Nanomedicine Manufacturing and Applications

Nanomedicine Manufacturing and Applications
Author: Francis Verpoort,Ikram Ahmad,Awais Ahmad,Anish Khan,Ching Yern Chee
Publsiher: Elsevier
Total Pages: 406
Release: 2021-06-22
ISBN: 0128209429
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Nanomedicine Manufacturing and Applications Book Excerpt:

Nanomedicine explores the modification and enhancement of the properties and performances of typical drugs to treat various diseases. Nano-based medicines have advantages in several ways, such as in nanotherapeutics, nanotheranostics, and nanodiagnostics. Nanomedicine Manufacturing and Applications effectively explores the major manufacturing techniques and applications of nanomaterial-based medicine in the areas of chemotherapy, biochips, insulin pumps, and other treatment methods. This book explains how nanomedicines are developed from nanoparticles as well as their biomedical and other applications related to healthcare. This book is an important reference source for nanoscientists, biomaterials scientists, and biomedical engineers who want to learn more about how nano-based medicines are made and used. Outlines the process of making nanomedicine as well as nanodrug carriers, with a focus on nanomedicine for cancer treatment. Explains the formulation and manufacturing process of nanomedicines, showing how to build these materials. Demonstrates how nano-based medicines are being used to tackle a range of diseases in a way that conventional medicines cannot.

Nanomedicine Manufacturing and Applications

Nanomedicine Manufacturing and Applications
Author: Francis Verpoort,Ikram Ahmad,Awais Ahmad,Anish Khan,Ching Yern Chee
Publsiher: Elsevier
Total Pages: 406
Release: 2021-06-23
ISBN: 0128207736
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Nanomedicine Manufacturing and Applications Book Excerpt:

Nanomedicine explores the modification and enhancement of the properties and performances of typical drugs to treat various diseases. Nano-based medicines have advantages in several ways, such as in nanotherapeutics, nanotheranostics, and nanodiagnostics. Nanomedicine Manufacturing and Applications effectively explores the major manufacturing techniques and applications of nanomaterial-based medicine in the areas of chemotherapy, biochips, insulin pumps, and other treatment methods. This book explains how nanomedicines are developed from nanoparticles as well as their biomedical and other applications related to healthcare. This book is an important reference source for nanoscientists, biomaterials scientists, and biomedical engineers who want to learn more about how nano-based medicines are made and used. Outlines the process of making nanomedicine as well as nanodrug carriers, with a focus on nanomedicine for cancer treatment. Explains the formulation and manufacturing process of nanomedicines, showing how to build these materials. Demonstrates how nano-based medicines are being used to tackle a range of diseases in a way that conventional medicines cannot.

Microfluidics for Pharmaceutical Applications

Microfluidics for Pharmaceutical Applications
Author: Helder A. Santos,Dongfei Liu,Hongbo Zhang
Publsiher: William Andrew
Total Pages: 495
Release: 2018-10-12
ISBN: 0128126604
Category: Science
Language: EN, FR, DE, ES & NL

Microfluidics for Pharmaceutical Applications Book Excerpt:

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness Includes a variety of case studies that explain principles Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

Theory and Applications of Nonparenteral Nanomedicines

Theory and Applications of Nonparenteral Nanomedicines
Author: Prashant Kesharwani,Sebastien Taurin,Khaled Greish
Publsiher: Academic Press
Total Pages: 540
Release: 2020-09-12
ISBN: 0128204672
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Theory and Applications of Nonparenteral Nanomedicines Book Excerpt:

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia

3D Printing Technology in Nanomedicine

3D Printing Technology in Nanomedicine
Author: Nabeel Ahmad,P. Gopinath,Rajiv Dutta
Publsiher: Elsevier
Total Pages: 202
Release: 2019-03-30
ISBN: 0128158913
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

3D Printing Technology in Nanomedicine Book Excerpt:

3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms Develops the concept of integrating different technologies along the hierarchical structure of biological systems

Design and Applications of Theranostic Nanomedicines

Design and Applications of Theranostic Nanomedicines
Author: Somasree Ray,Amit Kumar Nayak
Publsiher: Woodhead Publishing
Total Pages: 436
Release: 2022-09-10
ISBN: 0323885985
Category: Medical
Language: EN, FR, DE, ES & NL

Design and Applications of Theranostic Nanomedicines Book Excerpt:

Design and Applications of Theranostic Nanomedicines reviews the composition and design of various nanomedicines for theranostic applications, helping readers to make informed decisions when exploring novel treatments for disease. This book introduces readers to theranostic nanostructures as nanomedicines, beginning with a balanced look at the associated challenges, costs and benefits. The next section goes on to detail a range of different theranostic nanomedicines and their design, from nanodispersions and nanogels to exosomes and polymeric micelles. A variety of applications is covered, including in the treatment of pulmonary diseases, neurological disorders, cancers and more. The book also takes a look at the toxicological implications of nanotheranostics, an important aspect of any therapy or treatment. Design and Applications of Theranostic Nanomedicines provides a snapshot of the state-of-the-art, and will be of use to materials scientists, biomedical engineers and pharmaceutical scientists with an interest in nanotechnology and theranostics. Explores the challenges, costs, benefits and toxicological implications of nanotheranostics Reviews a range of nanomedicines and their design, including liposomes, nanohydrogels, nanocochleate and more Details a variety of applications, such as in drug delivery, neurological disorders, cardiovascular diseases and so on

Nanomedicine for Inflammatory Diseases

Nanomedicine for Inflammatory Diseases
Author: Lara Scheherazade Milane,Mansoor M. Amiji
Publsiher: CRC Press
Total Pages: 353
Release: 2017-09-19
ISBN: 1498749801
Category: Medical
Language: EN, FR, DE, ES & NL

Nanomedicine for Inflammatory Diseases Book Excerpt:

Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert – bridging the gap between the laboratory benchtop and the clinical bedside.

Nanopharmaceuticals Principles and Applications Vol 1

Nanopharmaceuticals  Principles and Applications Vol  1
Author: Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse
Publsiher: Springer Nature
Total Pages: 381
Release: 2020-07-14
ISBN: 3030449254
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Nanopharmaceuticals Principles and Applications Vol 1 Book Excerpt:

This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.

Computational Nanomedicine and Nanotechnology

Computational Nanomedicine and Nanotechnology
Author: Renat R. Letfullin,Thomas F. George
Publsiher: Springer
Total Pages: 682
Release: 2017-02-10
ISBN: 3319435779
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Computational Nanomedicine and Nanotechnology Book Excerpt:

This textbook, aimed at advanced undergraduate and graduate students, introduces the basic knowledge required for nanomedicine and nanotechnology, and emphasizes how the combined use of chemistry and light with nanoparticles can serve as treatments and therapies for cancer. This includes nanodevices, nanophototherapies, nanodrug design, and laser heating of nanoparticles and cell organelles. In addition, the book covers the emerging fields of nanophotonics and nanoplasmonics, which deal with nanoscale confinement of radiation and optical interactions on a scale much smaller than the wavelength of the light. The applications of nanophotonics and nanoplasmonics to biomedical research discussed in the book range from optical biosensing to photodynamic therapies.Cutting-edge and reflective of the multidisciplinary nature of nanomedicine, this book effectively combines knowledge and modeling from nanoscience, medicine, biotechnology, physics, optics, engineering, and pharmacy in an easily digestible format. Among the topics covered in-depth are:• The structure of cancer cells and their properties, as well as techniques for selective targeting of cancer and gene therapy.• Nanoplasmonics: Lorentz-Mie simulations of optical properties of nanoparticles and the use of plasmonic nanoparticles in diagnosis and therapy.• Nanophotonics: short and ultrashort laser pulse interactions with nanostructures, time and space simulations of thermal fields in and around the nanobioparticles, and nanoclusters heated by radiation.• Modeling of soft and hard biological tissue ablation by activated nanoparticles, as well as optical, thermal, kinetic, and dynamic modeling.• Detection techniques, including the design and methods of activation of nanodrugs and plasmon resonance detection techniques.• Design and fabrication of nanorobots and nanoparticles.• Effective implementation of nanotherapy treatments.• Nanoheat transfer, particularly the heating and cooling kinetics of nanoparticles.• ...and more!Each chapter contains a set of lectures in the form of text for student readers and PowerPoints for use by instructors, as well as homework exercises. Selected chapters also contain computer practicums, including Maple codes and worked-out examples. This book helps readers become more knowledgeable and versant in nanomedicine and nanotechnology, inspires readers to work creatively and go beyond the ideas and topics presented within, and is sufficiently comprehensive to be of value to research scientists as well as students.

Handbook of Clinical Nanomedicine

Handbook of Clinical Nanomedicine
Author: Raj Bawa,Gerald F. Audette,Brian Reese
Publsiher: CRC Press
Total Pages: 1502
Release: 2016-04-27
ISBN: 9814669237
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Clinical Nanomedicine Book Excerpt:

This unique handbook (60 chapters) examines the entire "product life cycle," from the creation of nanomedical products to their final market introduction. While focusing on critical issues relevant to nanoproduct development and translational activities, it tackles topics such as regulatory science, patent law, FDA law, ethics, personalized medicine, risk analysis, toxicology, nano-characterization and commercialization activities. A separate section provides fascinating perspectives and editorials from leading experts in this complex interdisciplinary field.

Advances and Challenges in Nanomedicine

Advances and Challenges in Nanomedicine
Author: Susan Hua,Sherry Y. Wu
Publsiher: Frontiers Media SA
Total Pages: 155
Release: 2019-02-28
ISBN: 2889457451
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Advances and Challenges in Nanomedicine Book Excerpt:

Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. Nanomedicines have demonstrated significant therapeutic advantages for a multitude of biomedical applications, however the clinical translation of these nanotechnology platforms has not progressed as quickly as the plethora of positive results would have suggested. Understanding the advances in nanomedicine to date and the challenges that still need to be overcome, will allow future research to improve on existing platforms and to address the current translational and regulatory limitations. This eBook “Advances and Challenges in Nanomedicine” has brought together experts in the fields of nanomedicine, nanotechnology, nanotoxicology, pharmaceutics, manufacturing, and translation to discuss the application of nanotechnology to drug delivery. This information is presented as original research, opinion, perspective, and review articles. The goal of this eBook is to generate collaborative discussion on the current status, general trends, challenges, strategies, and future direction of pharmaceutical nanotechnology, as well as highlight current and emerging nanoparticulate platforms with potential medical applications.

The Road from Nanomedicine to Precision Medicine

The Road from Nanomedicine to Precision Medicine
Author: Shaker A. Mousa,Raj Bawa,Gerald F. Audette
Publsiher: CRC Press
Total Pages: 669
Release: 2020-01-17
ISBN: 1000021270
Category: Medical
Language: EN, FR, DE, ES & NL

The Road from Nanomedicine to Precision Medicine Book Excerpt:

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Nanomanufacturing and Nanomaterials Design

Nanomanufacturing and Nanomaterials Design
Author: Subhash Singh,Sanjay K. Behura,Ashwani Kumar,Kartikey Verma
Publsiher: CRC Press
Total Pages: 293
Release: 2022-12-12
ISBN: 1000804208
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Nanomanufacturing and Nanomaterials Design Book Excerpt:

Nanomanufacturing includes bottom-up or top-down techniques, each of which gives an advanced, reliable, scaled-up, and economical methods in the production of nanomaterials. The text discusses fundamental concepts, advanced topics, and applications of nanomanufacturing in a comprehensive manner. Features Discussion of the design and fabrication of nano- and micro-devices in a comprehensive manner. Covers nanofabrication techniques for photovoltaics applications. Lists constitutive modelling and simulation of multifunctional nanomaterials. Introduces nanomanufacturing of nanorobots and their industrial applications. Presents nanomanufacturing of a high-performance piezoelectric nanogenerator for energy harvesting. Important topics include nanomanufacturing of high-performance piezoelectric nanogenerators for energy harvesting, nanosensor, nanorobots, nanomedicine, nano diagnostic tools, 3D nano printing, additive nanomanufacturing of functional materials for human‐integrated smart wearables, and nanofabrication techniques. Nanomanufacturing and Nanomaterials Design covers the latest applications of nanomanufacturing for a better understanding of the concepts. The text provides scientific and technological insights on novel routes of design and fabrication of few-layered nanostructures and their heterostructures based on a variety of advanced materials. It will be a valuable resource for senior undergraduate, graduate students and researchers in the fields of mechanical, manufacturing, industrial, production engineering and materials science.

Nanomedicine

Nanomedicine
Author: Yi Ge,Songjun Li,Shenqi Wang,Richard Moore
Publsiher: Springer
Total Pages: 413
Release: 2014-12-01
ISBN: 1461421403
Category: Science
Language: EN, FR, DE, ES & NL

Nanomedicine Book Excerpt:

Increasing demand for and awareness of the applications of nanotechnology in medicine has resulted in the emergence of a new fast-growing multidisciplinary area - nanomedicine. This book offers comprehensive knowledge of and diverse perspectives on nanomedicine through two independent volumes. It aims to bridge the gap between nanotechnology and medicine through contributions by world-renowned experts from wide range of backgrounds including academia, industry, professional consultancy, and government agencies. Each contribution integrates knowledge from a wide range of areas to present the fundamentals of new applications and products of nanomedicine, as well as an outlook for the future. This book can well serve as a reference and guide for students, academics, researchers, scientists, engineers, clinicians, government researchers, and healthcare professionals.

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications
Author: Krishnan Anand,Muthupandian Saravanan,Balakumar Chandrasekaran,Suvardhan Kanchi,Sarojini Jeeva Panchu,Quan-Sheng Chen
Publsiher: Elsevier
Total Pages: 610
Release: 2021-03-18
ISBN: 0128219149
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications Book Excerpt:

Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics

Understanding Nanomedicine

Understanding Nanomedicine
Author: Rob Burgess
Publsiher: CRC Press
Total Pages: 524
Release: 2012-06-18
ISBN: 9814303526
Category: Medical
Language: EN, FR, DE, ES & NL

Understanding Nanomedicine Book Excerpt:

This book comprehensively covers a broad range of therapeutic and diagnostic applications of nanotechnology, providing descriptions of cutting-edge discoveries along with historical perspectives. The text focuses on nanomaterials and nanoparticles, the sectors that hold the most promise for the future of medicine. The author look at how nanotechnology can impact cancer treatment, clinical neuroscience, tissue engineering, drug delivery, and diagnostics. He also discusses the worldwide governmental regulatory impact on nanomedicine.

Applications of Minimally Invasive Nanomedicine Based Therapies in 3D in vitro Cancer Platforms

Applications of Minimally Invasive Nanomedicine Based Therapies in 3D in vitro Cancer Platforms
Author: Layla Mohammad-Hadi,Marym Mohammad-Hadi
Publsiher: Springer Nature
Total Pages: 93
Release: 2022-05-31
ISBN: 3031023889
Category: Science
Language: EN, FR, DE, ES & NL

Applications of Minimally Invasive Nanomedicine Based Therapies in 3D in vitro Cancer Platforms Book Excerpt:

Minimally invasive techniques such as Photodynamic Therapy (PDT) and Photochemical Internalisation (PCI) have for years been under investigation for the treatment of solid cancers. A significant number of the recent research studies have applied PDT and PCI to biological three-dimensional (3D) cancer platforms with many of the studies also involving the use of nanoparticles in order to enhance the efficacy of these light-based therapies. Interest in the employment of 3D cancer platforms has increased considerably due to the ability of the platforms to mimic in vivo models better than the conventional two-dimensional (2D) cultures. Some of the advantages of the 3D cancer systems over their 2D counterparts include improved interaction between cancer cells and the surrounding extracellular matrix (ECM) as well as restricted drug penetration which would allow optimization of treatments prior to undertaking of in vivo studies. The different chapters of this book will discuss photosensitizers and nanoparticles used in PDT and PCI in addition to the applications of these treatments in various 3D cancer models.

Fundamentals of Nanomedicine

Fundamentals of Nanomedicine
Author: James F. Leary
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2022-03-31
ISBN: 1009258311
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Fundamentals of Nanomedicine Book Excerpt:

The first introductory book on the subject, this book will provide a complete grounding to this pioneering field for students and professionals across biomedical engineering, biology and medicine. It features a comprehensive overview of original work in this revolutionary field. Topics discussed include drug delivery, cell-material interaction and gene therapy, accompanied by real-world examples and over 100 illustrations. The book teaches readers how to design and test their own nanomedical systems for real-world applications in biomedical engineering, medicine and pharmacy. Presenting a thorough discussion of the science and engineering of nanomedicine, it discusses vital environmental, social and ethical impacts of this revolutionary technology. Including over 200 thought-provoking study questions, allowing the reader to self-assess their understanding, this book is a rich source of information that will be of interest and importance in nanomedicine.

Nanotoxicology

Nanotoxicology
Author: Nancy A. Monteiro-Riviere,C. Lang Tran
Publsiher: CRC Press
Total Pages: 516
Release: 2014-03-03
ISBN: 1482203871
Category: Medical
Language: EN, FR, DE, ES & NL

Nanotoxicology Book Excerpt:

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines. Topics include The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products—with a focus on potential health and safety implications Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels Toxicity of nanomaterials to specific organ systems, cell–based targeting to tumors, and other biomedical applications The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies A roadmap for future research The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Polymer Nanoparticles for Nanomedicines

Polymer Nanoparticles for Nanomedicines
Author: Christine Vauthier,Gilles Ponchel
Publsiher: Springer
Total Pages: 641
Release: 2018-07-12
ISBN: 9783319823492
Category: Medical
Language: EN, FR, DE, ES & NL

Polymer Nanoparticles for Nanomedicines Book Excerpt:

This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.