Energetics Of Biological Macromolecules

Author by : Jo M. Holt
Languange : en
Publisher by : Elsevier
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Description : This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin *Multiple-Binding of Ligands to a Linear Biopolymer *Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions *Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis


Energetics Of Biological Macromolecules Part E

Author by : Anonim
Languange : en
Publisher by : Elsevier
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Description : Energetics of Biological Macromolecules, Part E focuses on methods related to allosteric enzymes and receptors, including fluorescent proves, spectroscopic methods and quantitative analysis as well as on cooperativity in protein folding. NMR and mass spectrometry methods are discussed. Allosteric Enzymes and Receptors Cooperativity in Protein Folding and Assembly


Energetics Of Biological Macromolecules

Author by : Michael L. Johnson
Languange : en
Publisher by : Elsevier
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Total Read : 24
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Description : General Description of the Volume: The very existence of biological structures and their functional interactions are dictated by energetic relationships. Thus the central theme of this volume is that thermodynamic methods, i.e. techniques that probe the energetics of biological macromolecules, now comprise a powerful and practical family of tools for research in modern biology. The application of thermodynamics and statistical thermodynamics to biochemical and biophysical systems is presented. This volume supplements Methods in Enzymology, Volume 259. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Major topics covered include: * Deciphering rules of helix stability in peptides * Protein Folding in Membranes * Molecular Crowding * Study of the Bohr Effect in Hemoglobin Intermediates * Photoacoustic Calorimetry of Proteins * Theoretical Aspects of Isothermal Titration Calorimetry * Energetic Methods to Study Bifunctional Biotin Repressor


Part C

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 75
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Description :


Energetics Of Biological Macromolecules Part E

Author by : Jo M. Holt
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 46
Total Download : 770
File Size : 52,7 Mb
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Description : Energetics of Biological Macromolecules, Part E focuses on methods related to allosteric enzymes and receptors, including fluorescent proves, spectroscopic methods and quantitative analysis as well as on cooperativity in protein folding. NMR and mass spectrometry methods are discussed. Allosteric Enzymes and Receptors Cooperativity in Protein Folding and Assembly


Energetics Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 45
Total Download : 842
File Size : 44,7 Mb
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Description : Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology. Key Features * Probing Stability of Helical Transmembrane Proteins * Energetics of Vinca Alkaloid Interactions with Tubulin * Deriving Complex Ligand Binding Formulas * Mathematical Modeling of Cooperative Interactions in Hemoglobin * Analysis of Interactions of Regulatory Protein TyrR with DNA * Parsing Free Energy of Drug-DNA Interactions * Use of Fluorescence as Thermodynamics Tool


Energetics Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 12
Total Download : 181
File Size : 42,9 Mb
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Description : The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Thermodynamics as a tool for understanding molecular logic * Thermal denaturation methods in the study of protein folding * Predicting thermodynamic properties of RNA * Sedimentation equilibrium as a thermodynamic tool * Molecular volume * Thermodynamic parameters from hydrogen exchange measurements


Energetics Of Biological Macromolecules Part E

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 53
Total Download : 630
File Size : 44,5 Mb
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Description : Energetics of Biological Macromolecules, Part E focuses on methods related to allosteric enzymes and receptors, including fluorescent proves, spectroscopic methods and quantitative analysis as well as on cooperativity in protein folding. NMR and mass spectrometry methods are discussed. Allosteric Enzymes and Receptors Cooperativity in Protein Folding and Assembly


Methods In Enzymology

Author by : Sidney P. Colowick
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 20
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File Size : 49,8 Mb
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Description :


Energetics Of Biological Macromolecules

Author by : Jo M. Holt
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 991
File Size : 46,5 Mb
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Description : This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin *Multiple-Binding of Ligands to a Linear Biopolymer *Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions *Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis


Conformation Of Biological Molecules

Author by : G. Govil
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 41
Total Download : 807
File Size : 44,9 Mb
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Description : The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the oretical methods (quantum mechanical and classical potential energy calculations, Monte Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.


Water And Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Macmillan International Higher Education
Format Available : PDF, ePub, Mobi
Total Read : 74
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File Size : 43,7 Mb
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Description :


Folding And Self Assembly Of Biological Macromolecules

Author by : Noah Hardy
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 22
Total Download : 856
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Description : Organized by Alessandra Carbone ( IHeS, Bures-sur-Yvette, France ) Organized by Misha Gromov ( IHeS, Bures-sur-Yvette, France ) Organized by Fran ois K(r)p s ( CNRS-Genopole-, evry, France ) Organized by Eric Westhof ( Universit(r) Louis-Pasteur, Strasbourg, France ). This proceedings volume explores the pathways and mechanisms by which constituent residues interact and fold to yield native biological macromolecules (catalytic RNA and functional proteins), how ribosomes and other macromolecular complexes self-assemble, and relevant energetics considerations. At the week-long interactive conference, some 20 leading researchers reported their most pertinent results, confronting each other and an audience of more than 150 specialists from a wide range of scientific disciplines, including structural and molecular biology, biophysics, computer science, mathematics, and theoretical physics. The fourteen papers OCo and audience interaction OCo are edited and illustrated versions of the transcribed oral presentations. The proceedings have been selected for coverage in: . OCo Biochemistry & Biophysics Citation Index(tm). OCo Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings). OCo CC Proceedings OCo Biomedical, Biological & Agricultural Sciences. Contents: Evolution-Based Genome Analysis: An Alternative to Analyze Folding and Function in Proteins (S Benner); Conformation of Charged Polymers: Polyelectrolytes and Polyampholytes (J-F Joanny); Statistically Derived Rules for RNA Folding (M Zuker); Experimental Approaches to RNA Folding (S Woodson); Some Questions Concerning RNA Folding (F Michel); RNA Folding in Ribosome Assembly (J R Williamson); From RNA Sequences to Folding Pathways and Structures: A Perspective (H Isamber t); An Evolutionary Perspective on the Determinants of Protein Function and Assembly (O Lichtarg e); Some Residues are more Equal than Others: Application to Protein Classification and Structure Prediction (A Kister & I Gelfan d); Structure-Function Relationships in Polymerases (M Delarue); The Protein-Folding Nucleus: From Simple Models to Real Proteins (L Mirn y); Chaperonin-Mediated Protein Folding (D Thirumalai); Virus Assembly and Maturation (J E Johnson); The Animal in the Machine: Is There a Geometric Program in the Genetic Program? (A Danchin). Readership: Researchers, academics and graduate students in structural biology, cellular and molecular biology, biophysics, biochemistry and biomathematics/bioinformatics."


Binding And Linkage

Author by : Jeffries Wyman
Languange : en
Publisher by : University Science Books
Format Available : PDF, ePub, Mobi
Total Read : 88
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File Size : 50,6 Mb
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Description : Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.


Nuclear Magnetic Resonance Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 66
Total Download : 534
File Size : 44,7 Mb
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Description : The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. Nuclear Magnetic Resonance of Biological Macromolecules, Part C is written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules. * One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences


Dynamics And The Problem Of Recognition In Biological Macromolecules

Author by : Oleg Jardetzky
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 60
Total Download : 543
File Size : 48,6 Mb
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Description : From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.


Dynamics Structure And Function Of Biological Macromolecules

Author by : North Atlantic Treaty Organization. Scientific Affairs Division
Languange : en
Publisher by : IOS Press
Format Available : PDF, ePub, Mobi
Total Read : 28
Total Download : 202
File Size : 51,7 Mb
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Description : A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.


Energetics Of Biological Macromolecules Part C

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 24
Total Download : 763
File Size : 51,9 Mb
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Description : Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology. Key Features * Probing Stability of Helical Transmembrane Proteins * Energetics of Vinca Alkaloid Interactions with Tubulin * Deriving Complex Ligand Binding Formulas * Mathematical Modeling of Cooperative Interactions in Hemoglobin * Analysis of Interactions of Regulatory Protein TyrR with DNA * Parsing Free Energy of Drug-DNA Interactions * Use of Fluorescence as Thermodynamics Tool


Nuclear Magnetic Resonance Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 76
Total Download : 668
File Size : 40,7 Mb
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Description : This volume and its companion, Volume 338, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.


Nuclear Magnetic Resonance Of Biological Macromolecules

Author by : Anonim
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 31
Total Download : 424
File Size : 55,6 Mb
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Description : This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.


Effects Of R F Energy On Biological Macromolecules Ii

Author by : MELPAR INC FALLS CHURCH VA.
Languange : en
Publisher by : Unknown
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Total Read : 39
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Description : Radio frequency inactivation of the enzymes chymotrypsin and alpha-amylase and living cells of the Mouse L-929 line were studied with variables of frequency, time, temperature, voltage, and pulse duty cycle. Inactivation times of the order of 1 minute were found for the living cells, and cell death was morphologically different from that caused by heat inactivation. Although in some experiments enzyme inactivation of up to 30% was observed on irradiation for times of the order of 10 hours, statistical analysis of the data did not indicate close correlation of enzyme inactivation with any of the variables tested. (Author).


Dynamics Of Biological Macromolecules By Neutron Scattering

Author by : Salvatore Magazù
Languange : en
Publisher by : Bentham Science Publishers
Format Available : PDF, ePub, Mobi
Total Read : 18
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Description : Dynamics of Biological Macromolecules by Neutron Scattering provides insight into the study of the dynamics of biological macromolecules by neutron scattering techniques. The applicability of neutron scattering to expanding fields of biological studies is


Essentials Of Chemical Biology

Author by : Andrew D. Miller
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 13
Total Download : 977
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Description : “This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended...” CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.


Molecular Dynamics

Author by : Lichang Wang
Languange : en
Publisher by : BoD – Books on Demand
Format Available : PDF, ePub, Mobi
Total Read : 20
Total Download : 202
File Size : 42,5 Mb
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Description : Molecular Dynamics is a two-volume compendium of the ever-growing applications of molecular dynamics simulations to solve a wider range of scientific and engineering challenges. The contents illustrate the rapid progress on molecular dynamics simulations in many fields of science and technology, such as nanotechnology, energy research, and biology, due to the advances of new dynamics theories and the extraordinary power of today's computers. This second book begins with an introduction of molecular dynamics simulations to macromolecules and then illustrates the computer experiments using molecular dynamics simulations in the studies of synthetic and biological macromolecules, plasmas, and nanomachines. Coverage of this book includes: Complex formation and dynamics of polymers Dynamics of lipid bilayers, peptides, DNA, RNA, and proteins Complex liquids and plasmas Dynamics of molecules on surfaces Nanofluidics and nanomachines