Medical Enzymology

Author by : Tarek H. El-Metwally
Languange : en
Publisher by : Nova Science Pub Incorporated
Format Available : PDF, ePub, Mobi
Total Read : 92
Total Download : 209
File Size : 47,7 Mb
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Description : Understanding enzyme kinetics and structure-function relationship enables us to explain the metabolic regulation and integration. The information also helps us understanding action of specific toxins, drug metabolism and disease pathogenesis. This enables us to invent suitable interventions to circumvent unfavourable and invest the favourable effects on enzymes and to design more efficient biocatalysts for therapeutic and industrial uses. This book presents all of the fundamental knowledge of enzymology in a very simple way.


Medical Enzymology

Author by : Tarek H. El-Metwally
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 39
Total Download : 366
File Size : 52,8 Mb
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Essentials Of Enzymology

Author by : Rufus O. Okotore
Languange : en
Publisher by : Xlibris Corporation
Format Available : PDF, ePub, Mobi
Total Read : 99
Total Download : 552
File Size : 47,5 Mb
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Description : Essentials of Enzymology provides concise information on an important area of the subject, Biochemistry. This may serve as course material for an advanced treatise in Enzymology designed for undergraduate science degree programs, especially B.Sc. (Hons ) Biochemistry and Chemistry. The book is in 12 chapters which has been divided into four distinct sections, thus (1) Basic enzyme chemistry and physiology. (2) Enzyme Kinetics, (3) Enzyme catalysis, Mechanisms and Regulation,(4)Applications of Enzymology. The Part 1 consists of four chapters that deal with the nature of enzymes- (history, properties and classifi cation), enzyme physiology; structure of enzymes, and analytical enzymology. Part 2 deals with Enzyme Kinetics which is treated in three chapters, and Part 3, made up of three chapters discuss Enzyme catalysis, mechanisms and regulation. Lastly, Part 4 consisting of two chapters deal with the applications of enzymology. Signifi cantly, the kinetics of enzyme catalyzed reactions in diverse experimental conditions, and also under various inhibition types are presented in a simple, mathematical lucid approach. The mechanisms of action for two atypical proteins-chymotrypsin and lysozyme, so also the identifi cation of active sites of enzymes by specifi c labels are discussed concisely. Lastly, the specifi c applications of enzymes in diagnostic medicine, industry, and also the new emerging area of enzyme biotechnology and enzyme bioinformatics are presented


Urinary Enzymes

Author by : Klaus Jung
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 289
File Size : 54,6 Mb
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Description : Interest and research in urinary enzymology were incited about three decades ago by reports that urinary enzymes are elevated in diseases of the kidney and urinary tract. Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. Recognition of the quantitative distribution of enzymes in the various anatomical and functional parts of the nephron and advances in our understanding of the handling of proteins by the kidney have made it possible to associate urinary enzyme activity patterns with physiological and pathophysio logical functions of the nephron. Confidence in the diagnostic value of urinary enzymes is not unanimous among clinicians and among scientists. The main reason for the difference in opinion may well be that the variability in data exceeds the variability one is accustomed to in the diagnostic enzymology of blood plasma enzymes. In contrast to plasma enzymes, which are protected by an "enzyme friendly" milieu, enzymes released into the urine encounter an "enzyme hostile" environ ment: no or little protective protein, variable pH, variable volume, variable metabolite and salt concentrations, variable concentrations of enzyme in hibitors. Through advances in methodology some of these factors can now be controlled; standardization of urine collection periods and preanalytical treat ment are as important as optimization of assay methods.


A Study Of Enzymes

Author by : Stephen A. Kuby
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 48
Total Download : 249
File Size : 45,8 Mb
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Description : First published in 1990, this comprehensive monograph consists of two parts: Volume I, entitled Enzyme Catalysis, Kinetics, and Substrate Binding; and Volume II, entitled Mechanism of Enzyme Action. Volume I focuses on several aspects of enzyme catalytic behavior, their steady-state and transient-state kinetics, and the thermodynamic properties of substrate binding. Packed with figures, tables, schemes, and photographs, this volume contains over 1,000 references, including references regarding enzymology's fascinating history. This comprehensive book is of particular interest to enzymology students, teachers, and researchers. Volume II presents selected "cutting edge" examples of techniques and approaches being pursued in biochemistry. This up-to-date resource includes 11 chapters, which illustrate important theoretical and practical aspects of enzyme mechanisms. It also features selected examples in which today's most important techniques, ideas, and theories are used to elaborate on the intricate nature of enzyme action mechanisms. This particular volume provides important information for both the novice and the seasoned investigator.


Allosteric Regulatory Enzymes

Author by : Thomas W. Traut
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 89
Total Download : 270
File Size : 51,9 Mb
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Description : This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.


Research Advancements In Pharmaceutical Nutritional And Industrial Enzymology

Author by : Bharati, Shashi Lata
Languange : en
Publisher by : IGI Global
Format Available : PDF, ePub, Mobi
Total Read : 32
Total Download : 531
File Size : 54,5 Mb
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Description : Enzymes have interesting applications in our biological system and act as valuable biocatalysts. Their various functions allow enzymes to develop new drugs, detoxifications, and pharmaceutical chemistry. Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology provides emerging research on biosynthesis, enzymatic treatments, and bioengineering of medicinal waste. While highlighting issues such as structural implications for drug development and food applications, this publication explores information on various applications of enzymes in pharmaceutical, nutritional, and industrial aspects. This book is a valuable resource for medical professionals, pharmacists, pharmaceutical companies, researchers, academics, and upper-level students seeking current information on developing scientific ideas for new drugs and other enzymatic advancements.


Fundamentals Of Protein Structure And Function

Author by : Engelbert Buxbaum
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 366
File Size : 43,9 Mb
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Description : This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.


Diagnostic Enzymology

Author by : Steven Kazmierczak
Languange : en
Publisher by : Walter de Gruyter GmbH & Co KG
Format Available : PDF, ePub, Mobi
Total Read : 33
Total Download : 913
File Size : 41,9 Mb
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Description : This book is the2nd improved and expanded edition of "Clinical Enzymology" (Lott/Wolf, 1987). It includes case studies and guidelines for specialists of laboratory medicine and clinicians, devotes each chapter to a specific enzyme or protein marker, contains case studies and guidelines, a section on marker biochemistry and physiology as well as a section on special pathology and analysis. The clear, didactic structure and the multiple choice questions also make the book valuable reading for graduate students in the fields of clinical pathology and laboratory medicine.


Bioprospecting Of Enzymes In Industry Healthcare And Sustainable Environment

Author by : Hrudayanath Thatoi
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 969
File Size : 50,6 Mb
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Description : The rapid urbanization and industrialization of developing countries across the globe have necessitated for substantial resource utilization and development in the areas of Healthcare, Environment, and Renewable energy. In this context ,this resourceful book serves as a definitive source of information for the recent developments in application of microbial enzymes in various sectors. It covers applications in fermentation processes and their products, extraction and utilisation of enzymes from various sources and their application in health and biomass conversion for production of value added products. Different chapters discuss various areas of bioprospecting in enzyme technology, and describe why these are the mainstays for industrial production of value added products. The rich compilation of the cutting-edge advances and applications of the modern industrial based techniques hold feasible solutions for a range of current issues in enzyme technology. This book will be of particular interest for scientists, academicians, technical resource persons, engineers and members of industry. Undergraduate and graduate students pursuing courses in the area of industrial biotechnology will find the information in the book valuable. General readers having interest towards biofuels, enzyme technology, fermented food and value added products, phytochemicals and phytopharmaceutical products will also find the book appealing. Readers will discover modern concepts of enzymatic bioprocess technology for production of therapeutics and industrial value added products.


Zinc Enzyme Inhibitors

Author by : Claudiu T. Supuran
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 10
Total Download : 593
File Size : 42,8 Mb
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Description : Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.


Biochemical And Molecular Basis Of Pediatric Disease

Author by : Edward C.C. Wong
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 469
File Size : 40,7 Mb
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Description : Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult


Directory Of Therapeutic Enzymes

Author by : Taylor & Francis Group
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 53
Total Download : 774
File Size : 48,5 Mb
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Description : Carefully crafted to provide tightly focused and authoritative information, the Directory of Therapeutic Enzymes covers all approved therapeutic enzymes currently used in medicine. Written mainly by industry experts, the book includes information sourced directly from the company that developed or manufactured the product. It explores major development issues, from manufacturing and marketing to delivery of the finished product. Chapter 1 reviews applied enzymology while chapter 2 delineates theory and applications. Between them, the first two chapters set the appropriate backdrop for the remaining chapters, which focus on actual enzyme products that have gained regulatory approval for general medical use. The chapter authors discuss the biochemistry of the enzymes, the reactions they catalyze, how they are produced or manufactured, and their medical applications. The book highlights the many applications of approved therapeutic enzymes, including use in the treatment of blood-clotting disorders, certain cancers, and a variety of genetic disorders. Illustrated with tables and figures that support the text, the book is a single source of in-depth technical information.


Enzymes A Very Short Introduction

Author by : Paul Engel
Languange : en
Publisher by : Oxford University Press, USA
Format Available : PDF, ePub, Mobi
Total Read : 83
Total Download : 446
File Size : 55,8 Mb
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Description : Enzymes are the molecular machines that make life possible. Working as catalysts, teams of enzymes carry out the processes that power the bodies of living things, from making DNA to digesting food. This book explains what enzymes are, what they do, and how they do it, from enzymes inside our cells to those in washing powders and food production.


Enzymology And Medicine

Author by : Donald William Moss
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 80
Total Download : 497
File Size : 43,5 Mb
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The Enzymology Of The Cell Surface Tension At The Cell Surface

Author by : Aser Rothstein
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 26
Total Download : 419
File Size : 45,6 Mb
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Description : obvious properties, its structure, composition, electrical properties, me chanical properties, and most particularly, its permeability properties. None of these properties are obviously associated with surface enzymes. What are the functions of the cell surface that may require the presence of enzymes? From a purely hypothetical point of view, the cellular activities in which cell surface enzymes are potentially functional can be divided into two categories; first, those activities related to the production and maintenance of the cell surface structure itself, and second, those activities which are concerned with interactions between the cell and its environment. During growth of a cell, as it enlarges, new structural ma terial must be synthesized and assembled in the cell membrane. Although it is conceivable that new structural material is synthesized in the interior of the cell, it is difficult to visualize its complete synthesis and final assembly in the periphery of the cell, without the assistance of enzymes at the site. In the case of non-growing cells, although no net synthesis of new structural material is necessary, the turnover of the various components by a continuous degradation and resynthesis must be considered as a pos sibility.


Dna Repair Enzymes Structure Biophysics And Mechanism

Author by : Anonim
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 65
Total Download : 885
File Size : 46,6 Mb
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Description : DNA Repair Enzymes, Part B, Volume 592 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA Repair Enzymes. Topics in this updated volume include MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes, Production and Assay of Recombinant Multisubunit Chromatin Remodeling Complexes, Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR, the Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair, and Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein-Nucleic Acid Complexes. Includes contributions from leading authorities working in enzymology Focuses on DNA repair enzymes Informs and updates on all the latest developments in the field of enzymology


Class 1 Oxidoreductases Xi

Author by : Dietmar Schomburg
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 55
Total Download : 953
File Size : 54,6 Mb
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Description : The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.


Essentials Of Medical Biochemistry

Author by : N. V. Bhagavan
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 59
Total Download : 404
File Size : 41,7 Mb
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Description : Essentials of Medical Biochemistry, Second Edition: With Clinical Cases is the most condensed, yet detailed biochemistry overview available on the topic. It presents contemporary coverage of the fundamentals of biochemistry, emphasizing relevant physiologic and pathophysiologic biochemical concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find basic and fundamental concepts that will aid students and professionals in biochemistry, medicine, and other healthcare disciplines. the text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists. Presents essential biochemical concepts within the context of their biological functions Contains key clinical case studies in each chapter to enhance understanding of basic science and aid in further comprehension Offers instructional overview figures, flowcharts, tables and multicolored illustrations Includes integrated, recommended reading reference lists within the text Provides an online ancillary package inclusive of PowerPoint images and more than 500 study questions to aid in comprehension and USMLE exam preparation


Advances In Enzymology And Related Areas Of Molecular Biology

Author by : Alton Meister
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 43
Total Download : 406
File Size : 50,6 Mb
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Description : Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological process, and their application in both the laboratory and industry. Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability. With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.


Clinical Enzymology

Author by : George Kaldor
Languange : en
Publisher by : Praeger Publishers
Format Available : PDF, ePub, Mobi
Total Read : 95
Total Download : 168
File Size : 49,9 Mb
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Class 1 Oxidoreductases X

Author by : Dietmar Schomburg
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 92
Total Download : 516
File Size : 51,9 Mb
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Description : The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.


Enzymology In The Practice Of Laboratory Medicine

Author by : Philip Blume
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 9
Total Download : 297
File Size : 54,5 Mb
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Description : Enzymology in the Practice of Laboratory Medicine focuses on disease processes, enzymatic reactions and activities, and diagnosis and management of diseases. The selection first offers information on developments in the search for mechanisms of enzymic catalysis; application of the spin labeling technique to biological membranes; and the properties of membrane bound enzymes involved in energy transduction processes. Discussions focus on possible clinical interrelationships of membrane function, mitochondrial membrane transactions, mechanical details of chymotryptic catalysis, and physical nature of globular proteins. The text then elaborates on metalloenzymes, enzyme measurement, and enzymology, clinical chemistry, and development of fast analyzers. The publication examines the analytical uses of immobilized enzymes; origin of serum enzymes and the basis for their variation; and the screening methods for glycolytic enzyme deficiencies in red blood cells. Topics include factors contributing to normal variation of enzyme activity, catabolism of enzymes, mechanism of release from cells to plasma, and determination of urea in blood and urine. The selection is a dependable reference for researchers interested in the application of enzymology in laboratory medicine.