Long Acting Injections and Implants

Long Acting Injections and Implants
Author: Jeremy C. Wright,Diane J. Burgess
Publsiher: Springer Science & Business Media
Total Pages: 560
Release: 2012-01-29
ISBN: 1461405548
Category: Medical
Language: EN, FR, DE, ES & NL

Long Acting Injections and Implants Book Excerpt:

Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.

Long Acting Drug Delivery Systems

Long Acting Drug Delivery Systems
Author: Eneko Larraneta,Thakur Raghu Raj Singh,Ryan F. Donnelly
Publsiher: Woodhead Publishing
Total Pages: 392
Release: 2021-09-24
ISBN: 0128217596
Category: Medical
Language: EN, FR, DE, ES & NL

Long Acting Drug Delivery Systems Book Excerpt:

Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field. Brings together technical, clinical, regulatory and industrial perspectives for a complete overview of long acting and implantable drug delivery systems Provides up-to-date coverage of established and novel long-acting and implantable drug delivery systems, both in development and actively in use Appeals to a broad readership, including materials scientists, pharmaceutical scientists, biomedical engineers, clinicians and regulatory experts

Long Acting Animal Health Drug Products

Long Acting Animal Health Drug Products
Author: Michael J. Rathbone,Arlene McDowell
Publsiher: Springer Science & Business Media
Total Pages: 396
Release: 2012-10-11
ISBN: 1461444381
Category: Medical
Language: EN, FR, DE, ES & NL

Long Acting Animal Health Drug Products Book Excerpt:

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
Author: Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone
Publsiher: Springer Science & Business Media
Total Pages: 593
Release: 2011-12-14
ISBN: 1461408806
Category: Medical
Language: EN, FR, DE, ES & NL

Fundamentals and Applications of Controlled Release Drug Delivery Book Excerpt:

Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Fundamentals of Drug Delivery

Fundamentals of Drug Delivery
Author: Heather A. E. Benson,Michael S. Roberts,Adrian C. Williams,Xiaowen Liang
Publsiher: John Wiley & Sons
Total Pages: 580
Release: 2021-10-12
ISBN: 1119769604
Category: Medical
Language: EN, FR, DE, ES & NL

Fundamentals of Drug Delivery Book Excerpt:

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Translational Evaluation of Electrospun Drug Delivery Systems

Translational Evaluation of Electrospun Drug Delivery Systems
Author: Jamie L. Hernandez
Publsiher: Unknown
Total Pages: 0
Release: 2021
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Translational Evaluation of Electrospun Drug Delivery Systems Book Excerpt:

Pre-exposure prophylaxis (PrEP) is an oral regimen of antiretroviral (ARV) drugs for the prevention of HIV. However, near-perfect adherence to PrEP is needed to maintain protective drug concentrations in the lower female reproductive tract (FRT). To address issues of adherence to medications like PrEP, we investigate the use of drug-loaded electrospun materials as a long-acting drug delivery vehicle. Electrospinning has previously demonstrated the ability to formulate physiochemically diverse ARV drugs into stable solid dispersions. Here, we investigate various formulations of drug-loaded electrospun materials and further demonstrate the scalable potential of electrospinning. Electrospinning is used to formulate long-acting triple-drug releasing material as an adherence-independent subcutaneous implant, and we assess the pharmacokinetics and biocompatibility of these implants in mice. Finally, towards the development of adherence-independent and topical electrospun devices, we probe local tissue hosts responses in the FRT in baboons. Research from this thesis provides new insight into drug release kinetics and material biocompatibility resulting from drug delivery systems specifically within subcutaneous and FRT tissue environments.

Modeling and Control of Drug Delivery Systems

Modeling and Control of Drug Delivery Systems
Author: Ahmad Taher Azar
Publsiher: Academic Press
Total Pages: 408
Release: 2021-02-06
ISBN: 0128211954
Category: Computers
Language: EN, FR, DE, ES & NL

Modeling and Control of Drug Delivery Systems Book Excerpt:

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Innovative delivery systems for paediatric medicines

Innovative delivery systems for paediatric medicines
Author: Anonim
Publsiher: World Health Organization
Total Pages: 135
Release: 2021-11-10
ISBN: 9240008187
Category: Medical
Language: EN, FR, DE, ES & NL

Innovative delivery systems for paediatric medicines Book Excerpt:

Bioadhesive Drug Delivery Systems

Bioadhesive Drug Delivery Systems
Author: Vincent M. Lenaerts,Robert Gurny
Publsiher: CRC Press
Total Pages: 244
Release: 1989-11-30
ISBN: 9780849353673
Category: Medical
Language: EN, FR, DE, ES & NL

Bioadhesive Drug Delivery Systems Book Excerpt:

This comprehensively written text covers, in-depth, all aspects of bioadhesive systems. Bioadhesive systems are presently playing a major role in the field because of their ability to maintain a dosage form at a precise body-site for a prolonged period of time over which the active principle is progressively released. Included in this book are descriptions of the different mucosae in healthy and pathological situations, a theoretical approach of polymers-mucin interactions, and a comparative description of the methods used to evaluate bioadhesion. Up-to-date reviews of pharmaceutical applications are also given - subdivided according to the route of administration and type of system. It also contains a chapter devoted to the fundamentals of bioadhesion. This reference is an indispensable guide for researchers in the pharmaceutical field as well as academic researchers.

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems
Author: Loyd Allen,Howard C. Ansel
Publsiher: Lippincott Williams & Wilkins
Total Pages: 808
Release: 2013-12-23
ISBN: 1451188765
Category: Medical
Language: EN, FR, DE, ES & NL

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems Book Excerpt:

Long established as a trusted core text for pharmaceutics courses, this gold standard book is the most comprehensive source on pharmaceutical dosage forms and drug delivery systems available today. Reflecting the CAPE, APhA, and NAPLEX® competencies, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms, as well as the clinical application of the various dosing forms in patient care. This Tenth Edition has been fully updated to reflect new USP standards and features a dynamic new full color design, new coverage of prescription flavoring, and increased coverage of expiration dates.

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
Author: Jayvadan K. Patel
Publsiher: Springer Nature
Total Pages: 437
Release: 2022
ISBN: 303083395X
Category: Drug delivery systems
Language: EN, FR, DE, ES & NL

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems Book Excerpt:

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Long Acting Animal Health Drug Products

Long Acting Animal Health Drug Products
Author: Michael J. Rathbone,Arlene McDowell
Publsiher: Springer
Total Pages: 392
Release: 2014-11-09
ISBN: 9781489994103
Category: Medical
Language: EN, FR, DE, ES & NL

Long Acting Animal Health Drug Products Book Excerpt:

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.

Nanocarriers Drug Delivery System

Nanocarriers  Drug Delivery System
Author: Nirmal Shah
Publsiher: Springer Nature
Total Pages: 483
Release: 2021-01-22
ISBN: 9813344970
Category: Medical
Language: EN, FR, DE, ES & NL

Nanocarriers Drug Delivery System Book Excerpt:

A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems
Author: Yashwant Pathak,Nazrul Islam
Publsiher: CRC Press
Total Pages: 1065
Release: 2021-10-18
ISBN: 1000450805
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Lung Targeted Drug Delivery Systems Book Excerpt:

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Health Promotion and Disease Prevention Programs

Health Promotion and Disease Prevention Programs
Author: United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and the Environment
Publsiher: Unknown
Total Pages: 213
Release: 1987
ISBN: 1928374650XXX
Category: Health promotion
Language: EN, FR, DE, ES & NL

Health Promotion and Disease Prevention Programs Book Excerpt:

Emerging Areas in Bioengineering

Emerging Areas in Bioengineering
Author: Ho Nam Chang
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2017-12-20
ISBN: 3527803300
Category: Science
Language: EN, FR, DE, ES & NL

Emerging Areas in Bioengineering Book Excerpt:

With more than 40 contributions from expert authors, this is an extensive overview of all important research topics in the field of bioengineering, including metabolic engineering, biotransformations and biomedical applications. Alongside several chapters dealing with biotransformations and biocatalysis, a whole section is devoted to biofuels and the utilization of biomass. Current perspectives on synthetic biology and metabolic engineering approaches are presented, involving such example organisms as Escherichia coli and Corynebacterium glutamicum, while a further section covers topics in biomedical engineering including drug delivery systems and biopharmaceuticals. The book concludes with chapters on computer-aided bioprocess engineering and systems biology. This is a part of the Advanced Biotechnology book series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question. Invaluable reading for biotechnologists and bioengineers, as well as those working in the chemical and pharmaceutical industries. Advanced Biotechnology Biotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society as a whole. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang-Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

Novel Drug Delivery Systems for Chinese Medicines

Novel Drug Delivery Systems for Chinese Medicines
Author: Nianping Feng,Zhijun Yang
Publsiher: Springer Nature
Total Pages: 336
Release: 2021-12-01
ISBN: 9811634440
Category: Medical
Language: EN, FR, DE, ES & NL

Novel Drug Delivery Systems for Chinese Medicines Book Excerpt:

This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.

Biopharmaceutics of Ocular Drug Delivery

Biopharmaceutics of Ocular Drug Delivery
Author: Peter Edman
Publsiher: CRC Press
Total Pages: 215
Release: 2019-08-15
ISBN: 1000693775
Category: Medical
Language: EN, FR, DE, ES & NL

Biopharmaceutics of Ocular Drug Delivery Book Excerpt:

A significant new book on drug delivery to the eye Biopharmaceutics of Ocular Drug Delivery examines the current physiological, anatomical, pharmaceutical/technological, and biopharmaceutical knowledge on ocular drug delivery. Leading ophthalmic researchers cover topics such as the formulation and usage of ophthalmic solutions and suspensions, the influence of surfactants and preservatives on ocular drug absorption, and new techniques that include bioadhesion and the use of hyaluronic acid as an ophthalmic vehicle. Promising research on new delivery systems for improved drug therapy is highlighted, including new pharmaceutical vehicles, inserts, liposomes, nanoparticles, and prodrugs. Biopharmaceutics of Ocular Drug Delivery is one of the few books available on drug delivery to the eye and will be an important reference for ophthalmologists, pharmacologists, pharmaceutical researchers, and other scientists interested in the topic.

Handbook of Polyester Drug Delivery Systems

Handbook of Polyester Drug Delivery Systems
Author: M. N. V. Ravi Kumar
Publsiher: CRC Press
Total Pages: 738
Release: 2016-06-08
ISBN: 9814669660
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Polyester Drug Delivery Systems Book Excerpt:

In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.

Drug Delivery Systems Third Edition

Drug Delivery Systems  Third Edition
Author: Vasant V. Ranade,John B. Cannon
Publsiher: CRC Press
Total Pages: 610
Release: 2011-04-25
ISBN: 1439806187
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Systems Third Edition Book Excerpt:

Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems. Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.