Multiparametric Statistics

Multiparametric Statistics
Author: Vadim Ivanovich Serdobolskii
Publsiher: Elsevier
Total Pages: 334
Release: 2007-10-18
ISBN: 9780080555928
Category: Mathematics
Language: EN, FR, DE, ES & NL

Multiparametric Statistics Book Excerpt:

This monograph presents mathematical theory of statistical models described by the essentially large number of unknown parameters, comparable with sample size but can also be much larger. In this meaning, the proposed theory can be called "essentially multiparametric". It is developed on the basis of the Kolmogorov asymptotic approach in which sample size increases along with the number of unknown parameters. This theory opens a way for solution of central problems of multivariate statistics, which up until now have not been solved. Traditional statistical methods based on the idea of an infinite sampling often break down in the solution of real problems, and, dependent on data, can be inefficient, unstable and even not applicable. In this situation, practical statisticians are forced to use various heuristic methods in the hope the will find a satisfactory solution. Mathematical theory developed in this book presents a regular technique for implementing new, more efficient versions of statistical procedures. Near exact solutions are constructed for a number of concrete multi-dimensional problems: estimation of expectation vectors, regression and discriminant analysis, and for the solution to large systems of empiric linear algebraic equations. It is remarkable that these solutions prove to be not only non-degenerating and always stable, but also near exact within a wide class of populations. In the conventional situation of small dimension and large sample size these new solutions far surpass the classical, commonly used consistent ones. It can be expected in the near future, for the most part, traditional multivariate statistical software will be replaced by the always reliable and more efficient versions of statistical procedures implemented by the technology described in this book. This monograph will be of interest to a variety of specialists working with the theory of statistical methods and its applications. Mathematicians would find new classes of urgent problems to be solved in their own regions. Specialists in applied statistics creating statistical packages will be interested in more efficient methods proposed in the book. Advantages of these methods are obvious: the user is liberated from the permanent uncertainty of possible instability and inefficiency and gets algorithms with unimprovable accuracy and guaranteed for a wide class of distributions. A large community of specialists applying statistical methods to real data will find a number of always stable highly accurate versions of algorithms that will help them to better solve their scientific or economic problems. Students and postgraduates will be interested in this book as it will help them get at the foremost frontier of modern statistical science. - Presents original mathematical investigations and open a new branch of mathematical statistics - Illustrates a technique for developing always stable and efficient versions of multivariate statistical analysis for large-dimensional problems - Describes the most popular methods some near exact solutions; including algorithms of non-degenerating large-dimensional discriminant and regression analysis

Living Without Mathematical Statistics

Living Without Mathematical Statistics
Author: Herbert Ruefer
Publsiher: Springer
Total Pages: 507
Release: 2018-09-28
ISBN: 3319996320
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Living Without Mathematical Statistics Book Excerpt:

The underlying principles invented and developed by Dr. Genichi Taguchi (1924 - 2012), for the design of experiments or simulation calculations in multi-parameter systems, are today known as Taguchi Method. Due to the great success, it was extended to many other areas. The book explains the basics of this method in as much detail as necessary and as simply and graphically as possible. The author shows how broad the current application spectrum is and for which different tasks it can be used. The application examples range from optimizing a fermentation process in biotechnology to minimizing costs in mechanical production and maintaining and improving competitiveness in industrial production. The processes described are ideally suited to finding reliable and precise solutions for a wide variety of problems relatively quickly. A real competitive advantage not only in research but also for companies that want to remain competitive in international business competition. Contents Part 1: Analysis of Variables Part 2: Pattern Recognition and Diagnosis Part 3: Prognosis Target groups Students, scientists, engineers or those responsible for development and products learn to use the Taguchi Method with this book - even without any previous mathematical-statistical knowledge. The author Herbert Ruefer studied physics and obtained his doctorate at the Technical University Karlsruhe, Germany. After a research stay at IBM, San Jose, California, he taught at the San Marcos National University in Lima, Peru. He then took on research, development, and training tasks in the chemical industry in Germany. During this time, the first personal contacts with Dr. Genichi Taguchi and Dr. Yuin Wu took place. After his active professional life, he dedicated himself to special optical methods for astronomical observations. He also lectures at the Universidad Nacional Mayor de San Marcos which awarded him an honorary doctorate in 2017.

Introduction to the Science of Medical Imaging

Introduction to the Science of Medical Imaging
Author: R. Nick Bryan
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2009-11-19
ISBN: 1139482505
Category: Medical
Language: EN, FR, DE, ES & NL

Introduction to the Science of Medical Imaging Book Excerpt:

Revolutionary advances in imaging technology that provide high resolution, 3-D, non-invasive imaging of biological subjects have made biomedical imaging an essential tool in clinical medicine and biomedical research. Key technological advances include MRI, positron emission tomography (PET) and multidetector X-ray CT scanners. Common to all contemporary imaging modalities is the creation of digital data and pictures. The evolution from analog to digital image data is driving the rapidly expanding field of digital image analysis. Scientists from numerous disciplines now require in-depth knowledge of these complex imaging modalities. Introduction to the Science of Medical Imaging presents scientific imaging principles, introduces the major biomedical imaging modalities, reviews the basics of human and computer image analysis and provides examples of major clinical and research applications. Written by one of the world's most innovative and highly respected neuroradiologists, Introduction to the Science of Medical Imaging is a landmark text on image acquisition and interpretation.

Single Molecule Tools Part B Super Resolution Particle Tracking Multiparameter and Force Based Methods

Single Molecule Tools  Part B  Super Resolution  Particle Tracking  Multiparameter  and Force Based Methods
Author: Anonim
Publsiher: Academic Press
Total Pages: 720
Release: 2010-07-09
ISBN: 9780123814838
Category: Science
Language: EN, FR, DE, ES & NL

Single Molecule Tools Part B Super Resolution Particle Tracking Multiparameter and Force Based Methods Book Excerpt:

Single molecule tools have begun to revolutionize the molecular sciences, from biophysics to chemistry to cell biology. They hold the promise to be able to directly observe previously unseen molecular heterogeneities, quantitatively dissect complex reaction kinetics, ultimately miniaturize enzyme assays, image components of spatially distributed samples, probe the mechanical properties of single molecules in their native environment, and "just look at the thing" as anticipated by the visionary Richard Feynman already half a century ago. Single Molecule Tools, Part B: Super-Resolution, Particle Tracking, Multiparameter, and Force Based Methods captures a snapshot of this vibrant, rapidly expanding field, presenting articles from pioneers in the field intended to guide both the newcomer and the expert through the intricacies of getting single molecule tools. Includes time-tested core methods and new innovations applicable to any researcher employing single molecule tools Methods included are useful to both established researchers and newcomers to the field Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines

Quantitative MRI of the Brain

Quantitative MRI of the Brain
Author: Paul Tofts
Publsiher: John Wiley & Sons
Total Pages: 650
Release: 2005-08-19
ISBN: 0470869496
Category: Medical
Language: EN, FR, DE, ES & NL

Quantitative MRI of the Brain Book Excerpt:

2004 BMA Medical Book Competition Winner (Radiology category) “This is an exciting book, with a new approach to use of the MRI scanner. It bridges the gap between clinical research and general neuro-radiological practice. It is accessible to the clinical radiologist, and yet thorough in its treatment of the underlying physics and of the science of measurement. It is likely to become a classic.” British Medical Association This indispensable 'how to' manual of quantitative MR is essential for anyone who wants to use the gamut of modern quantitative methods to measure the effects of neurological disease, its progression, and its response to treatment. It contains both the methodology and clinical applications, reflecting the increasing interest in quantitative MR in studying disease and its progression. The editor is an MR scientist with an international reputation for high quality research The contributions are written jointly by MR physicists and MR clinicians, producing a practical book for both the research and medical communities A practical book for both the research and medical communities “Paul Tofts has succeeded brilliantly in capturing the essence of what needs to become the future of radiology in particular, and medicine in general – quantitative measurements of disease.” Robert I. Grossman, M.D. New York, University School of Medicine (from the Foreword)

High Throughput Screening Methods

High Throughput Screening Methods
Author: Joshua A Bittker,Nathan T Ross
Publsiher: Royal Society of Chemistry
Total Pages: 396
Release: 2016-12-05
ISBN: 1782626778
Category: Medical
Language: EN, FR, DE, ES & NL

High Throughput Screening Methods Book Excerpt:

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Progress in Pattern Recognition Image Analysis Computer Vision and Applications

Progress in Pattern Recognition  Image Analysis  Computer Vision  and Applications
Author: Alvaro Pardo,Josef Kittler
Publsiher: Springer
Total Pages: 787
Release: 2015-10-24
ISBN: 331925751X
Category: Computers
Language: EN, FR, DE, ES & NL

Progress in Pattern Recognition Image Analysis Computer Vision and Applications Book Excerpt:

This book constitutes the refereed proceedings of the 20th Iberoamerican Congress on Pattern Recognition, CIARP 2015, held in Montevideo, Uruguay, in November 2015. The 95 papers presented were carefully reviewed and selected from 185 submissions. The papers are organized in topical sections on applications on pattern recognition; biometrics; computer vision; gesture recognition; image classification and retrieval; image coding, processing and analysis; segmentation, analysis of shape and texture; signals analysis and processing; theory of pattern recognition; video analysis, segmentation and tracking.

Analytical Measurements in Aquatic Environments

Analytical Measurements in Aquatic Environments
Author: Jacek Namiesnik,Piotr Szefer
Publsiher: CRC Press
Total Pages: 503
Release: 2009-08-26
ISBN: 9781420082692
Category: Science
Language: EN, FR, DE, ES & NL

Analytical Measurements in Aquatic Environments Book Excerpt:

Even a cursory perusal of any analytical journal will demonstrate the increasing important of trace and ultra-trace analysis. And as instrumentation continues to develop, the definition of the term "trace element" will undoubtedly continue to change. Covering the composition and underlying properties of freshwater and marine systems, Analytical Measurements in Aquatic Environments provides the basis for understanding both. It discusses all aspects of analytical protocols from the handling of representative samples to the metrological evaluation of specific steps and whole procedures. The book covers: handling of representative samples sample preservation techniques extraction techniques speciation analytics solvent-free sample preparation for analysis application of biotests bioanalytical methods for monitoring green analytical chemistry-application of the concept of sustainability in analytical laboratories application of the Life Cycle Assessment approach quality control and quality assurance of analytical results enhanced techniques of sample preparation hyphenated analytical techniques Ecotoxicological considerations and the effort to achieve an increasingly accurate description of the state of the environment challenge analytical chemists who need to determine increasingly lower concentrations of various analytes in samples that have complex and even non-homogenous matrices. The newly coined expression "analytics" emphasizes the interdisciplinary nature of available methods for obtaining information about material systems, with many methods that exceed the strict definition of analytical chemistry. Drawing on the disciplines of chemistry, physics, computer science, electronics, material science, and chemometrics, this book provides in depth information on the most important problems in analytics of samples from aquatic ecosystems.

Diversity Oriented Synthesis

Diversity Oriented Synthesis
Author: Andrea Trabocchi
Publsiher: John Wiley & Sons
Total Pages: 664
Release: 2013-06-17
ISBN: 1118618149
Category: Science
Language: EN, FR, DE, ES & NL

Diversity Oriented Synthesis Book Excerpt:

Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing diversity-oriented synthetic libraries and screeningmethods for identifying ligands. Lastly, it explores some promisingnew applications based on diversity-oriented synthesis that havethe potential to dramatically advance studies in drug discovery andchemical biology. Diversity-Oriented Synthesis begins with an introductorychapter that explores the basics, including a discussion of therelationship between diversity-oriented synthesis and classiccombinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of smallmolecules using diversity-oriented principles, includingpeptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis bydescribing chemical libraries Provides modern approaches to screening diversity-orientedsynthetic libraries, including high-throughput and high-contentscreening, small molecule microarrays, and smart screeningassays Presents the applications of diversity-oriented syntheticlibraries and small molecules in drug discovery and chemicalbiology, reporting the results of key studies and forecasting therole of diversity-oriented synthesis in future biomedicalresearch This book has been written and edited by leading internationalexperts in organic synthesis and its applications. Theircontributions are based on a thorough review of the currentliterature as well as their own firsthand experience developingsynthetic methods and applications. Clearly written and extensively referenced,Diversity-Oriented Synthesis introduces novices to thishighly promising field of research and serves as a springboard forexperts to advance their own research studies and develop newapplications.

Encyclopedia of Ocean Sciences

Encyclopedia of Ocean Sciences
Author: Anonim
Publsiher: Academic Press
Total Pages: 4306
Release: 2019-04-12
ISBN: 0128130822
Category: Science
Language: EN, FR, DE, ES & NL

Encyclopedia of Ocean Sciences Book Excerpt:

The oceans cover 70% of the Earth’s surface, and are critical components of Earth’s climate system. This new edition of Encyclopedia of Ocean Sciences summarizes the breadth of knowledge about them, providing revised, up to date entries as well coverage of new topics in the field. New and expanded sections include microbial ecology, high latitude systems and the cryosphere, climate and climate change, hydrothermal and cold seep systems. The structure of the work provides a modern presentation of the field, reflecting the input and different perspective of chemical, physical and biological oceanography, the specialized area of expertise of each of the three Editors-in-Chief. In this framework maximum attention has been devoted to making this an organic and unified reference. Represents a one-stop. organic information resource on the breadth of ocean science research Reflects the input and different perspective of chemical, physical and biological oceanography, the specialized area of expertise of each of the three Editors-in-Chief New and expanded sections include microbial ecology, high latitude systems and climate change Provides scientifically reliable information at a foundational level, making this work a resource for students as well as active researches

Food Protected Designation of Origin

Food Protected Designation of Origin
Author: Anonim
Publsiher: Newnes
Total Pages: 800
Release: 2013-06-11
ISBN: 0444595724
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Food Protected Designation of Origin Book Excerpt:

Protected designation of origin (PDO) taken together with other geographical indicators, such as protected geographical indication (PGI) and traditional specialty guaranteed (TSG), offer the consumer additional guarantees on the quality and authentication of foods. They are important tools that protect the names of regional foods, such as wines, cheeses, hams, sausages and olives, so that only foods that genuinely originate in a particular region are allowed to be identified as such. The economic value of these regional foods, as well as the increased interest from consumers and the food industry about the traceability and origin of food, mean that it has become necessary to establish methods for PDO and PGI authentication based on the specific characteristics and chemical markers of these kinds of products. This book offers a complete guide of the methods available to authenticate food PDO, beginning with an explanation of the analytical and chemometric methods available for PDO authentication, before looking at the main foods covered, PGI labels and the social and legal framework for food PGIs. It will be of interest to people engaged in the fields of food production, commercialization and consumption, as well as policymakers and control laboratories. Offers a complete guide to the methods available for food Protected Designation of Origin (PDO) authentication Explains the analytical and chemometric methods Focuses on the various food products covered by authentication labels

Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine
Author: Claudio Carini,Sandeep M Menon,Mark Chang
Publsiher: CRC Press
Total Pages: 376
Release: 2014-03-27
ISBN: 1466593873
Category: Mathematics
Language: EN, FR, DE, ES & NL

Clinical and Statistical Considerations in Personalized Medicine Book Excerpt:

The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Quantitative MRI of the Brain

Quantitative MRI of the Brain
Author: Mara Cercignani,Nicholas G. Dowell,Paul S. Tofts
Publsiher: CRC Press
Total Pages: 342
Release: 2018-01-12
ISBN: 1315363569
Category: Science
Language: EN, FR, DE, ES & NL

Quantitative MRI of the Brain Book Excerpt:

Building on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment. The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications. This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body. This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment. Features: The first edition was awarded the book prize for Radiology by the British Medical Association in 2004 Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRI Gives specific ‘how to’ information for implementation of MRI measurement sequence techniques

Elements of Physical Oceanography

Elements of Physical Oceanography
Author: John H. Steele,Steve A. Thorpe,Karl K. Turekian
Publsiher: Academic Press
Total Pages: 647
Release: 2009-08-26
ISBN: 0123757258
Category: Science
Language: EN, FR, DE, ES & NL

Elements of Physical Oceanography Book Excerpt:

Elements of Physical Oceanography is a derivative of the Encyclopedia of Ocean Sciences, 2nd Edition and serves as an important reference on current physical oceanography knowledge and expertise in one convenient and accessible source. Its selection of articles—all written by experts in their field—focuses on ocean physics, air-sea transfers, waves, mixing, ice, and the processes of transfer of properties such as heat, salinity, momentum and dissolved gases, within and into the ocean. Elements of Physical Oceanography serves as an ideal reference for topical research. References related articles in physical oceanography to facilitate further research Richly illustrated with figures and tables that aid in understanding key concepts Includes an introductory overview and then explores each topic in detail, making it useful to experts and graduate-level researchers Topical arrangement makes it the perfect desk reference

Oceanography and Marine Biology

Oceanography and Marine Biology
Author: R. N. Gibson,R. J. A. Atkinson,J. D. M. Gordon,R. N. Hughes
Publsiher: CRC Press
Total Pages: 388
Release: 2012-06-05
ISBN: 1439890005
Category: Science
Language: EN, FR, DE, ES & NL

Oceanography and Marine Biology Book Excerpt:

Ever-increasing interest in oceanography and marine biology and their relevance to global environmental issues creates a demand for authoritative reviews summarising the results of recent research. Oceanography and Marine Biology: An Annual Review has catered to this demand since its founding by the late Harold Barnes fifty years ago. Its objectives are to consider, annually, the basic areas of marine research, returning to them when appropriate in future volumes; to deal with subjects of special and topical importance; and to add new subjects as they arise. The favourable reception accorded to all the volumes shows that the series is fulfilling a very real need: reviews and sales have been gratifying. A milestone in the history of the series, the fiftieth volume follows closely the objectives and style of the earlier volumes, continuing to regard the marine sciences—with all their various aspects—as a unity. Physical, chemical, and biological aspects of marine science are dealt with by experts actively engaged in these fields. The series is an essential reference text for researchers and students in all fields of marine science and related subjects, and it finds a place in libraries of not only marine stations and institutes, but also universities. It is consistently among the highest ranking impact factors for the marine biology category of the citation indices compiled by the Institute for Scientific Information.

Uncertainty aware Integration of Control with Process Operations and Multi parametric Programming Under Global Uncertainty

Uncertainty aware Integration of Control with Process Operations and Multi parametric Programming Under Global Uncertainty
Author: Vassilis M. Charitopoulos
Publsiher: Springer Nature
Total Pages: 266
Release: 2020-02-05
ISBN: 3030381374
Category: Science
Language: EN, FR, DE, ES & NL

Uncertainty aware Integration of Control with Process Operations and Multi parametric Programming Under Global Uncertainty Book Excerpt:

This book introduces models and methodologies that can be employed towards making the Industry 4.0 vision a reality within the process industries, and at the same time investigates the impact of uncertainties in such highly integrated settings. Advances in computing power along with the widespread availability of data have led process industries to consider a new paradigm for automated and more efficient operations. The book presents a theoretically proven optimal solution to multi-parametric linear and mixed-integer linear programs and efficient solutions to problems such as process scheduling and design under global uncertainty. It also proposes a systematic framework for the uncertainty-aware integration of planning, scheduling and control, based on the judicious coupling of reactive and proactive methods. Using these developments, the book demonstrates how the integration of different decision-making layers and their simultaneous optimisation can enhance industrial process operations and their economic resilience in the face of uncertainty.

Landscapes of Collectivity in the Life Sciences

Landscapes of Collectivity in the Life Sciences
Author: Snait B. Gissis,Ehud Lamm,Ayelet Shavit
Publsiher: MIT Press
Total Pages: 432
Release: 2018-01-12
ISBN: 0262036851
Category: Science
Language: EN, FR, DE, ES & NL

Landscapes of Collectivity in the Life Sciences Book Excerpt:

Broad perspective on collectivity in the life sciences, from microorganisms to human consensus, and the theoretical and empirical opportunities and challenges. Many researchers and scholars in the life sciences have become increasingly critical of the traditional methodological focus on the individual. This volume counters such methodological individualism by exploring recent and influential work in the life sciences that utilizes notions of collectivity, sociality, rich interactions, and emergent phenomena as essential explanatory tools to handle numerous persistent scientific questions in the life sciences. The contributors consider case studies of collectivity that range from microorganisms to human consensus, discussing theoretical and empirical challenges and the innovative methods and solutions scientists have devised. The contributors offer historical, philosophical, and biological perspectives on collectivity, and describe collective phenomena seen in insects, the immune system, communication, and human collectivity, with examples ranging from cooperative transport in the longhorn crazy ant to the evolution of autobiographical memory. They examine ways of explaining collectivity, including case studies and modeling approaches, and explore collectivity's explanatory power. They present a comprehensive look at a specific case of collectivity: the Holobiont notion (the idea of a multi-species collective, a host and diverse microorganisms) and the hologenome theory (which posits that the holobiont and its hologenome are a unit of adaption). The volume concludes with reflections on the work of the late physicist Eshel Ben-Jacob, pioneer in the study of collective phenomena in living systems. Contributors Oren Bader, John Beatty, Dinah R. Davison, Daniel Dor, Ofer Feinerman, Raghavendra Gadagkar, Scott F. Gilbert, Snait B. Gissis, Deborah M. Gordon, James Griesemer, Zachariah I. Grochau-Wright, Erik R. Hanschen, Eva Jablonka, Mohit Kumar Jolly, Anat Kolumbus, Ehud Lamm, Herbert Levine, Arnon Levy, Xue-Fei Li, Elisabeth A. Lloyd, Yael Lubin, Eva Maria Luef, Ehud Meron, Richard E. Michod, Samir Okasha, Simone Pika, Joan Roughgarden, Eugene Rosenberg, Ayelet Shavit, Yael Silver, Alfred I. Tauber, Ilana Zilber-Rosenberg

Immunity

Immunity
Author: Alfred I. Tauber
Publsiher: Oxford University Press
Total Pages: 304
Release: 2017-01-02
ISBN: 0190651253
Category: Science
Language: EN, FR, DE, ES & NL

Immunity Book Excerpt:

Modern immunology traditionally conceives of the immune system as providing defense against pathogens. Alfred I. Tauber criticizes this conception of immunity as too narrow, because it discounts much of the immune system's other normal functions. These include active tolerance of nutritional exchanges with the environment and the stabilization of cooperative relationships with resident micro-organisms. An expanded account extends immunity's functional role from singular 'defense' to broadened discernment of environmental 'exchange.' This ecological perspective has profound theoretical implications, for the basic notion of immune identity is reconfigured: highlighting the organism as a holobiont (a consortium of diverse organisms living in cooperative relationships) challenges prevailing concepts of individuality and the self/nonself dichotomy heretofore organizing immune theory. Indeed, if theoretical interest is focused on the challenges of maintaining immune balance in the full ecological context of the organism, then immune regulation assumes new complexity. Tauber maintains that the key to unravelling that puzzle requires a critical re-assessment of the cognitive processes that underlie immune effector functions. Accordingly, he provides the outline of a re-formulated 'cognitive paradigm' that dispenses with agent-based models and adopts an ecologically conceived understanding of perception and information processing. The implications of this revised configuration of immunity and its deconstructed notions of individuality and selfhood have wide significance for philosophers and life scientists working in immunology, ecology, and the cognitive sciences.

On the Asymptotic Equivalence of Two Classes of Tests of a Multiparameter Hypothesis

On the Asymptotic Equivalence of Two Classes of Tests of a Multiparameter Hypothesis
Author: Satya Prakash Agarwal
Publsiher: Unknown
Total Pages: 52
Release: 1957
ISBN: 1928374650XXX
Category: Mathematical statistics
Language: EN, FR, DE, ES & NL

On the Asymptotic Equivalence of Two Classes of Tests of a Multiparameter Hypothesis Book Excerpt:

Hybrid Artificial Intelligent Systems Part I

Hybrid Artificial Intelligent Systems  Part I
Author: Manuel Grana Romay,M. Teresa Garcia Sebastian
Publsiher: Springer
Total Pages: 606
Release: 2010-06-14
ISBN: 3642137695
Category: Computers
Language: EN, FR, DE, ES & NL

Hybrid Artificial Intelligent Systems Part I Book Excerpt:

th The 5 International Conference on Hybrid Artificial Intelligence Systems (HAIS 2010) has become a unique, established and broad interdisciplinary forum for researchers and practitioners who are involved in developing and applying symbolic and sub-symbolic techniques aimed at the construction of highly robust and reliable problem-solving techniques, and bringing the most relevant achievements in this field. Overcoming the rigid encasing imposed by the arising orthodoxy in the field of arti- cial intelligence, which has led to the partition of researchers into so-called areas or fields, interest in hybrid intelligent systems is growing because they give freedom to design innovative solutions to the ever-increasing complexities of real-world pr- lems. Noise and uncertainty call for probabilistic (often Bayesian) methods, while the huge amount of data in some cases asks for fast heuristic (in the sense of suboptimal and ad-hoc) algorithms able to give answers in acceptable time frames. High dim- sionality demands linear and non-linear dimensionality reduction and feature extr- tion algorithms, while the imprecision and vagueness call for fuzzy reasoning and linguistic variable formalization. Nothing impedes real-life problems to mix diffic- ties, presenting huge quantities of noisy, vague and high-dimensional data; therefore, the design of solutions must be able to resort to any tool of the trade to attack the problem. Combining diverse paradigms poses challenging problems of computational and methodological interfacing of several previously incompatible approaches. This is, thus, the setting of HAIS conference series, and its increasing success is the proof of the vitality of this exciting field.