Immunoinformatics

Immunoinformatics
Author: Darren R. Flower
Publsiher: Springer Science & Business Media
Total Pages: 438
Release: 2008-02-07
ISBN: 160327118X
Category: Science
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Excerpt:

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

Immunoinformatics

Immunoinformatics
Author: Gregory R. Bock,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 272
Release: 2004-03-05
ISBN: 0470090758
Category: Medical
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Excerpt:

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach

Immunoinformatics

Immunoinformatics
Author: Christian Schönbach,Shoba Ranganathan,Vladimir Brusic
Publsiher: Springer Science & Business Media
Total Pages: 200
Release: 2007-11-21
ISBN: 0387729682
Category: Medical
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Excerpt:

In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Immunoinformatics of Cancers

Immunoinformatics of Cancers
Author: Nima Rezaei,Parnian Jabbari
Publsiher: Academic Press
Total Pages: 282
Release: 2022-05-02
ISBN: 0128224304
Category: Medical
Language: EN, FR, DE, ES & NL

Immunoinformatics of Cancers Book Excerpt:

Immunoinformatics of Cancers: Practical Machine Learning Approaches Using R takes a bioinformatics approach to understanding and researching the immunological aspects of malignancies. It details biological and computational principles and the current applications of bioinformatic approaches in the study of human malignancies. Three sections cover the role of immunology in cancers and bioinformatics, including databases and tools, R programming and useful packages, and present the foundations of machine learning. The book then gives practical examples to illuminate the application of immunoinformatics to cancer, along with practical details on how computational and biological approaches can best be integrated. This book provides readers with practical computational knowledge and techniques, including programming, and machine learning, enabling them to understand and pursue the immunological aspects of malignancies. Presents the knowledge researchers need to apply computational techniques to immunodeficiencies Provides the most practical material for bioinformatics approaches to the immunology of cancers Gives straightforward and efficient explanations of programming and machine learning approaches in R Includes details of the most useful databases, tools, programming packages and algorithms for immunoinformatics Illuminates clear explanations with practical examples of immunoinformatic approaches to cancer

Frontiers in Molecular Pharming

Frontiers in Molecular Pharming
Author: Muhammad Sarwar Khan
Publsiher: Bentham Science Publishers
Total Pages: 413
Release: 2021-12-09
ISBN: 981503667X
Category: Science
Language: EN, FR, DE, ES & NL

Frontiers in Molecular Pharming Book Excerpt:

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Proceedings of ICI Milan 2013

Proceedings of ICI Milan 2013
Author: Alberto Martini,Francesco Dieli,Kendall A Smith,Paola Zanovello,Ronald H. Schwartz,Stefan Carl Wilhelm Meuer,Jerrold Weiss,Francesca Di Rosa,Elizabeth Anne Grice,Carlo Riccardi
Publsiher: Frontiers E-books
Total Pages: 197
Release: 2014-11-11
ISBN: 2889193381
Category: Immunologic diseases. Allergy
Language: EN, FR, DE, ES & NL

Proceedings of ICI Milan 2013 Book Excerpt:

This Research Topic covers all of the major lectures and symposia addresses delivered by invited speakers at the 2013 International Congress in Immunology (ICI) at Milan, Italy, August 22-27, 2013.

Immunoinformatics

Immunoinformatics
Author: Darren R. Flower
Publsiher: Humana Press
Total Pages: 438
Release: 2010-11-19
ISBN: 9781617377259
Category: Science
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Excerpt:

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

Computational Intelligence Techniques for Combating COVID 19

Computational Intelligence Techniques for Combating COVID 19
Author: Sandeep Kautish,Sheng-Lung Peng,Ahmed J. Obaid
Publsiher: Springer Nature
Total Pages: 392
Release: 2021
ISBN: 3030689360
Category: Biomedical engineering
Language: EN, FR, DE, ES & NL

Computational Intelligence Techniques for Combating COVID 19 Book Excerpt:

This book presents the latest cutting edge research, theoretical methods, and novel applications in the field of computational intelligence and computational biological approaches that are aiming to combat COVID-19. The book gives the technological key drivers behind using AI to find drugs that target the virus, shedding light on the structure of COVID-19, detecting the outbreak and spread of new diseases, spotting signs of a COVID-19 infection in medical images, monitoring how the virus and lockdown is affecting mental health, and forecasting how COVID-19 cases and deaths will spread across cities and why. Further, the book helps readers understand computational intelligence techniques combating COVID-19 in a simple and systematic way. Provides a comprehensive reference covering innovations and development of theories, conceptual models and computational algorithms focused on COVID-19; Asserts all relevant research, key themes, complex adaptive systems, metrics and paradigms dedicated towards COVID-19, enabled with evolutionary methods of computational sciences; Explores how AI and computational techniques can help to predict which patients with the virus would go on to develop Acute Respiratory Distress Syndrome (ARDS).

Immunology

Immunology
Author: Anil K. Sharma
Publsiher: CRC Press
Total Pages: 246
Release: 2019-03-07
ISBN: 1351366947
Category: Medical
Language: EN, FR, DE, ES & NL

Immunology Book Excerpt:

Immunology has emerged as a key component of the curricula of graduate and postgraduate courses in biotechnology, microbiology, biochemistry, bioinformatics, and other interdisciplinary fields of biology, including zoology, veterinary science, and medicine. As a basic introductory textbook on one of the fastest-moving and most challenging areas of immunological science, this book contains the most recent information about immunologic mechanisms and their importance, along with various molecular techniques employed in immunology. The short and concise text helps make the structures, processes, and interactions of the immune system easily comprehensible. The book includes chapters on immunoinformatics as well as the immune system of the brain, rarely found in any of the immunology books published so far. Many diverse and interesting aspects of the advances in immunology have also been covered, including tumor immunology and immunodeficiency disorders. The easy-to-understand concepts presented in the textbook make it an ideal companion for learners preparing for competitive and other examinations. Undergraduate, postgraduate, and PhD students, people from the industry and academia, and research scholars will immensely benefit from it.

Infectious Disease Informatics

Infectious Disease Informatics
Author: Vitali Sintchenko
Publsiher: Springer Science & Business Media
Total Pages: 434
Release: 2009-12-08
ISBN: 1441913270
Category: Medical
Language: EN, FR, DE, ES & NL

Infectious Disease Informatics Book Excerpt:

There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.

Structure and Function of Antibodies

Structure and Function of Antibodies
Author: Roy Jefferis,Koichi Kato,William R. (Bill) Strohl
Publsiher: MDPI
Total Pages: 440
Release: 2021-02-05
ISBN: 3039438972
Category: Science
Language: EN, FR, DE, ES & NL

Structure and Function of Antibodies Book Excerpt:

This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.

Preclinical Development Handbook

Preclinical Development Handbook
Author: Shayne Cox Gad
Publsiher: John Wiley & Sons
Total Pages: 1352
Release: 2008-03-21
ISBN: 0470249021
Category: Medical
Language: EN, FR, DE, ES & NL

Preclinical Development Handbook Book Excerpt:

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Translational Informatics

Translational Informatics
Author: Bairong Shen
Publsiher: Springer Nature
Total Pages: 218
Release: 2022-05-20
ISBN: 9811689695
Category: Medical
Language: EN, FR, DE, ES & NL

Translational Informatics Book Excerpt:

This book introduces the translational informatics applied to most aspects of virus infection, including tracking of virus origin, detection and prevention of infection, drug discovery, and vaccine design as well as smart city-level monitoring and controlling of the virus epidemic by government. It covers the informatics for data mining and modelling at molecular, tissue/organ, individual, and population levels. The informatics for immunological mechanisms and the personalized prediction and treatment of infected patients are also summarized. The perspectives on the application of artificial intelligence to the prevention of virus outbreaks are also given. This book will be helpful to readers who are interested in prevention of virus infection, biomedical informatics, and artificial intelligence in medicine and healthcare.

Advances in Bioinformatics

Advances in Bioinformatics
Author: Vijai Singh,Ajay Kumar
Publsiher: Springer Nature
Total Pages: 446
Release: 2021-07-31
ISBN: 9813361913
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Bioinformatics Book Excerpt:

This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.

In Silico Immunology

In Silico Immunology
Author: Darren D.R. Flower,Jon Timmis
Publsiher: Springer Science & Business Media
Total Pages: 451
Release: 2007-04-16
ISBN: 0387392416
Category: Medical
Language: EN, FR, DE, ES & NL

In Silico Immunology Book Excerpt:

This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.

AI for Immunology

AI for Immunology
Author: Louis J. Catania
Publsiher: CRC Press
Total Pages: 106
Release: 2021-01-28
ISBN: 1000369919
Category: Computers
Language: EN, FR, DE, ES & NL

AI for Immunology Book Excerpt:

The bioscience of immunology has given us a better understanding of human health and disease. Artificial intelligence (AI) has elevated that understanding and its applications in immunology to new levels. Together, AI for immunology is an advancing horizon in health care, disease diagnosis, and prevention. From the simple cold to the most advanced autoimmune disorders and now pandemics, AI for immunology is unlocking the causes and cures. Key features: A highly accessible and wide-ranging short introduction to AI for immunology Includes a chapter on COVID-19 and pandemics Includes scientific and clinical considerations, as well as immune and autoimmune diseases

Computer Aided Antibody Design

Computer Aided Antibody Design
Author: Kouhei Tsumoto,Daisuke Kuroda
Publsiher: Springer Nature
Total Pages: 481
Release: 2022-11-08
ISBN: 1071626094
Category: Medical
Language: EN, FR, DE, ES & NL

Computer Aided Antibody Design Book Excerpt:

This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Systems and Computational Biology

Systems and Computational Biology
Author: Ning-Sun Yang
Publsiher: BoD – Books on Demand
Total Pages: 350
Release: 2011-09-12
ISBN: 9533078758
Category: Computers
Language: EN, FR, DE, ES & NL

Systems and Computational Biology Book Excerpt:

Whereas some "microarray" or "bioinformatics" scientists among us may have been criticized as doing "cataloging research", the majority of us believe that we are sincerely exploring new scientific and technological systems to benefit human health, human food and animal feed production, and environmental protections. Indeed, we are humbled by the complexity, extent and beauty of cross-talks in various biological systems; on the other hand, we are becoming more educated and are able to start addressing honestly and skillfully the various important issues concerning translational medicine, global agriculture, and the environment. The two volumes of this book present a series of high-quality research or review articles in a timely fashion to this emerging research field of our scientific community.

Current trends in Bioinformatics An Insight

Current trends in Bioinformatics  An Insight
Author: Gulshan Wadhwa,P. Shanmughavel,Atul Kumar Singh,Jayesh R. Bellare
Publsiher: Springer
Total Pages: 332
Release: 2018-07-09
ISBN: 9811074836
Category: Science
Language: EN, FR, DE, ES & NL

Current trends in Bioinformatics An Insight Book Excerpt:

This book highlights the latest breakthrough developments in bioinformatics. It presents a series of timely, in-depth reviews, drug clinical trial studies, biodiversity informatics and thematic issues. In addition, it includes insightful reviews on advances in computational molecular/structural biology, which address areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Innovations in these fields have direct impacts on key issues related to healthcare, medicine, genetic disorders, the development of agricultural products, renewable energy, and environmental protection. Written by respected leaders in the field and covering a wide range of topics involving the integration of biology with computer and information science, the book offers an ideal basis for teaching at the undergraduate and graduate levels. It can also be used for self-instruction by research investigators interested in applying bioinformatics-based analytical methods and information technologists working with academic and industrial laboratories.

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS CoV2 Infection

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS CoV2 Infection
Author: Arpana Parihar,Raju Khan,Ashok Kumar,Ajeet Kumar Kaushik,Hardik Gohel
Publsiher: Academic Press
Total Pages: 618
Release: 2022-07-20
ISBN: 0323998003
Category: Medical
Language: EN, FR, DE, ES & NL

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS CoV2 Infection Book Excerpt:

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools