Enzyme Catalysis In Organic Synthesis

Author by : Karlheinz Drauz
Languange : en
Publisher by : Wiley-VCH
Format Available : PDF, ePub, Mobi
Total Read : 79
Total Download : 933
File Size : 50,5 Mb
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Description : This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.


Enzyme Catalysis In Organic Synthesis

Author by : Karlheinz Drauz
Languange : en
Publisher by : Wiley-VCH
Format Available : PDF, ePub, Mobi
Total Read : 72
Total Download : 658
File Size : 41,9 Mb
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Description : How to succeed with enzymes in organic synthesis Comprehensive in coverage, this handbook provides a thorough understanding of enzyme-catalyzed organic transformations. Using it, readers can easily apply the principles of enzyme catalysis to new chemical reactions. All techniques described are directly transferable to applications, from laboratory to industrial scale. Benefits for the user: * synthetic applications organized according to reaction type * tabular survey of all commercially available enzymes * two indexes offering easy access to enzymes, compounds, and reaction types * the latest synthetic methods, including use of catalytic antibodies and protein engineering


Enzymes As Catalysts In Organic Synthesis

Author by : Manfred P. Schneider
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 68
Total Download : 886
File Size : 55,9 Mb
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Description : Proceedings of the NATO Advanced Research Workshop, Reisensburg/Ulm, Donau, Germany, June 16-22, 1985


Enzyme Based Organic Synthesis

Author by : Cheanyeh Cheng
Languange : en
Publisher by : Wiley
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 495
File Size : 52,7 Mb
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Description : The recent advances in enzyme technology, such as protein engineering, site-directed evolution, metabolic engineering, and enzyme immobilization, have made enzyme-based organic synthesis more competitive with organic synthesis derived from fossil fuels. This book discusses the methods and applications of enzymatic and microbial processes for organic synthesis, in particular asymmetric synthesis. Coverage also includes basic principles associated of enzyme specificity and catalytic abilities. The author details organic syntheses with the main classes of enzymes, illustrating their important characteristics of substrate and chemical specificity, regioselectivity, and stereoselectivity that these enzymes bring to organic synthesis. Applications for pharmaceutical and medicinal industry, food industry, cosmetics, fragrance, and health care are also described.


Organic Synthesis With Enzymes In Non Aqueous Media

Author by : Giacomo Carrea
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 94
Total Download : 420
File Size : 47,8 Mb
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Description : Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.


Asymmetric Organic Synthesis With Enzymes

Author by : Vicente Gotor
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 42
Total Download : 486
File Size : 50,5 Mb
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Description : Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.


Multi Step Enzyme Catalysis

Author by : Eduardo Garcia-Junceda
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 73
Total Download : 171
File Size : 52,7 Mb
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Description : The first comprehensive coverage of this unique and interdisciplinary field provides a complete overview, covering such topics as chemoenzymatic synthesis, microbial production of DNA building blocks, asymmetric transformations by coupled enzymes and much more. By combining enzymatic and synthetic organic steps, the use of multi-enzyme complexes and other techniques opens the door to reactions hitherto unknown, making this monograph of great interest to biochemists, organic chemists, and chemists working with/on organometallics, as well as catalytic chemists, biotechnologists, and those working in the pharmaceutical and fine chemical industries.


Enzymes In Synthetic Organic Chemistry

Author by : Wong
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 9
Total Download : 855
File Size : 52,9 Mb
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Description : This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.


New Enzymes For Organic Synthesis

Author by : Thomas Scheper
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 76
Total Download : 521
File Size : 47,5 Mb
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Description : Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years. These six reviews show different steps in the development of enzymatic syntheses for useful compounds. Screening of novel enzymes, their biochemical characterisation as well as reaction engineering approaches in order to increase their performance are treated in three papers. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The supply of sufficient quantities of biocatalysts must not be neglected: fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.


Enzymatic Reactions In Organic Media

Author by : A. Koskinen
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 81
Total Download : 124
File Size : 46,9 Mb
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Description : The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.


Future Directions In Biocatalysis

Author by : Tomoko Matsuda
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 85
Total Download : 719
File Size : 43,9 Mb
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Description : In Future Directions in Biocatalysis the important topics within biocatalysis and enzymatic catalysis for organic synthesis are described for both experts and non-experts. This books focuses particularly on reactions under development at present and on future advances in the field. Consisting of four sections, this book examines enzymatic reactions under unusual conditions, unique biocatalytic reactions, synthesis of valuable compounds using biocatalysis and the latest molecular biology methods for biocatalysis. Each chapter deals with a specific theme and includes a summary of each area as well as the present state and future direction of research. * Describes methods for solving environmental issues through biocatalysis * Presents the integrated fields of biochemistry and organic chemistry * Unique research topics with high originality


Organic Synthesis Using Biocatalysis

Author by : Animesh Goswami
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 824
File Size : 40,8 Mb
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Description : Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis


Lewis Base Catalysis In Organic Synthesis

Author by : Edwin Vedejs
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 92
Total Download : 615
File Size : 40,8 Mb
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Description : This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.


Enzymes In Nonaqueous Solvents

Author by : Evgeny N. Vulfson
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 50
Total Download : 793
File Size : 54,8 Mb
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Description : In recent years, enzymatic catalysis in organic solvents-as opposed to aqueous solutions-has gained considerable attention as a powerful new approach to the preparation of natural products, pharmaceuticals, fine chemicals, and food ingredients. In Enzymes in Nonaqueous Solvents: Methods and Protocols, leading chemists, biochemists, biotechnologists, and process engineers summarize for the first time a wide range of methods for executing enzymatic transformations under nonaqueous conditions. Each method includes detailed step-by-step instructions for its successful completion, a list of materials, and ancillary notes that explain the scientific basis of the procedure, as well as troubleshooting. Also provided are a generic description of key reactions, advice on biocatalyst preparation, discussion of reaction conditions, and instructions on bioreactor design. Comprehensive and state-of-the-art, Enzymes in Nonaqueous Solvents: Methods and Protocols offers today's synthetic chemists, biochemists, and process engineers all the essential information needed to carry out enzymatic reactions in nonaqueous media, as well as to successfully scale up to production quantities.


Cooperative Catalysis

Author by : René Peters
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 34
Total Download : 896
File Size : 47,7 Mb
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Description : Written by experts in the field, this is a much–needed overview of the rapidly emerging field of cooperative catalysis. The authors focus on the design and development of novel high–performance catalysts for applications in organic synthesis (particularly asymmetric synthesis), covering a broad range of topics, from the latest progress in Lewis acid / Brønsted base catalysis to e.g. metal–assisted organo catalysis, cooperative metal/enzyme catalysis, and cooperative catalysis in polymerization reactions and on solid surfaces. The chapters are classified according to the type of cooperating activating groups, and describe in detail the different strategies of cooperative activation, highlighting their respective advantages and pitfalls. As a result, readers will learn about the different concepts of cooperative catalysis, their corresponding modes of operation and their applications, thus helping to find a solution to a specific synthetic catalysis problem.


Enzymes In Nonaqueous Solvents

Author by : Evgeny N. Vulfson
Languange : en
Publisher by : Humana Press
Format Available : PDF, ePub, Mobi
Total Read : 37
Total Download : 602
File Size : 54,9 Mb
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Description : Enzymatic catalysis has gained considerable attention in recent years as an efficient tool in the preparation of natural products, pharmaceuticals, fine chemicals, and food ingredients. The high selectivity and mild reaction con- tions associated with enzymatic transformations have made this approach an attractive alternative in the synthesis of complex bioactive compounds, which are often difficult to obtain by standard chemical routes. However, the maj- ity of organic compounds are not very soluble in water, which was traditi- ally perceived as the only suitable reaction medium for the application of biocatalysts. The realization that most enzymes can function perfectly well under nearly anhydrous conditions and, in addition, display a number of useful properties, e. g. , highly enhanced stability and different selectivity, has d- matically widened the scope of their application to the organic synthesis. Another great attraction of using organic solvents rather than water as a reaction solvent is the ability to perform synthetic transformations with re- tively inexpensive hydrolytic enzymes. It is worth reminding the reader that in vivo, the synthetic and hydrolytic pathways are catalyzed by different enzymes. However, elimination of water from the reaction mixture enables the “reversal” of hydrolytic enzymes and thus avoids the use of the expensive cofactors or activated substrates that are required for their synthetic count- parts.


Lactose Derived Prebiotics

Author by : Andrés Illanes
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 96
Total Download : 935
File Size : 41,8 Mb
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Description : Lactose-Derived Prebiotics: A Process Perspective is the first scientific reference to provide a comprehensive technological overview of the processes to derive oligosaccharides from dairy for use in functional foods. With their combined 90+ years in industry and research, the authors present the functional properties of prebiotics derived from lactose and the production technology required to make them. The book focuses on process engineering and includes an overview of green chemistry processes involving enzyme biocatalysis, providing detailed coverage of the use of whey lactose as raw material for producing oligosaccharides. The book’s focus on processes and products allows the reader to understand the constraints and impacts of technology on lactose-derived prebiotics. Presents the challenges of and opportunities for deriving oligosaccharides from lactose Details the technologies and methods required to produce lactose-derived prebiotics, including a comparison between chemical and enzymatic synthesis Discusses the potential use of whey as a raw material for the synthesis of non-digestible lactose-derived oligosaccharides Provides a process engineer perspective and includes valuable information about kinetics and reactor design for the enzymatic synthesis of lactose-derived oligosaccharides


Enzyme Catalyzed Synthesis Of Polymers

Author by : Shiro Kobayashi
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 60
Total Download : 994
File Size : 45,5 Mb
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Description :


Innovative Catalysis In Organic Synthesis

Author by : Pher G. Andersson
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 18
Total Download : 540
File Size : 51,5 Mb
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Description : C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry. The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.


Asymmetric Organic Synthesis With Enzymes

Author by : Vicente Gotor
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 57
Total Download : 494
File Size : 44,5 Mb
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Description : Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.


Industrial Biotransformations

Author by : Andreas Liese
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 24
Total Download : 346
File Size : 55,8 Mb
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Description : Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance. The data conferring each process is arranged in a convenient format to survey so that the processes can easily be compared. Each set of data is accompanied by key literature citations. As far as flow sheets of the processes are available, these are given reduced to their significant elements. An extensive index classified by substrates, products, enzymes, and companies provides direct access to each process organized in the order of enzyme classes. The reader will find all significant parameters characterizing the biotransformation itself and the process.


Enzymes In Organic Synthesis

Author by : Ruth Porter
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 61
Total Download : 477
File Size : 51,8 Mb
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Description : The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.


Directed Evolution Of Selective Enzymes

Author by : Manfred T. Reetz
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 48
Total Download : 788
File Size : 44,7 Mb
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Description : Authored by one of the world's leading organic chemists, this authoritative reference provides an overview of basic strategies in directed evolution and introduces common gene mutagenesis, screening and selection methods. Throughout the text, emphasis is placed on methodology development to maximize efficiency, reliability and speed of the experiments and to provide guidelines for efficient protein engineering. Professor Reetz highlights the application of directed evolution experiments to address limitations in the field of enzyme selectivity, substrate scope, activity and robustness. He critically reviews recent developments and case studies, takes a look at future applications in the field of organic synthesis, and concludes with lessons learned from previous experiments.