Molecular Aspects Of Chemotherapy

Author by : David Shugar
Languange : en
Publisher by : Springer
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Total Read : 56
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Description : While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter national Symposium on "Molecular Aspects of Chemotherapy", under the auspices of the International Society of Chemotherapy, and organized by the Committee on Drug Research, Polish Academy of Sciences, and the Department of Biotechnology and Biochemistry, Technical University of Gdansk. This volume includes the texts of the review lectures presented by invited participants on up-to-date achievements, and future perspectives, in molecular mechanisms of inhibition of cellular functions and metabolism, with emphasis on the design and mechanisms of action of chemotherapeutic agents for treatment of bacterial, neoplastic, viral and parasitic diseases. From the Contents, it will be seen that the range of disciplines represented was a broad one, including theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary sessions were supple mented by several poster sessions.


Molecular Aspects Of Chemotherapy

Author by : Edward Borowski
Languange : en
Publisher by : McGraw-Hill
Format Available : PDF, ePub, Mobi
Total Read : 84
Total Download : 418
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Molecular Aspects Of Chemotherapy

Author by : Edward Borowski
Languange : en
Publisher by : McGraw-Hill
Format Available : PDF, ePub, Mobi
Total Read : 76
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Molecular Aspects Of Chemotherapy

Author by : Polska Akademia Nauk. Committee on Drug Research
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 35
Total Download : 920
File Size : 54,8 Mb
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Description :


Molecular Aspects Of Chemotherapy

Author by : David Shugar
Languange : en
Publisher by : Springer Verlag
Format Available : PDF, ePub, Mobi
Total Read : 27
Total Download : 567
File Size : 42,6 Mb
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Molecular Aspects Of Chemotherapy

Author by : European Society for the Study of Purine and Pyrimidine Metabolism in Man
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 86
Total Download : 725
File Size : 55,8 Mb
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Description :


Molecular Aspects Of Chemotherapy

Author by : David Shugar
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 88
Total Download : 250
File Size : 53,8 Mb
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Description : While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter national Symposium on "Molecular Aspects of Chemotherapy", under the auspices of the International Society of Chemotherapy, and organized by the Committee on Drug Research, Polish Academy of Sciences, and the Department of Biotechnology and Biochemistry, Technical University of Gdansk. This volume includes the texts of the review lectures presented by invited participants on up-to-date achievements, and future perspectives, in molecular mechanisms of inhibition of cellular functions and metabolism, with emphasis on the design and mechanisms of action of chemotherapeutic agents for treatment of bacterial, neoplastic, viral and parasitic diseases. From the Contents, it will be seen that the range of disciplines represented was a broad one, including theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary sessions were supple mented by several poster sessions.


Bladder Tumors

Author by : Vinata B. Lokeshwar
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 74
Total Download : 385
File Size : 45,7 Mb
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Description : Bladder cancer is a common cancer of the urinary tract. It is the fourth leading cause of cancer-related death among men and the seventh among women. Clinical management of bladder cancer is challenging because of the heterogeneity among bladder tumors with respect to invasion and metastasis, frequent occurrence of new tumors in the bladder among patients treated with bladder preservation treatments and poor prognosis of patients with tumors that invade the bladder muscle and beyond. Due to these factors it has been said that the cost per patient of bladder cancer, from diagnosis to death is the highest of all cancers. In addition to it being a significant health problem, bladder cancer is an interesting cancer to study in many ways than one. For example, Environmental factors such as cigarette smoking and other carcinogens play a major role in the development of transitional carcinoma of the bladder, whereas, schitosomasis, a protozoan infection results in squamous cell carcinoma of the bladder. Different molecular pathways with distinct molecular signatures appear to be involved in the development of low-grade versus high-grade bladder tumors. Currently being monitored by an invasive endoscopic procedure, cystectomy, with urine cytology as an adjunct, bladder cancer is at the forefront of developing cancer biomarkers for non-invasive detection. Due to the differences in the invasive and metastatic potential of bladder tumors, treatment options differ depending upon tumor grade and stage. New advances are being made in treatment options to improve the outcome and quality of life for patients with bladder cancer. Similarly, new molecular nomograms are being discovered to predict treatment outcome so that individualized treatment options can be offered to patients.


Molecular Aspects Of Anticancer Drug Dna Interactions

Author by : Stephen Neidle
Languange : en
Publisher by : Macmillan International Higher Education
Format Available : PDF, ePub, Mobi
Total Read : 14
Total Download : 139
File Size : 42,8 Mb
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Description : Provides researchers in the biological and medical sciences with timely reviews of selected areas in molecular biology. Each volume is edited by an internationally recognised authority who selects authors and topics to provide a survey of current growth points in a specific field. Molecular Aspects of Anticancer Drug - DNA Interactions ; A definitive work in the cancer chemotherapy area, this second volume continues the work of the first in providing an up-to-date publication presenting the research of the most prominent workers in the field. Volume one was also published in 1993.