NK Myeloid Cell Interactions in the Tumor Microenvironment Implications for Cancer Immunotherapy

NK Myeloid Cell Interactions in the Tumor Microenvironment  Implications for Cancer Immunotherapy
Author: Erik Wennerberg,Andreas Lundqvist,Yumeng Mao,Dimitrios Mougiakakos
Publsiher: Frontiers Media SA
Total Pages: 144
Release: 2021-09-08
ISBN: 2889712710
Category: Medical
Language: EN, FR, DE, ES & NL

NK Myeloid Cell Interactions in the Tumor Microenvironment Implications for Cancer Immunotherapy Book Excerpt:

Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
Author: Benjamin Bonavida,Anahid Jewett
Publsiher: Academic Press
Total Pages: 538
Release: 2021-06-23
ISBN: 0128243961
Category: Science
Language: EN, FR, DE, ES & NL

Successes and Challenges of NK Immunotherapy Book Excerpt:

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

NK Cells in Cancer Immunotherapy Successes and Challenges

NK Cells in Cancer Immunotherapy  Successes and Challenges
Author: Anahid Jewett,Yuman Fong
Publsiher: Academic Press
Total Pages: 496
Release: 2022-12-15
ISBN: 0128226269
Category: Science
Language: EN, FR, DE, ES & NL

NK Cells in Cancer Immunotherapy Successes and Challenges Book Excerpt:

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia
Author: Eva Lion,Evelien Smits,Viggo Van Tendeloo
Publsiher: LAP Lambert Academic Publishing
Total Pages: 260
Release: 2012-07
ISBN: 9783659156717
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Added Value of Natural Killer Cells in Immunotherapy for Leukemia Book Excerpt:

The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Both innate and adaptive immune responses can contribute to the elimination of tumor cells, with natural killer (NK) cells and T lymphocytes as pivotal players, respectively. Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system, bridging innate and adaptive immune responses through interaction with NK cells and presenting tumor-associated antigens to T cells. A major hurdle in anti-tumor immunity, however, is the low immunogenicity and immunosuppressive character of tumor cells resulting in an immunotolerant environment. Here, the primary scope was to increase the immunogenicity of leukemic cells by introducing a danger signal to break immune tolerance. We clearly demonstrate that transfection of leukemic cells with the synthetic double-stranded RNA agonist poly(I: C) provides a way to overcome immune evasion, evidenced by their enhanced capacity to activate both NK cells and DC. We draw particular attention to the significance of NK cells, advocating for reinforcement of both cytotoxic and regulatory NK cell functions in cancer immunotherapy

Natural Killer Cells

Natural Killer Cells
Author: Mourad Aribi
Publsiher: BoD – Books on Demand
Total Pages: 210
Release: 2017-12-13
ISBN: 9535136712
Category: Medical
Language: EN, FR, DE, ES & NL

Natural Killer Cells Book Excerpt:

The book Natural Killer Cells is the result of a collective work that addresses in a clear and comprehensive way for readers and through as many sensuous details as possible, the most and various fundamental aspects of natural killer cells, as well as their clinical applications in cancer immunotherapy. This book will serve as an invaluable resource and pedagogical support for clinicians, researchers, basic scientists, immunology and immunopathology lecturers, as well as for students in biology and medicine, especially the ones with an advanced understanding of immunology.

Immunotherapy in Translational Cancer Research

Immunotherapy in Translational Cancer Research
Author: Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publsiher: John Wiley & Sons
Total Pages: 312
Release: 2018-02-08
ISBN: 1118684508
Category: Medical
Language: EN, FR, DE, ES & NL

Immunotherapy in Translational Cancer Research Book Excerpt:

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Cancer Immunotherapy and Biological Cancer Treatments

Cancer Immunotherapy and Biological Cancer Treatments
Author: Hilal Arnouk
Publsiher: BoD – Books on Demand
Total Pages: 114
Release: 2019-11-13
ISBN: 1789848628
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy and Biological Cancer Treatments Book Excerpt:

In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.

Emerging Engineering Approaches in Cancer Immunotherapy

Emerging Engineering Approaches in Cancer Immunotherapy
Author: Xin Ming,Yuanzeng Min,Chao Wang,Yueyin Pan
Publsiher: Frontiers Media SA
Total Pages: 205
Release: 2022-10-06
ISBN: 2832501605
Category: Medical
Language: EN, FR, DE, ES & NL

Emerging Engineering Approaches in Cancer Immunotherapy Book Excerpt:

Natural Killer Cells

Natural Killer Cells
Author: Jacques Zimmer
Publsiher: Springer
Total Pages: 428
Release: 2014-11-27
ISBN: 9783642426339
Category: Medical
Language: EN, FR, DE, ES & NL

Natural Killer Cells Book Excerpt:

Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.

Interaction of Immune and Cancer Cells

Interaction of Immune and Cancer Cells
Author: Magdalena Klink,Izabela Szulc-Kielbik
Publsiher: Springer Nature
Total Pages: 358
Release: 2022
ISBN: 3030913112
Category: Cancer
Language: EN, FR, DE, ES & NL

Interaction of Immune and Cancer Cells Book Excerpt:

Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Immunotherapy of Cancer

Immunotherapy of Cancer
Author: Yoshiyuki Yamaguchi
Publsiher: Springer
Total Pages: 358
Release: 2016-02-22
ISBN: 4431550313
Category: Medical
Language: EN, FR, DE, ES & NL

Immunotherapy of Cancer Book Excerpt:

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Tumor Immunology and Cancer Therapy

Tumor Immunology and Cancer Therapy
Author: R. H. Goldfarb
Publsiher: CRC Press
Total Pages: 346
Release: 1993-12-14
ISBN: 9780824791797
Category: Medical
Language: EN, FR, DE, ES & NL

Tumor Immunology and Cancer Therapy Book Excerpt:

Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.

Engineered Targeted Cancer Immunotherapies

Engineered Targeted Cancer Immunotherapies
Author: Massimo Fantini,Roberto Bei
Publsiher: Frontiers Media SA
Total Pages: 285
Release: 2022-08-01
ISBN: 2889766691
Category: Medical
Language: EN, FR, DE, ES & NL

Engineered Targeted Cancer Immunotherapies Book Excerpt:

Cancer Immunotherapies From Efficacy to Resistance Mechanisms

Cancer Immunotherapies  From Efficacy to Resistance Mechanisms
Author: Morten Hansen,Janin Chandra,Fernando Guimaraes,Nicolas Jacquelot,Yoshinobu Koguchi,Nathalie Labarriere,Ilaria Marigo,Lazar Vujanovic
Publsiher: Frontiers Media SA
Total Pages: 470
Release: 2022-06-29
ISBN: 2889764419
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunotherapies From Efficacy to Resistance Mechanisms Book Excerpt:

Dr. Koguchi receives funding from Tesaro, a GSK company, Bristol-Myers Squibb, and Shimadzu Corporation.. Dr. Vujanovic is a co-inventor of a methodology licensed to INmune Bio, Inc. where a selective inhibitor of soluble TNF can be used to prevent or treat malignancies. Dr. Hansen is the recipient of a private grant from Eurostars Eureka. The other Topic Editors declare no competing interests.

Cancer Immunotherapy Principles and Practice

Cancer Immunotherapy Principles and Practice
Author: Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publsiher: Springer Publishing Company
Total Pages: 920
Release: 2017-06-28
ISBN: 1617052736
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy Principles and Practice Book Excerpt:

Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. Key Features: Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book

Immunotherapy of Cancer

Immunotherapy of Cancer
Author: Mary L. Disis
Publsiher: Springer Science & Business Media
Total Pages: 517
Release: 2005-12-15
ISBN: 1588295648
Category: Medical
Language: EN, FR, DE, ES & NL

Immunotherapy of Cancer Book Excerpt:

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

HIV and Cancer Immunotherapy Similar Challenges and Converging Approaches

HIV and Cancer Immunotherapy  Similar Challenges and Converging Approaches
Author: Mirko Paiardini,Rafi Ahmed,Steven Grant Deeks,Kavita M. Dhodapkar
Publsiher: Frontiers Media SA
Total Pages: 157
Release: 2020-05-15
ISBN: 2889637166
Category: Electronic Book
Language: EN, FR, DE, ES & NL

HIV and Cancer Immunotherapy Similar Challenges and Converging Approaches Book Excerpt:

Cancer Immunology

Cancer Immunology
Author: Nima Rezaei
Publsiher: Springer Nature
Total Pages: 658
Release: 2020-09-24
ISBN: 3030502872
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunology Book Excerpt:

This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.

Cancer Immunotherapy

Cancer Immunotherapy
Author: Tyler J. Curiel
Publsiher: Springer Science & Business Media
Total Pages: 486
Release: 2012-11-07
ISBN: 1461447321
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy Book Excerpt:

This work will provide a historical perspective on tumor immunotherapy, discuss fundamental mechanisms of failed tumor rejection, look at passive strategies to boost anti-tumor immunity, as well as have an in-depth look at active strategies to boost anti-tumor immunity.

Tumor Immunology and Immunotherapy

Tumor Immunology and Immunotherapy
Author: Robert C. Rees
Publsiher: Oxford University Press, USA
Total Pages: 469
Release: 2014
ISBN: 0199676860
Category: Medical
Language: EN, FR, DE, ES & NL

Tumor Immunology and Immunotherapy Book Excerpt:

A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.