Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author: Rudolf Jaenisch,Feng Zhang,Fred Gage
Publsiher: Springer
Total Pages: 123
Release: 2017-09-22
ISBN: 9783319601915
Category: Medical
Language: EN, FR, DE, ES & NL

Genome Editing in Neurosciences Book Excerpt:

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author: Rudolf Jaenisch,Feng Zhang,Fred Gage
Publsiher: Springer
Total Pages: 123
Release: 2017-09-14
ISBN: 331960192X
Category: Medical
Language: EN, FR, DE, ES & NL

Genome Editing in Neurosciences Book Excerpt:

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Neuroscience and the Problem of Dual Use

Neuroscience and the Problem of Dual Use
Author: Malcolm R. Dando
Publsiher: Springer Nature
Total Pages: 210
Release: 2020-08-20
ISBN: 3030537900
Category: Medical
Language: EN, FR, DE, ES & NL

Neuroscience and the Problem of Dual Use Book Excerpt:

This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state’s chemical and biological non-proliferation regime’s during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

Programmed Cells from Basic Neuroscience to Therapy

Programmed Cells from Basic Neuroscience to Therapy
Author: Fred H. Gage,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 130
Release: 2013-05-13
ISBN: 3642366481
Category: Medical
Language: EN, FR, DE, ES & NL

Programmed Cells from Basic Neuroscience to Therapy Book Excerpt:

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

Transgenic Neuroscience Research

Transgenic Neuroscience Research
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 90
Release: 2019-04-03
ISBN: 0309488761
Category: Medical
Language: EN, FR, DE, ES & NL

Transgenic Neuroscience Research Book Excerpt:

To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.

Neuroscience and Law

Neuroscience and Law
Author: Antonio D’Aloia,Maria Chiara Errigo
Publsiher: Springer Nature
Total Pages: 568
Release: 2020-06-01
ISBN: 3030388409
Category: Law
Language: EN, FR, DE, ES & NL

Neuroscience and Law Book Excerpt:

There have been extraordinary developments in the field of neuroscience in recent years, sparking a number of discussions within the legal field. This book studies the various interactions between neuroscience and the world of law, and explores how neuroscientific findings could affect some fundamental legal categories and how the law should be implemented in such cases. The book is divided into three main parts. Starting with a general overview of the convergence of neuroscience and law, the first part outlines the importance of their continuous interaction, the challenges that neuroscience poses for the concepts of free will and responsibility, and the peculiar characteristics of a “new” cognitive liberty. In turn, the second part addresses the phenomenon of cognitive and moral enhancement, as well as the uses of neurotechnology and their impacts on health, self-determination and the concept of being human. The third and last part investigates the use of neuroscientific findings in both criminal and civil cases, and seeks to determine whether they can provide valuable evidence and facilitate the assessment of personal responsibility, helping to resolve cases. The book is the result of an interdisciplinary dialogue involving jurists, philosophers, neuroscientists, forensic medicine specialists, and scholars in the humanities; further, it is intended for a broad readership interested in understanding the impacts of scientific and technological developments on people’s lives and on our social systems.

Latin American Perspectives on Scientific Research

Latin American Perspectives on Scientific Research
Author: Fernando Lolas,Eduardo Rodriguez
Publsiher: Cambridge Scholars Publishing
Total Pages: 154
Release: 2019-10-28
ISBN: 1527542335
Category: Medical
Language: EN, FR, DE, ES & NL

Latin American Perspectives on Scientific Research Book Excerpt:

This collection of papers presents case studies and reflections on research bioethics from the standpoint of two Latin American academics involved in the teaching and dissemination of good practices and essential information on bioethics and various related topics. While limited in scope to a few key issues, the text may be read as an inspiration to comparative analyses of research practices involving human subjects and as an example of the reception of fundamental ideas on science and technology adopted in the Latin American region after their development in other areas of the globe.

Neuroscience and Philosophy

Neuroscience and Philosophy
Author: Felipe De Brigard,Walter Sinnott-Armstrong
Publsiher: MIT Press
Total Pages: 506
Release: 2022-02-08
ISBN: 0262362406
Category: Science
Language: EN, FR, DE, ES & NL

Neuroscience and Philosophy Book Excerpt:

Philosophers and neuroscientists address central issues in both fields, including morality, action, mental illness, consciousness, perception, and memory. Philosophers and neuroscientists grapple with the same profound questions involving consciousness, perception, behavior, and moral judgment, but only recently have the two disciplines begun to work together. This volume offers fourteen original chapters that address these issues, each written by a team that includes at least one philosopher and one neuroscientist who integrate disciplinary perspectives and reflect the latest research in both fields. Topics include morality, empathy, agency, the self, mental illness, neuroprediction, optogenetics, pain, vision, consciousness, memory, concepts, mind wandering, and the neural basis of psychological categories. The chapters first address basic issues about our social and moral lives: how we decide to act and ought to act toward each other, how we understand each other’s mental states and selves, and how we deal with pressing social problems regarding crime and mental or brain health. The following chapters consider basic issues about our mental lives: how we classify and recall what we experience, how we see and feel objects in the world, how we ponder plans and alternatives, and how our brains make us conscious and create specific mental states.

Decision Neuroscience

Decision Neuroscience
Author: Jean-Claude Dreher,Leon Tremblay
Publsiher: Academic Press
Total Pages: 440
Release: 2016-09-27
ISBN: 0128053313
Category: Medical
Language: EN, FR, DE, ES & NL

Decision Neuroscience Book Excerpt:

Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological, lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson’s disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience. Provides comprehensive coverage of approaches to studying individual and social decision neuroscience, including primate neurophysiology, brain imaging in healthy humans and in various disorders, and genetic and hormonal influences on decision making Covers multiple levels of analysis, from molecular mechanisms to neural-systems dynamics and computational models of how we make choices Discusses clinical implications of process dysfunctions, including schizophrenia, Parkinson’s disease, eating disorders, drug addiction, and pathological gambling Features chapters from top international researchers in the field and full-color presentation throughout with numerous illustrations to highlight key concepts

The Neuroscience of Intelligence

The Neuroscience of Intelligence
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2022
ISBN: 1107089778
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Neuroscience of Intelligence Book Excerpt:

Model Animals in Neuroendocrinology

Model Animals in Neuroendocrinology
Author: Mike Ludwig,Gil Levkowitz
Publsiher: John Wiley & Sons
Total Pages: 460
Release: 2018-11-05
ISBN: 111939094X
Category: Medical
Language: EN, FR, DE, ES & NL

Model Animals in Neuroendocrinology Book Excerpt:

Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

CRISPR Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

CRISPR  Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases
Author: Luis María Vaschetto
Publsiher: CRC Press
Total Pages: 268
Release: 2022-01-31
ISBN: 1000540812
Category: Mathematics
Language: EN, FR, DE, ES & NL

CRISPR Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases Book Excerpt:

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

The Tools of Neuroscience Experiment

The Tools of Neuroscience Experiment
Author: John Bickle,Carl F. Craver,Ann-Sophie Barwich
Publsiher: Routledge
Total Pages: 362
Release: 2021-12-31
ISBN: 1000531740
Category: Science
Language: EN, FR, DE, ES & NL

The Tools of Neuroscience Experiment Book Excerpt:

This volume establishes the conceptual foundation for sustained investigation into tool development in neuroscience. Neuroscience relies on diverse and sophisticated experimental tools, and its ultimate explanatory target—our brains and hence the organ driving our behaviors—catapults the investigation of these research tools into a philosophical spotlight. The chapters in this volume integrate the currently scattered work on tool development in neuroscience into the broader philosophy of science community. They also present an accessible compendium for neuroscientists interested in the broader theoretical dimensions of their experimental practices. The chapters are divided into five thematic sections. Section 1 discusses the development of revolutionary research tools across neuroscience’s history and argues to various conclusions concerning the relationship between new research tools and theory progress in neuroscience. Section 2 shows how a focus on research tools and their development in neuroscience transforms some traditional epistemological issues and questions about knowledge production in philosophy of science. Section 3 speaks to the most general questions about the way we characterize the nature of the portion of the world that this science addresses. Section 4 discusses hybrid research tools that integrate laboratory and computational methods in exciting new ways. Finally, Section 5 extends research on tool development to the related science of genetics. The Tools of Neuroscience Experiment will be of interest to philosophers and philosophically minded scientists working at the intersection of philosophy and neuroscience.

Neurolaw The Call for Adjusting Theory Based on Scientific Results

Neurolaw  The Call for Adjusting Theory Based on Scientific Results
Author: José M. Muñoz,Eric García-López,Elena Rusconi
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-10
ISBN: 288966208X
Category: Science
Language: EN, FR, DE, ES & NL

Neurolaw The Call for Adjusting Theory Based on Scientific Results Book Excerpt:

Issues in Neuroscience Research and Application 2013 Edition

Issues in Neuroscience Research and Application  2013 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 1210
Release: 2013-05-01
ISBN: 1490107789
Category: Medical
Language: EN, FR, DE, ES & NL

Issues in Neuroscience Research and Application 2013 Edition Book Excerpt:

Issues in Neuroscience Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Clinical Neuroscience. The editors have built Issues in Neuroscience Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Neuroscience in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Translational Neuroscience

Translational Neuroscience
Author: Karoly Nikolich,Steven E. Hyman
Publsiher: MIT Press
Total Pages: 320
Release: 2015-08-21
ISBN: 0262029863
Category: Medical
Language: EN, FR, DE, ES & NL

Translational Neuroscience Book Excerpt:

Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience. Contributors Tobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig

Biotech in China

Biotech in China
Author: Rolf Schmid,Xin Xiong
Publsiher: CRC Press
Total Pages: 344
Release: 2021-07-16
ISBN: 1000294641
Category: Medical
Language: EN, FR, DE, ES & NL

Biotech in China Book Excerpt:

In her quest for global leadership in science and technology, the People’s Republic of China has attained top ranks in the number of scientific publications, "hot papers," or national and international patent applications. However, analysis of the underlying structures and mechanisms is hindered by the sheer flood of data, stringent government control of all media, and ambiguities inherent in translation from Chinese. This book overcomes these difficulties and provides a concise picture of biotechnology-related research and development in China. It begins with brief accounts of China’s geography, people, political and administrational structure, economy, finance, infrastructure related to science and technology, and educational system. It presents succinct accounts on structures and developments in biomedicine, diagnostics, agriculture, fermented food, bioindustry, and environmental biotechnology, with reference to government, industry, and academia. Finally, it predicts the next steps in Chinese biotechnology for the national agenda and, in view of China’s ambitious global development strategy, the Belt and Road Initiative.

Swaiman s Pediatric Neurology E Book

Swaiman s Pediatric Neurology E Book
Author: Kenneth F. Swaiman,Stephen Ashwal,Donna M Ferriero,Nina F Schor,Richard S Finkel,Andrea L Gropman,Phillip L Pearl,Michael Shevell
Publsiher: Elsevier Health Sciences
Total Pages: 2969
Release: 2017-09-21
ISBN: 0323374816
Category: Medical
Language: EN, FR, DE, ES & NL

Swaiman s Pediatric Neurology E Book Book Excerpt:

Since 1975, Dr. Kenneth Swaiman’s classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that’s new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly. New content includes 12 new epilepsy chapters, 5 new cerebrovascular chapters, and 13 new neurooncology chapters, as well as new chapters on neuroimmunology and neuromuscular disorders, as well as chapters focused on clinical care (e.g., Counseling Families, Practice Guidelines, Transitional Care, Personalized Medicine, Special Educational Law, Outcome Measurements, Neurorehabilitation, Impact of Computer Resources, and Training Issues). Additional new chapters cover topics related to the developmental connectome, stem cell transplantation, and cellular and animal models of neurological disease. Greatly expanded sections to increase your knowledge of perinatal acquired and congenital disorders, neurodevelopmental disabilities, pediatric epilepsy, and nonepileptiform paroxysmal disorders and disorders of sleep. Coverage of new, emerging, or controversial topics includes developmental encephalopathies, non-verbal learning disorders, and the pharmacological and future genetic treatment of neurodevelopmental disabilities.

Psychiatric Neuroethics

Psychiatric Neuroethics
Author: Walter Glannon
Publsiher: Oxford University Press
Total Pages: 320
Release: 2018-12-13
ISBN: 0191076619
Category: Medical
Language: EN, FR, DE, ES & NL

Psychiatric Neuroethics Book Excerpt:

Advances in psychiatric research and clinical psychiatry in the last 30 years have given rise to a host of new questions that lie at the intersection of psychiatry, neuroscience, philosophy and law. Such questions include: -Are psychiatric disorders diseases of the brain, caused by dysfunctional neural circuits and neurotransmitters? -What role do genes, neuro-endocrine, neuro-immune interactions and the environment play in the development of these disorders? -How do different explanations of the etiology and pathophysiology of mental illness influence diagnosis, prognosis and decisions about treatment? -Would it be rational for a person with a chronic treatment-resistant disorder to request euthanasia or assisted suicide to end their suffering? -Could psychiatric disorders be predicted and prevented? Psychiatric Neuroethics explores these questions in a comprehensive and systematic way, discussing the medical and philosophical implications of neuroscience and the Research Domain Criteria (RDoc) in the fields of psychiatry and mental health. It examines the extent to which circuit-based criteria can offer a satisfactory explanation of psychiatric disorders and how they compare with the symptom-based criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSMV). This book will be of interest to a multidisciplinary audience, including psychiatrists, neurologists, neurosurgeons, philosophers, psychologists and legal theorists.

Frontiers in Aging Neuroscience Editor s Pick 2021

Frontiers in Aging Neuroscience Editor   s Pick 2021
Author: Thomas Wisniewski
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-08-03
ISBN: 2889711374
Category: Science
Language: EN, FR, DE, ES & NL

Frontiers in Aging Neuroscience Editor s Pick 2021 Book Excerpt: