Genetics Of Steroid Biosynthesis And Function

Author by : J.I. Mason
Languange : en
Publisher by : CRC Press
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Description : Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attent


Yen And Jaffe S Reproductive Endocrinology

Author by : Jerome F. Strauss
Languange : en
Publisher by : Elsevier Health Sciences
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Description : Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015 Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine. Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter. Conveniently access the fully searchable text and view all of the images online at Expert Consult. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery and online videos demonstrating key techniques.


Genetic Steroid Disorders

Author by : Walter L. Miller
Languange : en
Publisher by : Elsevier Inc. Chapters
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Description : Steroidogenesis begins with internalization of low-density lipoprotein particles and subsequent intracellular processing of cholesterol. Disorders in these steps include adrenoleukodystrophy, Wolman disease, and Niemann–Pick type C disease, which may present as adrenal insufficiency. Cholesterol delivery to the inner mitochondrial membrane is regulated by the steroidogenic acute regulatory protein, StAR, and cholesterol is converted to pregnenolone within mitochondria by the cholesterol side chain cleavage enzyme, P450scc. Severe StAR mutations cause classic congenital lipoid adrenal hyperplasia (CAH), characterized by adrenal insufficiency and 46,XY disorders of sexual development (DSD). The lipoid CAH phenotype, including spontaneous puberty in 46,XX females, is explained by a two-hit model. StAR mutations that retain partial function cause milder non-classic disease characterized by glucocorticoid deficiency, with lesser disorders of mineralocorticoid and sex steroid synthesis. Rare P450scc mutations are clinically and hormonally indistinguishable from lipoid CAH, and may also present as milder non-classic disease. Adrenal imaging may distinguish these but is not 100% reliable, necessitating DNA sequencing.


Gene Regulation By Steroid Hormones Ii

Author by : A.K. Roy
Languange : en
Publisher by : Springer
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Description : Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. We have become comfortable with the totally unanticipated fact that the coding sequences of genes are in discontinuous arrangements and that the RNA transcribed from them must be extensively processed to form messenger RNA. We have also learned about the strategy of "mixing and matching" of genetic segments so that a small amount of DNA can go a long way in producing a huge variety of different proteins, as in the immunoglobulin system. The explosive effort directed toward DNA sequence analysis has led us to the conclusion that there are signals within the DNA that specify sites of transcription initiation and possibly sites for interacting with regulatory molecules such as hor mones and their receptors. The current intense interest in the structure of chromatin beyond the nucleosome-that is, the superstructural characteris tics of the genetic material-is finally yielding meaningful results that give promise for understanding the regulation of gene activity. ROBERT F. GOLDBERGER Preface Research on the molecular mechanism of steroid hormone action continues at an extraordinary pace and a great deal of progress has been made. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation. Purified steroid receptors have been dissected to identify different functional domains.


Endocrinology Adult And Pediatric Reproductive Endocrinology

Author by : J. Larry Jameson
Languange : en
Publisher by : Elsevier Health Sciences
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Description : Endocrinology: Adult and Pediatric: Reproductive Endocrinology is a new eBook from the same experts responsible for the highly acclaimed two-volume Endocrinology clinical reference book. It puts all of the latest advances in adult and pediatric reproductive endocrinology at your fingertips, instantly accessible on your favorite eReader - so you can give your patients the benefit of today’s best know-how. Stay abreast of the newest knowledge in reproductive endocrinology, including endocrinology of sexual behavior and gender identity; genetic pathways that control gonadal development and sex differentiation; management of PCOS and hirsutism; management of male androgen deficiency; management of gynecomastia; and much more. Effectively review the causes and management of precocious or delayed puberty. Count on all the authority that has made Endocrinology, 6th Edition, edited by leading endocrinologists Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.


Characterization Of The Role Of Acid Ceramidase In Adrenocortical Steroid Hormone Biosynthesis

Author by : Natasha Chrystman Lucki
Languange : en
Publisher by : Unknown
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Description : Sphingolipids modulate multiple cellular functions, including steroid hormone biosynthesis. Sphingosine is an antagonist ligand for the nuclear receptor steroidogenic factor 1 (SF-1), which is the primary transcriptional regulator of most steroidogenic genes. Furthermore, sphingosine-dependent repression of SF-1 function is dependent on the expression of acid ceramidase (ASAH1), an enzyme that forms sphingosine. Based on these data, I hypothesized that ACTH/cAMP signaling regulates ASAH1 function at both transcriptional and post-transcriptional levels. In addition, because SF-1 is predominantly a nuclear protein, I postulated that ASAH1 modulates SF-1 function and, therefore, steroidogenic gene expression by controlling the nuclear concentrations of SPH. To test these hypotheses, I first examined the effect of chronic ACTH/cAMP signaling on the transcription of the ASAH1 gene. Next, the functional significance of ASAH1 expression in adrenocortical cells was probed by generating an ASAH1-knockdown cell line. I subsequently characterized the role of ASAH1 as a transcriptional nuclear receptor coregulator. Finally, I defined the role of sphingosine-1-phosphate, a bi-product of ASAH1 activity, in the acute phase of cortisol biosynthesis. Using a variety of experimental approaches, I identified cAMP response element binding protein as an essential transcriptional activator of the ASAH1 gene. Analysis of adrenocortical cells lacking ASAH1 revealed that ASAH1 is a global regulator of steroidogenic capacity. Furthermore, I identified ASAH1 as a nuclear protein and defined the molecular determinants of the interaction between ASAH1 and SF-1. Collectively, this body of work establishes the integral role of ASAH1 in the regulation of ACTH-dependent adrenocortical cortisol biosynthesis.


Gene Regulation By Steroid Hormones Iii

Author by : Arun K. Roy
Languange : en
Publisher by : Springer
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Description : The field of steroid hormone action has continued to expand into the realm of molecular biology at a pace even faster than most of us ever imagined. techniques of molecular biology have made it possible to clone The hormone-regulated genes and to examine steroid-receptor interactions with these genes. Nucleotide sequences of these genes, which show preferential binding of steroid receptors, have been identified. These results are complemented by the identification of chromatin acceptor proteins, which also show preferential binding for steroid-receptor complexes. Thus, one can envision the day when cloned genes, purified acceptor proteins, and receptor-steroid complexes will be recombined in vitro to form a functional unit. Cellular localization of steroid receptors has undergone recent revision, and it now appears that receptors are localized primarily in the nuclear compartment. These findings, although controversial, will lead to a reassessment of many of the previous concepts of steroid-receptor interactions and regulation. The way in which these observations at the of physiology, molecular and cellular levels fit into the overall scheme development, and evolution are continuing to progress, and the future promises some very exciting syntheses of understanding at all levels of biological organization. The third Meadow Brook Conference on hormones was held in order to bring together investigators who will undoubtedly contribute heavily to this future synthesis and to permit a free exchange of ideas and concepts as they relate to the current state-of-the-art in molecular endocrinology. Spring 1986 ARUN K. Roy JAMES H. CLARK Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .


Gene Regulation By Steroid Hormones Iv

Author by : Arun K. Roy
Languange : en
Publisher by : Springer Science & Business Media
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Description : The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.


Steroid Hormone Resistance

Author by : George P. Chrousos
Languange : en
Publisher by : Springer Science & Business Media
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Description : This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.


Cancer Research

Author by : Anonim
Languange : en
Publisher by : Unknown
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Genetic Steroid Disorders

Author by : Yves Morel
Languange : en
Publisher by : Elsevier Inc. Chapters
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Description : The transformation of Δ5-3β-hydroxysteroids into the corresponding Δ4-3-keto-steroids is an essential step for the biosynthesis of all classes of active steroids: progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. These steroid hormones play a crucial role in the differentiation, development, growth, and physiological function of most human tissues. The 3β-HSD deficiency (OMIM +201810), transmitted in an autosomic recessive disorder, is characterized by varying degrees of salt wasting; in genetic males, fetal testicular 3ß-HSD deficiency causes an undervirilized male genitalia (male pseudohermaphroditism); females exhibit either normal sexual differentiation or mild virilization.


Steroid Hormones And Metabolism

Author by : Kenneth W. McKerns
Languange : en
Publisher by : Unknown
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Role Of Protein Protein Interactions In Metabolism Genetics Structure Function 2nd Edition

Author by : Amit V. Pandey
Languange : en
Publisher by : Frontiers Media SA
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Description : Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms.


Endocrine Genetics

Author by : Society for Endocrinology
Languange : en
Publisher by : Unknown
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Genetic Steroid Disorders

Author by : Maria I. New
Languange : en
Publisher by : Academic Press
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Description : This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It will assist these specialists in the diagnosis and treatment of steroid disorders. The book is written for postgraduate and faculty-level physicians. The content consists of steroid disorders, genetic bases for the disorder and case presentations of each disorder. Provides a common language for professionals to discuss and diagnose genetic steroid disorders Includes the very latest details on genetic tests and diagnoses Offers a strong understanding of the molecular basis for the diseases and therefore correct diagnosis and treatment of steroid disorders Presents insight into which medications to use based on the genetic makeup of a patient Teaches the best strategies and most effective use of genetic information in the patient counseling setting


Pediatric Endocrinology

Author by : Mark A. Sperling
Languange : en
Publisher by : Elsevier Health Sciences
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Description : In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today’s technological and scientific advances. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter. Stay up to date with today’s hottest topics, including neonatal diabetes mellitus, Type II childhood diabetes, molecular endocrinology, and genetics. Explore the impact of today’s advances and challenges, including explosive growth in molecular biology, sophisticated imaging techniques, and an increase in both pediatric diabetes and obesity. Quickly access the information you need with a new, streamlined organization (Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging).


Human Adrenal Androgens Regulation Of Biosynthesis And Role In Estrogen Responsive Breast Cancer In A Mouse Model

Author by : Peter Hornsby
Languange : en
Publisher by : Unknown
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Description : These experiments investigate a mouse model for the biosynthesis of the human adrenal androgens (dehydroepiandrosterone, DHEA, and its sulfate, DHEAS) and the role of these steroids in human breast cancer growth. An androgen-dependent human breast cancer model was established in immunodeficient (scid) mice. Zona reticularis cells in the human adrenal cortex are responsible for adrenal androgen biosynthesis because of the suppressed expression of 3 beta-hydroxysteroid dehydrogenase (3beta-HSD) in these cells. A protein present in the non-DHEA-secreting zones of the cortex and absent from the zona reticularis which binds to a regulatory region of the type II 3 beta-HSD gene was partially purified. Human adrenocortical cells were transplanted into scid mice and were shown to replace the animals own adrenal function. Although zona reticularis cells were transplanted, DHEAS was not detected in mouse plasma. As an alternative to the use of human zona reticularis cells, clonal bovine adrenocortical cells were shown to be capable of forming tissue in scid mice that replaces the animals adrenal glands. This was shown both with normal clonal cells and with cells genetically modified by the insertion of marker genes. The ability to genetically modify the cells provides a means to test whether suppression of 3 beta-HSD by an antisense strategy can create a tissue with a very high rate of DHEA biosynthesis in the mouse transplant model.


Research Awards Index

Author by : Anonim
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Publisher by : Unknown
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Origin Of Life

Author by : Charles D Schaper, PH D
Languange : en
Publisher by : Unknown
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Description : The origin of life is one of the greatest mysteries. Despite many prior attempts at scientifically determining the origin of life, there is no available solution that clearly determines the beginnings of the DNA molecule, the Genetic Code of Life, and the Biological Cell. Here, principal research findings are presented that indicate for the first time the origin of DNA, the Genetic Code, the Biological Cell, and the initiation mechanism for Life Forms. The basis for this work is the discovery of a molecular primer evident in the structural symmetry between DNA nucleotides, steroid molecules, and steroid hormones. Following this discovery, the research introduces a new concept of synthesizing both structural and functional characteristics of DNA at the same time within a single unified complex of interleaved steroid molecules which form reaction vessels that serve as co-enzymatic building blocks. The establishment of the DNA nucleotide code is among the very first synthesis steps, thereby inducing a digital communications channel of encoding, transmission, decoding, translation, including error correction and replication. Moreover, as a consequence of the intermolecular synthesis of both structure and function within a unified complex, there is a culminating process step that sets forth in motion both DNA and the steroid structures that subsequently control translation and replication, thereby resulting in the instantaneous release of life function.This work follows the publication of the book by Dr. Schaper, "Design of DNA, Genetic Codes, and Life Function", extending the results to include the Biological Cell, and the initiation processes for Life Forms. It is shown that in addition to the instantaneous release of life function, there was also the instantaneous creation of the first cellular life form, as the process was initiated in a biological cellular construct. Dr. Schaper indicates the mechanism of forming the First Cells, and its direct relationship with DNA and the steroid molecules, which enable function. The extension of these processes to induce differentiated multicellular structures is also indicated.


Behavioral And Neural Genetics Of Zebrafish

Author by : Robert T. Gerlai
Languange : en
Publisher by : Academic Press
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Description : Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics


Biochemical Actions Of Hormones

Author by : G. Litwack
Languange : en
Publisher by : Unknown
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Description : V.4 - Affinity labeling as a technique in determining hormone mechanisms; Mechanisms of prostaglandin action in endocrine glands; Regulation of protein synthesis and degradation in heart and skeletal muscle; Hormonal regulation of cholesterol synthesis; The B-adrenergic receptor and the regulation of circadian rhythms in the pineal gland; Cell culture studies of thyrotropin-releasing hormone action; The insulin receptor: properties and regulation; Molecular actions of androgens; Actions of cyclic AMP and its relationship to transmitter function in nervous tissue; v.5 - postsynthetic modifications of histone primary structure: phosphorylation and acetylation as related to chromatin conformation and function; Regulation of exocytosis; The somatomedins and their actions; The ontogeny of estrogen receptors; Epidermal growth factors; Sites of action of androgens and follicle stimulating hormone on cells of the seminiferous tubule; Biochemical properties of the intestinal receptor system for the steroid hormone 1,25-dihydroxyvitamin D; The chick oviduct progesterone receptor; Integrated mammary tumor virus genes: transcriptional regulation by glucocorticoids and specific effects on host gene expression; Induction and regulation of vitellogenin synthesis by estrogen; Multihormonal control of the messenger RNA for the hepatic protein globulin; v.6 - The physiological regulation and function of cAMP-dependent protein kinases; Hormonal and metabolic control of phosphoprotein phosphatase; Structural aspects of steroid hormone and carcinogenic polycyclic aromatic hydrocarbons; Modulation of chemical carcinogenesis by hormones; How important are steroid in regulating the growth of mamary tumors? Biochemical actions of neurohypophysial hormones and nuerophysin; Biochemistry and physiology of cytokinins; Steroid hormone receptors in the central nervous system; Properties of estrogen receptor purified to homogeneity; Hormonal regulation of Globulin in rat liver; v.7 - Chemistry and biological actions of products with thymic hormone-like activity; The hypothalamo-pituitary-liver axis: a new hormonal system in control of hepatic steroid and drug metabolism; Hormonal control of protein degradation in liver and isolated cells; Hormonal regulation in lipid mobilization from adipose tissue; Cell genetics of glucocorticoid responsiveness; The mero-receptor; Hypothalamic control of LHRH and somatostatin: role of central neurotransmitters and intracellular messengers;Androgenic regulation of generalized and specific responses in acessory sexual tissues of the male rat; The molecular biology of thyroid hormone action; v.8 - The messenger function of calcium in endocrine systems; Neuronal regulation of blood pressure; Regulation of protein synthesis by prosphorylation; Hormonal control of hepatic glyconeogenesis; Effects of insulin on intracellular functions; Membrane recognition and effector sites in steroid hormone action; Activation of steroid-receptor complexes; Estradiol and progesterone receptors in human endometrium; v.9 - The lipotropins; Regulation of adenylate cyclase by adrenergic receptors; Nutritional regulation of K+ conductance: an unsettled aspect of pancreatic B cell physiology; Insulin sensitive glucoregulator chemoreceptors in the central nervous system: their putative role in glucose homeostasis; Estrogen-inducible growth factors: proposal of new mechanisms of estrogen-promoted tumor cell growth; Chemical characterization of nuclear acceptors for the avian progesterone receptor; The use of pyridoxal 5'-phosphate as a tool in the study of steroid receptors; Affinity labeling of glucocorticoid receptors: news method in affinity labeling; Immunochemical approaches to the study of glucocorticoid receptors; The properties and the endocrine control of the production of the steroid sulfotransferases; Chemical substitution of steroid hormones: effect on receptor binding and pharmacokinetics; v.10 - The application of recombinant techniques to the study of the control of globulin gene expression; The role of the nuclear matrix in steroid hormone action; Nerve growth factor related hormones; Hormonal regulation of growth hormone synthesis in cell cultures: role of thyroid and glucocorticoid hormone receptors; Factors affecting mammary cells in culture; The secretion and actions of melotonin; The Ah receptor: controlling factor in the induction of drug-metabolizing enzymes by certain chemical carcinogens and other environmental pollutants; Specificity of nucleic acid structure for binding steroid receptors; Mammary tumor growth and response to ovariectomy; Hormonal regulation of estrogen and progesterone receptor systems; Genetic and biochemical studies on glucocorticoid-induced cleft palate; Molecular basis of glucocorticoid resistance in experimental and human leukemia; v.11 - The leukotrienes; Molecular approaches to the study of cyclic AMP action; Molecular mechanism of gonadotropin releasing hormone action; Mechanisms of biological signaling by the insulin receptor; Antibodies to the insulin receptor: studies of receptor structure and function; Insulin biology from the perspective of studies on mammary gland development; Steroid hormone action interpreted from X-ray crystallographic studies; Application of immunochemical techniques to the analysis of estrogen receptors structure and function; Role of the estrogen receptor in estrogen-responsive mammalian cells; Catechol estrogens; Peroxidase: a marker for estrogen expression; Inactivation, activation, and stabilization of glucocorticoid receptors.


Genetic Steroid Disorders

Author by : Sowmya Krishnan
Languange : en
Publisher by : Elsevier Inc. Chapters
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Description : Ambiguous genitalia can be associated with disorders of sex development (DSD). DSD occurs when a person is born with discordant genetic, gonadal, or anatomic sex. Here we discuss typical-appearing external genital appearance in unaffected males and females followed by descriptions of ambiguous genitalia in newborns with 46,XY DSD, 46,XX DSD, syndromes associated with multiple congenital anomalies including, but not limited to, ambiguous genitalia, ovotesticular DSD, and mixed gonadal dysgenesis in newborns who possess a Y chromosome. We provide guidance to proceed with a clinical work-up to differentiation between types of DSD that result in ambiguous genitalia at birth. Finally, we discuss how gender assignments are made for newborns with DSD including ambiguous genitalia.


Cumulated Index Medicus

Author by : Anonim
Languange : en
Publisher by : Unknown
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Neuroactive Steroids In Brain Function Behavior And Neuropsychiatric Disorders

Author by : Abraham Weizman
Languange : en
Publisher by : Springer Science & Business Media
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Description : This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.


Dna And Cell Biology

Author by : Anonim
Languange : en
Publisher by : Unknown
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Research Grants

Author by : National Institutes of Health (U.S.)
Languange : en
Publisher by : Unknown
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Adrenal In Toxicology

Author by : Philip W. Harvey
Languange : en
Publisher by : CRC Press
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Description : The adrenal gland is vitally important to health and secretes hormones that control many bodily processes ranging from normal metabolism to the response to stressful circumstances. The corticosteroid hormones are the basis for anti-inflammatory medicines and are very widely prescribed. Changes in the function of the adrenal gland, either naturally through stress or disease, or through the action of drugs and chemicals, can have a major impact on the body.; This text focuses on adrenal toxicity, examining how drugs and chemicals can directly and indirectly affect this gland. Coverage includes: classification of the types of adrenal and endocrine toxicity; the mechanistic and molecular basis of toxicity; reasons why the adrenal is the most common target organ in the endocrine system; drug toxicity specific to patients with adrenal disorders; drug- corticosteroid interactions; adverse drug reactions; and how the adrenal gland is vital in tolerance to toxic insult.