Liquid Biopsy

Liquid Biopsy
Author: Antonio Russo,Ettore Capoluongo,Antonio Galvano,Antonio Giordano
Publsiher: Academic Press
Total Pages: 250
Release: 2021-05-15
ISBN: 9780128227039
Category: Science
Language: EN, FR, DE, ES & NL

Liquid Biopsy Book Excerpt:

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research. The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy. Presents a "highlights section” in every chapter to help readers summarize the main aspects discussed Encompasses case reports to guide the reader on applying what they read in their clinical practice Includes several tables and figures specially created for the book to illustrate the meaning of what is expressed in the text

Liquid Biopsy as a Tool for Precision Oncology New Challenges to Assess Clinical Response

Liquid Biopsy as a Tool for Precision Oncology  New Challenges to Assess Clinical Response
Author: Gloria Ravegnini,Ambra A. Grolla,Marzia Del Re,Sabrina Angelini,Ron H. van Schaik
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-10
ISBN: 2889662020
Category: Science
Language: EN, FR, DE, ES & NL

Liquid Biopsy as a Tool for Precision Oncology New Challenges to Assess Clinical Response Book Excerpt:

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author: Claudio Carini,Mark Fidock,Alain van Gool
Publsiher: CRC Press
Total Pages: 631
Release: 2019-04-16
ISBN: 0429576730
Category: Mathematics
Language: EN, FR, DE, ES & NL

Handbook of Biomarkers and Precision Medicine Book Excerpt:

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Advances in Genetics

Advances in Genetics
Author: Dhavendra Kumar
Publsiher: Academic Press
Total Pages: 396
Release: 2021-12-01
ISBN: 0128237864
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Genetics Book Excerpt:

Advances in Genetics, Volume 108 provides the latest information on genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Clinical applications of cancer genetics and genomics, Epigenetic mutations in childhood tumors- the paradigm of Wilms tumor, Preventive population genomics-the model of BRCA related cancers, Recent advances of PARP inhibitors in medical oncology, Role of single cell and liquid biopsy in cancer research and clinical applications. Other chapters cover Recent advances and clinical utility of prostate cancer genomics, Recent advances in lung cancer genomics- applications in targeted therapy, and more. Critically analyzes future directions for the study of clinical genetics Written and edited by recognized leaders in the field Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics

Cancer Complexity Computation

Cancer  Complexity  Computation
Author: Igor Balaz,Andrew Adamatzky
Publsiher: Springer Nature
Total Pages: 349
Release: 2022-09-17
ISBN: 3031043790
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Cancer Complexity Computation Book Excerpt:

This book presents unique compendium of groundbreaking ideas where scientists from many different backgrounds are united in their interest in interdisciplinary approaches towards origins and development of cancers, innovative ways of searching for cancer treatment and the role of cancer in the evolution. Chapters give an unequivocal slice of all areas that relate to a quest for understanding cancer and its origin as many-fold nonlinear system, complexity of the cancer developments, a search for cancer treatment using artificial intelligence and evolutionary optimisation, novel modelling techniques, molecular origin of cancer, the role of cancer in evolution of species, interpretation of cancer in terms of artificial life and artificial immune systems, swarm intelligence, cellular automata, computational systems biology, genetic networks, cellular computing, validation through in vitro/vivo tumour models and tumour on chip devices. The book is an inspiring blend of theoretical and experimental results, concepts and paradigms. Distinctive features The book advances widely popular topics of cancer origin, treatment and understanding of its progress The book is comprised of unique chapters written by world top experts in theoretical and applied oncology, complexity theory, mathematics, computer science. The book illustrates attractive examples of mathematical and computer models and experimental setups.

Advancing the Science of Cancer in Latinos

Advancing the Science of Cancer in Latinos
Author: Amelie G. Ramirez,Edward J. Trapido
Publsiher: Springer Nature
Total Pages: 329
Release: 2019-11-21
ISBN: 303029286X
Category: Medical
Language: EN, FR, DE, ES & NL

Advancing the Science of Cancer in Latinos Book Excerpt:

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. EnvironmentBreast cancer risk and mortality in women of Latin American originDifferential cancer risk in Latinos: The role of dietOvercoming barriers for Latinos on cancer clinical trialsEs tiempo: Engaging Latinas in cervical cancer researchEmerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.

Advancing Healthcare Through Personalized Medicine

Advancing Healthcare Through Personalized Medicine
Author: Priya Hays
Publsiher: Springer Nature
Total Pages: 745
Release: 2021
ISBN: 3030801004
Category: Electronic books
Language: EN, FR, DE, ES & NL

Advancing Healthcare Through Personalized Medicine Book Excerpt:

This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate he healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine
Author: Nosheen Masood,Saima Shakil Malik
Publsiher: Springer Nature
Total Pages: 499
Release: 2020-03-20
ISBN: 9811510679
Category: Medical
Language: EN, FR, DE, ES & NL

Essentials of Cancer Genomic Computational Approaches and Precision Medicine Book Excerpt:

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Precision Medicine and Distributive Justice

Precision Medicine and Distributive Justice
Author: Leonard M. Fleck
Publsiher: Oxford University Press
Total Pages: 433
Release: 2022
ISBN: 0197647723
Category: Health care rationing
Language: EN, FR, DE, ES & NL

Precision Medicine and Distributive Justice Book Excerpt:

Metastatic cancer and costly precision medicines generate extremely complex problems of health care justice. Targeted cancer therapies yield only very marginal gains in life expectancy for most patients at very great cost, thereby threatening the just allocation of limited health careresources. Philosophers have high hopes for the utility of their theories of justice in addressing the challenges of resource allocation; however, none of these theories can address adequately the "wicked" ethical problems that have resulted from these targeted therapies.What we need instead, bioethicist Leonard M. Fleck argues, is a political conception of health care justice, following Rawls, and a fair and inclusive process of rational democratic deliberation governed by public reason. His account makes the basic assumption that we have only limited health careresources to meet unlimited health care needs generated by emerging medical technologies. The primary ethical and political virtue of rational democratic deliberation is that it allows citizens to fashion autonomously shared understandings of how to fairly address the complex problems of healthcare justice generated by precision medicine. While ideally just outcomes are a moral and political impossibility, "wicked" problems can metastasize if rationing decisions are made invisibly--in ways effectively hidden from those affected by those decisions. As Fleck demonstrates, a fair andinclusive process of democratic deliberation could make these "wicked" problems visible, and subject, to public reason.

Illuminating Colorectal Cancer Genomics by Next Generation Sequencing

Illuminating Colorectal Cancer Genomics by Next Generation Sequencing
Author: Khalid El Bairi
Publsiher: Springer Nature
Total Pages: 185
Release: 2020-09-28
ISBN: 3030538214
Category: Medical
Language: EN, FR, DE, ES & NL

Illuminating Colorectal Cancer Genomics by Next Generation Sequencing Book Excerpt:

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care.

Partha s Current Trends in Diagnosis Management for Pediatric Adolescent Practitioners

Partha s Current Trends in Diagnosis   Management for Pediatric   Adolescent Practitioners
Author: A Parthasarathy,Alok Gupta
Publsiher: Jaypee Brothers Medical Publishers
Total Pages: 534
Release: 2021-03-10
ISBN: 9390595150
Category: Medical
Language: EN, FR, DE, ES & NL

Partha s Current Trends in Diagnosis Management for Pediatric Adolescent Practitioners Book Excerpt:

Breast Cancer From Bench to Personalized Medicine

Breast Cancer  From Bench to Personalized Medicine
Author: Saima Shakil Malik,Nosheen Masood
Publsiher: Springer Nature
Total Pages: 536
Release: 2022-05-14
ISBN: 981190197X
Category: Medical
Language: EN, FR, DE, ES & NL

Breast Cancer From Bench to Personalized Medicine Book Excerpt:

This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.

Cancer Immunotherapies From Efficacy to Resistance Mechanisms

Cancer Immunotherapies  From Efficacy to Resistance Mechanisms
Author: Morten Hansen,Janin Chandra,Fernando Guimaraes,Nicolas Jacquelot,Yoshinobu Koguchi,Nathalie Labarriere,Ilaria Marigo,Lazar Vujanovic
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-06-29
ISBN: 2889764419
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunotherapies From Efficacy to Resistance Mechanisms Book Excerpt:

Dr. Koguchi receives funding from Tesaro, a GSK company, Bristol-Myers Squibb, and Shimadzu Corporation.. Dr. Vujanovic is a co-inventor of a methodology licensed to INmune Bio, Inc. where a selective inhibitor of soluble TNF can be used to prevent or treat malignancies. Dr. Hansen is the recipient of a private grant from Eurostars Eureka. The other Topic Editors declare no competing interests.

Atlas of Liquid Biopsy

Atlas of Liquid Biopsy
Author: Ludmilla Thomé Domingos Chinen
Publsiher: Springer Nature
Total Pages: 204
Release: 2021-05-31
ISBN: 3030698793
Category: Medical
Language: EN, FR, DE, ES & NL

Atlas of Liquid Biopsy Book Excerpt:

This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in late stages. Even with all the advances that have been made in its treatment, cancer is still challenging, as many patients do not respond to any therapy. Many health agencies have considered early diagnosis as a feasible tool. In this context, it is of the utmost importance to know the morphology and characteristics of CTCs to determine a correct diagnosis. Currently much of the scientific community is committed to expanding our knowledge of CTCs, and this work makes a valuable contribution, presenting hundreds of cell images from patients with various types of cancer, in many different stages of disease, and after receiving various treatments. The Atlas of Liquid Biopsy: Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood is an essential reference guide for all physicians, biologists, biomedics, and professionals working at clinical and research laboratories, hospitals and research centers.

Practical Medical Oncology Textbook

Practical Medical Oncology Textbook
Author: Antonio Russo,Marc Peeters,Lorena Incorvaia,Christian Rolfo
Publsiher: Springer Nature
Total Pages: 1112
Release: 2021-10-06
ISBN: 3030560511
Category: Medical
Language: EN, FR, DE, ES & NL

Practical Medical Oncology Textbook Book Excerpt:

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.

Pharmacogenomics in Drug Discovery and Development

Pharmacogenomics in Drug Discovery and Development
Author: Qing Yan
Publsiher: Springer Nature
Total Pages: 617
Release: 2022-10-08
ISBN: 107162573X
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacogenomics in Drug Discovery and Development Book Excerpt:

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Advancement in Cancer Stem Cell Biology and Precision Medicine

Advancement in Cancer Stem Cell Biology and Precision Medicine
Author: Nikhil Baban Ghate,Eliza Chakraborty,Vicky Yamamoto
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-04-19
ISBN: 2889749444
Category: Science
Language: EN, FR, DE, ES & NL

Advancement in Cancer Stem Cell Biology and Precision Medicine Book Excerpt:

Advances in Prostate Cancer Model Systems Molecular and Cellular Mechanisms Early Detection and Therapies

Advances in Prostate Cancer  Model Systems  Molecular and Cellular Mechanisms  Early Detection  and Therapies
Author: Tanya I. Stoyanova,Antonina Mitrofanova,Andrew Goldstein
Publsiher: Frontiers Media SA
Total Pages: 232
Release: 2022-08-08
ISBN: 2889767396
Category: Medical
Language: EN, FR, DE, ES & NL

Advances in Prostate Cancer Model Systems Molecular and Cellular Mechanisms Early Detection and Therapies Book Excerpt:

Paediatric Haemotology and Oncology

Paediatric Haemotology and Oncology
Author: Simon Bailey,Rod Skinner
Publsiher: Oxford University Press
Total Pages: 752
Release: 2022-03-15
ISBN: 0198779186
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Paediatric Haemotology and Oncology Book Excerpt:

Fully revised and updated for its second edition, Paediatric Haematology and Oncology provides an easily accessible source of information about all of the basic principles of childhood cancer and leukaemia, and detailed specialist knowledge on how to care for children with those conditions.

Early Detection and Treatment of Head Neck Cancers

Early Detection and Treatment of Head   Neck Cancers
Author: Rami El Assal,Dyani Gaudilliere,Stephen Thaddeus Connelly
Publsiher: Springer Nature
Total Pages: 248
Release: 2021-05-07
ISBN: 3030698599
Category: Medical
Language: EN, FR, DE, ES & NL

Early Detection and Treatment of Head Neck Cancers Book Excerpt:

Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. Volume I begins with a general overview, including the industry landscape, of HNC detection, diagnosis, and treatment. Next, it covers the applications of innovative technologies such as microfluidics, nanotechnology, and deep learning to early detect as well as study HNC. For example, studying the cellular features at a single-cell level became possible with the advancement of technologies such as mass cytometry or specifically, Cytometry by Time Of Flight Mass Spectrometry (CyTOF), which has revolutionized the way we can study complex human diseases such as HNC. Finally, the last few chapters are dedicated to describing the standard of care of HNC. The first volume of Early Detection and Treatment of Head & Neck Cancers is highly pertinent to the next generation of interdisciplinary clinicians, scientists, residents, and students who are particularly interested in HNC and in the translation of early detection methods, technologies, and research to clinical practice.