Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier Science
Total Pages: 0
Release: 2023-07-01
ISBN: 9780128185490
Category: Science
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Excerpt:

Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier
Total Pages: 400
Release: 2008-06-04
ISBN: 9780080559629
Category: Medical
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Excerpt:

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Anticancer Therapeutics

Anticancer Therapeutics
Author: Adam Todd,Paul W. Groundwater,Jason H. Gill
Publsiher: John Wiley & Sons
Total Pages: 446
Release: 2018-02-20
ISBN: 111862212X
Category: Science
Language: EN, FR, DE, ES & NL

Anticancer Therapeutics Book Excerpt:

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

Key Heterocyclic Cores for Smart Anticancer Drug Design Part II

Key Heterocyclic Cores for Smart Anticancer Drug   Design Part II
Author: Rajesh Kumar Singh
Publsiher: Bentham Science Publishers
Total Pages: 231
Release: 2022-09-02
ISBN: 9815040057
Category: Medical
Language: EN, FR, DE, ES & NL

Key Heterocyclic Cores for Smart Anticancer Drug Design Part II Book Excerpt:

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 2 of the book set covers these topics: - Anticancer targets for heterocyclic lead compounds - Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity - Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds - Natural products as anticancer agents

Outlines and Highlights for Medicinal Chemistry of Anticancer Drugs by Carmen Avendano

Outlines and Highlights for Medicinal Chemistry of Anticancer Drugs by Carmen Avendano
Author: Cram101 Textbook Reviews
Publsiher: Academic Internet Pub Incorporated
Total Pages: 146
Release: 2011-07-01
ISBN: 9781618307927
Category: Education
Language: EN, FR, DE, ES & NL

Outlines and Highlights for Medicinal Chemistry of Anticancer Drugs by Carmen Avendano Book Excerpt:

Never HIGHLIGHT a Book Again! Virtually all of the testable terms, concepts, persons, places, and events from the textbook are included. Cram101 Just the FACTS101 studyguides give all of the outlines, highlights, notes, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanys: 9780444528247 .

Medicinal Chemistry of Chemotherapeutic Agents

Medicinal Chemistry of Chemotherapeutic Agents
Author: Pratap Chandra Acharya,Michio Kurosu
Publsiher: Academic Press
Total Pages: 700
Release: 2022-09-15
ISBN: 9780323905756
Category: Medical
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Chemotherapeutic Agents Book Excerpt:

Research into the two types of chemotherapeutic agents, antimicrobials and anticancer, is an ongoing process, due to increasing resistance to the agents leading to subsequent failure of the treatment. This continues to challenge the pharmaceutical industry in developing newer antibiotics or safer antineoplastic agents. Medicinal Chemistry of Chemotherapeutic Agents focuses on the basics and fundamentals of chemistry involved in the chemotherapeutic agents. Each chapter comprises the distinct chemical classifications with structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure-activity relationship (SAR) studies. It covers the current research focused on the drug resistance and the method to overcome it, development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials and newly approved drugs, if any. The book is a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents. Included current research focused on the drug resistance and the method to overcome Outlines the synthetic schemes and metabolic pathways of the chemotherapeutic agents Discusses molecules under clinical trials and newly approved drugs

Studyguide for Medicinal Chemistry of Anticancer Drugs by Avendano Carmen

Studyguide for Medicinal Chemistry of Anticancer Drugs by Avendano  Carmen
Author: Cram101 Textbook Reviews
Publsiher: Cram101
Total Pages: 146
Release: 2013-05
ISBN: 9781490212111
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Studyguide for Medicinal Chemistry of Anticancer Drugs by Avendano Carmen Book Excerpt:

Never HIGHLIGHT a Book Again Includes all testable terms, concepts, persons, places, and events. Cram101 Just the FACTS101 studyguides gives all of the outlines, highlights, and quizzes for your textbook with optional online comprehensive practice tests. Only Cram101 is Textbook Specific. Accompanies: 9780872893795. This item is printed on demand.

Advances in Metallodrugs

Advances in Metallodrugs
Author: Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2020-07-08
ISBN: 1119640423
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Metallodrugs Book Excerpt:

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Key Heterocyclic Cores for Smart Anticancer Drug Design Part I

Key Heterocyclic Cores for Smart Anticancer Drug   Design Part I
Author: Rajesh Kumar Singh
Publsiher: Bentham Science Publishers
Total Pages: 285
Release: 2022-07-05
ISBN: 9815040081
Category: Medical
Language: EN, FR, DE, ES & NL

Key Heterocyclic Cores for Smart Anticancer Drug Design Part I Book Excerpt:

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Medicinal Chemistry Approaches to Personalized Medicine

Medicinal Chemistry Approaches to Personalized Medicine
Author: Karen Lackey,Bruce Roth
Publsiher: John Wiley & Sons
Total Pages: 408
Release: 2013-11-22
ISBN: 3527677275
Category: Science
Language: EN, FR, DE, ES & NL

Medicinal Chemistry Approaches to Personalized Medicine Book Excerpt:

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas, such as neurosciences and inflammation, are also covered. With its careful balance of current and future approaches, this handbook is a prime knowledge source for every drug developer, and one that will remain up to date for some time to come. From the content: * Discovery of Predictive Biomarkers for Anticancer Drugs * Discovery and Development of Vemurafenib * Targeting Basal-Cell Carcinoma * G-Quadruplexes as Therapeutic Targets in Cancer * From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease * Therapeutic Potential of Kinases in Asthma * DNA Damage Repair Pathways and Synthetic Lethality * Medicinal Chemistry in the Context of the Human Genome and many more

Novel Anticancer Agents

Novel Anticancer Agents
Author: Alex A. Adjei,John K. Buolamwini
Publsiher: Academic Press
Total Pages: 492
Release: 2006
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Novel Anticancer Agents Book Excerpt:

Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field Presents drug discovery strategies Discusses regulatory issues surrounding drug development

Cisplatin

Cisplatin
Author: Bernhard Lippert
Publsiher: John Wiley & Sons
Total Pages: 628
Release: 1999
ISBN: 9783906390208
Category: Medical
Language: EN, FR, DE, ES & NL

Cisplatin Book Excerpt:

30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

Anticancer Agents from Natural Products Second Edition

Anticancer Agents from Natural Products  Second Edition
Author: Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publsiher: CRC Press
Total Pages: 786
Release: 2011-10-10
ISBN: 1439813825
Category: Science
Language: EN, FR, DE, ES & NL

Anticancer Agents from Natural Products Second Edition Book Excerpt:

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

New Strategies Targeting Cancer Metabolism

New Strategies Targeting Cancer Metabolism
Author: Galal H. Elgemeie,Reham A. Mohamed-Ezzat
Publsiher: Elsevier
Total Pages: 628
Release: 2022-06-07
ISBN: 0128217839
Category: Science
Language: EN, FR, DE, ES & NL

New Strategies Targeting Cancer Metabolism Book Excerpt:

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields. Provides the only resource dedicated to synthetic strategies of antimetabolites Features synthetic strategies for nucleosides and their analogues Includes coverage of purine-, pyrimidine- and antifolate-based anticancer drugs The most significant anticancer alkylating agents and natural products are demonstrated

Natural Products in Medicinal Chemistry

Natural Products in Medicinal Chemistry
Author: Stephen Hanessian
Publsiher: John Wiley & Sons
Total Pages: 652
Release: 2013-12-18
ISBN: 3527676554
Category: Medical
Language: EN, FR, DE, ES & NL

Natural Products in Medicinal Chemistry Book Excerpt:

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Essentials of Inorganic Chemistry

Essentials of Inorganic Chemistry
Author: Katja A. Strohfeldt
Publsiher: John Wiley & Sons
Total Pages: 290
Release: 2015-02-16
ISBN: 0470665580
Category: Science
Language: EN, FR, DE, ES & NL

Essentials of Inorganic Chemistry Book Excerpt:

A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective. Written for students of pharmacy and pharmacology, pharmaceutical sciences, medicinal chemistry and other health-care related subjects, this accessible text introduces chemical principles with relevant pharmaceutical examples rather than as stand-alone concepts, allowing students to see the relevance of this subject for their future professions. It includes exercises and case studies.

Drug Repurposing

Drug Repurposing
Author: Shailendra K. Saxena
Publsiher: BoD – Books on Demand
Total Pages: 385
Release: 2022-06-01
ISBN: 1839699574
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Repurposing Book Excerpt:

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.

Metals in Medicine

Metals in Medicine
Author: James C. Dabrowiak
Publsiher: John Wiley & Sons
Total Pages: 480
Release: 2017-05-02
ISBN: 1119191343
Category: Science
Language: EN, FR, DE, ES & NL

Metals in Medicine Book Excerpt:

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Author: Franco Cataldo,Tatiana da Ros
Publsiher: Springer Science & Business Media
Total Pages: 408
Release: 2008-09-08
ISBN: 140206845X
Category: Science
Language: EN, FR, DE, ES & NL

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes Book Excerpt:

Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks. Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances. In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications. The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.

Advances in Anticancer Agents in Medicinal Chemistry

Advances in Anticancer Agents in Medicinal Chemistry
Author: Michelle Prudhomme
Publsiher: Unknown
Total Pages: 491
Release: 2014-05-27
ISBN: 9781608054930
Category: Medical
Language: EN, FR, DE, ES & NL

Advances in Anticancer Agents in Medicinal Chemistry Book Excerpt:

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series copmrising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume presents reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small inhibitors of various proteins involved in cancer development.