Epigenetics of the Immune System

Epigenetics of the Immune System
Author: Dieter Kabelitz,Jaydeep Bhat
Publsiher: Academic Press
Total Pages: 384
Release: 2020-06-04
ISBN: 0128179651
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics of the Immune System Book Excerpt:

Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity
Author: Rongxin Zhang
Publsiher: Academic Press
Total Pages: 432
Release: 2018-04-25
ISBN: 0128099283
Category: Medical
Language: EN, FR, DE, ES & NL

The Epigenetics of Autoimmunity Book Excerpt:

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

Human Epigenetics How Science Works

Human Epigenetics  How Science Works
Author: Carsten Carlberg,Ferdinand Molnár
Publsiher: Springer Nature
Total Pages: 153
Release: 2019-09-24
ISBN: 3030229076
Category: Medical
Language: EN, FR, DE, ES & NL

Human Epigenetics How Science Works Book Excerpt:

The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Author: Constanze Bonifer,Peter N. Cockerill
Publsiher: Springer Science & Business Media
Total Pages: 416
Release: 2014-03-12
ISBN: 3642451985
Category: Medical
Language: EN, FR, DE, ES & NL

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development Book Excerpt:

During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

Epigenetics in Psychiatry Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy

Epigenetics in Psychiatry   Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy
Author: Nicole Katherin Moschny
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy Book Excerpt:

Epigenetics for Beginners and Intermediate 2 Books in 1

Epigenetics for Beginners and Intermediate  2 Books in 1
Author: Frank Brown
Publsiher: Youcanprint
Total Pages: 330
Release: 2021-09-15
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics for Beginners and Intermediate 2 Books in 1 Book Excerpt:

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes • The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Epigenetics Book

Epigenetics Book
Author: Roy Carroll
Publsiher: Youcanprint
Total Pages: 168
Release: 2022-01-25
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Book Book Excerpt:

You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!

The Aging Immune System and Health

The Aging Immune System and Health
Author: Valquiria Bueno,Rafael Solana,Annemieke Boots
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-01-15
ISBN: 2889633616
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Aging Immune System and Health Book Excerpt:

The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.

Epigenetics for Intermediate The Most Comprehensive Exploration of the Practical Social and Ethical Impact of DNA on Our Society and Our World

Epigenetics for Intermediate  The Most Comprehensive Exploration of the Practical  Social and Ethical Impact of DNA on Our Society and Our World
Author: Frank Brown
Publsiher: Youcanprint
Total Pages: 170
Release: 2021-09-15
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics for Intermediate The Most Comprehensive Exploration of the Practical Social and Ethical Impact of DNA on Our Society and Our World Book Excerpt:

You Are About To Develop An Insider Understanding Of Epigenetics, Including Their Relationship With The DNA, Environmental Factors, Human Development And Evolution; Their Role In Human Mental And Physical Health, Including Their Use In The Treating Of Different Conditions And Diseases Along With The Most Current Epigenetic Practices And Research! What started as a broad research focused on combining genetics and developmental biology during the mid-twentieth century has evolved into the field we currently refer to as epigenetics- the mechanism of gene control that can either promote or repress gene expression without altering the genetic coding of the organism. Today, we know that the environment factors and individual lifestyles can have a direct interaction with epigenetic change, which can be reflected at various stages throughout the life of an individual and even in the later generations. You've heard that a mother's exposure to pollution can affect her child's asthma susceptibility, haven't you? No? How about the argument that a child's mental fitness can be (epigenetically) influenced by his/her dad's diet? Epigenetic change, which has nothing to do with the changes to the underlying DNA sequence, does affect how cells read genes and this biological change is influenced by several factors which include environment, lifestyle and health state through a mechanisms including a popular one known as DNA methylation. But what is the relationship between the epigenetic change and physical and physiological conditions as regards to their onset and improvement? How are epigenetic modifications being used to understand our environment, society and increasing human adaptation? How exactly do epigenetic therapies work? How does DNA affect epigenetic changes? How can we exploit epigenetic mechanisms to understand life better and improve it? If you have these and other related questions, this book is for you. More precisely, you will learn: What epigenetics are and their role in developmental psychology The influence of epigenetics at the molecular level and the impact of DNA damage in epigenetic change How epigenetics are studied The functions and consequences of epigenetics, and their specific benefits in mindfulness training, healthy eating and physical activity How genes control the growth and division of cells The role of epigenetic therapy in diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia and many more How epigenetic modifications are used in cancer treatment, and plant and animal evolution How epigenetic mechanisms are used in processes including human adaptation, memory formation, growth and infant neuro-behavior. How epigenetic mechanisms are used in maternal care How environmental chemical exposures affect epigenetics The role of epigenetics in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system …And so much more! So if you've been exposed to the concept of epigenetics as a novel way of understanding disorders, inheritance and evolution and wondered what it's really all about and how it's related with environmental exposure and different therapy practices, this book is all you need! Scroll up and click Buy Now With 1-Click or Buy Now to get started!

Genie in Your Genes

Genie in Your Genes
Author: Dawson Church
Publsiher: Hay House, Inc
Total Pages: 395
Release: 2018-09-02
ISBN: 1604152397
Category: Self-Help
Language: EN, FR, DE, ES & NL

Genie in Your Genes Book Excerpt:

Your genes respond to your thoughts, emotions and beliefs. The way you use your mind shapes your brain, turning genes on and off in ways that can dramatically affect your health and wellbeing. In this best-selling, award-winning book, researcher Dawson Church reveals the exciting applications of the new science of Epigenetics (epi=above, i.e. control above the level of the gene) to healing. Citing hundreds of scientific studies, and telling the stories of dozens of people who have used his ideas for their own healing, he shows how you can apply these discoveries in your own life. He explains how electromagnetic energy flows in your body and affects your cells, and how the new fields of energy medicine and energy psychology can help cases that are beyond the reach of conventional medicine. He shows how your hormonal, neurological, connective tissue, and neurotransmitter systems all work in harmony to conduct a coordinated flow of information throughout your body. As you take conscious control of the process, you produce a positive effect on your health, becoming an "epigenetic engineer" of your own wellbeing. Practical and scientific, this book has transformed the lives of tens of thousands of people. This new edition is updated with the latest research and clinical breakthroughs.

Epigenetics Explained How Modern Biology is Changing the Concepts of Genetics and Inheritance How the environment can affect our genes

Epigenetics Explained  How Modern Biology is Changing the Concepts of Genetics and Inheritance  How the environment can affect our genes
Author: Frank Brown
Publsiher: Youcanprint
Total Pages: 340
Release: 2021-09-15
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Explained How Modern Biology is Changing the Concepts of Genetics and Inheritance How the environment can affect our genes Book Excerpt:

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes •The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Epigenetics and Proteomics of Leukemia

Epigenetics and Proteomics of Leukemia
Author: R ̄uta Navakauskien ̇e,Dalius Navakauskas,Veronika Borutinskait ̇e,Dalius Matuzevi ̆cius
Publsiher: Springer Nature
Total Pages: 406
Release: 2021-09-14
ISBN: 3030687082
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics and Proteomics of Leukemia Book Excerpt:

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Medical Epigenetics

Medical Epigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 970
Release: 2021-08-27
ISBN: 0128243260
Category: Medical
Language: EN, FR, DE, ES & NL

Medical Epigenetics Book Excerpt:

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Epigenetics Explained

Epigenetics Explained
Author: Frank Brown
Publsiher: Charlie Creative Lab
Total Pages: 342
Release: 2020-10-15
ISBN: 9781801123174
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Epigenetics Explained Book Excerpt:

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Here is a bit of what you'll learn from this 2 in 1 book: - What epigenetics are, why they're important and how they work - How epigenetics relate with our experiences - How cells divide, and how genes control the growth and division of cells - The difference between the DNA, gene and chromosomes - The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance - The ins and outs of epigenetics mechanisms - The types of epigenetic therapies available today, including their risks, benefits and research on them - The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping - How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change - The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise - How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more - How epigenetic modifications are used in understanding plant and animal evolution - How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. - The role of epigenetic mechanisms in maternal care - The role of environmental chemicals in epigenetics - How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. - The role of environmental exposures in pathophysiology of IPF - Modulation of epigenetic marks by environmental exposures - How epigenetic regulation affects the immune system ...And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait....

Medical Epigenetics

Medical Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 924
Release: 2016-06-21
ISBN: 0128032405
Category: Science
Language: EN, FR, DE, ES & NL

Medical Epigenetics Book Excerpt:

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 682
Release: 2017-07-10
ISBN: 0128054778
Category: Science
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Excerpt:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Epigenetic Regulation and Epigenomics

Epigenetic Regulation and Epigenomics
Author: Robert A. Meyers
Publsiher: John Wiley & Sons
Total Pages: 1254
Release: 2012-05-29
ISBN: 3527326820
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetic Regulation and Epigenomics Book Excerpt:

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Epigenetics Brain and Behavior

Epigenetics  Brain and Behavior
Author: Paolo Sassone Corsi,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 166
Release: 2012-10-19
ISBN: 3642279139
Category: Medical
Language: EN, FR, DE, ES & NL

Epigenetics Brain and Behavior Book Excerpt:

Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Impact of Early Life Nutrition on Immune System Development and Related Health Outcomes in Later Life

Impact of Early Life Nutrition on Immune System Development and Related Health Outcomes in Later Life
Author: Laxmi Yeruva,Daniel Munblit,Maria Carmen Collado
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-05-28
ISBN: 2889668134
Category: Medical
Language: EN, FR, DE, ES & NL

Impact of Early Life Nutrition on Immune System Development and Related Health Outcomes in Later Life Book Excerpt:

The Epigenetics of Autoimmune Diseases

The Epigenetics of Autoimmune Diseases
Author: Moncef Zouali
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2009-04-01
ISBN: 9780470743560
Category: Medical
Language: EN, FR, DE, ES & NL

The Epigenetics of Autoimmune Diseases Book Excerpt:

The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.