Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
Author: Claudio Cobelli,Ewart Carson
Publsiher: Academic Press
Total Pages: 384
Release: 2019-08-01
ISBN: 0128158050
Category: Computers
Language: EN, FR, DE, ES & NL

Introduction to Modeling in Physiology and Medicine Book Excerpt:

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning

Personalized Predictive Modeling in Type 1 Diabetes

Personalized Predictive Modeling in Type 1 Diabetes
Author: Eleni I. Georga,Dimitrios I Fotiadis,Stelios K. Tigas
Publsiher: Academic Press
Total Pages: 252
Release: 2017-12-11
ISBN: 0128051469
Category: Medical
Language: EN, FR, DE, ES & NL

Personalized Predictive Modeling in Type 1 Diabetes Book Excerpt:

Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures. Describes fundamentals of modeling techniques as applied to glucose control Covers model selection process and model validation Offers computer code on a companion website to show implementation of models and algorithms Features the latest developments in the field of diabetes predictive modeling

Introduction to Modeling in Physiology and Medicine

Introduction to Modeling in Physiology and Medicine
Author: Claudio Cobelli,Ewart Carson
Publsiher: Academic Press
Total Pages: 328
Release: 2008-02-06
ISBN: 9780080559988
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Introduction to Modeling in Physiology and Medicine Book Excerpt:

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Military Quantitative Physiology

Military Quantitative Physiology
Author: Karl Friedl,Office of the Surgeon General,William R. Santee,Borden Institute (U.S.),Martha K. Lenhart
Publsiher: Department of the Army
Total Pages: 383
Release: 2012
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Military Quantitative Physiology Book Excerpt:

NOTE: NO FURTHER DISCOUNT FOR THIS PRINT PRODUCT- OVERSTOCK SALE -- Significantly reduced list price Few human activities demand or deserve as much attention of the citizens of a nation as the array of man-made and natural "environmental" threats faced by the soldiers and other warriors defending the nation - those that pose the risk of disease, injury, combat wounds, and even death. This book is the Army's first detailing research in computational physiology models and highlighting pivotal research. It outlines the extent to which basic and applied biomedical scientists, clinicians, modelers, and others stribe to understand the extent of these threats, and provide intellectual and materiel options to mitigate these risks. This book summarizes major Army research efforts to quantify and model military relevant physiology. These chapters highlight the translation of this research into useful predictive tools. The tools are of importance to medical planners, materiel developers, commanders, and in many cases, every soldier. These chapters detail the experimental basis for many of the predictive tools that are currently in use. This book is written for military clinicians, and medical researchers who may be reasonably expected to explain some of the background, as well as those who will extend the research. Many people will find this book interesting because it details research on topics that affect everyone in everyday life, including how we sleep, eat, and exercise, as well as more specific topics such as the effects of caffeine on performance, risks associated with laser pointers, and even Army blast models that have influenced safety thresholds for car airbag deployments.

Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine
Author: Ewart Carson,Claudio Cobelli
Publsiher: Newnes
Total Pages: 588
Release: 2013-12-05
ISBN: 0124095259
Category: Science
Language: EN, FR, DE, ES & NL

Modelling Methodology for Physiology and Medicine Book Excerpt:

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

Modeling and Simulation in Medicine and the Life Sciences

Modeling and Simulation in Medicine and the Life Sciences
Author: Frank C. Hoppensteadt,Charles S. Peskin
Publsiher: Springer Science & Business Media
Total Pages: 355
Release: 2012-12-06
ISBN: 0387215719
Category: Mathematics
Language: EN, FR, DE, ES & NL

Modeling and Simulation in Medicine and the Life Sciences Book Excerpt:

The result of lectures given by the authors at New York University, the University of Utah, and Michigan State University, the material is written for students who have had only one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well as solutions to selected exercises, so as to lead readers to discover interesting extensions of that material. Throughout, illustrations depict physiological processes, population biology phenomena, corresponding models, and the results of computer simulations. Topics covered range from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models.

Nonlinear Dynamic Modeling of Physiological Systems

Nonlinear Dynamic Modeling of Physiological Systems
Author: Professor Vasilis Z. Marmarelis
Publsiher: John Wiley & Sons
Total Pages: 560
Release: 2004-09-03
ISBN: 9780471469605
Category: Medical
Language: EN, FR, DE, ES & NL

Nonlinear Dynamic Modeling of Physiological Systems Book Excerpt:

The study of nonlinearities in physiology has been hindered by the lack of effective ways to obtain nonlinear dynamic models from stimulus-response data in a practical context. A considerable body of knowledge has accumulated over the last thirty years in this area of research. This book summarizes that progress, and details the most recent methodologies that offer practical solutions to this daunting problem. Implementation and application are discussed, and examples are provided using both synthetic and actual experimental data. This essential study of nonlinearities in physiology apprises researchers and students of the latest findings and techniques in the field.

Pain Mechanisms and Management

Pain Mechanisms and Management
Author: S. N. Ayapetian,A. V. Apkarian
Publsiher: IOS Press
Total Pages: 390
Release: 1998
ISBN: 9789051993066
Category: Medical
Language: EN, FR, DE, ES & NL

Pain Mechanisms and Management Book Excerpt:

The overall themes of this book are recent advances in mechanisms of pain and the application of those in clinics. Specific attention is paid to developing countries where practice of pain management seriously lags behind current scientific understanding. Both the local traditions for curing pain and the substances used are presented in this book.

Modelling Organs Tissues Cells and Devices

Modelling Organs  Tissues  Cells and Devices
Author: Socrates Dokos
Publsiher: Springer
Total Pages: 502
Release: 2017-03-08
ISBN: 3642548016
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Modelling Organs Tissues Cells and Devices Book Excerpt:

This book presents a theoretical and practical overview of computational modeling in bioengineering, focusing on a range of applications including electrical stimulation of neural and cardiac tissue, implantable drug delivery, cancer therapy, biomechanics, cardiovascular dynamics, as well as fluid-structure interaction for modelling of organs, tissues, cells and devices. It covers the basic principles of modeling and simulation with ordinary and partial differential equations using MATLAB and COMSOL Multiphysics numerical software. The target audience primarily comprises postgraduate students and researchers, but the book may also be beneficial for practitioners in the medical device industry.

Modeling and Simulation in the Medical and Health Sciences

Modeling and Simulation in the Medical and Health Sciences
Author: John A. Sokolowski,Catherine M. Banks
Publsiher: John Wiley & Sons
Total Pages: 228
Release: 2012-01-25
ISBN: 1118003195
Category: Mathematics
Language: EN, FR, DE, ES & NL

Modeling and Simulation in the Medical and Health Sciences Book Excerpt:

This edited book is divided into three parts: Fundamentals of Medical and Health Sciences Modeling and Simulation introduces modeling and simulation in the medical and health sciences; Medical and Health Sciences Models provides the theoretical underpinnings of medical and health sciences modeling; and Modeling and Simulation Applications in Medical and Health Sciences focuses on teaching, training, and research applications. The book begins with a general discussion of modeling and simulation from the modeling and simulation discipline perspective. This discussion grounds the reader in common terminology. It also relates this terminology to concepts found in the medical and health care (MHC) area to help bridge the gap between developers and MHC practitioners. Three distinct modes of modeling and simulation are described: live, constructive, and virtual. The live approach explains the concept of using real (live) people employing real equipment for training purposes. The constructive mode is a means of engaging medical modeling and simulation. In constructive simulation, simulated people and simulated equipment are developed to augment real-world conditions for training or experimentation purposes. The virtual mode is perhaps the most fascinating as virtual operating rooms and synthetic training environments are being produced for practitioners and educators at break-neck speed. In this mode, real people are employing simulated equipment to improve physical skills and decision-making ability.

Modeling of Physiological Flows

Modeling of Physiological Flows
Author: Davide Ambrosi,Alfio Quarteroni,Gianluigi Rozza
Publsiher: Springer Science & Business Media
Total Pages: 418
Release: 2012-10-31
ISBN: 8847019354
Category: Mathematics
Language: EN, FR, DE, ES & NL

Modeling of Physiological Flows Book Excerpt:

This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.

Safety Pharmacology Risk Assessment QT Interval Prolongation and Beyond

Safety Pharmacology   Risk Assessment QT Interval Prolongation and Beyond
Author: Esther Pueyo,Blanca Rodriguez
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-08-16
ISBN: 2889455394
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Safety Pharmacology Risk Assessment QT Interval Prolongation and Beyond Book Excerpt:

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

Mathematics in Medicine and the Life Sciences

Mathematics in Medicine and the Life Sciences
Author: Frank C. Hoppensteadt,Charles S. Peskin
Publsiher: Springer Science & Business Media
Total Pages: 252
Release: 2013-03-09
ISBN: 1475741316
Category: Mathematics
Language: EN, FR, DE, ES & NL

Mathematics in Medicine and the Life Sciences Book Excerpt:

The aim of this book is to introduce the subject of mathematical modeling in the life sciences. It is intended for students of mathematics, the physical sciences, and engineering who are curious about biology. Additionally, it will be useful to students of the life sciences and medicine who are unsatisfied with mere description and who seek an understanding of biological mechanism and dynamics through the use of mathematics. The book will be particularly useful to premedical students, because it will introduce them not only to a collection of mathematical methods but also to an assortment of phenomena involving genetics, epidemics, and the physiology of the heart, lung, and kidney. Because of its introductory character, mathematical prerequisites are kept to a minimum; they involve only what is usually covered in the first semester of a calculus sequence. The authors have drawn on their extensive experience as modelers to select examples which are simple enough to be understood at this elementary level and yet realistic enough to capture the essence of significant biological phenomena drawn from the areas of population dynamics and physiology. Because the models presented are realistic, the book can serve not only as an introduction to mathematical methods but also as a mathematical introduction to the biological material itself. For the student, who enjoys mathematics, such an introduction will be far more stimulating and satisfying than the purely descriptive approach that is traditional in the biological sciences.

Modeling and Simulation in Biomedical Engineering Applications in Cardiorespiratory Physiology

Modeling and Simulation in Biomedical Engineering  Applications in Cardiorespiratory Physiology
Author: Willem van Meurs
Publsiher: McGraw Hill Professional
Total Pages: 224
Release: 2011-08-07
ISBN: 0071714464
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Modeling and Simulation in Biomedical Engineering Applications in Cardiorespiratory Physiology Book Excerpt:

THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN: 1928374650XXX
Category: Bibliography, National
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Excerpt:

Mathematical Modeling of Cardiovascular Systems From Physiology to the Clinic

Mathematical Modeling of Cardiovascular Systems  From Physiology to the Clinic
Author: Julius Guccione,Ghassan S. Kassab
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-01-13
ISBN: 2889633233
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Mathematical Modeling of Cardiovascular Systems From Physiology to the Clinic Book Excerpt:

Control Theory in Biomedical Engineering

Control Theory in Biomedical Engineering
Author: Olfa Boubaker
Publsiher: Academic Press
Total Pages: 396
Release: 2020-06-30
ISBN: 0128226218
Category: Science
Language: EN, FR, DE, ES & NL

Control Theory in Biomedical Engineering Book Excerpt:

Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices). Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation

World Congress on Medical Physics and Biomedical Engineering June 7 12 2015 Toronto Canada

World Congress on Medical Physics and Biomedical Engineering  June 7 12  2015  Toronto  Canada
Author: David A. Jaffray
Publsiher: Springer
Total Pages: 1778
Release: 2015-07-13
ISBN: 3319193872
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

World Congress on Medical Physics and Biomedical Engineering June 7 12 2015 Toronto Canada Book Excerpt:

This book presents the proceedings of the IUPESM World Biomedical Engineering and Medical Physics, a tri-annual high-level policy meeting dedicated exclusively to furthering the role of biomedical engineering and medical physics in medicine. The book offers papers about emerging issues related to the development and sustainability of the role and impact of medical physicists and biomedical engineers in medicine and healthcare. It provides a unique and important forum to secure a coordinated, multileveled global response to the need, demand and importance of creating and supporting strong academic and clinical teams of biomedical engineers and medical physicists for the benefit of human health.

Announcement

Announcement
Author: University of California, Los Angeles. School of Medicine
Publsiher: Unknown
Total Pages: 135
Release: 1992
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Announcement Book Excerpt:

Systems Medicine

Systems Medicine
Author: Anonim
Publsiher: Academic Press
Total Pages: 1589
Release: 2020-08-24
ISBN: 0128160780
Category: Science
Language: EN, FR, DE, ES & NL

Systems Medicine Book Excerpt:

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information