Engineering Drug Delivery Systems

Engineering Drug Delivery Systems
Author: Ali Seyfoddin,Seyedehsara Masoomi Dezfooli,Carol Ann Greene
Publsiher: Woodhead Publishing
Total Pages: 250
Release: 2019-11-15
ISBN: 0081025491
Category: Medical
Language: EN, FR, DE, ES & NL

Engineering Drug Delivery Systems Book Excerpt:

Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology. This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry. Examines the properties and synthesis of biomaterials for successful drug delivery Discusses the important connection between drug delivery and tissue engineering Includes techniques and approaches applicable to a wide range of users Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery
Author: Rebecca A. Bader,David A. Putnam
Publsiher: John Wiley & Sons
Total Pages: 496
Release: 2014-01-17
ISBN: 1118747801
Category: Social Science
Language: EN, FR, DE, ES & NL

Engineering Polymer Systems for Improved Drug Delivery Book Excerpt:

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Drug Delivery

Drug Delivery
Author: Eric P. Holowka,Sujata K. Bhatia
Publsiher: Springer
Total Pages: 355
Release: 2014-11-22
ISBN: 1493919989
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Drug Delivery Book Excerpt:

Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Engineering of Biomaterials for Drug Delivery Systems

Engineering of Biomaterials for Drug Delivery Systems
Author: Anilkumar Parambath
Publsiher: Woodhead Publishing
Total Pages: 404
Release: 2018-02-01
ISBN: 0081017510
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Engineering of Biomaterials for Drug Delivery Systems Book Excerpt:

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Drug Delivery

Drug Delivery
Author: W. Mark Saltzman
Publsiher: Oxford University Press
Total Pages: 384
Release: 2001-03-15
ISBN: 9780198024699
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Book Excerpt:

Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems
Author: Naoya Ogata,Sung W. Kim,Jan Feijen,Teruo Okano
Publsiher: Springer Science & Business Media
Total Pages: 381
Release: 2012-12-06
ISBN: 4431658831
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems Book Excerpt:

First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

Natural Polymer Drug Delivery Systems

Natural Polymer Drug Delivery Systems
Author: Saurabh Bhatia
Publsiher: Springer
Total Pages: 225
Release: 2016-09-23
ISBN: 3319411292
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Natural Polymer Drug Delivery Systems Book Excerpt:

This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.

Drug Delivery

Drug Delivery
Author: Yitzhak Rosen,Pablo Gurman,Noel Elman
Publsiher: CRC Press
Total Pages: 602
Release: 2017-09-19
ISBN: 1466565950
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Book Excerpt:

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Handbook of Research on Nano Drug Delivery and Tissue Engineering

Handbook of Research on Nano Drug Delivery and Tissue Engineering
Author: Rajakumari Rajendran,Hanna J. Maria,Sabu Thomas,Nandakumar Kalarikkal
Publsiher: CRC Press
Total Pages: 606
Release: 2022-03-10
ISBN: 1000369536
Category: Science
Language: EN, FR, DE, ES & NL

Handbook of Research on Nano Drug Delivery and Tissue Engineering Book Excerpt:

With contributions from leading researchers in the nanomedicine field from industry, academia, and government and private research institutions across the globe, the volume provides an up-to-date report on topical issues in nano-drug delivery and nanotechnological approaches to tissue engineering. The volume offers research on a variety of diverse nano-based drug delivery systems along with discussions of their efficacy, safety, toxicology, and applications for different purposes. Focusing on nanotechnology approaches to tissue engineering, this volume considers the use of hydrogel systems, nanoceria and micro- and nano-structured biomaterials for bone tissue engineering, mesenchymal stem cells, and more.

Supramolecular Nanomaterials for Engineering Drug Delivery and Medical Applications

Supramolecular Nanomaterials for Engineering  Drug Delivery  and Medical Applications
Author: Yohann Corvis,Hicham Fenniri,Tu Lee,Elise Lepeltier,Jianliang Shen,Nathalie Mignet,Vincent Levet
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-01-21
ISBN: 2889664120
Category: Science
Language: EN, FR, DE, ES & NL

Supramolecular Nanomaterials for Engineering Drug Delivery and Medical Applications Book Excerpt:

Delivery of Drugs

Delivery of Drugs
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 242
Release: 2020-02-01
ISBN: 0128177772
Category: Medical
Language: EN, FR, DE, ES & NL

Delivery of Drugs Book Excerpt:

Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
Author: Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone
Publsiher: Springer Science & Business Media
Total Pages: 592
Release: 2011-12-14
ISBN: 1461408806
Category: Medical
Language: EN, FR, DE, ES & NL

Fundamentals and Applications of Controlled Release Drug Delivery Book Excerpt:

Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Author: Emmanuel C. Opara
Publsiher: CRC Press
Total Pages: 351
Release: 2020-02-28
ISBN: 0429584652
Category: Medical
Language: EN, FR, DE, ES & NL

Controlled Drug Delivery Systems Book Excerpt:

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Nanopharmaceuticals

Nanopharmaceuticals
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 244
Release: 2020-01-10
ISBN: 0128177799
Category: Medical
Language: EN, FR, DE, ES & NL

Nanopharmaceuticals Book Excerpt:

Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 Encompasses functional aspects of nanocarriers Discusses Intellectual Property landscapes of micro-nano drug carriers Contains in-depth investigation of specific aspects of drug delivery systems

Biodegradable Systems in Tissue Engineering and Regenerative Medicine

Biodegradable Systems in Tissue Engineering and Regenerative Medicine
Author: Rui L. Reis,Julio San Román
Publsiher: CRC Press
Total Pages: 592
Release: 2004-11-29
ISBN: 0203491238
Category: Medical
Language: EN, FR, DE, ES & NL

Biodegradable Systems in Tissue Engineering and Regenerative Medicine Book Excerpt:

Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health

Advanced Materials in Drug Release and Drug Delivery Systems

Advanced Materials in Drug Release and Drug Delivery Systems
Author: Katarzyna Winnicka
Publsiher: MDPI
Total Pages: 234
Release: 2021-09-03
ISBN: 3036510583
Category: Science
Language: EN, FR, DE, ES & NL

Advanced Materials in Drug Release and Drug Delivery Systems Book Excerpt:

Development of new drug molecules is costly and requires longitudinal, wide-ranging studies; therefore, designing advanced pharmaceutical formulations for existing and well-known drugs seems to be an attractive device for the pharmaceutical industry. Properly formulated drug delivery systems can improve pharmacological activity, efficacy and safety of the active substances. Advanced materials applied as pharmaceutical excipients in designing drug delivery systems can help solve problems concerning the required drug release—with the defined dissolution rate and at the determined site. Novel drug carriers enable more effective drug delivery, with improved safety and with fewer side effects. Investigations concerning advanced materials represent a rapidly growing research field in material/polymer science, chemical engineering and pharmaceutical technology. Exploring novel materials or modifying and combining existing ones is now a crucial trend in pharmaceutical technology. Eleven articles included in the the Special Issue “Advanced Materials in Drug Release and Drug Delivery Systems” present the most recent insights into the utilization of different materials with promising potential in drug delivery and into different formulation approaches that can be used in the design of pharmaceutical formulations.

Modeling and Control of Drug Delivery Systems

Modeling and Control of Drug Delivery Systems
Author: Ahmad Taher Azar
Publsiher: Academic Press
Total Pages: 408
Release: 2021-02-06
ISBN: 0128211954
Category: Computers
Language: EN, FR, DE, ES & NL

Modeling and Control of Drug Delivery Systems Book Excerpt:

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Handbook of Polyester Drug Delivery Systems

Handbook of Polyester Drug Delivery Systems
Author: M. N. V. Ravi Kumar
Publsiher: CRC Press
Total Pages: 738
Release: 2017-03-27
ISBN: 1315341166
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Polyester Drug Delivery Systems Book Excerpt:

In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.

Biomaterials Fabrication and Processing Handbook

Biomaterials Fabrication and Processing Handbook
Author: Paul K. Chu,Xuanyong Liu
Publsiher: CRC Press
Total Pages: 720
Release: 2008-03-27
ISBN: 9780849379741
Category: Medical
Language: EN, FR, DE, ES & NL

Biomaterials Fabrication and Processing Handbook Book Excerpt:

Focusing on a lucrative and increasingly important area of biomedicine, the Biomaterials Fabrication and Processing Handbook brings together various biomaterials production and processing aspects, including tissue engineering scaffold materials, drug delivery systems, nanobiomaterials, and biosensors. With contributions from renowned international experts and extensive reference lists in each chapter, the volume provides detailed, practical information to produce and use biomaterials. The different facets of biomaterials technology are split into four sections in the book— Part I The development of new materials and devices capable of interacting specifically with biological tissues and the preparation of scaffolds using materials with appropriate composition and structure Part II The necessary materials to create a drug delivery system capable of controlled release and the incorporation of drug reservoirs into implantable devices for sustained controlled release Part III The significant role nanotechnology plays in the biomedical and biotechnology fields Part IV More biomaterials, including synthetic and natural degradable polymeric biomaterials, electroactive polymers as smart materials, and biomaterials for gastrointestinal and cartilage repair and reconstruction

Marine Biomaterials

Marine Biomaterials
Author: Sougata Jana
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN: 9811647879
Category: Biomedical materials
Language: EN, FR, DE, ES & NL

Marine Biomaterials Book Excerpt:

This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.