Description : Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Description : Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning
Description : Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices). Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation
Description : The present text sets itself in relief to other titles on the subject in that it addresses the means and methodologies versus a narrow specific-task oriented approach. Concepts and their developments which evolved to meet the changing needs of applications are addressed. This approach provides the reader with a general tool-box to apply to their specific needs. Two important tools are presented: dimensional analysis and the similarity analysis methods. The fundamental point of view, enabling one to sort all models, is that of information flux between a model and an original expressed by the similarity and abstraction Each chapter includes original examples and applications. In this respect, the models can be divided into several groups. The following models are dealt with separately by chapter; mathematical and physical models, physical analogues, deterministic, stochastic, and cybernetic computer models. The mathematical models are divided into asymptotic and phenomenological models. The phenomenological models, which can also be called experimental, are usually the result of an experiment on an complex object or process. The variable dimensionless quantities contain information about the real state of boundary conditions, parameter (non-linearity) changes, and other factors. With satisfactory measurement accuracy and experimental strategy, such models are highly credible and can be used, for example in control systems.
Description : The articles in The Encyclopedia of Medical Devices and Instrumentation focus on what is currently useful or is likely to be useful in future medicine. They answer the question, What are the branches of medicine and how does technology assist each of them? Articles focus on the practice of medicine that is assisted by devices, rather than including, for example, the use of drugs to treat disease. The title is the only resource on the market dealing with the subject in encyclopedic detail. * Accessible to practitioners with a broad range of backgrounds from students to researchers and physicians * Articles cover the latest developments such as nanotechnology, fiber optics, and signal processing
Description : Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.
Description : Many recently improved medical diagnostic techniques and therapeutic innovations have resulted from physiological systems modeling. This comprehensive book will help undergraduate and graduate students and biomedical scientists to gain a better understanding of how the principles of control theory, systems analysis, and model identification are used in physiological regulation. Ample Simulink? and MATLAB? examples throughout the text and posted at an IEEE FTP site will provide you with a hands-on approach for exploring modeling and analysis of biological control systems. You will learn about classical control theory and its application to physiological systems, and contemporary topics and methodologies shaping bioengineering research today. Discussions on the latest developments in system identification, optimal control, and nonlinear dynamical analysis will keep you up-to-date with recent bioengineering advances. From modeling and stability analysis to feedback control in physiological regulatory mechanisms, Physiological Control Systems provides an in-depth study of key bioengineering principles that is simply unmatched in the field. To obtain instructor material, please send an email to: [email protected]
Description : The thirty nine papers accepted for pub1 ication in the First International Conference on 'Interfaces in Medicine & Meehani cs' at Swansea in Apri 1, 1988 represent the current state of the art in the science of implant surgery. This initial venture was planned and undertaken when the present editors and their colleagues realised the need for a closer interaction and dialogue between the clinician and. those basic scientists working in the area of implant surgery. Thi s interface, together with the real interface at the material/tissue borders, thus forms the basis of the present conference. These two ideas, we felt, were nicely and effectively captured in the drawing by Edgar Rubins (1915), a perception psycho 1 ogi st, used on the book cover and elsewhere in our 1 iterature. The Proceedings were planned with some difficulty, due to the wi de scope of the conference. However, we felt the best format was to follow the logical progression of implant development. The introductory papers and talks therefore demonstrate the scope of surgical implants in current use. The development of an implant starts with modelling of the proposed implant and its potential environment and the proceedings follow the same format. Following this, materials in current use are discussed.