Modeling and Control of Drug Delivery Systems

Modeling and Control of Drug Delivery Systems
Author: Ahmad Taher Azar
Publsiher: Academic Press
Total Pages: 408
Release: 2021-02-06
ISBN: 0128211954
Category: Computers
Language: EN, FR, DE, ES & NL

Modeling and Control of Drug Delivery Systems Book Excerpt:

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Encyclopedia of Optimization

Encyclopedia of Optimization
Author: Christodoulos A. Floudas,Panos M. Pardalos
Publsiher: Springer Science & Business Media
Total Pages: 4646
Release: 2008-09-04
ISBN: 0387747583
Category: Mathematics
Language: EN, FR, DE, ES & NL

Encyclopedia of Optimization Book Excerpt:

The goal of the Encyclopedia of Optimization is to introduce the reader to a complete set of topics that show the spectrum of research, the richness of ideas, and the breadth of applications that has come from this field. The second edition builds on the success of the former edition with more than 150 completely new entries, designed to ensure that the reference addresses recent areas where optimization theories and techniques have advanced. Particularly heavy attention resulted in health science and transportation, with entries such as "Algorithms for Genomics", "Optimization and Radiotherapy Treatment Design", and "Crew Scheduling".

Modelling Optimization and Control of Biomedical Systems

Modelling Optimization and Control of Biomedical Systems
Author: Efstratios N. Pistikopoulos,Ioana Nascu,Eirini G. Velliou
Publsiher: John Wiley & Sons
Total Pages: 326
Release: 2018-01-09
ISBN: 1118965590
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Modelling Optimization and Control of Biomedical Systems Book Excerpt:

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Control of Biological and Drug Delivery Systems for Chemical Biomedical and Pharmaceutical Engineering

Control of Biological and Drug Delivery Systems for Chemical  Biomedical  and Pharmaceutical Engineering
Author: Laurent Simon
Publsiher: John Wiley & Sons
Total Pages: 384
Release: 2012-11-27
ISBN: 1118396480
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Control of Biological and Drug Delivery Systems for Chemical Biomedical and Pharmaceutical Engineering Book Excerpt:

Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
Author: Davide Manca
Publsiher: Elsevier
Total Pages: 418
Release: 2018-07-18
ISBN: 0444639675
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Quantitative Systems Pharmacology Book Excerpt:

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Bioavailability Control by Drug Delivery System Design

Bioavailability Control by Drug Delivery System Design
Author: Victor F. Smolen,LuAnn Ball
Publsiher: Wiley-Interscience
Total Pages: 438
Release: 1985
ISBN: 1928374650XXX
Category: Bioavailability
Language: EN, FR, DE, ES & NL

Bioavailability Control by Drug Delivery System Design Book Excerpt:

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Author: Emmanuel C. Opara
Publsiher: CRC Press
Total Pages: 351
Release: 2020-02-28
ISBN: 0429584652
Category: Medical
Language: EN, FR, DE, ES & NL

Controlled Drug Delivery Systems Book Excerpt:

This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Drug Delivery Systems

Drug Delivery Systems
Author: Kewal K. Jain
Publsiher: Springer Science & Business Media
Total Pages: 255
Release: 2008-03-07
ISBN: 1588298914
Category: Science
Language: EN, FR, DE, ES & NL

Drug Delivery Systems Book Excerpt:

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
Author: Jayvadan K. Patel
Publsiher: Springer Nature
Total Pages: 437
Release: 2022
ISBN: 303083395X
Category: Drug delivery systems
Language: EN, FR, DE, ES & NL

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems Book Excerpt:

A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Assessing Bioavailablility of Drug Delivery Systems

Assessing Bioavailablility of Drug Delivery Systems
Author: Jean-Maurice Vergnaud,Iosif-Daniel Rosca
Publsiher: CRC Press
Total Pages: 248
Release: 2005-05-26
ISBN: 1420037854
Category: Medical
Language: EN, FR, DE, ES & NL

Assessing Bioavailablility of Drug Delivery Systems Book Excerpt:

Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma le

Artificial Neural Network for Drug Design Delivery and Disposition

Artificial Neural Network for Drug Design  Delivery and Disposition
Author: Munish Puri,Yashwant Pathak,Vijay Kumar Sutariya,Srinivas Tipparaju,Wilfrido Moreno
Publsiher: Academic Press
Total Pages: 440
Release: 2015-10-15
ISBN: 0128017449
Category: Medical
Language: EN, FR, DE, ES & NL

Artificial Neural Network for Drug Design Delivery and Disposition Book Excerpt:

Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences. Written by leading academic and industry scientists who have contributed significantly to the field and are at the forefront of artificial neural network (ANN) research Focuses on ANN in drug design, discovery and delivery, as well as adopted methodologies and their applications to the treatment of various diseases and disorders Chapters cover important topics across the pharmaceutical process, such as ANN in structure-based drug design and the application of ANN in modern drug discovery Presents the future potential of ANN-based strategies in biomedical image analysis and much more

Engineering Drug Delivery Systems

Engineering Drug Delivery Systems
Author: Ali Seyfoddin,Seyedehsara Masoomi Dezfooli,Carol Ann Greene
Publsiher: Woodhead Publishing
Total Pages: 250
Release: 2019-11-15
ISBN: 0081025491
Category: Medical
Language: EN, FR, DE, ES & NL

Engineering Drug Delivery Systems Book Excerpt:

Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology. This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry. Examines the properties and synthesis of biomaterials for successful drug delivery Discusses the important connection between drug delivery and tissue engineering Includes techniques and approaches applicable to a wide range of users Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery

The ADME Encyclopedia

The ADME Encyclopedia
Author: Alan Talevi
Publsiher: Springer Nature
Total Pages: 1209
Release: 2022-06-14
ISBN: 3030848604
Category: Medical
Language: EN, FR, DE, ES & NL

The ADME Encyclopedia Book Excerpt:

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advance knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries and subentries, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties.

Drug Delivery Systems

Drug Delivery Systems
Author: Anonim
Publsiher: Academic Press
Total Pages: 792
Release: 2019-10-23
ISBN: 0128145080
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Systems Book Excerpt:

Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Collagen Biografts for Tunable Drug Delivery

Collagen Biografts for Tunable Drug Delivery
Author: Rucha Joshi
Publsiher: Springer Nature
Total Pages: 107
Release: 2021-01-31
ISBN: 3030638170
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Collagen Biografts for Tunable Drug Delivery Book Excerpt:

This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen​; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.

Treatise on Controlled Drug Delivery

Treatise on Controlled Drug Delivery
Author: Agis F. Kydonieus
Publsiher: Routledge
Total Pages: 659
Release: 2017-10-02
ISBN: 1351406876
Category: Medical
Language: EN, FR, DE, ES & NL

Treatise on Controlled Drug Delivery Book Excerpt:

An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
Author: Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon
Publsiher: Springer Science & Business Media
Total Pages: 662
Release: 2008-10-29
ISBN: 9780387776682
Category: Medical
Language: EN, FR, DE, ES & NL

Nanotechnology in Drug Delivery Book Excerpt:

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Advanced Control of Chemical Processes 1994

Advanced Control of Chemical Processes 1994
Author: D. Bonvin
Publsiher: Elsevier
Total Pages: 560
Release: 2014-05-23
ISBN: 1483297594
Category: Science
Language: EN, FR, DE, ES & NL

Advanced Control of Chemical Processes 1994 Book Excerpt:

This publication brings together the latest research findings in the key area of chemical process control; including dynamic modelling and simulation - modelling and model validation for application in linear and nonlinear model-based control: nonlinear model-based predictive control and optimization - to facilitate constrained real-time optimization of chemical processes; statistical control techniques - major developments in the statistical interpretation of measured data to guide future research; knowledge-based v model-based control - the integration of theoretical aspects of control and optimization theory with more recent developments in artificial intelligence and computer science.

16th European Symposium on Computer Aided Process Engineering and 9th International Symposium on Process Systems Engineering

16th European Symposium on Computer Aided Process Engineering and 9th International Symposium on Process Systems Engineering
Author: Wolfgang Marquardt,Costas Pantelides
Publsiher: Elsevier
Total Pages: 2318
Release: 2006-08-02
ISBN: 9780080525808
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

16th European Symposium on Computer Aided Process Engineering and 9th International Symposium on Process Systems Engineering Book Excerpt:

This proceedings book contains the papers presented at the joint conference event of the 9th Symposium on Process Systems Engineering (PSE'2006) and the 16th European Symposium on Computer Aided Process Engineering (ESCAPE-16), held in Garmisch-Partenkirchen, Germany, from July 9 – July 13, 2006. The symposium follows the first joint event PSE’97 / ESCAPE-7 in Trondheim, Norway (1997). The last two venues of the ESCAPE symposia were Barcelona, Spain (2005) and Lisbon, Portugal (2004) and the most recent PSE symposia were held in Kunming, China (2003) and Keystone, Colorado, USA (2000). The purpose of both series is to bring together the international community of researchers engineers who are interested in computing-based methods in process engineering. The main objective of the symposium is to review and present the latest developments and current state in Process Systems Engineering and Computer Aided Process Engineering. The focus of PSE’2006 / ESCAPE-16 has been on Modelling and Numerical Methods, Product and Process Design, Operations and Control, Biological Systems, Infrastructure Systems, and Business decision support. * reviews and presents the latest developments and current state of Process Systems Engineering and Computer Aided Process Engineering * contains papers presented at a joint conference event * bringing together an international community of researchers and engineers interested in computing-based methods in Process Engineering

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery
Author: Rebecca A. Bader,David A. Putnam
Publsiher: John Wiley & Sons
Total Pages: 496
Release: 2014-01-17
ISBN: 1118747801
Category: Social Science
Language: EN, FR, DE, ES & NL

Engineering Polymer Systems for Improved Drug Delivery Book Excerpt:

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.