Epigenetics in Cancer Prevention

Epigenetics in Cancer Prevention
Author: Mukesh Verma,Barbara K. Dunn,Asad Umar
Publsiher: Unknown
Total Pages: 352
Release: 2003
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics in Cancer Prevention Book Excerpt:

This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention
Author: Anupam Bishayee,Deepak Bhatia
Publsiher: Academic Press
Total Pages: 464
Release: 2018-12-07
ISBN: 9780128124949
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Epigenetics of Cancer Prevention Book Excerpt:

Epigenetics of Cancer Prevention is the first of its kind to look at epigenetics and chemoprevention together. Although there are numerous scientific data available on how epigenetics can lead to cancer and separately how chemoprevention can be beneficial in the treatment or in improving quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol; and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is intended for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Cancer Epigenetics

Cancer Epigenetics
Author: Mukesh Verma
Publsiher: Humana Press
Total Pages: 804
Release: 2016-08-23
ISBN: 9781493948949
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Epigenetics Book Excerpt:

This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention
Author: Anupam Bishayee,Deepak Bhatia
Publsiher: Academic Press
Total Pages: 442
Release: 2018-11-27
ISBN: 0128125667
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics of Cancer Prevention Book Excerpt:

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease
Author: Nilanjana Maulik,Tom Karagiannis
Publsiher: Springer
Total Pages: 505
Release: 2016-09-17
ISBN: 9781493946235
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular mechanisms and physiology of disease Book Excerpt:

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Epigenetics and Cancer

Epigenetics and Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 314
Release: 2010-11-23
ISBN: 9780123808653
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics and Cancer Book Excerpt:

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Epigenetics and Cancer

Epigenetics and Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 394
Release: 2010-11-22
ISBN: 9780123808677
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics and Cancer Book Excerpt:

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Epigenetics and Human Health

Epigenetics and Human Health
Author: Alexander Haslberger,Sabine Greßler
Publsiher: John Wiley & Sons
Total Pages: 316
Release: 2011-08-24
ISBN: 352764475X
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics and Human Health Book Excerpt:

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Epigenetics in Cancer Prevention

Epigenetics in Cancer Prevention
Author: Mukesh Verma,Barbara K. Dunn,Asad Umar
Publsiher: Unknown
Total Pages: 352
Release: 2003
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics in Cancer Prevention Book Excerpt:

This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

Beat Breast Cancer

Beat Breast Cancer
Author: Daniella Chace
Publsiher: Skyhorse
Total Pages: 192
Release: 2020-09-01
ISBN: 9781510755789
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Beat Breast Cancer Book Excerpt:

A Cutting-Edge Guide to Preventing and Healing from Breast Cancer Beat Breast Cancer is a comprehensive and targeted program for using nutrition and detoxification to prevent and heal from breast cancer. Rooted in the science of epigenetics—how gene expression is affected by nutrients and toxins—Daniella Chace teaches readers to restore their own genes via diet, supplementation, and detoxification. Readers will learn how to: Nourish their bodies with more than one hundred foods that combat breast cancer. Chace also offers supplement recommendations for pre- and postmenopausal women. Restore their bodies by using new genetic tests to determine their personal nutrition and detox needs. Detoxify their bodies by flushing out the toxins that contribute to breast cancer development and disturb cellular communication. Carefully researched and incredibly comprehensive, Beat Breast Cancer forges a clear path toward health and healing.

Epigenetics Territory and Cancer

Epigenetics Territory and Cancer
Author: Parvin Mehdipour
Publsiher: Springer
Total Pages: 539
Release: 2015-03-31
ISBN: 9789401796385
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Territory and Cancer Book Excerpt:

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.

Selenium and Selenoproteins in Cancer

Selenium and Selenoproteins in Cancer
Author: Francesco Galli
Publsiher: Academic Press
Total Pages: 316
Release: 2017-10-19
ISBN: 0128120177
Category: Science
Language: EN, FR, DE, ES & NL

Selenium and Selenoproteins in Cancer Book Excerpt:

Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium. Provides information on cancer research and prevention Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention Serves as an indispensable reference for researchers and students alike

Nutrition and Cancer Prevention

Nutrition and Cancer Prevention
Author: Thomas Prates Ong,Fernando Salvador Moreno
Publsiher: Royal Society of Chemistry
Total Pages: 450
Release: 2019-12-03
ISBN: 1788013417
Category: Medical
Language: EN, FR, DE, ES & NL

Nutrition and Cancer Prevention Book Excerpt:

Cancer is a major global public health problem. Among different environmental and lifestyle factors contributing to cancer risk, diet is a key one. On the one hand, obesity and increased consumption of red and processed meat, ethanol, sugar and saturated fatty acids are associated with increased cancer risk. On the other hand, consumption of micronutrients such as vitamin D, selenium, zinc, folate and bioactive compounds from fruits and vegetables is associated with decreased risk. Written by an influential, international team of experts, this book presents and discusses current topics on nutrition and cancer prevention. It covers both nutritional influences on different cancers plus specific chapters on the commonly occurring cancers. Nutritional genomics-based studies show that some dietary components modulate carcinogenesis through complex cellular and molecular mechanisms. A better understanding of these different cellular and molecular mechanisms is needed to establish efficient dietary recommendations for cancer prevention. This book will provide such an understanding, serving as an important book for all those working in nutritional health, food science and cancer research.

Epigenetics and Cancer

Epigenetics and Cancer
Author: Fazlul H. Sarkar
Publsiher: Springer
Total Pages: 287
Release: 2015-07-16
ISBN: 9789401780803
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics and Cancer Book Excerpt:

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Cancer Epigenetics for Precision Medicine

Cancer Epigenetics for Precision Medicine
Author: Ramona G. Dumitrescu,Mukesh Verma
Publsiher: Humana Press
Total Pages: 298
Release: 2018-10-12
ISBN: 9781493987504
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Epigenetics for Precision Medicine Book Excerpt:

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Epigenetics and Epigenomics

Epigenetics and Epigenomics
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2014
ISBN: 9789535153917
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Epigenetics and Epigenomics Book Excerpt:

The Elusive Road Towards Effective Cancer Prevention and Treatment

The Elusive Road Towards Effective Cancer Prevention and Treatment
Author: Franklyn De Silva,Jane Alcorn
Publsiher: CRC Press
Total Pages: 231
Release: 2022-10-28
ISBN: 1000738957
Category: Medical
Language: EN, FR, DE, ES & NL

The Elusive Road Towards Effective Cancer Prevention and Treatment Book Excerpt:

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text.

Progress and Challenges in Precision Medicine

Progress and Challenges in Precision Medicine
Author: Mukesh Verma,Debmalya Barh
Publsiher: Academic Press
Total Pages: 450
Release: 2017-01-16
ISBN: 9780128094112
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Progress and Challenges in Precision Medicine Book Excerpt:

Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Epigenetics and Reproductive Health

Epigenetics and Reproductive Health
Author: Anonim
Publsiher: Academic Press
Total Pages: 444
Release: 2020-09-12
ISBN: 0128197544
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics and Reproductive Health Book Excerpt:

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Epigenetics to Optogenetics

Epigenetics to Optogenetics
Author: Anonim
Publsiher: BoD – Books on Demand
Total Pages: 178
Release: 2022-08-31
ISBN: 1838809937
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics to Optogenetics Book Excerpt:

Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines.