The Neurobiology of Disease

The Neurobiology of Disease
Author: Hugh Bostock,P. A. Kirkwood,A. H. Pullen
Publsiher: Cambridge University Press
Total Pages: 443
Release: 1996-04-18
ISBN: 9780521451321
Category: Medical
Language: EN, FR, DE, ES & NL

The Neurobiology of Disease Book Excerpt:

Combining the knowledge of distinguished clinicians and scientists, this valuable reference seeks to inspire further understanding of neurological disease.

Neurobiology of Disease

Neurobiology of Disease
Author: Anonim
Publsiher: Elsevier
Total Pages: 1104
Release: 2011-09-06
ISBN: 9780080466385
Category: Science
Language: EN, FR, DE, ES & NL

Neurobiology of Disease Book Excerpt:

Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. Provides cutting edge information about fundamental mechanisms underlying neurological diseases Amply supplied with tables, illustrations and references Includes supporting clinical information putting the mechanisms of disease into perspective

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
Author: Michael J. Zigmond,Clayton A. Wiley,Marie-Francoise Chesselet
Publsiher: Academic Press
Total Pages: 1134
Release: 2022-05-27
ISBN: 0323898254
Category: Science
Language: EN, FR, DE, ES & NL

Neurobiology of Brain Disorders Book Excerpt:

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions

Functional Neurobiology of Aging

Functional Neurobiology of Aging
Author: Patrick R. Hof,Charles V. Mobbs
Publsiher: Academic Press
Total Pages: 960
Release: 2001-01-11
ISBN: 9780080525587
Category: Science
Language: EN, FR, DE, ES & NL

Functional Neurobiology of Aging Book Excerpt:

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Neurobiology of Alzheimer s Disease

Neurobiology of Alzheimer s Disease
Author: David Dawbarn,Shelley J. Allen
Publsiher: Oxford University Press, USA
Total Pages: 468
Release: 2007
ISBN: 9780198566618
Category: Medical
Language: EN, FR, DE, ES & NL

Neurobiology of Alzheimer s Disease Book Excerpt:

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Cingulate Neurobiology and Disease

Cingulate Neurobiology and Disease
Author: Brent Vogt
Publsiher: Oxford University Press
Total Pages: 829
Release: 2009-06-04
ISBN: 0198566964
Category: Medical
Language: EN, FR, DE, ES & NL

Cingulate Neurobiology and Disease Book Excerpt:

One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: M. Flint Beal,Anthony E. Lang,Albert C. Ludolph
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2005-06-02
ISBN: 1139443453
Category: Medical
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Excerpt:

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Metal Related Neurodegenerative Disease

Metal Related Neurodegenerative Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 434
Release: 2013-11-07
ISBN: 0124105351
Category: Medical
Language: EN, FR, DE, ES & NL

Metal Related Neurodegenerative Disease Book Excerpt:

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease
Author: Hoa Huu Phuc Nguyen,M. Angela Cenci
Publsiher: Springer
Total Pages: 397
Release: 2015-05-23
ISBN: 366246344X
Category: Medical
Language: EN, FR, DE, ES & NL

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease Book Excerpt:

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Molecular Neurobiology of Alzheimer Disease and Related Disorders

Molecular Neurobiology of Alzheimer Disease and Related Disorders
Author: Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 297
Release: 2004
ISBN: 380557603X
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular Neurobiology of Alzheimer Disease and Related Disorders Book Excerpt:

Alzheimers disease affects 6-10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss. The articles in this book were selected from contributions presented by leading scientists in this field at the international symposium which took place in Osaka in 2002. This publication is essential reading for all researchers, clinicians, basic and social scientists, neurologists and psychiatrists to promote the understanding of this formidable disease.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: M. Flint Beal,Anthony E. Lang,Albert C. Ludolph
Publsiher: Cambridge University Press
Total Pages: 1008
Release: 2005-06-02
ISBN: 9780521811668
Category: Medical
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Excerpt:

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease
Author: Donald C. Lo,Robert E. Hughes
Publsiher: CRC Press
Total Pages: 338
Release: 2010-07-02
ISBN: 1420008250
Category: Science
Language: EN, FR, DE, ES & NL

Neurobiology of Huntington s Disease Book Excerpt:

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Clinical Neuropsychology and Cognitive Neurology of Parkinson s Disease and Other Movement Disorders

Clinical Neuropsychology and Cognitive Neurology of Parkinson s Disease and Other Movement Disorders
Author: Alexander I. Troster
Publsiher: Oxford University Press
Total Pages: 560
Release: 2014-10-09
ISBN: 0199812381
Category: Psychology
Language: EN, FR, DE, ES & NL

Clinical Neuropsychology and Cognitive Neurology of Parkinson s Disease and Other Movement Disorders Book Excerpt:

The book provides an up-to-date account of the neuropsychological, cognitive-neurological, and neuropsychiatric aspects of movement disorders. The past ten years have seen an explosion of research covering non-motor aspects of Parkinson's disease and, more recently, movement disorders such as essential tremor, dystonia, corticobasal syndrome, progressive supranuclear palsy, and multiple system atrophy. It is often these neurobehavioral features that become troubling to the patient: they are sometimes difficult to recognize and treat, are associated with diminished patient and caregiver quality of life, and may hasten disease progression, loss of independence, and institutionalization. This book discusses the most recent diagnostic and treatment guidelines for such cognitive and psychiatric conditions in Parkinson's disease and other movement disorders, while providing practical tips and strategies for general assessment. The rapid accumulation of research in this field makes it increasingly difficult for one or two people to author a comprehensive text in an expert manner. The world-class team assembled for this volume succeeds in covering widely diverse areas such as the pathology, neuroimaging, assessment, and treatment of an ever-growing set of neurobehavioral features of movement disorders -- cognitive impairment and dementia, depression, apathy, anxiety, psychosis, and impulse control disorders. The text also surveys fundamental knowledge about basal ganglia function and dysfunction, assessment and evaluation techniques applicable to a range of movement disorders, and quality of life issues more broadly.

Drug Discovery and Development for Alzheimer s Disease 2000

Drug Discovery and Development for Alzheimer s Disease  2000
Author: Howard M. Fillit, MD,Alan W. O'Connell, PhD
Publsiher: Springer Publishing Company
Total Pages: 296
Release: 2002-01-03
ISBN: 9780826115348
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Discovery and Development for Alzheimer s Disease 2000 Book Excerpt:

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Philip Beart,Michael Robinson,Marcus Rattray,Nicholas J. Maragakis
Publsiher: Springer
Total Pages: 542
Release: 2017-07-03
ISBN: 3319571931
Category: Medical
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Excerpt:

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology
Author: Moussa B.H. Youdim,Abel Lajtha,Peter Riederer,Leontino Battistin,Sylvia A. Mandel
Publsiher: Springer Science & Business Media
Total Pages: 432
Release: 2007-12-14
ISBN: 0387303448
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Neurochemistry and Molecular Neurobiology Book Excerpt:

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome
Author: Elizabeth Head,Ira Lott
Publsiher: Academic Press
Total Pages: 352
Release: 2021-08-31
ISBN: 0128188464
Category: Medical
Language: EN, FR, DE, ES & NL

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome Book Excerpt:

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Diseases of the Nervous System

Diseases of the Nervous System
Author: Arthur K. Asbury,Guy M. McKhann,W. Ian McDonald
Publsiher: Unknown
Total Pages: 1653
Release: 1986
ISBN: 9780721621470
Category: Nervous system
Language: EN, FR, DE, ES & NL

Diseases of the Nervous System Book Excerpt:

Huntington s Disease New Insights for the Healthcare Professional 2013 Edition

Huntington s Disease  New Insights for the Healthcare Professional  2013 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 179
Release: 2013-07-22
ISBN: 1481653210
Category: Medical
Language: EN, FR, DE, ES & NL

Huntington s Disease New Insights for the Healthcare Professional 2013 Edition Book Excerpt:

Huntington’s Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Huntington’s Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Huntington’s Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Balance Dysfunction in Parkinson s Disease

Balance Dysfunction in Parkinson   s Disease
Author: Martina Mancini,John G. Nutt,Fay B. Horak
Publsiher: Academic Press
Total Pages: 226
Release: 2019-09-14
ISBN: 0128138750
Category: Medical
Language: EN, FR, DE, ES & NL

Balance Dysfunction in Parkinson s Disease Book Excerpt:

Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control