Nanocarriers for the Delivery of Combination Drugs

Nanocarriers for the Delivery of Combination Drugs
Author: Sanjula Baboota,Javed Ali
Publsiher: Elsevier
Total Pages: 540
Release: 2021-05-18
ISBN: 0128209402
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Nanocarriers for the Delivery of Combination Drugs Book Excerpt:

Nanocarriers for the Delivery of Combination Drugs focuses on the role of nanocarriers in the delivery of combination drugs for the management and treatment of various diseases. Nanocarriers belonging to the category of polymeric nanoparticles, dendrimers, lipidic nanocarriers (like nanoemulsions), liposomes, solid lipid nanoparticles, nanostructured lipid carriers are now being used in the drug delivery of combination drugs. This book helps readers assimilate all the information available surrounding the application of various nanocarrier technologies for the delivery of combination drugs of synthetic and natural origin, including small and large molecules. This is an important reference source for pharmaceutical scientists and biomaterials scientists who are looking to gain an increased understanding on how nanotechnology is improving the efficiency of combination drug delivery. Outlines how nanocarriers are used to enhance combination drug delivery systems Assesses the major challenges of delivering combination drugs successfully, and explains how nanocarriers can help meet these challenges Explores the characteristics of a variety of nanocarrier material types

Functionalization of Nanocarriers for Efficient Combination Drug Delivery

Functionalization of Nanocarriers for Efficient Combination Drug Delivery
Author: Che-Ming Jack Hu
Publsiher: Unknown
Total Pages: 104
Release: 2011
ISBN: 9781267078452
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Functionalization of Nanocarriers for Efficient Combination Drug Delivery Book Excerpt:

Therapeutic Nanoparticles have shown significant impact in the field of medicine, particularly in anticancer drug delivery. Prolonged circulation time, functionalization with tumor-targeting ligands, and encapsulation of multiple drug types are among the key features of nanoparticles that make them desirable anticancer drug carriers. This dissertation will focus on these three major features of therapeutic nanoparticles and provide novel improvements in these areas. The first area of research is multi-drug coencapsulation, where precise control over drug-to-drug ratio has a major impact on the particles' therapeutic efficacy. A drug-polymer conjugate system is used to overcome the intrinsic differences in the physicochemical properties of different drug molecules. By adapting metal alkoxide chemistry, we synthesize highly hydrophobic drug-poly-l-lactide (drug-PLA) conjugates, of which the polymer has the same chain length while the drug may differ. These drug-polymer conjugates are then encapsulated into lipid-coated polymeric nanoparticles through a single-step nanoprecipitation method. Using doxorubicin (DOX) and camptothecin (CPT) as two model chemotherapy drugs, various ratios of DOX-PLA and CPT-PLA conjugates are loaded into the nanoparticles with over 90% loading efficiency. The resulting nanoparticles are uniform in size, size distribution and surface charge. The loading yield of DOX and CPT in the particles can be precisely controlled by simply adjusting the DOX-PLA:CPT-PLA molar ratio. Cellular cytotoxicity results show that the dual-drug loaded nanoparticles are superior to the corresponding cocktail mixtures of single-drug loaded nanoparticles. This dual-drug delivery approach offers a solution to the long-standing challenge in ratiometric control over the loading of different types of drugs onto the same drug delivery vehicle. The second area is nanoparticle functionalization for tumor-targeted delivery. we synthesize anti-CEA half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding non-targeted nanoparticles. The half-antibody approach offers the advantage of reduced ligand size, site-specific conjugation, and easy accessibility over existing functionalization approaches. The third area of research presented herein is a novel nature-inspired approach to camouflage nanoparticles for long systemic circulation. A top-down approach in coating biodegradable polymeric nanoparticles with natural erythrocyte membranes is reported. The structure, size and surface zeta potential, and protein contents of the erythrocyte membrane-coated nanoparticles were verified using transmission electron microscopy, dynamic light scattering, and gel electrophoresis respectively. Mice injections with fluorophore-loaded nanoparticles revealed superior circulation half-life by the erythrocyte-mimicking nanoparticles as compared to control particles coated with the state-of-the-art synthetic stealth materials. Biodistribution study revealed significant particle retention in the blood 72 hours following the particle injection. The translocation of natural cellular membranes, their associated proteins and the corresponding functionalities to the surface of synthetic particles represents a novel approach in nanoparticle functionalization. The developments on these three areas are compatible with one another and could be integrated as one multifunctional nanoparticle platform. Each of these features aims to target a distinctive barrier in cancer drug delivery.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases
Author: Prashant Kesharwani
Publsiher: Academic Press
Total Pages: 436
Release: 2022-04-08
ISBN: 0323858767
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases Book Excerpt:

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations. Provides an accounting of vital aspects on various combination drug delivery approaches, presenting next generation diagnostics and therapeutics Discusses the perspectives of current technologies in highly organized tables, illustrative figures and flow charts Defines major gaps in knowledge that can lead to significant scientific discoveries

Targeted Delivery of Drug Combinations Via Nanocarriers for Cancer Treatment

Targeted Delivery of Drug Combinations Via Nanocarriers for Cancer Treatment
Author: Kruti S. Soni
Publsiher: Unknown
Total Pages: 180
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Targeted Delivery of Drug Combinations Via Nanocarriers for Cancer Treatment Book Excerpt:

Combination therapy is preferred over monotherapy to treat cancer as it can show better therapeutic outcomes and also delay the onset of resistance by targeting multiple cell-survival pathways in cancer cells. Rationally developed combinations with monoclonal antibodies and small molecule drugs in the form of antibody-drug conjugates or antibody nanoparticle conjugates allow us to take advantage of the cellular targeting of the potent cytotoxic agents, thereby widening the scope for dose reduction while maintaining the required therapeutic response. This can in turn improve patient tolerability by reducing the off target toxicities. For the therapy of ErbB2 positive breast cancer, the monoclonal antibody, Trastuzumab, is the FDA approved therapy. The receptor tyrosine kinase, ErbB2 is a viable target in 20-25 % breast cancer patients due to its overexpression. Its degradation is associated with slower progression of the disease and increased survival times. While the monoclonal antibody Trastuzumab (HerceptinTM) is the first line therapy in such patients, monotherapy with Trastuzumab has shown little benefit and therefore must be given with chemotherapeutic agents. Such combinations also help in delaying the development of resistance to Trastuzumab, since multiple cellular pathways can be targeted simultaneously. ErbB2 is a client protein of heat shock protein 90 and 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) is a potent inhibitor of HSP90. Previous work in our lab has demonstrated strong synergy of action between 17-AAG and a model cytotoxic agent doxorubicin. In order to further improve the efficacy of the therapy, our goal was to replace doxorubicin with a more potent, clinically relevant agent paclitaxel (PTX), which has been shown to have strong synergistic antitumor effect with 17-AAG in ErbB2-driven breast cancers. Since synergy of such therapy is often sequence and dose ratio specific, co-delivery of the drugs via the same vehicle is desirable as well as beneficial. For this purpose, polymeric micelles prepared from a biodegradable block copolymer were chose. Polypeptides have an inherent property to assemble into supramolecular structures in solution. The formation of supramolecular structures is a controlled and organized process that depends by and large on the nature of the polypeptide and conditions of the solvent it is exposed to. Formation of amphiphilic copolymers based on such polypeptides can allow for tailoring the assembly process to a predefined nanoscale supramolecular structure, which can then be used as drug delivery vehicles. The overall process of self-assembly of such amphiphilic copolymers can then be regarded as a complex phenomenon of structural organization that is governed by the nature of constituent hydrophilic and hydrophobic blocks, their relative lengths, as well as properties of the solvent-phobic block that is the driving force for self-assembly. The inherent biocompatibility and biodegradability of polypeptides is of additional advantage for their biological applications. For the purpose of the current study, amphiphilic block copolymer with following composition was chosen: polyethylene glycol (PEG) as the hydrophilic, stealth imparting block and polyleucine (PLeu) as the hydrophobic part and the initiator of micelle formation in aqueous environment. The variables explored in the current study were altering the ratio of lengths of constituent blocks as well as chirality of PLeu block and the temperature of solvent used for preparation of micelles via the film rehydration method. The impact of all these variables on the thermodynamic stability as well as type of secondary structures formed and the influence of these attributes on the ability of the micelles to encapsulate a combination of hydrophobic drugs into their core are also described. Dual drug-loaded micelles thus prepared could load 17-AAG and PTX in a ratio 2:1 by weight. The formulation showed a high level of synergy on BT-474 cells that express a high amount of ErbB2 while the synergy was negligible in ErbB2low MCF-7 cells. The strong synergy also observed when the formulation was tested in an orthotopic breast cancer mouse model developed using ErbB2 overexpressing BT-474 cells, and an arrest in the growth of tumors in animals treated with dual drug-loaded micelles was observed, while both 17-AAG and PTX were used at sub therapeutic doses of 10 mg and 5 mg equivalents per kg body weight. The lower doses also helped avoid toxicity associated with the therapy. We also show the importance of simultaneously delivering the two drugs via a single carrier system as opposed to cocktail of individual drug-loaded micelles administered at equivalent doses, which has a better therapeutic outcome than the cocktail therapy. These combination drug-loaded micelles were developed as a platform for chemotherapy with Trast. The triple therapeutic system of Trast with combination drug-loaded micelles containing 17-AAG and PTX exhibited an even stronger anticancer effect, with complete regression of tumors at the end of treatment, which reached a palpable size again after day 45 with much slower progression than other treatment controls. Pancreatic cancer (PC) is one of the most lethal malignancies, due to aggressive tumorigenicity, early metastasis and development of drug resistance to standard care chemotherapy. Since its approval in 1997, Gemcitabine (Gem) has been the first-line treatment for advanced disease. However, there is no standard second-line therapy after Gem failure. FOLFIRINOX, a combination of four agents, folinic acid, fluorouracil, irinotecan and oxaliplatin was approved by the FDA in 2010. The rationale for this combination was based on these drugs having a different mechanism of action, and, more importantly, non-overlapping toxicities. In cases that could tolerate FOLFIRINOX, an overall improvement in the survival times as well as quality of life was noted. However, even the toxicities are non-overlapping, the cumulative toxicity profile for FOLFIRINOX can become the dose limiting factor. In the first trial itself, 50.8% of the patients needed dose adjustment. The common toxicities observed with FOLFIRINOX include Febrile neutropenia, Thrombocytopenic bleeding, ≥ grade 3 platelets, Grade 2 persistent neurotoxicity, Grade 3 persistent neurotoxicity OR Grade 4 neurotoxicity and many more non-hematological toxicities. Most of the toxicities are severe enough to require discontinuation of the treatment or switching to lower doses or alternative agents. The combination of Gem with Cisplatin (CDDP) has been explored in clinical trials for metastatic disease. As a part of FOLFIRINOX, platinum compounds showed significant efficacy. Cisplatin acts by damaging the DNA. It is known to first get converted into the aqua form within the cell, which happens by the replacement of the labile chloro groups with water molecules. This active form is then able to form covalently linked adducts with the DNA. This initial assault then goes on to activate a series of signaling pathways that ultimately lead to apoptosis and cell death. The DNA adducts thus formed can cause distortion of the DNA and subsequent recognition by various cellular proteins. This leads to problems in DNA synthesis and replication and is reported to cause a prolonged G2 cell-cycle phase arrest. However, the exact mechanism of activation of the apoptotic pathways remains unclear. On the other hand, gemcitabine is a deoxycytidine analog. Its mechanism of activation involves conversion into its triphosphate form, which can then be incorporated into the DNA as a false nucleotide. Usually, one more deoxynucleotide can be incorporated into the DNA before the synthesis stops. Another minor mechanism of action of gemcitabine is its ability to inhibit ribonucleotide reductase, which plays a key role in the repair mechanism of the DNA. Many studies report the benefit of administration of gemcitabine prior to that of cisplatin; the reason cited for this is the increase in the formation of Pt-DNA adducts when the DNA had already been damaged and exposed due to the incorporation of deoxycytidine or active gemcitabine. The gemcitabine in turn inhibits the repair of the formed Pt-DNA adducts as well as reduces the efficacy of nucleotide excision repair by its ability to inhibit the action of ribonucleotide reductase. On the other hand, when Pt compounds are administered prior to gemcitabine, the formed Pt-DNA adducts can no longer allow for the incorporation of gemcitabine and that leaves no scope for gemcitabine to act. Our preliminary in vitro studies with the free drugs on T3M4 Simple Cells (COSMC deleted cells) showed that synergy of the combination is schedule-dependent, and Gem administration followed by CDDP showed the most potent cytotoxic activity. However, this combination proved to be only marginally effective in actual practice due to combined increased toxicity of both the agents. We have shown that encapsulation of CDDP in polymeric nanogels with cross-linked ionic cores enhanced its tumor accumulation and improved its safety profile. Additionally, sustained release profile of CDDP from nanogels allows for the administration of free Gem and CDDP loaded nanogels in a single injection while still retaining schedule-dependent synergy of the combination. Pancreatic ductal adenocarcinoma cells are known to express truncated O-glycans (Tn and STn antigens) and it was shown that decorating the nanogels with an antibody directed against this antigen further enhanced their uptake by tumor cells while reducing off-target accumulation in an in vivo pancreatic cancer model.

Self Assembled Bio Nanomaterials

Self Assembled Bio Nanomaterials
Author: Gang Wei
Publsiher: MDPI
Total Pages: 134
Release: 2020-03-25
ISBN: 303928536X
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Self Assembled Bio Nanomaterials Book Excerpt:

Biomolecular self-assembly provides a green, facile, and highly effective method to synthesize various functional nanomaterials that have exhibited considerable potential in the fields of nanotechnology, materials science, biomedicine, tissue engineering, food science, energy storage, and environmental science. In this collection of articles, we presented recent advance in the synthesis, characterization, and applications of self-assembled bio-nanomaterials. In a comprehensive review article, the controlled self-assembly of biomolecules including DNA, protein, peptide, enzymes, virus, and biopolymers via internal interactions and external simulations is introduced and discussed in detail. In other research articles, the self-assembly of DNA, protein, peptide, bio-drugs, liquid crystal polycarbonates, and diblock copolymers to various biomimetic/bioinspired nanomaterials and their potential applications in nanopatterning, sensors/biosensors, drug delivery, anti-parasite, and water purification are demonstrated.

Multifunctional Nanocarriers

Multifunctional Nanocarriers
Author: Neelesh Kumar Mehra,Saurabh Srivastava,Jitender Madan,Pankaj Kumar Singh
Publsiher: Elsevier
Total Pages: 450
Release: 2022-06-15
ISBN: 9780323850414
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Multifunctional Nanocarriers Book Excerpt:

Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale

Nanopharmaceuticals

Nanopharmaceuticals
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 244
Release: 2020-01-10
ISBN: 0128177799
Category: Medical
Language: EN, FR, DE, ES & NL

Nanopharmaceuticals Book Excerpt:

Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 Encompasses functional aspects of nanocarriers Discusses Intellectual Property landscapes of micro-nano drug carriers Contains in-depth investigation of specific aspects of drug delivery systems

Frontiers in Nanomedicine

Frontiers in Nanomedicine
Author: Maria Luisa Bondì ,Chiara Botto , Erika Amore
Publsiher: Bentham Science Publishers
Total Pages: 270
Release: 2015-04-16
ISBN: 168108046X
Category: Science
Language: EN, FR, DE, ES & NL

Frontiers in Nanomedicine Book Excerpt:

Frontiers in Nanomedicine offers an up-to-date understanding of nanomaterials to readers having clinical or biomolecular research interests. Scientists, both aspiring and experienced, will find, in each volume, a comprehensive overview of current molecular strategies for using nanoscale materials in medicine. This volume explains the use of nanotechnology in medicine to improve the diagnosis of disease and the role of nanoparticles in targeted drug delivery systems for theranostic applications. This volume also covers the applications of nanoparticles in breast cancer research, liver disease therapy and Alzheimer’s disease treatment.

Delivery of Drugs

Delivery of Drugs
Author: Ranjita Shegokar
Publsiher: Elsevier
Total Pages: 242
Release: 2020-02-01
ISBN: 0128177772
Category: Medical
Language: EN, FR, DE, ES & NL

Delivery of Drugs Book Excerpt:

Delivery of Drugs: Expectations and Realities of Multifunctional Drug Delivery Systems, Volume Two examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects. This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders. This level of discussion makes it a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about the status of drug delivery systems. Delivery of Drugs examines the fabrication, optimization, scale-up, biological aspects, regulatory and clinical success of various micro and nano drug delivery systems. The volume covers site and organ specific targeting approaches, technologies used in preparation of micro - nanoparticles, challenges of complex type of drug delivery forms and role of physical methods in achieving targeted drug effect. Written by a diverse range of international researchers the chapters examine the specific aspects of characterization and manufacturing of drug delivery system for pharmaceutical application and its regulatory aspects. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

Lipid Modification of Polymeric Nanocarriers for Drug and SiRNA Delivery

Lipid Modification of Polymeric Nanocarriers for Drug and SiRNA Delivery
Author: Arash Falamarzian
Publsiher: Unknown
Total Pages: 308
Release: 2013
ISBN: 1928374650XXX
Category: Drug delivery systems
Language: EN, FR, DE, ES & NL

Lipid Modification of Polymeric Nanocarriers for Drug and SiRNA Delivery Book Excerpt:

The use of nanotechnology in pharmaceutical development has progressed significantly in recent decades. This rapid advancement is driven by crucial need for improving the performance of present diagnostic and therapeutic modalities, as well as development of a new class of delivery systems for complex entities such as genes and proteins. Nanocarriers currently in use for the delivery of drugs and genetic materials can be generally divided to two categories: those made from lipids and those made from synthetic or natural polymers. Although lipid-based carriers are generally regarded to be safe and efficient, they do not possess sufficient chemical flexibility to fit individual requirements in delivery. In this thesis, we have explored lipid-substitution of three different polymer-based nanocarriers as means to develop optimum structures for drug as well as siRNA delivery. For the delivery of a potent amphiphilic antifungal drug, amphotericin B (AmB), lipid modification (particularly cholesteryl modification) of the core structure in poly(ethylene oxide)-poly(caprolactone) micelles was proved to be efficient in enhancing the solubility while reducing the hemolytic activity of encapsulated AmB. On the other hand, lipid modification of low molecular weight (2 kDa) polyethyleneimine (PEI2) has enhanced the properties of the nanocarriers in the delivery of STAT3-siRNA in wild type and resistant breast cancer cell models leading to an improved anti-cancer efficacy in combination with chemotherapeutic drugs, i.e. DOX and PTX. Finally, cholesteryl modification of poly(ethylene oxide)-poly(caprolactone-g-spermine) enhanced the properties of these nanocarriers for in vivo delivery of siRNA. This modification enhanced the stability, safety and cellular uptake of complexed siRNA leading to better silencing activity at the mRNA level. Overall, our results pointed to the positive impact of lipid modification in enhancing the properties of polymeric nanocarriers leading to viable formulations for effective delivery of AmB and siRNA therapeutics.

Multifunctional Pharmaceutical Nanocarriers

Multifunctional Pharmaceutical Nanocarriers
Author: Vladimir Torchilin
Publsiher: Springer Science & Business Media
Total Pages: 474
Release: 2008-03-21
ISBN: 0387765549
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Multifunctional Pharmaceutical Nanocarriers Book Excerpt:

The editors have brought together leading experts in multifunctional nanopharmaceuticals to provide cutting edge information; a critical overview of the field; and analysis of current and potential future developments to speed the subject’s rapid development.

Current Applications for Overcoming Resistance to Targeted Therapies

Current Applications for Overcoming Resistance to Targeted Therapies
Author: Myron R. Szewczuk,Bessi Qorri,Manpreet Sambi
Publsiher: Springer
Total Pages: 320
Release: 2019-07-15
ISBN: 303021477X
Category: Medical
Language: EN, FR, DE, ES & NL

Current Applications for Overcoming Resistance to Targeted Therapies Book Excerpt:

Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.

Biogenic Nanoparticles for Cancer Theranostics

Biogenic Nanoparticles for Cancer Theranostics
Author: Chittaranjan Patra,Irshad Ahmad,Muhammad Ayaz,Ali Talha Khalil,Sudip Mukherjee,Muhammad Ovais
Publsiher: Elsevier
Total Pages: 284
Release: 2021-06-01
ISBN: 0128214686
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Biogenic Nanoparticles for Cancer Theranostics Book Excerpt:

Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types. Metal nanoparticles have traditionally been synthesized by classical physico-chemical methods which have many drawbacks, such as high energy demand, high cost and potential ecotoxicity. As a result, the biosynthesis of metal nanoparticles is gaining increasing prominence. Biosynthesis approaches to metal nanoparticles are clean, safe, energy efficient and environment friendly. Explains the synthesis methods and applications of biogenic nanoparticles for cancer theranostics Outlines the distinctive features of biogenic nanoparticles that make them effective cancer treatment agents Assesses the major challenges of using biogenic nanoparticles on a mass scale

Drug Delivery Using Nanomaterials

Drug Delivery Using Nanomaterials
Author: Yasser Shahzad,Syed A.A. Rizvi,Abid Mehmood Yousaf,Talib Hussain
Publsiher: CRC Press
Total Pages: 430
Release: 2022-01-19
ISBN: 1000529495
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Delivery Using Nanomaterials Book Excerpt:

After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.

Polysaccharide based Nano Biocarrier in Drug Delivery

Polysaccharide based Nano Biocarrier in Drug Delivery
Author: Tapan Kumar Giri,Bijaya Ghosh
Publsiher: CRC Press
Total Pages: 368
Release: 2018-09-03
ISBN: 042983067X
Category: Medical
Language: EN, FR, DE, ES & NL

Polysaccharide based Nano Biocarrier in Drug Delivery Book Excerpt:

This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
Author: Loutfy H. Madkour
Publsiher: Academic Press
Total Pages: 650
Release: 2019-08-27
ISBN: 0128197781
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book Excerpt:

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Nanoparticle Based Drug Delivery in Cancer Treatment

Nanoparticle Based Drug Delivery in Cancer Treatment
Author: Loutfy H. Madkour
Publsiher: CRC Press
Total Pages: 558
Release: 2022-03-03
ISBN: 100053216X
Category: Science
Language: EN, FR, DE, ES & NL

Nanoparticle Based Drug Delivery in Cancer Treatment Book Excerpt:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

Nanophytomedicine

Nanophytomedicine
Author: Sarwar Beg,Md Abul Barkat,Farhan Jalees Ahmad
Publsiher: Springer Nature
Total Pages: 218
Release: 2020-07-27
ISBN: 9811549095
Category: Medical
Language: EN, FR, DE, ES & NL

Nanophytomedicine Book Excerpt:

Nanophytomedicine is a field that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology. This book assesses the clinical successes and failures of nanophytomedicine and also highlights emerging concepts in this field. The content is divided into three sections, the first of which describes core issues in the pharmaceuticals industry in connection with the successes, failures and prospects of nanophytomedicine. The second section highlights recent advances in phytomedicine formulation development based on nanotechnology approaches, while also discussing a variety of nanocarrier systems for the successful delivery of phytomedicines. Focusing on the clinical perspective, the third section addresses the current clinical status of nanophytomedicine as a single drug therapy or combinatorial drug therapy, pharmacovigilance, pharmacokinetics, drug interactions and toxicological profiles, while also providing concluding remarks on recent experimental findings, and considering ethical issues & regulatory challenges in nanophytomedicine. Given its scope, the book offers a valuable guide for early career researchers, young scientists, master level students, academics and industrial scientists working in various healthcare fields, e.g. the pharmaceutical and biological sciences, life sciences, biotechnology, biomedical engineering, and nanobiotechnology.

Design and Development of New Nanocarriers

Design and Development of New Nanocarriers
Author: Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 766
Release: 2017-12-12
ISBN: 0128136286
Category: Science
Language: EN, FR, DE, ES & NL

Design and Development of New Nanocarriers Book Excerpt:

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Polymeric Micelles for Combination Drug Delivery in Cancer Therapy

Polymeric Micelles for Combination Drug Delivery in Cancer Therapy
Author: Anonim
Publsiher: Unknown
Total Pages: 188
Release: 2015
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Polymeric Micelles for Combination Drug Delivery in Cancer Therapy Book Excerpt:

Single small molecule drug therapy is often hindered by drug resistance that develops in cancer cells. Delivery of small interfering RNA (siRNA) to cells via drug delivery systems (DDS) is one effective approach to silence these resistance genes, often successfully re-sensitizing cancer cells to anticancer drugs. Polymeric nanoparticles have been widely explored to protect and deliver siRNA therapeutically. Combination delivery of siRNA and chemotherapeutic drugs is effective against different molecular targets and can increase the sensitization of cancer cells to chemotherapy, thereby overcoming drug resistance. A three layer (trilayer) polymeric micelle system based on the self-association of the triblock copolymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly([epsilon]-caprolactone) (PEG-b-PAsp(DET)-b-PCL) was synthesized to deliver rapamycin (RAP) and siRNA targeting Y-box binding protein-1 (siYB-1). The trilayer micelle is composed of (a) a hydrophilic poly(ethylene glycol) (PEG) block constituting the outer layer to improve pharmacokinetics, (b) an intermediate compartment composed of the cationic poly{2-[(2-aminoethyl)amino] ethyl aspartamide} (PAsp(DET)) segment for interacting with siYB-1, and (c) an inner hydrophobic poly([epsilon]-caprolactone) (PCL) compartment for encapsulation of RAP. PEG and PCL are both approved by the FDA, and PAsp(DET) is a non-toxic pH responsive cationic poly(amino acid)-based polymer. We showed that PCL can encapsulate RAP with high loading efficiencies, and PAsp(DET) interacts with siRNA for efficient transfection/knockdown with negligible cytotoxicity. Enhanced therapeutic efficacy of RAP/siYB-1 micelles was demonstrated in cell cultures and in a PC3 xenograft nude mouse model of human prostate cancer. We also developed a micelle formulation based on the self-association of PEG-b-PCL to deliver another anticancer drug, citral. Citral is found in the essential oils of many plants. Although it is composed of a random mixture of the two terpenoid isomers geranial (trans-citral) and neral (cis-citral), few studies have directly compared the in vivo antitumor properties of these isomers. The antitumor properties of drug formulations were evaluated on the 4T1 xenograft mouse model. Geranial was found to be the more potent isomer of citral and western blot of tumor tissues confirmed that autophagy and not apoptosis was the major mechanism of tumor growth inhibition in p53-null 4T1 cells.