Description : This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals
Description : Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Description : Recent breakthroughs in understanding the effectiveness of brain hypothermia treatment have been brought about by rapid progress in experimental gene studies along with new findings in the areas of brain-injury mechanisms, brain thermo-pooling, hemoglobin dysfunction, insulin-resistant hyperglycemia, radical damage involving states of consciousness, management of lipid-dominant metabolism in the intensive care unit (ICU), and management of immune crises under conditions of hypothermia. This book explains the mechanism of brain hypothermia and presents advanced techniques for ICU management of brain hypothermia for critically brain-injured patients. Especially useful for bedside care in the ICU are the easy-reference care-management "cards" in the appendix of the book. Brain Hypothermia Treatment provides a valuable resource and practical guide for professionals in the fields of neurosurgery and emergency and critical care medicine.
Description : The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders. Key illnesses such as epilepsy, multiple sclerosis and Parkinson’s are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.
Description : With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 7th Edition helps you understand the most important and the most complex pathophysiology concepts. More than 1,200 full-color illustrations and photographs make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW Epigenetics and Disease chapter along with additional What's New boxes highlighting the latest advances in pathophysiology. Written by well-known educators Kathryn McCance and Sue Huether, and joined by a team of expert contributors, this resource is the most comprehensive and authoritative pathophysiology text available! Over 1,200 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text. A fully updated glossary includes 1,000 terms, and makes lookup easier by grouping together similar topics and terms. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Chapter summary reviews provide concise synopses of the main points of each chapter. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Algorithms and flowcharts of diseases and disorders make it easy to follow the sequential progression of disease processes. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. EXTENSIVELY Updated content reflects advances in pathophysiology including tumor biology invasion and metastases, the epidemiology of cancer, diabetes mellitus, insulin resistance, thyroid and adrenal gland disorders, female reproductive disorders including benign breast diseases and breast cancer, and a separate chapter on male reproductive disorders and cancer. NEW! Chapter on epigenetics and disease. Additional What's New boxes highlight the most current research and clinical development.
Description : There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.
Description : Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos sible role of reactive oxygen species in many types of organ dys functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is sues important for understanding reactive oxygen species and their role in tissue damage.
Description : These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European society for the Study of Purine and Pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in Switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in vii rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.
Description : What are antioxidants? What do they do? Should you be taking them? How much is enough, or too much? Dr. John Smythies explores these and other questions you need to have answered about antioxidants in Every Person's Guide to Antioxidants. Oxidants are naturally occuring chemicals in our bodies that derive from oxygen to facilitate essential biochemical processes. However, most oxidants are potentially toxic molecules and the body contains a number of antioxidants for protection against these toxic effects. Overproduction of oxidants, or underproduction of antioxidants, leads to oxidative stress, which has been linked to a wide range of chronic diseases, including heart disease, cancer, diabetes, and Alzheimer's. Smythies thoroughly evaluates current scientific work on this subject and suggests that a high proportion of many of these diseases can be prevented, or their onset delayed, by proper intake of antioxidants. He examines the pros and cons of the debate over how this necessary intake should be achieved, by eating more fruits and vegetables or by taking supplements in pill form. Smythies surveys the toxicity of antioxidants and recommends under what circumstances they should be given with caution or not at all. He also discusses whether taking supplements requires medical supervision and lists good sources of antioxidants in fruits and vegetables
Description : This volume is a review which presents both a basic science and clinical perspective on neuroprotective approaches to acute and chronic neurodegenerative conditions. Experts from both fields review current areas of neuroprotection. The book describes basic science discovery in stroke research and the application of such research within the pharmaceutical industry leading to the development of neuroprotective drugs.