Liposomes Lipid Bilayers And Model Membranes

Author by : Georg Pabst
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 65
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File Size : 51,5 Mb
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Description : As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.


Advances In Planar Lipid Bilayers And Liposomes

Author by : A. Leitmannova Liu
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 486
File Size : 42,7 Mb
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Description : The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series. This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications * Authoritative timely reviews by experts in this field * Indispensable source of information for new scientists


Liposomes Lipid Bilayers And Model Membranes

Author by : Georg Pabst
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 17
Total Download : 582
File Size : 50,5 Mb
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Description : As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evo


Advances In Biomembranes And Lipid Self Assembly

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 25
Total Download : 292
File Size : 51,9 Mb
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Description : Advances in Biomembranes and Lipid Self-assembly, Volume 31, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Moreover, the book discusses how lipids self-assemble into a wide range of other structures, including micelles and the liquid crystalline hexagonal and cubic phases. Chapters in this volume present both original research and comprehensive reviews written by world leading experts and young researchers. Surveys recent theoretical and experimental results on lipid micro- and nanostructures Presents potential use applications, such as clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products Includes both original research and comprehensive reviews written by world-leading experts and young researchers Provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes, and lipid self-assemblies, from the micro- to the nanoscale


Liposomes

Author by : Volkmar Weissig
Languange : en
Publisher by : Humana Press
Format Available : PDF, ePub, Mobi
Total Read : 46
Total Download : 539
File Size : 46,6 Mb
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Description : Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.


Advances In Planar Lipid Bilayers And Liposomes

Author by : A. Leitmannova Liu
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 9
Total Download : 460
File Size : 47,9 Mb
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Description : Advances in Planar Lipid Bilayers and Liposomes, Volume 7, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group. Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide. * Contributions from newcomers and established and experienced researchers * Exploring theoretically and experimentally the planar lipid bilayer systems and spherical liposomes * Indispensable source of information for new scientists


Structure And Dynamics Of Membranes

Author by : R. Lipowsky
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 99
Total Download : 744
File Size : 44,6 Mb
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Description : The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateral phase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes with polymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process of contact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned about the interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.


Advances In Planar Lipid Bilayers And Liposomes

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 68
Total Download : 174
File Size : 46,7 Mb
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Description : Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists


Lipid Bilayers

Author by : J. Katsaras
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 24
Total Download : 306
File Size : 41,8 Mb
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Description : Provides the reader with an up to date insight of the current state of the art in the field of lipid bilayer research and the important insights derived for the understanding of the complex and varied behaviour of biological membranes and its function.


Structure And Dynamics Of Membranes

Author by : R. Lipowsky
Languange : en
Publisher by : North Holland
Format Available : PDF, ePub, Mobi
Total Read : 34
Total Download : 730
File Size : 50,6 Mb
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Description : The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateral phase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes with polymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process of contact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned about the interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.


Drug Biomembrane Interaction Studies

Author by : A. Wiśniewska-Becker
Languange : en
Publisher by : Elsevier Inc. Chapters
Format Available : PDF, ePub, Mobi
Total Read : 11
Total Download : 727
File Size : 49,6 Mb
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Description : Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical techniques are used with these models to study membrane properties and their changes under different environmental factors. This chapter describes common membrane models and some of their applications. There are two groups of models: vesicular models (micelles, bicelles and liposomes) and planar ones (lipid monolayers, supported lipid bilayers, black lipid membranes). The advantages and disadvantages of both types are discussed as well as their usefulness for particular biophysical techniques.


Planar Lipid Bilayers

Author by : W. Hanke
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 36
Total Download : 642
File Size : 52,6 Mb
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Description : Biological Techniques is a series of volumes aimed at introducing to a wide audience the latest advances in methodology. The pitfalls and problems of new techniques are given due consideration, as are those small but vital details not always explicit in the methods sections of journal papers. In recent years, most biological laboratories have been invaded by computers and a wealth of new DNA technology and this will be reflected in many of the titles appearing in the series. The books will be of value to advanced researchers and graduate students seeking to learn and apply new techniques, and will be useful to teachers of advanced undergraduate courses involving practical or project work. Methods of constructing artificial membranes (planar lipid bilayers) from the main components of cell membranes (lipids) date from the early 1960s. Planar bilayers offer direct, quantitative experimental approaches to the study of membranes of precisely determined composition which can be manipulated by the experimenter. Pore-forming molecules, transporter molecules, ATP-dependent enzymes and other entities can be incorporated into the bilayers to simulate biological functions. Reconstitution of such functions in this way remains a key final step in attributing a functional role to purified cell membrane proteins. This book aims to demystify these techniques and begins with a broad overview of the development of the subject before dealing with the protocols involved. Key references are provided at the end of the book together with a list of suppliers. Full practical details include: How to set up conventional painted and folded bilayer experiments Patch-dipping methods and use of giant liposomes Lipid characterization, preparation and purification Discussion of construction of essential apparatus, flux measurements, electrical recording, data acquisition and computer support Biochemical methods for use in planar bilayer experiments Techniques for incorporation of native proteins and other molecules


Permeability And Stability Of Lipid Bilayers

Author by : E. Anibal Disalvo
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 84
Total Download : 468
File Size : 46,7 Mb
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Description : This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.


Membrane Active Peptides

Author by : Miguel A. R. B. Castanho
Languange : en
Publisher by : Internat'l University Line
Format Available : PDF, ePub, Mobi
Total Read : 35
Total Download : 896
File Size : 53,8 Mb
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Description :


Current Trends And Future Developments On Bio Membranes

Author by : Angelo Basile
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 19
Total Download : 360
File Size : 45,8 Mb
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Description : Current Trends and Future Developments on (Bio-) Membranes: Membrane Processes in the Pharmaceutical and Biotechnological field presents the main membrane techniques along with their basic principles, mode of operations, and applications. It covers well-known techniques such as ultrafiltration and membrane chromatography, while also exploring emerging membrane technologies which are finding their way in pharmaceutical and biotechnology industries, including membrane emulsification, membrane bioreactors, and solvent-resistant nanofiltration. State-of-the-art applications of membrane systems in areas such as drug delivery and virus removal are also investigated by leading experts in the field. Current Trends and Future Developments on (Bio-) Membranes: Membrane Processes in the Pharmaceutical and Biotechnological field is a definitive reference for academics, post-graduates, and researchers in the subjects of biochemical engineering, pharmaceutics, and biotechnology. It is also useful to R&D companies and institutions in these areas, specifically those interested in bioseparations, biopurification, bioproduction, and drug delivery. Offers an overview of classical membrane-based separation techniques such as ultrafiltration, microfiltration and virus filtration Discusses emerging membrane-based separation techniques such as nofiltration in the presence of solvent, membrane emulsification and membrane crystallization Outlines their applications to bioseparation, biopurification and bioproduction Includes examples in the production of vaccines, antibiotics, biomolecules, drugs, DNA and cells Lists membranes systems for drug delivery like liposomes, nanocapsules and bilayer membranes


Advances In Planar Lipid Bilayers And Liposomes

Author by : A. Leitmannova Liu
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 143
File Size : 55,6 Mb
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Description : Advances in Planar Lipid Bilayers and Liposomes, Volume 9, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group. Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide. * Incorporates contributions from newcomers and established and experienced researchers * Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives * Serves as an indispensable source of information for new scientists


Drug Partitioning And Solvation Environments In Lipid Bilayers

Author by : Anonim
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 89
Total Download : 776
File Size : 46,5 Mb
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Description : The main goal of this research project was to investigate various factors influencing solute partitioning and solvation in lipid bilayer membranes using liposomes as biomembrane models and applying a combination of spectroscopic and capillary electrophoresis techniques. The first area of investigation involved using a series of polarity sensitive solvatochromic indicators to probe the dipolarity of various phospholipid and synthetic surfactant vesicles. A homologous series of probes of varying hydrophobicity allowed a systematic probing of the dipolarity in the interfacial region of the vesicles and resulted in very specific polarity information for various regions or microenvironments depending on the probes positions. This dipolarity was examined in terms of vesicle size and composition, in addition to indicator partitioning behavior. To develop Liposome Electrokinetic Chromatography (LEKC) as a method for rapidly determining liposome - water distribution coefficients, the effects of various parameters on the retention of basic drugs in liposomes were examined. This included characterizing the electrostatics of interactions between charged drugs and charged lipid membranes by examining the effect of membrane and buffer compositions. Additionally, LEKC was used to determine the effect of pH on the partitioning of basic drugs into liposomes composed of lipids which mimic the composition of natural cell membranes. Drug partitioning as a function of pH is examined in detail in terms of the fractions of charged and neutral drug forms in the aqueous and lipid phases. An increase in pH results in a smaller degree of ionization of the basic drugs and consequently leads to a lower degree of interaction with the negatively charged membranes. Finally, LEKC retention was used in QSAR studies for the evaluation of membrane permeability and intestinal absorption. LEKC retention factor data was correlated with human oral absorption in comparison with other methods such as octano.


Membrane Biophysics As Viewed From Experimental Bilayer Lipid Membranes

Author by : H.T. Tien †
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 20
Total Download : 373
File Size : 55,5 Mb
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Description : This book summarizes the current status of research on bilayer lipid membranes (planar lipid bilayers and spherical liposomes). In addition to describing the properties of lipid bilayers and examining biomembrane phenomena, the book has two other objectives. The first is to present practical methods for the formation and study of lipid bilayers with either aqueous or metal-lipid bilayer interfaces. The second aim is to treat planar lipid bilayers as a new type of interfacial adsorption phenomena. The first nine chapters cover properties of biomembranes, basic principles of membrane biophysics, transport, electrochemistry, physiology, bioenergetics, and photobiology. Chapter 10 presents the following topics: lipid bilayers in medicine, supported lipid bilayers as sensors, a short discussion of liposomes, and solar energy transduction via semiconductor septum photovoltaic cells based on natural photosynthesis.


Liposomes

Author by : Volkmar Weissig
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 77
Total Download : 228
File Size : 43,7 Mb
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Description :


Characterization Of Biological Membranes

Author by : Mu-Ping Nieh
Languange : en
Publisher by : Walter de Gruyter GmbH & Co KG
Format Available : PDF, ePub, Mobi
Total Read : 89
Total Download : 286
File Size : 54,8 Mb
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Description : The study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.


Liposomes

Author by : Volkmar Weissig
Languange : en
Publisher by : Humana
Format Available : PDF, ePub, Mobi
Total Read : 43
Total Download : 645
File Size : 47,8 Mb
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Description : Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.


Advances In Planar Lipid Bilayers And Liposomes

Author by : H.T. Tien ?
Languange : en
Publisher by : Gulf Professional Publishing
Format Available : PDF, ePub, Mobi
Total Read : 79
Total Download : 679
File Size : 44,8 Mb
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Description : The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series. This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications * Authoritative timely reviews by experts in this field * Indispensable source of information for new scientists


Biomimetic Lipid Membranes Fundamentals Applications And Commercialization

Author by : Fatma N. Kök
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 73
Total Download : 244
File Size : 55,9 Mb
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Description : This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.


Characterization Of Biological Membranes

Author by : Mu-Ping Nieh
Languange : en
Publisher by : Walter de Gruyter GmbH & Co KG
Format Available : PDF, ePub, Mobi
Total Read : 62
Total Download : 469
File Size : 50,8 Mb
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Description : The study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.


Advances In Planar Lipid Bilayers And Liposomes

Author by : Ales Iglic
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 52
Total Download : 681
File Size : 50,7 Mb
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Description : Advances in Planar Lipid Bilayers and Liposomes, Volume 11, includes invited chapters on a broad range of topics, covering both of the main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. This volume addresses the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide. Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists


Membrane Biophysics

Author by : H. Ti Tien
Languange : en
Publisher by : Elsevier Science Serials
Format Available : PDF, ePub, Mobi
Total Read : 53
Total Download : 402
File Size : 53,9 Mb
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Description : This book summarizes the current status of research on bilayer lipid membranes (planar lipid bilayers and spherical liposomes). In addition to describing the properties of lipid bilayers and examining biomembrane phenomena, the book has two other objectives. The first is to present practical methods for the formation and study of lipid bilayers with either aqueous or metal-lipid bilayer interfaces. The second aim is to treat planar lipid bilayers as a new type of interfacial adsorption phenomena. The first nine chapters cover properties of biomembranes, basic principles of membrane biophysics, transport, electrochemistry, physiology, bioenergetics, and photobiology. Chapter 10 presents the following topics: lipid bilayers in medicine, supported lipid bilayers as sensors, a short discussion of liposomes, and solar energy transduction via semiconductor septum photovoltaic cells based on natural photosynthesis.


Drug Biomembrane Interaction Studies

Author by : T. Musumeci
Languange : en
Publisher by : Elsevier Inc. Chapters
Format Available : PDF, ePub, Mobi
Total Read : 42
Total Download : 118
File Size : 52,6 Mb
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Description : Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the effects of such drugs. We discuss interaction studies in the recent literature that use calorimetric techniques, regarding the mechanism of action or side effects of antimicrobial agents. For interaction studies with mimetic membrane models using DSC analysis, we will try to answer some key questions: (a) Does lipid composition affect the interaction? (b) Does the composition of bilayers influence the secondary structure of a peptide antimicrobial? (c) Does lipid polymorphism influence the activity and toxicity of the molecules? We underline the importance of phospholipids (neutral or anionic) chosen to produce biomembrane vesicles as models for the different studies.


Handbook Of Nonmedical Applications Of Liposomes

Author by : Danilo D. Lasic
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 12
Total Download : 588
File Size : 45,6 Mb
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Description : Liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. They are thoroughly studied in several applications, such as drug delivery systems in medical applications and as controlled release systems, microencapsulating media, signal carriers, support matrices, and solubilizers in other applications. While medical applications have been extensively reviewed in recent literature, there is a need for easily accessible information on applications for liposomes beyond pharmacology and medicine. The Handbook of Nonmedical Applications of Liposomes fills this void. This unique new handbook series presents recent developments in the use of liposomes in many scientific disciplines, from studies on the origin of life, protein function, and vesicle shapes, to applications in cosmetics, diagnostics, ecology, bioreclamation, and the food industry. In these volumes many of the top experts contribute extensive reviews of their work.


A Calorimetric And Spectroscopic Study Of The Interactions Between Model Lipid Membrane Bilayers And Simple Sugars

Author by : Edward Pennington
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 36
Total Download : 155
File Size : 55,7 Mb
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Description : It is well known that various organisms, such as the tardigrade, naturally use carbohydrates, particularly disaccharides, to help preserve their cell structural and functional integrity during freezing or dehydration. There have been many different studies that have focused on investigating how certain sugars may help to preserve the structural and functional integrity of biological cells throughout such extreme conditions. These studies have used lipids as a simple and effective alternative to studying how small molecules, such as disaccharides, interact with model lipid membrane bilayers. Lipid bilayers, also known as liposomes, have classically been used to study and better understand the structure of membrane bilayers since their phase behavior is very well understood. Therefore, liposomes are often used to investigate how small molecules interact with membrane bilayers, and how these interactions translate into physical, structural, and potential biological changes. Differential scanning calorimetry (DSC) and infrared spectroscopy were used to examine the thermotropic phase behavior of model liposome membranes in the presence of either sucrose or sucralose. The data indicates that membranes are dehydrated and form an interdigitated layer in the presence of sucralose, but not in the presence of sucrose. We hypothesize that this behavior is due to the different hydrophobic properties of the sugars and that sucralose may penetrate the bilayer whereas sucrose will not. Additionally, at higher concentrations of sucralose the data suggests that sucralose may hydrogen bond to the polar head groups, particularly to the phosphate region of the lipid molecule, in an effort to stabilize the membrane bilayer and Van de Waals forces upon interdigitation. This study demonstrates that sucralose has a significant effect on the phase behavior of liposomes, and its usefulness as a possible cryoprotecting agent for the preservation of biological cells and tissues is of great interest and needs to be comprehensively investigated.


Novel Drug Delivery Systems For Phytoconstituents

Author by : Madhu Gupta
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 47
Total Download : 209
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Description : Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.