Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry
Author: Karoly Vekey,Andreas Telekes,Akos Vertes
Publsiher: Elsevier
Total Pages: 606
Release: 2011-08-11
ISBN: 0080554652
Category: Science
Language: EN, FR, DE, ES & NL

Medical Applications of Mass Spectrometry Book Excerpt:

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry
Author: Karoly Vekey,Andreas Telekes,Akos Vertes
Publsiher: Elsevier
Total Pages: 608
Release: 2008
ISBN: 0444519807
Category: Medical
Language: EN, FR, DE, ES & NL

Medical Applications of Mass Spectrometry Book Excerpt:

A guide to help medical professionals understand mass spectrometry in clinical laboratories.

Quadrupole Mass Spectrometry and Its Applications

Quadrupole Mass Spectrometry and Its Applications
Author: Peter H. Dawson
Publsiher: Elsevier
Total Pages: 372
Release: 2013-10-22
ISBN: 1483165043
Category: Science
Language: EN, FR, DE, ES & NL

Quadrupole Mass Spectrometry and Its Applications Book Excerpt:

Quadrupole Mass Spectrometry and Its Applications provides a comprehensive discussion of quadrupoles and their applications. It proceeds from a general explanation of the action of radiofrequency quadrupole fields to the description of their utilization in mass analyzers—such as the quadrupole mass filter, the monopole, the three-dimensional quadrupole ion trap, and various time-of-flight spectrometers—and finally to the characteristic applications of quadrupoles. A multi-author format has been adopted to provide broader-than-usual viewpoint in the book. The book begins by explaining the principles of operation of quadrupole devices. These include ion trajectories and computer simulations of performance; analytical theory; numerical methods of calculation of performance, including the recently developed application of phase-space dynamics; and fringing fields and other field imperfections. Subsequent chapters provide design and performance evaluations of the mass filter, the monopole, ion traps, and time-of-flight instruments; and describe areas of application where quadrupole devices have made the greatest impact because of their particular advantages and disadvantages.

The Medical and Biological Application of Mass Spectrometry

The Medical and Biological Application of Mass Spectrometry
Author: James Patrick Payne,J. A. Bushman,Dennis Walter Hill
Publsiher: Unknown
Total Pages: 203
Release: 1979
ISBN: 1928374650XXX
Category: Biochemistry
Language: EN, FR, DE, ES & NL

The Medical and Biological Application of Mass Spectrometry Book Excerpt:

Encyclopedia of Spectroscopy and Spectrometry

Encyclopedia of Spectroscopy and Spectrometry
Author: Anonim
Publsiher: Academic Press
Total Pages: 3584
Release: 2016-09-22
ISBN: 0128032251
Category: Science
Language: EN, FR, DE, ES & NL

Encyclopedia of Spectroscopy and Spectrometry Book Excerpt:

This third edition of the Encyclopedia of Spectroscopy and Spectrometry provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

The Encyclopedia of Mass Spectrometry

The Encyclopedia of Mass Spectrometry
Author: Anonim
Publsiher: Newnes
Total Pages: 406
Release: 2015-12-04
ISBN: 0080913253
Category: Science
Language: EN, FR, DE, ES & NL

The Encyclopedia of Mass Spectrometry Book Excerpt:

Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry of The Encyclopedia of Mass Spectrometry describes and analyzes the development of many aspects of Mass Spectrometry. Beginning with the earliest types of Mass Analyzers, Historical Perspectives explores the development of many different forms of analytical processes and methods. The work follows various instruments and interfaces, to the current state of detectors and computerization. It traces the use of Mass Spectrometry across many different disciplines, including Organic Chemistry, Biochemistry, and Proteomics; Environmental Mass Spectrometry; Forensic Science; Imaging; Medical Monitoring and Diagnosis; Earth and Planetary Sciences; and Nuclear Science. Finally, the book covers the history of manufacturers and societies as well as the professionals who form the Mass Spectrometry community. Also available: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development. Preserves the history and development of Mass Spectrometry for use across scientific fields Written and edited by Mass Spectrometry experts Coordinates with Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry, a collection of short biographies on many of the major people who carried out this development

Mass Spectrometry of Nucleosides and Nucleic Acids

Mass Spectrometry of Nucleosides and Nucleic Acids
Author: Joseph H. Banoub,Patrick A. Limbach
Publsiher: CRC Press
Total Pages: 504
Release: 2009-12-21
ISBN: 9781420044034
Category: Science
Language: EN, FR, DE, ES & NL

Mass Spectrometry of Nucleosides and Nucleic Acids Book Excerpt:

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Mass Spectrometry for the Novice

Mass Spectrometry for the Novice
Author: John Greaves,John Roboz
Publsiher: CRC Press
Total Pages: 309
Release: 2013-10-16
ISBN: 1420094203
Category: Medical
Language: EN, FR, DE, ES & NL

Mass Spectrometry for the Novice Book Excerpt:

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers

Pharmaceutical and Medical Applications of Near Infrared Spectroscopy

Pharmaceutical and Medical Applications of Near Infrared Spectroscopy
Author: Emil W. Ciurczak,Benoit Igne
Publsiher: CRC Press
Total Pages: 172
Release: 2014-12-15
ISBN: 1498704468
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmaceutical and Medical Applications of Near Infrared Spectroscopy Book Excerpt:

Since the completion of the first edition of this book, major developments have occurred in the pharmaceutical industry that have shaped the field of near-infrared (NIR) spectroscopy. A new initiative from the U.S. Food and Drug Administration (FDA) to modernize regulations of pharmaceutical manufacturing and drug quality has helped position NIR sp

Organic Chemistry

Organic Chemistry
Author: David R. Klein
Publsiher: John Wiley & Sons
Total Pages: 1312
Release: 2017-08-14
ISBN: 111944425X
Category: Science
Language: EN, FR, DE, ES & NL

Organic Chemistry Book Excerpt:

In Organic Chemistry, 3rd Edition, Dr. David Klein builds on the phenomenal success of the first two editions, which presented his unique skills-based approach to learning organic chemistry. Dr. Klein’s skills-based approach includes all of the concepts typically covered in an organic chemistry textbook, and places special emphasis on skills development to support these concepts. This emphasis on skills development in unique SkillBuilder examples provides extensive opportunities for two-semester Organic Chemistry students to develop proficiency in the key skills necessary to succeed in organic chemistry.

Mass Spectrometry

Mass Spectrometry
Author: Kevin Downard
Publsiher: Royal Society of Chemistry
Total Pages: 228
Release: 2004
ISBN: 0854046097
Category: Science
Language: EN, FR, DE, ES & NL

Mass Spectrometry Book Excerpt:

Mass Spectrometry: A Foundation Course is a textbook covering the field of mass spectrometry across the chemical, physical, biological, medical and environmental sciences. Sufficient depth is provided for the reader to appreciate the reasons behind and basis for particular experiments. It is uniquely and logically organised to enable the book to form the basis for a university course in mass spectrometry at the undergraduate or postgraduate level. This is achieved by combining specific core sections coupled to optional areas of study tailored to students of the chemical, physical, biological, medical and environmental sciences. Recommended course structures are provided in the front of the book. Dedicated chapters are included on: organic mass spectrometry; ion chemistry - to emphasise the role of mass spectrometry in fundamental chemistry and physics; biological mass spectrometry including proteomics; mass spectrometry in medicine, environmental and surface science and accelerator mass spectrometry, to emphasise the importance of these areas. Each chapter concludes with key references and additional recommended reading material, making the book an excellent springboard to further study. Highly readable, easy-to-use and logically presented, Mass Spectrometry: A Foundation Course is an ideal text for students and for those who work with mass spectrometers who wish to gain a solid understanding of the basics in modern mass spectrometry. "From the reviews: " " Although I am not a fan or either "eras" or "omes" you hear all the time that we now live in the era of the proteome. Setting aside the issues of what constitutes proteomics (after all people have been sequencingproteins and studying their structure for a few years now? ), and whether the regular appearance of reports of another organisms genome sequence prevents you from saying that we are in the post-genomic era, it is clear that the analysis of large numbers of complex protein mixtures is just about in all of our reach. This is going to be a very important way to look for molecular markers and targets in the battle against cancer. The bedrock of proteomic analysis is mass spectrometry, which allows you to accurately measure the mass of molecules. In proteomics this can mean studying the mass of intact proteins, which can give you a clue as to their identity, and help you rapidly identify modifications. It can also mean busting the protein into many component fragments and measuring their mass, which can lead to protein identification via clever algorithms that compare measured fragment sizes to predicted ones using the genome databases. One sign that this technology is about to become widely distributed is the appearance of relatively small softcover textbooks for beginners. These represent a reasonable first step towards initiation in this area, for those of us who left school a few years ago. There are two recent ones that I have read that I found to be particularly useful. The first is Mass Spectrometry: A Foundation Course by Kevin Downard of Sydney, Australia. This book covers many aspects of the field in under 200 pages, and has a handy guide to what sections are useful to individuals from different disciplines. It starts with history and concepts, and then devotes a significant amount of space to the instrumentation. This is very useful to anyone who has been to a massspectrometry meeting and trade show or even browsed the relevant companies websites. Dr. Downard covers the basics of how each variant works, and what it is best suited for, and includes discussion of single and tandem instruments. By the end you'll be able to raise your eyebrows appreciatively the next time a salesman fires an acronym and figure at you (or at least you'll know where to look it up once you have reached a safe distance). The second half of the book looks at specific applications for mass spectrometry, and here you can read selectively on what you are inter

ADMET for Medicinal Chemists

ADMET for Medicinal Chemists
Author: Katya Tsaioun,Steven A. Kates
Publsiher: John Wiley & Sons
Total Pages: 512
Release: 2011-02-15
ISBN: 9780470922811
Category: Medical
Language: EN, FR, DE, ES & NL

ADMET for Medicinal Chemists Book Excerpt:

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.

Breath Analysis for Medical Applications

Breath Analysis for Medical Applications
Author: David Zhang,Dongmin Guo,Ke Yan
Publsiher: Springer
Total Pages: 309
Release: 2017-06-23
ISBN: 9811043221
Category: Medical
Language: EN, FR, DE, ES & NL

Breath Analysis for Medical Applications Book Excerpt:

This book describes breath signal processing technologies and their applications in medical sample classification and diagnosis. First, it provides a comprehensive introduction to breath signal acquisition methods, based on different kinds of chemical sensors, together with the optimized selection and fusion acquisition scheme. It then presents preprocessing techniques, such as drift removing and feature extraction methods, and uses case studies to explore the classification methods. Lastly it discusses promising research directions and potential medical applications of computerized breath diagnosis. It is a valuable interdisciplinary resource for researchers, professionals and postgraduate students working in various fields, including breath diagnosis, signal processing, pattern recognition, and biometrics.

Carbohydrate Chemistry Biology and Medical Applications

Carbohydrate Chemistry  Biology and Medical Applications
Author: Hari G. Garg,Mary K. Cowman,Charles A. Hales
Publsiher: Elsevier
Total Pages: 432
Release: 2011-09-06
ISBN: 9780080558141
Category: Science
Language: EN, FR, DE, ES & NL

Carbohydrate Chemistry Biology and Medical Applications Book Excerpt:

The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. Explains how carbohydrates are important to life Details the chemistry, biology and medical aspects of carbohydrates Interdisciplinary and international team of authors

Medical Applications of Artificial Intelligence

Medical Applications of Artificial Intelligence
Author: Arvin Agah
Publsiher: CRC Press
Total Pages: 526
Release: 2013-11-06
ISBN: 143988434X
Category: Medical
Language: EN, FR, DE, ES & NL

Medical Applications of Artificial Intelligence Book Excerpt:

Enhanced, more reliable, and better understood than in the past, artificial intelligence (AI) systems can make providing healthcare more accurate, affordable, accessible, consistent, and efficient. However, AI technologies have not been as well integrated into medicine as predicted. In order to succeed, medical and computational scientists must develop hybrid systems that can effectively and efficiently integrate the experience of medical care professionals with capabilities of AI systems. After providing a general overview of artificial intelligence concepts, tools, and techniques, Medical Applications of Artificial Intelligence reviews the research, focusing on state-of-the-art projects in the field. The book captures the breadth and depth of the medical applications of artificial intelligence, exploring new developments and persistent challenges.

Bibliography of Mass Spectroscopy Literature for 1971

Bibliography of Mass Spectroscopy Literature for 1971
Author: Anonim
Publsiher: Unknown
Total Pages: 607
Release: 1973
ISBN: 1928374650XXX
Category: Mass spectrometry
Language: EN, FR, DE, ES & NL

Bibliography of Mass Spectroscopy Literature for 1971 Book Excerpt:

Ion Molecule Attachment Reactions Mass Spectrometry

Ion Molecule Attachment Reactions  Mass Spectrometry
Author: Toshihiro Fujii
Publsiher: Springer
Total Pages: 332
Release: 2015-08-03
ISBN: 1489975888
Category: Science
Language: EN, FR, DE, ES & NL

Ion Molecule Attachment Reactions Mass Spectrometry Book Excerpt:

This book explores the mechanism of alkali-metal ion/molecule association reaction, surveys the instrumental basis to study its kinetic, and describes the instrumentation to the measurement of alkali-metal ion affinities. The applications of the ion complexation mechanism in the condensed phase in reaction to direct analysis MS are also covered. Other topics include mechanism and reaction rate, experimental and theoretical ion affinities, applications of ion attachment reactions (IAR) to mass spectrometry such as alkali ion CIMS, ion attachment MS and cationization mass spectrometry of ESI, FAB, FD, LD, MALDI and SIMS and topics of IAR-based direct analysis mass spectrometry.

Biomedical Applications of Mass Spectrometry

Biomedical Applications of Mass Spectrometry
Author: Clarence H. Suelter,J. Throck Watson
Publsiher: John Wiley & Sons
Total Pages: 413
Release: 2009-09-25
ISBN: 0470110961
Category: Medical
Language: EN, FR, DE, ES & NL

Biomedical Applications of Mass Spectrometry Book Excerpt:

Biomedical Applications of Mass Spectrometry Edited by Clarence H. Suelter and J. Throck Watson This unusual text is not simply a compilation of mass spectrometric methods but provides, instead, insight into specific approaches mass spectroscopists use when applying the technique to a variety of biological problems. Each chapter provides guidance in using the appropriate methods for isolating and purifying the compound class prior to mass spectrometric analysis. Covered in-depth are the mass spectrometry of carbohydrates, peptide sequencing by mass spectrometry, mass spectrometry of nucleic acid components, and mass spectrometry in pharmacology. This definitive look at a growing facet of the science is an essential reference for biochemists, biological chemists, bioanalytical chemists, and students. 1990 (0-471-61303-7) 396 pp.

Mass Spectrometry Handbook

Mass Spectrometry Handbook
Author: Mike S. Lee
Publsiher: John Wiley & Sons
Total Pages: 1362
Release: 2012-05-08
ISBN: 047053673X
Category: Science
Language: EN, FR, DE, ES & NL

Mass Spectrometry Handbook Book Excerpt:

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Metabolomics

Metabolomics
Author: Xianquan Zhan
Publsiher: BoD – Books on Demand
Total Pages: 170
Release: 2021-09-01
ISBN: 1839690836
Category: Science
Language: EN, FR, DE, ES & NL

Metabolomics Book Excerpt:

Metabolomics is the methodology and theory to study the metabolome, including targeted approaches based on selected/multiple reaction monitoring (SRM/MRM) and untargeted approaches based on nuclear magnetic resonance (NMR) or mass spectrometry (MS). The metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body fluid in a metabolic network system. Metabolomic variations directly link to molecular mechanisms of a disease, reliable therapeutic targets, and effective biomarkers for prediction, diagnosis, and prognostic assessment of disease. This book presents new advances in the concept and methodology of metabolomics, as well as applications of metabolomics in the research and practice of medical and life sciences.