Epigenetics Brain and Behavior

Epigenetics  Brain and Behavior
Author: Paolo Sassone Corsi,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 171
Release: 2012-08-28
ISBN: 3642279120
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Brain and Behavior Book Excerpt:

What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.

Behavioral Neurogenomics

Behavioral Neurogenomics
Author: Elisabeth B. Binder,Torsten Klengel
Publsiher: Springer Nature
Total Pages: 259
Release: 2019-12-12
ISBN: 3030312658
Category: Medical
Language: EN, FR, DE, ES & NL

Behavioral Neurogenomics Book Excerpt:

This book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease. It focuses on our current understanding of genetic and epigenetic mechanisms of brain function and how they contribute to the complex formation of behavioral traits and psychiatric disorders. Readers experience diverse perspectives of the contributing authors starting from the genetic viewpoint and the effort to establish functional connection between genetic variants and behavioral phenotypes. Particular attention is given to the broad spectrum of epigenetic mechanisms and behavior. The chapter 'Role of MicoRNAs in Anxiety and Anxiety-Related Disorders' is available open access under a CC BY 4.0 license at link.springer.com

Epigenetic Mechanisms in the Brain

Epigenetic Mechanisms in the Brain
Author: Andrew J. Kennedy,Gabriella N. L. Chua
Publsiher: Academic Press
Total Pages: 350
Release: 2020-06
ISBN: 9780128164976
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms in the Brain Book Excerpt:

Epigenetic mechanisms are the biological processes that determine how our genome is used and the same principle can be applied to our neuron genes. In recent findings in the field of neuroepigenetics, it has been determined that our genes encode our memories, transmit information about stressful events, and play apart in our addictions. This book helps to unlock these abstract processes, leading to improved individualized treatments.

Epigenetics and Neuroplasticity Evidence and Debate

Epigenetics and Neuroplasticity   Evidence and Debate
Author: Anonim
Publsiher: Academic Press
Total Pages: 250
Release: 2014-11-05
ISBN: 0128010851
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics and Neuroplasticity Evidence and Debate Book Excerpt:

The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease. Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain. All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
Author: J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publsiher: Unknown
Total Pages: 362
Release: 2013
ISBN: 9780123914941
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in the Nervous System Book Excerpt:

"Elsevier science & technology books"--P. facing t.p.

Epigenetics Book

Epigenetics Book
Author: Roy Carroll
Publsiher: Youcanprint
Total Pages: 147
Release: 2022-01-25
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Book Book Excerpt:

You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!

The Inductive Brain in Development and Evolution

The Inductive Brain in Development and Evolution
Author: Nelson R. Cabej
Publsiher: Academic Press
Total Pages: 290
Release: 2021-06-22
ISBN: 0323851665
Category: Science
Language: EN, FR, DE, ES & NL

The Inductive Brain in Development and Evolution Book Excerpt:

The Inductive Brain in Development and Evolution provides readers with a substantial biological education on animal nervous systems and their role in the development, adaptation, homeostasis, and evolution of species. The book begins by delving into the embryonic development of the brain and then discusses epigenetic information and neural activity post-birth. It then analyzes the inductive brain’s neural and brain control of such factors like myogenesis, bone development, sensory organs, metamorphosis in vertebrates and invertebrates, and wing development in insects. The book closes with an examination of phenotypic evolution in neural control, mechanisms, and drivers of animal brains. The Inductive Brain in Development and Evolution will offer evolutionary biologists, specifically those researching development, adaptation, and evolution of animals, a comprehensive text that covers a variety of valuable topics. Presents the first book devoted to the inductive role of the brain in development, in adaptation, and in the evolution processes in animals Examines the central nervous system (CNS) from embryonic to adult life stages Provides detailed evidence to investigate the role of the CNS in molding animal morphology and life histories

Epigenetic Mechanisms in Neural Plasticity

Epigenetic Mechanisms in Neural Plasticity
Author: Daniel Ortuño-Sahagún,Reinhard Schliebs,Merce Pallàs
Publsiher: Frontiers Media SA
Total Pages: 159
Release: 2019-09-20
ISBN: 2889630005
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms in Neural Plasticity Book Excerpt:

Neural plasticity is a unique and adaptive feature of nervous system, which allows neurons to reorganize their interactions in response to a stimulation (intrinsic or extrinsic) to maintain their function. For these reasons, epigenetics emerges as a potential field for developing strategies to modulate changes in pathological situation because extrinsic factors and pharmacological tools can modify neural functioning in organisms during their life. Diet, exercise, environmental aspects, stressors or drugs are available to alter those mechanisms. Epigenetic involves certain molecular signaling pathways, as DNA methylation and histone acetylation and deacetylation, and the emerging non-coding small RNA, mainly microRNA, as a commanders of a number of translation processes. As most of molecular nervous cell alterations, epigenetic mechanisms play an important role in neural plasticity. This eBook collects the burgeoning advances in epigenetic mechanisms, focusing on new insights into cellular and molecular neurobiological mechanisms that underlie brain functioning in health and pathological conditions. Contributions go from basic cellular mechanism to therapeutic opportunities to tackle the challenges on nervous central system development and neurodegeneration.

Search for Age dependent Transcriptomic and Epigenetic Changes in Murine Cerebral Endothelial Cells

Search for Age dependent Transcriptomic and Epigenetic Changes in Murine Cerebral Endothelial Cells
Author: Kshitij Mohan
Publsiher: Unknown
Total Pages: 0
Release: 2022
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Search for Age dependent Transcriptomic and Epigenetic Changes in Murine Cerebral Endothelial Cells Book Excerpt:

Intracerebral hemorrhage (ICH) is associated with disruption of the blood-brain barrier (BBB) and rupture of blood vessels, leading to the leakage of blood into brain. In humans, increasing age is the biggest risk factor for ICH, with people above the age of 75 years being at the highest risk of developing the disease. Other risk factors for ICH include hypertension and cerebral amyloid angiopathy. Although hemorrhagic stroke is a leading global cause of death and disability, the mechanisms leading to blood-brain barrier dysfunction with age and development of ICH is poorly understood. The endothelial cells (ECs) constitute the core component of the BBB in the central nervous system vasculature and provide a physical barrier due to the presence of tight junctions, adherens junctions and basement membrane. This study in wild-type mice and mice having floxed, yet non-recombined Srf and Mrtf alleles, thereby having functional Srf and Mrtf genes (wild-type phenotype), demonstrates increased incidents of bleeding in brain with increasing age. Transgenic Cdh5-mT H2B-GFP mice were used to isolate pure population of ECs and RNA-seq was used to study the mRNA expression levels in ECs isolated from murine brains of increasing age - 2, 6, 12, 18 and 24 months. Linear regression analysis performed on the RNA-seq data reveal age-dependent dysregulation of 1388 genes, including many responsible for the maintenance of BBB and vascular integrity. However, no significant age-dependent changes in the expression levels of Srf and Mrtf, encoding two cooperating transcription factors whose endothelial knockout had previously been shown to cause hemorrhagic stroke-like symptoms, were observed. As epigenetic mechanisms are known to regulate gene expression, age-dependent changes at the CpG methylation and chromatin structure were investigated in this study. Reduced representation bisulfite sequencing (RRBS) was used to investigate change in CpG methylation with age. Interestingly, the older mice (18 months-old) show increased average CpG methylation. However, only two 1000 bp tiles annotated to Arid5b and Adgrg1 genes show a significant age-dependent change in methylation level, with both the tiles showing decrease in methylation with age. Assay for transposase-accessible chromatin sequencing (ATAC-seq) performed to investigate changes at the level of chromatin structure reveals approximately 2290 peaks that undergo age-dependent changes in the chromatin structure with a majority of the peaks (2013) closing with age. Comparing RNA-seq and ATAC-seq data reveals 27 peaks associated with 25 genes that show a correlation between age-dependent changes in chromatin structure and changes in gene expression. The study finds a strong age-dependent downregulation of the apelin receptor (Aplnr) gene, known to play a crucial role in positive regulation of vasodilation and implicated in vascular health. Also, the promoter of Aplnr gene shows an age-dependent reduction in chromatin accessibility as revealed by the ATAC-seq data. Interestingly, the study demonstrates an age-dependent reduction in the expression levels of apelin receptor protein in the brain, thereby suggesting a potential association of apelin receptor with increased risk of intracerebral hemorrhage.

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex
Author: Magdalena Götz,Wieland B. Huttner,Mareike Albert
Publsiher: Frontiers Media SA
Total Pages: 139
Release: 2021-11-30
ISBN: 288971778X
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex Book Excerpt:

Nutrition Epigenetic Mechanisms and Human Disease

Nutrition  Epigenetic Mechanisms  and Human Disease
Author: Nilanjana Maulik,Gautam Maulik
Publsiher: CRC Press
Total Pages: 446
Release: 2010-12-03
ISBN: 1439804826
Category: Medical
Language: EN, FR, DE, ES & NL

Nutrition Epigenetic Mechanisms and Human Disease Book Excerpt:

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as

Epigenetic Mechanisms and Their Involvement in Rare Diseases

Epigenetic Mechanisms and Their Involvement in Rare Diseases
Author: Mojgan Rastegar,Dag H. Yasui
Publsiher: Frontiers Media SA
Total Pages: 182
Release: 2021-10-20
ISBN: 2889715140
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms and Their Involvement in Rare Diseases Book Excerpt:

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders
Author: Elena Martín-García,Patrick E. Williams,Noèlia Fernàndez-Castillo
Publsiher: Frontiers Media SA
Total Pages: 200
Release: 2022-07-06
ISBN: 2889765156
Category: Science
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders Book Excerpt:

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Academic Press
Total Pages: 846
Release: 2021-08-16
ISBN: 0128235780
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Excerpt:

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Epigenetic Mechanisms of the Cambrian Explosion

Epigenetic Mechanisms of the Cambrian Explosion
Author: Nelson R. Cabej
Publsiher: Academic Press
Total Pages: 256
Release: 2019-10-12
ISBN: 0128143126
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms of the Cambrian Explosion Book Excerpt:

Epigenetic Mechanisms of the Cambrian Explosion provides readers with a basic biological knowledge and epigenetic explanation of the biological puzzle of the Cambrian explosion, the unprecedented rapid diversification of animals that began 542 million years ago. During an evolutionarily instant of ~10 million years, which represents only 0.3% of the time of existence of life on Earth, or less than 2% of the time of existence of metazoans, all of the 30 extant body plans, major animal groups (phyla) and several extinct groups appeared. The work helps address this phenomena and tries to answer remaining questions for evolutionary biology, epigenetics, and scientific researchers. The book recognizes and presents objective representations of alternative theories for epigenetic evolution in this period, with the author drawing on his epigenetic theory of evolution to explain the causal basis of the Cambrian explosion. Both empirical evidence and theoretical arguments are presented in support of this thought-provoking epigenetic theory. Explains the Cambrian explosion from an entirely epigenetic view Takes a causal rather than descriptive approach to the phenomenon Allows for a broad readership, including those with only a basic biological knowledge, while maintaining scientific rigor

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 920
Release: 2022-09-08
ISBN: 0323919502
Category: Science
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Excerpt:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

Stress and Steroid regulation of synaptic transmission from physiology to pathophysiology

Stress and Steroid regulation of synaptic transmission  from physiology to pathophysiology
Author: Menahem Segal,Harmen J. Krugers,Nicola Maggio
Publsiher: Frontiers E-books
Total Pages: 105
Release: 2023
ISBN: 9782889191031
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Stress and Steroid regulation of synaptic transmission from physiology to pathophysiology Book Excerpt:

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process. In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

Medical Epigenetics

Medical Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 944
Release: 2016-06-21
ISBN: 0128032405
Category: Science
Language: EN, FR, DE, ES & NL

Medical Epigenetics Book Excerpt:

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Epigenetics and Neuroendocrinology

Epigenetics and Neuroendocrinology
Author: Dietmar Spengler,Elisabeth Binder
Publsiher: Springer
Total Pages: 264
Release: 2016-04-02
ISBN: 3319244930
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics and Neuroendocrinology Book Excerpt:

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

Epigenetics in Organ Specific Disorders

Epigenetics in Organ Specific Disorders
Author: Anonim
Publsiher: Academic Press
Total Pages: 668
Release: 2022-12-09
ISBN: 0128239328
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics in Organ Specific Disorders Book Excerpt:

Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth. Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies. Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities Explores organ specific epigenetic mechanisms to enable drug discovery and development Features chapter contributions from leading researchers in the field