Folding And Self Assembly Of Biological Macromolecules

Author by : Noah Hardy
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 30
Total Download : 886
File Size : 46,8 Mb
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Description : Organized by Alessandra Carbone ( IHeS, Bures-sur-Yvette, France ) Organized by Misha Gromov ( IHeS, Bures-sur-Yvette, France ) Organized by Fran ois K(r)p s ( CNRS-Genopole-, evry, France ) Organized by Eric Westhof ( Universit(r) Louis-Pasteur, Strasbourg, France ). This proceedings volume explores the pathways and mechanisms by which constituent residues interact and fold to yield native biological macromolecules (catalytic RNA and functional proteins), how ribosomes and other macromolecular complexes self-assemble, and relevant energetics considerations. At the week-long interactive conference, some 20 leading researchers reported their most pertinent results, confronting each other and an audience of more than 150 specialists from a wide range of scientific disciplines, including structural and molecular biology, biophysics, computer science, mathematics, and theoretical physics. The fourteen papers OCo and audience interaction OCo are edited and illustrated versions of the transcribed oral presentations. The proceedings have been selected for coverage in: . OCo Biochemistry & Biophysics Citation Index(tm). OCo Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings). OCo CC Proceedings OCo Biomedical, Biological & Agricultural Sciences. Contents: Evolution-Based Genome Analysis: An Alternative to Analyze Folding and Function in Proteins (S Benner); Conformation of Charged Polymers: Polyelectrolytes and Polyampholytes (J-F Joanny); Statistically Derived Rules for RNA Folding (M Zuker); Experimental Approaches to RNA Folding (S Woodson); Some Questions Concerning RNA Folding (F Michel); RNA Folding in Ribosome Assembly (J R Williamson); From RNA Sequences to Folding Pathways and Structures: A Perspective (H Isamber t); An Evolutionary Perspective on the Determinants of Protein Function and Assembly (O Lichtarg e); Some Residues are more Equal than Others: Application to Protein Classification and Structure Prediction (A Kister & I Gelfan d); Structure-Function Relationships in Polymerases (M Delarue); The Protein-Folding Nucleus: From Simple Models to Real Proteins (L Mirn y); Chaperonin-Mediated Protein Folding (D Thirumalai); Virus Assembly and Maturation (J E Johnson); The Animal in the Machine: Is There a Geometric Program in the Genetic Program? (A Danchin). Readership: Researchers, academics and graduate students in structural biology, cellular and molecular biology, biophysics, biochemistry and biomathematics/bioinformatics."


Folding And Self Assembly Of Biological Macromolecules

Author by : Eric Westhof
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 51
Total Download : 599
File Size : 51,8 Mb
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Description : This proceedings volume explores the pathways and mechanisms by which constituent residues interact and fold to yield native biological macromolecules (catalytic RNA and functional proteins), how ribosomes and other macromolecular complexes self-assemble, and relevant energetics considerations. At the week-long interactive conference, some 20 leading researchers reported their most pertinent results, confronting each other and an audience of more than 150 specialists from a wide range of scientific disciplines, including structural and molecular biology, biophysics, computer science, mathematics, and theoretical physics. The fourteen papers - and audience interaction - are edited and illustrated versions of the transcribed oral presentations.


Energy Landscape Exploration Of The Folding Processes Of Biological Molecules

Author by : Megan Clare Engel
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 76
Total Download : 554
File Size : 47,9 Mb
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Description : For decades, scientists from every discipline have struggled to understand the mechanism of biological self-assembly, which allows proteins and nucleic acids to fold reliably into functional three-dimensional structures. Such an understanding may hold the key to eliminating diseases such as Alzheimer's and Parkinson's and to effective protein engineering. The current best framework for describing biological folding processes is that of statistical mechanical energy landscape theory, and one of the most promising experimental techniques for exploring molecular energy landscapes is single molecule force spectroscopy (SMFS), in which molecules are mechanically denatured. Theoretical advances have enabled the extraction of complete energy landscape profiles from SMFS data. Here, SMFS experiments performed using laser optical tweezers are analyzed to yield the first ever full landscape profile for an RNA pseudoknot. Further, a promising novel landscape reconstruction technique is validated for the first time using experimental data from a DNA hairpin.


Self Assembly Monolayer Structures Of Lipids And Macromolecules At Interfaces

Author by : K.S. Birdi
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 54
Total Download : 528
File Size : 46,6 Mb
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Description : Self-assembly monolayer (SAM) structures of lipids and macromolecules have been found to play an important role in many industrial and biological phenomena. This book describes two procedures, namely the STM and AFM, that are used to study SAMs at solid surfaces. K.S. Birdi examines the SAMs at both liquid and solid surfaces by using the Langmuir monolayer method. This book is intended for researchers, academics and professionals.


The Emergence Of Life

Author by : Pier Luigi Luisi
Languange : en
Publisher by : Cambridge University Press
Format Available : PDF, ePub, Mobi
Total Read : 81
Total Download : 190
File Size : 47,5 Mb
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Description : This fully updated and expanded edition addresses the origins of biological and synthetic life from a systems biology perspective.


Labs On Chip

Author by : Eugenio Iannone
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 98
Total Download : 383
File Size : 40,7 Mb
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Description : Labs on Chip: Principles, Design and Technology provides a complete reference for the complex field of labs on chip in biotechnology. Merging three main areas— fluid dynamics, monolithic micro- and nanotechnology, and out-of-equilibrium biochemistry—this text integrates coverage of technology issues with strong theoretical explanations of design techniques. Analyzing each subject from basic principles to relevant applications, this book: Describes the biochemical elements required to work on labs on chip Discusses fabrication, microfluidic, and electronic and optical detection techniques Addresses planar technologies, polymer microfabrication, and process scalability to huge volumes Presents a global view of current lab-on-chip research and development Devotes an entire chapter to labs on chip for genetics Summarizing in one source the different technical competencies required, Labs on Chip: Principles, Design and Technology offers valuable guidance for the lab-on-chip design decision-making process, while exploring essential elements of labs on chip useful both to the professional who wants to approach a new field and to the specialist who wants to gain a broader perspective.


The Systems View Of Life

Author by : Fritjof Capra
Languange : en
Publisher by : Cambridge University Press
Format Available : PDF, ePub, Mobi
Total Read : 38
Total Download : 159
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Description : The first volume to integrate life's biological, cognitive, social, and ecological dimensions into a single, coherent framework.


Molecular Biophysics For The Life Sciences

Author by : Norma Allewell
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 90
Total Download : 918
File Size : 54,5 Mb
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Description : This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions. Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions.


Springer Handbook Of Nanotechnology

Author by : Bharat Bhushan
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 68
Total Download : 713
File Size : 43,7 Mb
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Description : Since 2004 and with the 2nd edition in 2006, the Springer Handbook of Nanotechnology has established itself as the definitive reference in the nanoscience and nanotechnology area. It integrates the knowledge from nanofabrication, nanodevices, nanomechanics, Nanotribology, materials science, and reliability engineering in just one volume. Beside the presentation of nanostructures, micro/nanofabrication, and micro/nanodevices, special emphasis is on scanning probe microscopy, nanotribology and nanomechanics, molecularly thick films, industrial applications and microdevice reliability, and on social aspects. In its 3rd edition, the book grew from 8 to 9 parts now including a part with chapters on biomimetics. More information is added to such fields as bionanotechnology, nanorobotics, and (bio)MEMS/NEMS, bio/nanotribology and bio/nanomechanics. The book is organized by an experienced editor with a universal knowledge and written by an international team of over 150 distinguished experts. It addresses mechanical and electrical engineers, materials scientists, physicists and chemists who work either in the nano area or in a field that is or will be influenced by this new key technology.


Fibrous Proteins Coiled Coils Collagen And Elastomers

Author by : David A.D. Parry
Languange : en
Publisher by : Gulf Professional Publishing
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 720
File Size : 54,8 Mb
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Description : Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards. Reveals new structural and functional aspects of fibrous proteins Based on Fibrous Protein workshop in Alpbach, Austria that gave rise to 2003 Nobel Prize winners in Chemistry


Energetics Of Biological Macromolecules

Author by : Michael L. Johnson
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 47
Total Download : 663
File Size : 50,5 Mb
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Description : General Description of the Volume: The very existence of biological structures and their functional interactions are dictated by energetic relationships. Thus the central theme of this volume is that thermodynamic methods, i.e. techniques that probe the energetics of biological macromolecules, now comprise a powerful and practical family of tools for research in modern biology. The application of thermodynamics and statistical thermodynamics to biochemical and biophysical systems is presented. This volume supplements Methods in Enzymology, Volume 259. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Major topics covered include: * Deciphering rules of helix stability in peptides * Protein Folding in Membranes * Molecular Crowding * Study of the Bohr Effect in Hemoglobin Intermediates * Photoacoustic Calorimetry of Proteins * Theoretical Aspects of Isothermal Titration Calorimetry * Energetic Methods to Study Bifunctional Biotin Repressor


Biomems And Biomedical Nanotechnology

Author by : Abraham P. Lee
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 473
File Size : 53,6 Mb
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Description : blends materials, fabrication, and structure issues of developing nanobio devices in a single volume. treats major nanobio application areas such as drug delivery, molecular diagnostics, and imaging. chapters written by the leading researchers in the field.


Physical Aspects Of Polymer Self Assembly

Author by : P. R. Sundararajan
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 12
Total Download : 229
File Size : 44,8 Mb
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Description : Offering an overview of principles and techniques, this book covers all major categories of self-assembled polymers – properties, processes, and design. Each chapter focuses on morphology, applications, and advanced concepts to illustrate the advantages of polymer self-assembly across industrial and academic research. • Provides an organized, comprehensive overview of polymer self-assembly, its fundamentals, principles, and applications • Includes chapters on block copolymers, amphiphilic polymers, supramolecular polymers, rotaxenes, polymer gels, dendrimers, and small molecules in polymer matrices • Focuses on novel applications, block copolymer assembly to nanotechnology, photonics and metamaterials, molecular machines and artificial muscle, gels that can be applied to polymer science, materials science, and nanotechnology • Examines state-of-the-art concepts, like lithographic patterning and foldaxane • Discusses challenges and future outlook of a popular and emerging field of study


Biological Soft Matter

Author by : Corinne Nardin
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 70
Total Download : 226
File Size : 50,9 Mb
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Description : Biological Soft Matter Explore a comprehensive, one-stop reference on biological soft matter written and edited by leading voices in the field Biological Soft Matter: Fundamentals, Properties and Applications delivers a unique and indispensable compilation of up-to-date knowledge and material on biological soft matter. The book presents a thorough overview about biological soft matter, beginning with different substance classes, including proteins, nucleic acids, lipids, and polysaccharides. It goes on to describe a variety of superstructures and aggregated and how they are formed by self-assembly processes like protein folding or crystallization. The distinguished editors have included materials with a special emphasis on macromolecular assembly, including how it applies to lipid membranes, and proteins fibrillization. Biological Soft Matter is a crucial resource for anyone working in the field, compiling information about all important substance classes and their respective roles in forming superstructures. The book is ideal for beginners and experts alike and makes the perfect guide for chemists, physicists, and life scientists with an interest in the area. Readers will also benefit from the inclusion of: An introduction to DNA nano-engineering and DNA-driven nanoparticle assembly Explorations of polysaccharides and glycoproteins, engineered biopolymers, and engineered hydrogels Discussions of macromolecular assemblies, including liquid membranes and small molecule inhibitors for amyloid aggregation A treatment of inorganic nanomaterials as promoters and inhibitors of amyloid fibril formation An examination of a wide variety of natural and artificial polymers Perfect for materials scientists, biochemists, polymer chemists, and protein chemists, Biological Soft Matter: Fundamentals, Properties and Applications will also earn a place in the libraries of biophysicists and physical chemists seeking a one-stop reference summarizing the rapidly evolving topic of biological soft matter.


Thermodynamics And Biophysics Of Biomedical Nanosystems

Author by : Costas Demetzos
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 67
Total Download : 989
File Size : 44,9 Mb
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Description : This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.


Molecular Self Assembly In Nanoscience And Nanotechnology

Author by : Ayben Kilislioglu
Languange : en
Publisher by : BoD – Books on Demand
Format Available : PDF, ePub, Mobi
Total Read : 64
Total Download : 271
File Size : 51,5 Mb
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Description : Self-assembly is a common principle in molecular fabrication of natural and synthetic systems and has many important applications in the fields of nanoscience and nanotechnology. This book provides clear explanations of the principles of self-assembly with the limitations along with examples and research-based results with discussion for students, researchers, and professions.


Trends In Biomaterials

Author by : G. P. Kothiyal
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 54
Total Download : 794
File Size : 41,8 Mb
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Description : Biomaterials research requires the union of materials scientists, engineers, biologists, biomedical doctors, and surgeons. Societal implications have invoked tremendous interest in this area of research in recent years. What started as a search for strong and durable implant materials has now led to path-breaking developments in tissue engineering, targeted drug delivery, and tissue scaffolds. Viable applications of mesoporous structures, polymer biocomposites, and fibers (synthetic and natural) in the areas of clinical orthopedics, controlled drug delivery, tissue engineering, orthodontics, etc., have emerged as relatively recent concepts. This book presents recent results related to both materials aspects and implant issues. The focus is on structural, magnetic, antibacterial, bioactivity/compatibility, mechanical, and other related properties and the implication of these results on biomedical applications. The book discusses technical problems faced by the surgeon during implant fixation in total hip replacement and the selection of materials based on the patient’s requirement. It also addresses recent advances in implant materials, including the reinforcement and biocompatibility issues.


Internet Of Things Smart Spaces And Next Generation Networks And Systems

Author by : Olga Galinina
Languange : en
Publisher by : Springer Nature
Format Available : PDF, ePub, Mobi
Total Read : 13
Total Download : 664
File Size : 42,6 Mb
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Description : This book constitutes the joint refereed proceedings of the 20th International Conference on Next Generation Teletraffic and Wired/Wireless Advanced Networks and Systems, NEW2AN 2020, and the 13th Conference on Internet of Things and Smart Spaces, ruSMART 2020. The conference was held virtually due to the COVID-19 pandemic. The 79 revised full papers presented were carefully reviewed and selected from 225 submissions. The papers of NEW2AN address various aspects of next-generation data networks, with special attention to advanced wireless networking and applications. In particular, they deal with novel and innovative approaches to performance and efficiency analysis of 5G and beyond systems, employed game-theoretical formulations, advanced queuing theory, and stochastic geometry, while also covering the Internet of Things, cyber security, optics, signal processing, as well as business aspects. ruSMART 2020, provides a forum for academic and industrial researchers to discuss new ideas and trends in the emerging areas.


Molecular Modeling At The Atomic Scale

Author by : Ruhong Zhou
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 88
Total Download : 753
File Size : 47,9 Mb
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Description : Although molecular modeling has been around for a while, the groundbreaking advancement of massively parallel supercomputers and novel algorithms for parallelization is shaping this field into an exciting new area. Developments in molecular modeling from experimental and computational techniques have enabled a wide range of biological applications. Responding to this renaissance, Molecular Modeling at the Atomic Scale: Methods and Applications in Quantitative Biology includes discussions of advanced techniques of molecular modeling and the latest research advancements in biomolecular applications from leading experts. The book begins with a brief introduction of major methods and applications, then covers the development of cutting-edge methods/algorithms, new polarizable force fields, and massively parallel computing techniques, followed by descriptions of how these novel techniques can be applied in various research areas in molecular biology. It also examines the self-assembly of biomacromolecules, including protein folding, RNA folding, amyloid peptide aggregation, and membrane lipid bilayer formation. Additional topics highlight biomolecular interactions, including protein interactions with DNA/RNA, membrane, ligands, and nanoparticles. Discussion of emerging topics in biomolecular modeling such as DNA sequencing with solid-state nanopores and biological water under nanoconfinement round out the coverage. This timely summary contains the perspectives of leading experts on this transformation in molecular biology and includes state-of-the-art examples of how molecular modeling approaches are being applied to critical questions in modern quantitative biology. It pulls together the latest research and applications of molecular modeling and real-world expertise that can boost your research and development of applications in this rapidly changing field.


Nanobiotechnology Ii

Author by : Chad A. Mirkin
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 465
File Size : 54,8 Mb
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Description : This second volume on a burgeoning field retains the proven concept of the spectacularly successful first one, extending and supplementing it. Individual sections are each dedicated to nanoparticles, nanostructures and patterns, nanodevices and machines, and nanoanalytics. Essential reading for an entire generation of scientists, this authoritative survey defines one of the most important new scientific fields to have emerged for many decades.


The Nanobiotechnology Handbook

Author by : Yubing Xie
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 28
Total Download : 208
File Size : 47,5 Mb
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Description : A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular and biomedical nanotechnology, biosensors, biocatalysis and biofuel, and education and workforce development. It includes a companion CD that contains all figures in the book. The book begins with discussions of biomimetic nanotechnology, including a comprehensive overview of DNA nanostructure and DNA-inspired nanotechnology, aptamer-functionalized nanomaterials as artificial antibodies, artificial enzymes, molecular motors, and RNA structures and RNA-inspired nanotechnology. It shows how nanotechnology can be inspired by nature as well as adverse biological events in diagnostic and therapeutic development. From there, the chapters cover major important and widely used nanofabrication techniques, applications of nanotechnology for bioprocessing followed by coverage of the applications of atomic force microscopy (AFM), optical tweezers and nanofluidics as well as other nanotechnology-enabled biomolecular and cellular manipulation and detection. Focusing on major research trends, the book highlights the importance of nanobiotechnology to a range of medical applications such as stem cell technology and tissue engineering, drug development and delivery, imaging, diagnostics, and therapeutics. And with coverage of topics such as nanotoxicity, responsible nanotechnology, and educational and workforce development, it provides a unique overview and perspective of nanobiotechnology impacts from a researcher’s, entrepreneur’s, economist’s and educator’s point of view. It provides a resource for current applications and future development of nanobiotechnology.


Molecular Biology Of Assemblies And Machines

Author by : Alasdair Steven
Languange : en
Publisher by : Garland Science
Format Available : PDF, ePub, Mobi
Total Read : 17
Total Download : 692
File Size : 54,9 Mb
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Description : Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology,


Self Assembly Of Polymers

Author by : Dmitry Volodkin
Languange : en
Publisher by : MDPI
Format Available : PDF, ePub, Mobi
Total Read : 70
Total Download : 623
File Size : 52,9 Mb
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Description : Nowadays, polymer self-assembly has become extremely attractive for both biological (drug delivery, tissue engineering, scaffolds) and non-biological (packaging, semiconductors) applications. In nature, a number of key biological processes are driven by polymer self-assembly, for instance protein folding. Impressive morphologies can be assembled from polymers thanks to a diverse range of interactions involved, e.g., electrostatics, hydrophobic, hots-guest interactions, etc. Both 2D and 3D tailor-made assemblies can be designed through modern powerful techniques and approaches such as the layer-by-layer and the Langmuir-Blodgett deposition, hard and soft templating. This Special Issue highlights contributions (research papers, short communications, review articles) that focus on recent developments in polymer self-assembly for both fundamental understanding the assembly phenomenon and real applications.


Macromolecular Self Assembly

Author by : Laurent Billon
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 27
Total Download : 861
File Size : 41,9 Mb
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Description : This book describes techniques of synthesis and self-assembly of macromolecules for developing new materials and improving functionality of existing ones. Because self-assembly emulates how nature creates complex systems, they likely have the best chance at succeeding in real-world biomedical applications. • Employs synthetic chemistry, physical chemistry, and materials science principles and techniques • Emphasizes self-assembly in solutions (particularly, aqueous solutions) and at solid-liquid interfaces • Describes polymer assembly driven by multitude interactions, including solvophobic, electrostatic, and obligatory co-assembly • Illustrates assembly of bio-hybrid macromolecules and applications in biomedical engineering


Life S Ratchet

Author by : Peter M Hoffmann
Languange : en
Publisher by : Hachette UK
Format Available : PDF, ePub, Mobi
Total Read : 88
Total Download : 692
File Size : 53,5 Mb
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Description : Life is an enduring mystery. Yet, science tells us that living beings are merely sophisticated structures of lifeless molecules. If this view is correct, where do the seemingly purposeful motions of cells and organisms originate? In Life's Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. Below the calm, ordered exterior of a living organism lies microscopic chaos, or what Hoffmann calls the molecular storm -- specialized molecules immersed in a whirlwind of colliding water molecules. Our cells are filled with molecular machines, which, like tiny ratchets, transform random motion into ordered activity, and create the "purpose" that is the hallmark of life. Tiny electrical motors turn electrical voltage into motion, nanoscale factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city -- an unfathomable, complex collection of molecular workers working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through these sophisticated structures of our evolved machinery. We are agglomerations of interacting nanoscale machines more amazing than anything in science fiction. Rather than relying on some mysterious "life force" to drive them -- as people believed for centuries -- life's ratchets harness instead the second law of thermodynamics and the disorder of the molecular storm. Grounded in Hoffmann's own cutting-edge research, Life's Ratchet reveals the incredible findings of modern nanotechnology to tell the story of how the noisy world of atoms gives rise to life itself.


Peptide Based Materials

Author by : Timothy Deming
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 46
Total Download : 443
File Size : 42,9 Mb
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Description : Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-


Design And Information In Biology

Author by : J. A. Bryant
Languange : en
Publisher by : WIT Press
Format Available : PDF, ePub, Mobi
Total Read : 9
Total Download : 476
File Size : 43,9 Mb
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Description : Highlighted with individual contributions from eminent specialists, these multiauthored volumes combine authority, inspiration and state-of-the-art knowledge. Both informative and inspiring they are designed to appeal to scientists and interested laypeople alike. Volume 2 complements and extends the scope of the first, with the biological viewpoint being stressed. Following an introductory chapter on design as understood in biology, the various aspects of the biological information revolution are addressed. Areas discussed include molecular structure, the genome, development, and neural networks. A section on information theory provides a link with engineering, and the scope is also broadened to include the implications of motion in nature and engineering.


Advances In Macromolecules

Author by : Maria Vittoria Russo
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 18
Total Download : 755
File Size : 48,7 Mb
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Description : "Polymeric and Nanostructured Macromolecules" presents the recent advances made in the synthesis, characterization, and applications of polymeric macromolecules. This book provides an excellent overview of the recent breakthroughs in the science of macromolecules, with an emphasis on nanostructured macromolecules and the perspectives that these versatile materials offer to different fields such as optoelectronics and biotechnology. Advanced undergraduate, graduate students and researchers alike will find the topics concerning physical and chemical properties of advanced macromolecular materials of great interest.


Calorimetric And Dielectric Studies Of Self Assembled Bio Molecules In An Aqueous Environment

Author by : Klaida Kashuri
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 72
Total Download : 713
File Size : 51,9 Mb
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Description : Abstract: Self-assembly and the induced orientation of microscopic biological systems is of great scientific interest, because it holds the promise of many pharmaceutical applications. This dissertation presents experimental studies done on proteins, short DNA fragments, and cholesterol structures self-assembled in an aqueous environment. The goal is to probe the thermo-physical properties of these systems, their phases and phase transitions, in order to better under-stand the principles behind their unique assemblies and function. It is accepted that in all these systems the solvent water plays an important role on the assembly folding, orientation, and activity of biopolymers. However, the abundance of water in typical samples presents many experimental challenges. It is indeed the case that changes in the properties of hydration in watery environments are responsible for the dynamics of protein and DNA biomolecules. We have explored in more detail the thermodynamics, the structural properties, and the dynamics near structural transitions of biomolecules in their native aqueous environment.


Proteins In Solution And At Interfaces

Author by : Juan M. Ruso
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 11
Total Download : 496
File Size : 40,8 Mb
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Description : Explores new applications emerging from our latestunderstanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as thestarting point for exciting new applications, from biomimeticmaterials to nanoparticle patterning. This book surveys the stateof the science in the field, offering investigators a currentunderstanding of the characteristics of proteins in solution and atinterfaces as well as the techniques used to study thesecharacteristics. Moreover, the authors explore many of the new andemerging applications that have resulted from the most recentstudies. Topics include protein and protein aggregate structure;computational and experimental techniques to study proteinstructure, aggregation, and adsorption; proteins in non-standardconditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided intotwo parts: Part One introduces concepts as well as theoretical andexperimental techniques that are used to study protein systems,including X-ray crystallography, nuclear magnetic resonance, smallangle scattering, and spectroscopic methods Part Two examines current and emerging applications,including nanomaterials, natural fibrous proteins, and biomolecularthermodynamics The book's twenty-three chapters have been contributed byleading experts in the field. These contributions are based on athorough review of the latest peer-reviewed findings as well as theauthors' own research experience. Chapters begin with a discussionof core concepts and then gradually build in complexity, concludingwith a forecast of future developments. Readers will not only gain a current understanding of proteinsin solution and at interfaces, but also will discover howtheoretical and technical developments in the field can betranslated into new applications in material design, geneticengineering, personalized medicine, drug delivery, biosensors, andbiotechnology.