and experimental techniques that make modern NMR spectroscopy a powerful and flexible tool for probing molecular dynamics in chemical, physical, and biochemical systems. Individual chapters, written by leaders in the development and application of NMR from around the world, treat systems that range from synthetic polymers, liquid crystals, and catalysts to proteins and oligonucleotides and techniques that include deuterium NMR, magic angle spinning, multidimensional spectroscopy, and magnetic resonance imaging. A combination of elementary and advanced material makes the book a useful introduction to the field for students at the graduate level as well as an important reference for practising NMR spectroscopists.


Stochastic Dynamics Of Reacting Biomolecules

Author by : Werner Ebeling
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 45
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Description : This is a book about the physical processes in reacting complex molecules, particularly biomolecules. In the past decade scientists from different fields such as medicine, biology, chemistry and physics have collected a huge amount of data about the structure, dynamics and functioning of biomolecules. Great progress has been achieved in exploring the structure of complex molecules. However, there is still a lack of understanding of the dynamics and functioning of biological macromolecules. In particular this refers to enzymes, which are the basic molecular machines working in living systems. This book contributes to the exploration of the physical mechanisms of these processes, focusing on critical aspects such as the role of nonlinear excitations and of stochastic effects. An extensive range of original results has been obtained in the last few years by the authors, and these results are presented together with a comprehensive survey of the state of the art in the field. Contents:Introduction to the Reaction Theory and Cluster Dynamics of Enzymes (W Ebeling, A Netrebko & Yu Romanovsky)Tools of Stochastic Dynamics (L Schimansky-Geier & P Talkner)Motion of Test Particles in a 2-D Potential Landscape (O A Chichigina, A V Netrebko & N V Netrebko)Microscopic Simulations of Activation and Dissociation (W Ebeling, V Yu Podlipchuk, M G Sapeshinsky & A A Valuev)Excitations on Rings of Molecules (A Chetverikov, W Ebeling, M Jenssen & Yu Romanovsky)Fermi Resonance and Kramers Problem in 2-D Force Field (S V Kroo, A V Netrebko, Yu M Romanovsky & L Schimansky-Geier)Molecular Scissors. Cluster Model of Acetylcholinesterase (A Yu Chikishev, S V Kroo, A V Netrebko, N V Netrebko & Yu Romanovsky)Dynamics of Proton Transfer in the Active Site of Chymotrypsin (A Yu Chikishev, B A Grishanin & E V Shuvalova)On the Damping of Cluster Oscillations in Protein Molecules (A Yu Chikishev, A V Netrebko & Yu M Romanovsky)Protein Dynamics and New Approaches to the Molecular Mechanisms of Protein Functioning (K V Shaitan) Readership: Researchers and graduate students in physics, biophysics, molecular biology and the life sciences; experts on nonlinear dynamics and the stochastic process in molecular systems and biomolecules. Keywords:Stochastic Dynamics;Reacting Complex Molecules;Biomolecules;Enzymatic Reactions;Molecular Dynamics;Nonlinear Excitations;Resonances


Research Grants Index

Author by : National Institutes of Health (U.S.). Division of Research Grants
Languange : en
Publisher by : Unknown
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Dynamics Of Biological Macromolecules By Neutron Scattering

Author by : Salvatore Magazù
Languange : en
Publisher by : Bentham Science Publishers
Format Available : PDF, ePub, Mobi
Total Read : 84
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Description : Dynamics of Biological Macromolecules by Neutron Scattering provides insight into the study of the dynamics of biological macromolecules by neutron scattering techniques. The applicability of neutron scattering to expanding fields of biological studies is


National Science Foundation

Author by : United States. Congress. House. Committee on Appropriations. Subcommittee on VA, HUD, and Independent Agencies
Languange : en
Publisher by : Unknown
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Total Read : 25
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Dynamics Of Soft Matter

Author by : VICTORIA GARCIA SAKAI
Languange : en
Publisher by : Springer Science & Business Media
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Total Read : 27
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Description : Dynamics of Soft Matter: Neutron Applications provides an overview of neutron scattering techniques that measure temporal and spatial correlations simultaneously, at the microscopic and/or mesoscopic scale. These techniques offer answers to new questions arising at the interface of physics, chemistry, and biology. Knowledge of the dynamics at these levels is crucial to understanding the soft matter field, which includes colloids, polymers, membranes, biological macromolecules, foams, emulsions towards biological & biomimetic systems, and phenomena involving wetting, friction, adhesion, or microfluidics. Emphasizing the complementarities of scattering techniques with other spectroscopic ones, this volume also highlights the potential gain in combining techniques such as rheology, NMR, light scattering, dielectric spectroscopy, as well as synchrotron radiation experiments. Key areas covered include polymer science, biological materials, complex fluids and surface science.


Research Awards Index

Author by : Anonim
Languange : en
Publisher by : Unknown
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Description :